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ThermoFisher Scientific thermo scientific imPULSE S.U.M., User Manual

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ThermoFisher Scientific thermo scientific imPULSE S.U.M. User Manual Download Page 178

Thermo Scientific

imPULSE S.U.M. with Touchscreen Console User’s Guide 

  |  

 173

Chapter 8

  

 | 

  Specifications and parts information

Will pneumatic 

pinch valves be 

used on the 

S.U.M. and 

controlled by the 

Touchscreen 

Console?

No

Yes

Choose 

the pinch 

valve 

location

Harvest

Feed/fill

Both

Figure 8.27. Pinch valve options.

Summary of Contents for thermo scientific imPULSE S.U.M.

Page 1: ...imPULSE S U M with Touchscreen Console User s Guide DOC0099 Revision A October 2020...

Page 2: ...es 14 Chapter 2 Hardware installation 15 2 1 Site preparation 16 2 1 1 Electrical connections 16 2 1 2 Hardware preparation 16 2 1 3 Recommended tools and resources 16 2 2 Installation instructions 17...

Page 3: ...13 Configuring the Liquid Pressure module 87 3 4 14 Configuring the Auxiliary Output module 92 3 4 15 Configuring the Auxiliary Input module 94 Chapter 4 Calibration procedures 99 4 1 Calibrating pum...

Page 4: ...ts prior to liquid fill 127 6 3 Filling the imPULSE S U M 127 6 4 Controlling agitation 129 6 5 Using the timer 130 6 6 Monitoring and controlling functions 130 6 6 1 Mixing 130 6 6 2 Adjusting pH and...

Page 5: ...rmation 144 8 1 Hardware features 145 8 2 Hardware specifications 145 8 3 Touchscreen Console specifications 162 8 4 BPC specifications 163 8 5 Parts and accessories ordering information 165 8 6 Confi...

Page 6: ...this guide if you encounter the warning symbol see left displayed on the unit The user s guide will assist in determining the nature of the hazard and any necessary precautions for avoiding exposure W...

Page 7: ...g is in place and properly functioning It is the responsibility of the end user to assess this equipment and ensure that equipment and safeguards are in good working condition and that all operators a...

Page 8: ...Do not exceed 5 psi 0 34 bar inlet pressure Assure vent filter is correctly positioned and working properly WARNING Hot surface do not touch The heating jacket is designed to heat the inner vessel wal...

Page 9: ...dered dangerous Due to the sensitivity of GFCIs to electrical leakage a few mA it is recommended that the imPULSE Single Use Mixer NOT be plugged into a GFCI outlet Vessel jacket information The imPUL...

Page 10: ...ment according to our operation and maintenance guide l installation of software or interfacing or use of the equipment in combination with software or products we have not approved m the performance...

Page 11: ...s responsible for ensuring that country specific codes and seismic values are assessed for suitability of equipment installation and safety at the designated site In addition it is the buyer s respons...

Page 12: ...o this document are listed below Revision Date Section Change Author Rev A 10 2020 Initial release C Jones How to use this guide Publication name Doc number Thermo Scientific BioProcess Container Unpa...

Page 13: ...ns of abbreviations and acronyms used in this publication BPC BioProcess Container E Box Electrical control panel E Stop Emergency stop button GFCI Ground fault circuit interrupter HMI Human machine i...

Page 14: ...the imPULSE S U M with Touchscreen Console Introduction to the imPULSE S U M with Touchscreen Console Chapter contents 1 1 Overview 1 2 Motor drive assembly 1 3 Pressure control device 1 4 Load cells...

Page 15: ...of the imPULSE mixer include Hexagonal stainless steel vessel with an open top sloped bottom and openings for the BioProcess Container BPC and tubing outlets Integrated rolling diaphragm that provides...

Page 16: ...the motor if it is removed 1 3 Pressure control device The imPULSE pressure control device PCD is an optional feature that allows users to inflate the BPC during installation prior to operation The PC...

Page 17: ...holds the container of powder above the mixer and attaches it to the BPC with a clamp The adjustable powder port provides versitility allowing you to position it as you would like on the S U M 1 6 BP...

