Spectra Optia Apheresis System Operator’s Manual
95
Therapeutic Plasma Exchange (TPE) Procedures
7
Optimizing the Run
Prediction for Removing a Substance From the Patient’s Plasma
Table 7-3 shows how the number of plasma volumes exchanged correlates to the removal of a hypothetical
substance from the patient’s plasma. The percentage that is removed is based on the assumption that there is no
equilibration with the extravascular compartment and that the patient’s plasma volume remains constant during the
procedure. Consider using this guideline to help you determine your procedure goals.
Handling Turbulence or Platelet Swirling in the Connector
If extreme turbulence or platelet swirling persists for more than 10 seconds, the system begins using the entered
hematocrit to calculate the plasma pump flow rate, and the algorithm control icon ( ) appears on the main run
screen in place of the interface image. Consider the following options when this condition occurs:
•
Take no action. The AIM system automatically resumes control of the interface position after the position
stabilizes.
•
Decrease the inlet pump flow rate to help reduce the turbulence. It could be necessary to decrease the flow rate
to 62 mL/min or less to achieve the optimal packing factor of 20.0.
Table 7-3:
Plasma exchange efficiency of a TPE procedure
Plasma Volumes Exchanged
Percentage Removed
0.5
39
1.0
63
1.5
78
2.0
86
2.5
92
3.0
95
Source:
George W. Buffaloe, et al., “Technical Considerations,”
Therapeutic Plasma Exchange Disease Compendium
, 1983,
Dau P (ed.).
SpectraOptiaOpsManual.book Page 95 Thursday, May 17, 2018 11:24 AM
