Waters Xevo G2 QTof, Operator'S, Overview And Maintenance Manual, Page: 27 / 248

NanoLockSpray source and ionization modes 1-9
Combined electrospray and atmospheric pressure chemical
ionization (ESCi)
In combined electrospray and atmospheric pressure chemical ionization
(ESCi
©
) mode, the standard ESI probe is used in conjunction with a corona
pin, to allow alternating acquisition of ESI and APCI ionization data,
facilitating high-throughput processing and wider compound coverage.
NanoLockSpray source and ionization modes
The NanoLockSpray source allows electrospray ionization performed in the
flow rate range of 5 to 1000 nL/min. For a given sample concentration, the ion
currents for similar experiments approximate those in normal flow rate
electrospray. However, because sample consumption is greatly reduced, the
sensitivity gains are significant when similar scan parameters are used.
Lock-mass correction with the NanoLockSpray source works as the LockSpray
source does in electrospray ionization mode.
The NanoLockSpray source enclosure consists of a sprayer—universal,
borosilicate glass capillary, or CE (see below)—mounted on a ZSpray,
three-axis manipulator.
A light within the source provides illumination for the spray, which you can
observe using the video camera mounted on the corner of the source housing.
See
Chapter 4 “Configuring the NanoLockSpray Source” .