Page 18: ...ng page shows the components of the Touchscreen Console hardware Note Custom BPCs may be configured differently Side probe ports AseptiQuik G connector Inflate vent line Pressure sensing line Outlet r...

Page 19: ...ionality needed for their operations For more detailed information see Chapter 3 Touchscreen Console Setup Touchscreen Emergency stop E Stop button Reset button Stainless steel body Figure 1 3 Front a...

Page 20: ...Thermo Scientific imPULSE S U M with Touchscreen Console User s Guide 15 Hardware installation Chapter contents 2 1 Site preparation 2 2 Installation instructions 2 Chapter 2 Hardware installation...

Page 21: ...t require the Touchscreen Console to be open must be performed with the main electrical disconnect in the locked out position and all power sources removed from the Touchscreen Console For operator sa...

Page 22: ...nt ensuring correct seismic anchoring tethering designs for both the equipment and facility 2 2 1 Moving the imPULSE S U M All manual movements of mobile imPULSE S U M hardware should be made over smo...

Page 23: ...is loosened enough remove the centering spacers Figure 2 3 The bolt should remain loosened until the vessel needs to be moved again 3 Prior to inserting the screw jack from load cell unlocking kit Me...

Page 24: ...screw jack by turning clockwise Figure 2 5 Figure 2 5 Using adjustable wrench to raise jack 5 Once the load cell is raised enough remove the large locking plate Figure 2 6 Then lower and remove the sc...

Page 25: ...wer the jack use an adjustable wrench to turn the bolt counter clockwise Figure 2 8 Remove the jack at this point Figure 2 7 Replacing the stainless steel plate 3 Replace the stainless steel spacers i...

Page 26: ...g the connectors We recommend adding insulation to any exposed inlet and outlet jacket fittings Notes Refer to the TCU manufacturer s guidelines for detailed TCU setup and operating instructions Figur...

Page 27: ...water air and process gas should be made with flexible connections to ensure accurate readings from the load cells 2 2 3 Setting up the imPULSE S U M with Touchscreen Console hardware Figure 2 12 on...

Page 28: ...Touchscreen Console User s Guide 23 Motor Controller AC motor module COM Figure 2 12 Ports and connections on the back of the Touchscreen Console USB port AC output ports 4 Legacy port Speaker Pinch c...

Page 29: ...sengaged pulled out by turning the knob clockwise Figure 2 14 Note The E Stop disconnects all power to the system An alarm buzzer will sound when the E Stop is activated 3 Ensure that the E Stop jumpe...

Page 30: ...2 16 2 Plug the pumps into the proper power source Note To calibrate pumps after they have been set up first become familiar with sections 3 1 3 2 Then see section 4 1 Calibrating pumps Verify the las...

Page 31: ...to connect the male end of the supplied M12 5 pin cable to the Spare RS485 port on the back of Touchscreen Console Figure 2 19 Then connect the female end to the right most port on the bottom of the P...

Page 32: ...Console 1 If you are not using a PCD or are using pinch valves connect facility air to the S U M system by connecting an 8 mm 5 16 in outer diameter OD air line Figure 2 23 not supplied to the Air Inl...

Page 33: ...ol Figure 2 28 to connect any communication cables you will be using temperature sensor pH sensor pressure sensor conductivity sensor load cells etc to the input ports on the back of the Touchscreen C...

Page 34: ...y that the auxiliary breaker on the back of the Touchscreen Console is in the on position before use CAUTION All four auxiliary power ports share the same breaker 8 amps A of power out of the Touchscr...

Page 35: ...ntific 3 Touchscreen Console setup Chapter contents 3 1 Configuring the Touchscreen Console Home screen 3 2 Module overview 3 3 Required external components for modules 3 4 Configuring modules imPULSE...

Page 36: ...e user to the Alarm Status screen where alarms can be viewed and acknowledged 3 Settings icon Directs the user to the System Settings screen where the user can adjust the date time set up an Administr...

Page 37: ...modules you would like to use to the Home screen 1 First time users will see the Configure Modules screen Figure 3 2 after turning on the Touchscreen Console Select Start to begin Figure 3 2 Configur...

Page 38: ...a pump or auxiliary output touch the button again When you are finished touch Next Figure 3 4 Selecting pumps and or auxiliary outputs 4 The Select Modules screen appears Figure 3 5 Touch the modules...

