Therapeutic Plasma Exchange (TPE) Procedures
84
Spectra Optia Apheresis System Operator’s Manual
Functional Description of a Therapeutic Plasma Exchange (TPE)
Procedure
During a TPE procedure, the system pumps the patient's blood into the tubing set and spins the centrifuge at the
speed required to target the optimal (default) packing factor of 20. The AIM system monitors the interface
position and adjusts the flow rate of the plasma pump to maintain the optimal interface position to remove the
plasma. When the AIM system determines that the buffy coat has reached a specific thickness in the connector, or
when an inlet volume equal to 0.25 of the patient's TBV has been processed, the system slows the plasma pump
and flushes the buffy coat through the RBC port and into the reservoir. The replace pump pumps replacement
fluid into the reservoir, where it combines with the RBC and the other cellular components for return to the
patient. The system manages the volume of plasma that is removed and fluid that is replaced according to the fluid
balance the operator selects.
TPE Procedures Using a Single Needle
During a TPE procedure using a single needle, the system performs therapeutic plasma exchange using a single
patient access. The run consists of two phases. During the first phase, the system pumps the patient’s blood into
the tubing set, separates and removes the plasma, and pumps replacement fluid and the RBC and the other cellular
components from the channel into the reservoir. When the high-level reservoir sensor detects fluid, indicating that
the reservoir is full, the first phase stops and the second phase begins. During the second phase, the system returns
the contents of the reservoir to the patient. When the low-level reservoir sensor no longer detects fluid, indicating
the reservoir is empty, the second phase stops and the first phase restarts. The system repeats this cycle until the run
ends.
Preparing to Perform a Procedure
Supplies
Assemble the supplies listed on page 62 before you begin a procedure. You will also need the following additional
supplies:
•
Replacement fluid prescribed by the patient’s physician
•
Spectra Optia
®
Single-Needle Connector, if performing a TPE procedure using a single needle
Optional supplies:
•
Filters for the replacement fluid
Selecting the Procedure and Loading the Tubing Set
Follow the instructions starting on page 64 to select the procedure and load the tubing set. Before you load the
tubing set, verify that the set and the solutions you are using have not expired by checking the expiration date
printed on the packaging. Do not use an item if the current date is past the expiration date.
SpectraOptiaOpsManual.book Page 84 Thursday, May 17, 2018 11:24 AM
