Beckman Coulter Multisizer 4, User Manual

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Introduction
About the Multisizer 4
The Beckman Coulter Multisizer™ 4 is a flexible, multi-channel analyzer employing the industry
standard Electrical Sensing Zone (ESZ) method, together with state-of-the-art Digital Pulse
Processing (DPP) technology to provide both particle sizing and counting within an overall size
range of 0.4 µm to 1600 µm. Data is acquired and processed using proprietary Digital Signal
Processing (DSP) circuitry and may be archived, displayed, and re-analyzed on any PC equipped
with a Pentium® II or similar microprocessor running Beckman Coulter’s Multisizer™ 4 software on
Microsoft Windows® operating system versions NT 4.0, 2000, or XP.
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Figure 1 Multisizer 4 Analyzer
How the Multisizer 4 Works
The Multisizer 4 uses a unique, mercury-free “isolated piston” system to draw suspensions through
the aperture at a steady rate and to meter these liquid volumes precisely enough to measure
accurate particle concentrations. The instrument is also equipped with a continuous flow
alternative for applications where accuracy of liquid metering is less important or less critical, as
well as options that allow the user to define analysis parameters based on elapsed time or particle
count.
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