Page 39: ...d them to your Home screen Figure 3 6 Workspace Confirmation screen 6 The configured Home screen appears with your selected modules Figure 3 7 If more than eight modules are added they will span multi...

Page 40: ...and Sensors available High and Low alarms High High and Low Low alarms Alarm designation pumps and Diagnostics System settings Export sensor logs About instrument Maintenance and services Instrument...

Page 41: ...e Administrator profile has been created Touch Done 4 After you have created the Administrator profile you can use the Administrator option under System settings to sign in and out of the profile Figu...

Page 42: ...e or more pumps have been set up This module can be used to fill the BPC with liquid deliver acid base or buffer solutions and harvest liquid The use of pinch valves is optional but without them you m...

Page 43: ...in liquid from the BPC after the mixing process is complete Using pinch valves is optional but without them you must drain the BPC by manually opening a pinch clamp on a BPC line Fill This module requ...

Page 44: ...rnal scales Note AuxIn1 is reserved for the laser distance sensor used to home the carriage to either the top or bottom position As such it is grayed out and cannot be used in the same manner 3 3 Requ...

Page 45: ...an set High and Low alarms or High High and Low Low alarms High and Low alarms provide a visual alert when specified setpoints are reached When triggered the alarm icon and affected module on the Home...

Page 46: ...r configuring modules in the following sections for more information 3 4 2 Configuring the Agitation module Use the following information and steps to configure the Agitation module To begin locate th...

Page 47: ...8 1 8 8 1 The default setpoint limits vary by vessel size 0 50 2 00 Hz for 30 250 L vessels and 0 10 2 00 Hz for 500 5 000 L vessels If you would like to change the limits touch field next to Set poin...

Page 48: ...conditions are outside of specified operating parameters 1 If you would like to set High Low alarms for agitation touch the High and Low alarms field The screen that appears has separate sections for...

Page 49: ...ctive Interlock and Hysteresis fields Figure 3 14 To enable a High High or Low Low alarm move the corresponding slider to the On position Figure 3 14 Agitation High High and Low Low alarms screen 3 To...

Page 50: ...y of agitation readings 1 If you would like calibrate agitation touch Calibration 2 Follow the calibration instructions in Chapter 4 Calibration Procedures 3 Touch Done to return to the Home screen 3...

Page 51: ...Low alarms for mass touch the High and Low alarms field The screen that appears has separate sections for both High and Low alarms Figure 3 16 2 To enable a High or Low alarm move the corresponding sl...

Page 52: ...een that appears there are separate sections for both High High and Low Low alarms each with respective Interlock and Hysteresis fields Figure 3 17 To enable a High High or Low Low alarm move the corr...

Page 53: ...corresponding Alarm designation field Figure 3 18 on the Mass Module Configuration screen Figure 3 18 Alarm designation fields for the Mass Module Configuration screen Note Enabling a pump or pinch v...

Page 54: ...n on the alarm s for agitation or the selected pump or pinch valve Figure 3 20 4 When you are finished touch Done to return to the Alarm Designation screen 5 Set any other desired alarm designations A...

Page 55: ...ld like to set up a mass calibration touch the Calibration field 2 Follow the calibration instructions in Chapter 4 Calibration procedures 3 Touch Done to return to the Home screen 3 4 5 Configuring t...

Page 56: ...to use that unit of measurement Once you make a selection the BPC Module Configuration screen will reappear and your changes will be reflected in the Units field Optional fields High and Low alarms Ch...

Page 57: ...uration screen the values in the High and Low alarms field will reflect your changes High High and Low Low alarms Choose to enable or disable High High and or Low Low alarms These alarms provide a vis...

Page 58: ...in either PSI or mbar and the Time to hold before operations can resume in seconds If Stop is set as the action taken operations must be resumed manually 5 Touch Done to return to the previous screen...

Page 59: ...High High and or Low Low alarms to turn on the alarm s for the selected pump 4 When you are finished touch Done to return to the Alarm Designation screen 5 After setting all desired alarm designations...

Page 60: ...ar Figure 3 25 Note You can touch Done at the bottom of the Configuration screen at any time to save your current settings and so you can resume later Figure 3 25 BPC Module Configuration screen Requi...

