Beckman Coulter UniCel DxC 600, Instructions For Use Manual

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System Description
Theory of Operation
1
Theory of Operation
Introduction
The UniCel DxC Synchron Clinical Systems are microprocessor-controlled, random access clinical
analyzers capable of processing a wide variety of operator-selected chemistries in a single run.
Cartridge Chemistries (CC)
The optical system of the DxC enables rate, endpoint, and nonlinear analyses to be performed
simultaneously. These analyses are referred to as cartridge chemistries because the reagents are
stored in cartridges.
Cartridge Chemistry (CC): Sample and Reagent Processing
During operation, a number of events occur simultaneously and are under direct control of the
instrument microprocessors.
Cartridge Chemistry: Calibration Theory
Introduction
Calibration determines the relationship between measured reaction responses and known
concentrations. Calibration factors are derived from this relationship. These factors are used to
convert the measured reaction responses to final concentration results.
Calibrated chemistries include endpoint and first-order rate chemistries, drugs, DATs, and specific
proteins. Zero-order rate chemistries include enzymes, which are precalibrated and require no
routine calibration. Enzyme verification can be performed on some of the enzymes to conform to
International Federation of Clinical Chemistry (IFCC) guidelines at +37°C.