Page 61: ...alarms Figure 3 26 2 To set either alarm move the corresponding slider to the On position 3 Touch the High or Low alarm field and enter the pressure value in either mbar or PSI that will trigger the H...

Page 62: ...3 Touch the Interlock field of an enabled alarm to enter the Interlock equation screen 4 Fill out the Interlock equation by entering the Control setpoint in either PSI or mbar and selecting the Actio...

Page 63: ...screen that appears Figure 3 28 you will see the interlock and hysteresis parameters that you entered for the High High and or Low Low alarm s Below that the pumps that have been set up with the syste...

Page 64: ...e at the bottom of the Configuration screen at any time to save your current settings and so you can resume later Figure 3 29 Pump Configuration screen Required fields RPM scaling Convert the output s...

Page 65: ...in the Set point limits field will reflect your changes RPM limits Set the maximum and minimum RPM values for the pump 1 Touch the RPM Limits field 2 On the screen that appears Figure 3 31 set the pu...

Page 66: ...total can be given a distinct name to specify the purpose of the pumps For example one pump might be named Acid and another Harvest to help you distinguish between pumps 1 If you would like to name t...

Page 67: ...ation instructions that are detailed in Chapter 4 Calibration Procedures 3 Touch Done to return to the Home screen 3 4 8 Configuring the Fill module The Mass module must be configured and pumps must b...

Page 68: ...es no setup Units and liquid density Select the units you would like to use either liters L or kilograms kg 1 Touch the Units and Liquid Density field 2 On the screen that appears Figure 3 35 select t...

Page 69: ...l appear as selectable options Also if you changed the name of a pump during the pump module setup that name change will be reflected here After touching the pump you would like to use for filling the...

Page 70: ...top conditions Start Description Stop Description Mass Starts filling when the mass in vessel reaches a specified value Fill delivered Stop filling when the specified Fluid target is reached see step...

Page 71: ...ngs and so you can resume later 4 Enter your desired values for the following fields Fluid target The total amount of liquid you would like to pump into the BPC Note This is the only option available...

Page 72: ...s you would like to use either liters L or kilograms kg 1 Touch the Units and Liquid Density field 2 On the screen that appears Figure 3 40 select the units you would like to use either mass by select...

Page 73: ...pumps will appear as selectable options Also if you changed the name of a pump during the pump module setup that name change will be reflected here After touching the pump you would like to use for h...

Page 74: ...vessel reaches a specified value Fill delivered Stop filling when the specified Fluid target is reached see step 4 Previous step complete Starts harvesting when the previous step completes AuxIn1 N A...

Page 75: ...st Module Configuration screen 4 Enter your desired values for the following fields Fluid target The total amount of liquid you would like to pump out of the BPC Note This is the only option available...

Page 76: ...for use You may select either Temperature1 or Temperature2 3 Touch Done when you are finished Note You can change the active sensor at any time by touching the top of the Temperature panel and select...

Page 77: ...rms for temperature touch the High and Low alarms field The screen that appears has separate sections for both High and Low alarms Figure 3 45 Figure 3 45 Temperature High and Low Alarms screen 2 To s...

Page 78: ...ove the corresponding slider to the On position Figure 3 46 High High and Low Low Alarms screen 3 Touch the Interlock field of an enabled alarm to enter the Interlock equation screen 4 Fill out the In...

Page 79: ...n parameters TCU setup and calibration parameters The following graphics illustrate the setup and calibration parameters for Lauda Integral T series Lauda Varicool series and Neslab TF series TCUs Not...

Page 80: ...QUICK START SETTINGS CALIBRATION CALIBRATE t1 MATCH TO KNOWN TEMPERATURE BATH FOR LOW AND HIGH TEMPERATURES Figure 3 50 TCU calibration procedures for Neslab TF series MENU INTERFACES EXTERN Pt100 CA...

Page 81: ...screen will appear Figure 3 53 Note You can touch Done at the bottom of the Configuration screen at any time to save your current settings and so you can resume later Figure 3 53 pH Module Configurat...

Page 82: ...elected wil be visible in the pH Sensors Available field Active pH sensor Select the pH sensor you would like to make active You may select either pH1 or pH2 1 Touch the Active pH Sensor field 2 On th...

Page 83: ...perature compensation If the Temperature module has not been configured enter the Expected Vessel Temperature which will be used instead You may also choose to configure the Temperature module before...

Page 84: ...High and Low Alarms screen 2 To set either alarm move the corresponding slider to the On position 3 Touch the High or Low alarm field and enter the pH values that will trigger the alarm 4 Touch Enter...

Page 85: ...creen 4 Fill out the Interlock equation by entering the Control setpoint in Hz and selecting the Action taken either Pause or Stop If Pause is set as the action taken you must fill out the Hysteresis...

Page 86: ...d or Low Low alarm s Below that the pumps that have been set up with the system are shown Touch a pump option Figure 3 59 pH Pump Designation screen 3 On the screen that appears move the corresponding...

Page 87: ...onsole Home screen and touch Configure The Conductivity Module Configuration screen will appear Figure 3 60 Note You can touch Done at the bottom of the Configuration screen at any time to save your c...

Page 88: ...ductivity sensor you would like to make active You may select either Conductivity1 or Conductivity2 1 Touch Active Conductivity Sensor 2 The screen that appears will prompt you to select the conductiv...

Page 89: ...High and Low alarms Figure 3 63 To set the High or Low alarm move the corresponding slider to the On position 3 Touch the High or Low field and enter the mass value in the adjacent field that will tr...

Page 90: ...gh High and Low Low alarms each with respective Interlock and Hysteresis fields 3 Touch the Interlock field of an enabled alarm to enter the equation screen 4 Fill out the Interlock equation by enteri...

Page 91: ...on After setting up High High and or Low Low conductivity alarms use this field to select which pumps you would like these alarms to apply to e g for Pump 1 enable the Low Low alarm and disable the Hi...

Page 92: ...return to the Home screen 3 4 13 Configuring the Liquid Pressure module Use the following information and steps to configure the Liquid Pressure module To begin Locate the Liquid Pressure module on t...

Page 93: ...PSI or mbar Figure 3 67 The Liquid Pressure Module Configuration screen will reappear and your selected units will be displayed in the Units field Optional fields High and Low alarms Choose to enable...

Page 94: ...e Configuration screen the values in the High and Low field will reflect your changes High High and Low Low alarms Choose to enable or disable High High and or Low Low alarms These alarms provide a vi...

Page 95: ...er PSI or mbar and the Time to hold before operations can resume in seconds If Stop is set as the action taken operations must be resumed manually 5 Touch Done to return to the previous screen 6 Once...

Page 96: ...rresponding slider to the On position for the High High and or Low Low alarms to turn on the alarm s for the selected pump When you are finished touch Done You will be returned to the BPC Alarm Design...

Page 97: ...figuration screen will appear see Figure 3 71 Note You can touch Done at the bottom of the Configuration screen at any time to save your current settings and so you can resume later Figure 3 71 Aux Ou...

Page 98: ...on the module you have selected to duplicate Before configuring an Auxiliary Output module become familiar with the module you will be duplicating sections 3 5 2 to 3 5 13 These sections provide infor...

Page 99: ...type the units you would like to use and touch Enter 3 When you are finished touch Done The system will confirm the settings Touch Done again to return to the Auxiliary Input Module Configuration scre...

Page 100: ...uch Done 4 After a moment a confirmation screen will appear Touch Done again to return to the Auxiliary Input Module Configuration screen Optional fields High and Low alarms Enter the pH values that w...

Page 101: ...reen the values in the High and Low field will reflect your changes High High and Low Low alarms Choose to enable or disable High High and or Low Low alarms These alarms provide a visual and audible a...

Page 102: ...ust be resumed manually 5 Touch Done to return to the previous screen 6 Once you finish setting the High High and or Low Low alarms touch Done 7 After a moment a confirmation screen will appear Touch...

Page 103: ...Low Low alarm s Below that the pumps that have been set up with the system are shown Touch a pump option 3 On the screen that appears move the corresponding slider to the On position to turn on the Hi...

Page 104: ...alibrating pumps 4 2 Calibrating pH 4 3 Calibrating conductivity 4 4 Calibrating agitation speed 4 5 Calibrating mass 4 6 Calibrating PCD pressure 4 7 Calibrating BPC air pressure 4 8 Calibrating liqu...

Page 105: ...ile the Mass option only uses grams Both options require you to enter RPM limits top and bottom speeds and fluid density 4 You can select either Prime Set Up or Skip Prime after you have filled in the...

Page 106: ...uid pumped during the calibration point 1 2 3 or 4 and touch Calibrate The screen for the next calibration point will appear 6 After all four calibration points have been completed touch Done in the l...

Page 107: ...Once the value has stabilized the pH value field will automatically populate to match the exact buffer value You may also change the value if desired Touch Calibrate d The screen that appears will pr...

Page 108: ...the Conductivity Settings screen 4 Follow the steps below for 2 point calibration Note 3 point calibration uses the same steps but will repeat steps d and e for the third calibration point a On the sc...

Page 109: ...Touch Calibration 2 Select the type of calibration you would like to use 1 point 2 point or 3 point 3 The steps below detail the process for 2 point calibration Note 1 point and 3 point calibration us...

Page 110: ...lete screen appears the calibration is complete Touch Done in the lower right corner of the screen to return to the BPC Pressure Settings screen 4 7 Calibrating BPC air pressure If a PCD is NOT presen...

Page 111: ...er right corner of the screen to return to the Liquid Pressure Settings screen 4 9 Calibrating temperature 1 Touch the Temperature module on the Touchscreen Console Home screen to open the Temperature...

Page 112: ...ing instructions Thermo Scientific BPC loading instructions Chapter contents 5 1 General handling guidelines 5 2 BPC loading 5 3 Probe preparation and insertion 5 imPULSE S U M with Touchscreen Consol...

Page 113: ...ubing and the BPC for storage and transport 5 1 3 Working volume Each imPULSE S U M is designed for a specific working volume range The minimum working volume and rated working volume are listed in Ch...

Page 114: ...into the outer support container Larger systems also require access to a ladder or other elevated platform 5 2 1 Preparing to load 1 Prior to installing the BPC ensure that the motor drive is in the d...

Page 115: ...om the BPC by cutting just below the seams using a safety cutter or a similar tool Figure 5 6 Use caution to avoid cutting the BPC Remove the BPC from the packaging Figure 5 7 Figure 5 2 Removing the...

Page 116: ...8 Removing round foam from BPC folds Figure 5 9 Removing foam packaging Figure 5 10 Removing bubble wrap from tubing sets Figure 5 11 C clips on the edge of the mixing disc 5 2 2 Loading the BPC Stan...

Page 117: ...n be either toward the front or the back of the vessel Figure 5 16 2 Press the down button on the hoist lift controller to lower the lift Lower the lift only as far as you need to attach it to the BPC...

Page 118: ...Figure 5 17 Rolling diaphragm flange through the tank cutout Figure 5 18 Rolling diaphragm and tubes centered and not twisted 4 Lower the BPC into the tank Continue loading the BPC 5 The inside floor...

Page 119: ...inflate vent air to the top 1 5 in tri clamp port on the left hand side of the PCD box Then connect the pressure sensor line to the lower 3 4 in tri clamp port on the left hand side of the PCD box Fi...

Page 120: ...he BPC Pressure module to begin inflation Note Ensure that the PCD Pressure module is set to Inflate Touch the top of module to open the settings and select Types and units If the PCD pressure type is...

Page 121: ...er case ensure that the diaphragm is straight and not twisted Figure 5 26 Note For reference a drawing of a flanged locking and flangeless non locking rolling diaphragm is shown in Figure 5 28 Figure...

Page 122: ...mation 3 Insert the probe into the probe assembly through the threaded adapter It is critical to probe insertion to ensure the threads do not become cross threaded Otherwise the O ring will not seal a...

Page 123: ...changes of autoclaving Many dry cycle parameters are not slow exhaust 8 Allow sufficient time for the probe assembly to cool completely before connecting to the BPC for probe insertion 9 When stored p...

Page 124: ...ructions The following steps outline the process of making a sterile aseptic connection using CPC AseptiQuik G genderless connectors Note The vessel shown in the following figures is the 5 1 HyPerform...

Page 125: ...igure 5 34 Pulling the tear strip Figure 5 35 Removing the plastic covering 3 Unsnap and flip open the protective cover pull tabs on both connectors Figures 5 36 and 5 37 Figure 5 36 Opening protectiv...

Page 126: ...5 39 The pull tabs will also be removed Figure 5 39 Pulling tabs to remove paper membranes 5 3 3 Probe insertion Note The vessel shown in the following figures is the 5 1 HyPerforma S U B but the con...

Page 127: ...s 2 Insert the probe by collapsing the bellows Figures 5 41 and 5 42 Note If the BPC is already filled with liquid the best practice is to squeeze the bellows to expel air prior to collapsing it Then...

Page 128: ...a small amount of glycerol 0 5 mL in the thermowell to aid in heat transfer The glycerol also serves as a lubricant and aids in insertion Twist the temperature sensor slightly as you begin to insert i...

Page 129: ...General hardware operating information 6 2 Checkpoints prior to liquid fill 6 3 Filling the imPULSE S U M 6 4 Controlling agitation 6 5 Using the timer 6 6 Monitoring and controlling functions 6 7 Ha...

Page 130: ...ccurrence of a fault condition 6 1 3 Circuit protection Electrical components of the imPULSE S U M are equipped with circuit protection The AC motor module used to power the mixer motor is protected b...

Page 131: ...before filling the BPC with liquid Note If you are using load cells the Mass module must be configured on the Touchscreen Console before you can tare the system See section 3 4 3 for information about...

Page 132: ...in the outer support container 9 The load cell display has been tared 9 All sensors are inserted and connected to their respective transmitters Sensors must be properly oriented to ensure that they ar...

Page 133: ...trol screen you will be prompted to select a method of filling either by pressure or by pump If you select pressure Enter the fluid target Then touch Done If you select pump Enter the fluid target by...

Page 134: ...BPC is filled to an adequate volume level for your individual operating processes before you begin agitation Notes We recommend always having agitation speed below max speed whenever the liquid fill...

Page 135: ...xing On the Touchscreen Console Home screen the pH and Conductivity modules show the current values read by the system Adjusting these levels requires the use of pumps that have been set up for acid b...

Page 136: ...n the center of the screen If you have entered a control equation the equation will be shown at the bottom of the screen If a control equation has not been entered Control Equation Disabled will be sh...

Page 137: ...sure module Figure 6 4 will show the current BPC pressure in psi Figure 6 3 PCD Pressure module Figure 6 4 BPC Pressure module 6 6 5 Monitoring alarms Many of the modules on the Touchscreen Console al...

Page 138: ...an select diagnostics and adjust RPM scaling Auxiliary inputs The Auxiliary Input module allows you to monitor sensors and transmitters that use a 4 20 mA signal and do not have a specified module on...

Page 139: ...ringe or sterile manifold 1 Remove the dust cover from the SmartSite Figure 6 5 2 Clean the SmartSite with a sanitary wipe Then connect the sanitary luer lock type syringe Figure 6 6 Figure 6 5 Removi...

Page 140: ...he module to open the Harvest Settings screen then select Harvest Control 2 The screen that appears will prompt you to select a method of harvesting either by gravity or by pump If you select Gravity...

Page 141: ...tion line Y Open the clamp on the 30 5 cm 12 in section of tubing on the recirculation loop Y and connect to the intended transfer line Use the peristaltic pump already installed on the recirculation...

Page 142: ...cted areas with a light water rinse followed by a routine cleaning See Chapter 7 Maintenance and Troubleshooting for more information 3 Return any loose items such as tools to their storage locations...

Page 143: ...and should be marked with the WEEE symbol Thermo Scientific products will continue to meet the requirements of all relevant directives including those of Restriction of Hazardous Substances RoHS Dire...

Page 144: ...ubleshooting Chapter contents 7 1 Routine maintenance guidelines 7 2 Touchscreen Console software maintenance 7 3 Preventive maintenance guidelines 7 4 imPULSE S U M troubleshooting 7 5 Touchscreen Co...

Page 145: ...es to clean the exterior of the imPULSE S U M This will improve the appearance and overall longevity of the hardware system Between runs the outer support container motor drive and Touchscreen Console...

Page 146: ...e will not run Check the guard and guard sensor to ensure they are fully in place Adjust the guard until it is in the correct position and or adjust the guard sensor as necessary On larger units check...

Page 147: ...n cable issue Power to AC motor module issue Motor power cord issue Mass reading is not displaying Load cell load cell cable issue Load cell summing box issue Mass readings are inaccurate Vessel size...

Page 148: ...arameters on external component Issue with cordset Touchscreen Console fails to recognize auxiliary input 4 20 mA input Issue with external 4 20 mA supply Issue with cordset Auxiliary breaker has mult...

Page 149: ...ications and parts information Chapter contents 8 1 Hardware features 8 2 Hardware specifications 8 3 Touchscreen Console specifications 8 4 Parts and accessories 8 5 Ordering information 8 6 Configur...

Page 150: ...ote The Electrical power supply requirement applies to U S systems only Other voltages are available for country specific voltage requirements Figure 8 1 Features of a 500 L imPULSE S U M with Touchsc...

Page 151: ...psi Temperature Ambient PCD inlet air connection 3 8 in OD push to connect tube TSC inlet air connection 5 16 in OD push to connect tube Process air pressure 30 psig Instrument air pressure Regulate...

Page 152: ...ouchscreen Console front view Figure 8 3 Dimensions of 30 L imPULSE S U M with Touchscreen Console top view 112 88 cm 44 44 in 88 99 cm 35 04 in 30 20 cm 11 90 in 78 74 cm 31 00 in 91 44 cm 36 00 in 1...

Page 153: ...psi Temperature Ambient PCD inlet air connection 3 8 in OD push to connect tube TSC inlet air connection 5 16 in OD push to connect tube Process air pressure 30 psig Instrument air pressure Regulate...

Page 154: ...uchscreen Console front view Figure 8 5 Dimensions of 100 L imPULSE S U M with Touchscreen Console top view 104 77 cm 41 25 in 43 18 cm 17 00 in 92 84 cm 36 60 in 121 12 cm 47 68 in 101 60 cm 40 00 in...

Page 155: ...n operation air pressure PCD 80 psi TSC 95 psi Temperature Ambient PCD inlet air connection 3 8 in OD push to connect tube TSC inlet air connection 5 16 in OD push to connect tube Process air pressure...

Page 156: ...uchscreen Console front view Figure 8 7 Dimensions of 250 L imPULSE S U M with Touchscreen Console top view 136 25 cm 53 64 in 119 84 cm 47 18 in 59 69 cm 23 50 in 92 10 cm 36 26 in 121 92 cm 48 00 in...

Page 157: ...in vessel 40 C Inflation cover gas utility requirements Maximum inflation operation air pressure PCD 80 psi TSC 95 psi Temperature Ambient PCD inlet air connection 3 8 in OD push to connect tube TSC i...

Page 158: ...igure 8 9 Dimensions of 500 L imPULSE S U M with Touchscreen Console top view 150 41 cm 59 22 in 141 03 cm 55 52 in 127 00 cm 50 00 in 136 26 cm 53 65 in 76 20 cm 30 00 in 111 76 cm 44 00 in 327 37 cm...

Page 159: ...0 C Inflation cover gas utility requirements Maximum inflation operation air pressure PCD 80 psi TSC 95 psi Temperature Ambient PCD inlet air connection 3 8 in OD push to connect tube TSC inlet air co...

Page 160: ...11 Dimensions of 1 000 L imPULSE S U M with Touchscreen Console top view 173 79 cm 68 42 in 158 43 cm 62 37 in 97 83 cm 38 50 in 127 00 cm 50 00 in 153 82 cm 60 56 in 132 08 cm 52 00 in 234 88 cm 92 4...

Page 161: ...C Inflation cover gas utility requirements Maximum inflation operation air pressure PCD 80 psi TSC 95 psi Temperature Ambient PCD inlet air connection 3 8 in OD push to connect tube TSC inlet air con...

Page 162: ...onsole front view Figure 8 13 Dimensions of 2 000 L imPULSE S U M with Touchscreen Console top view 190 05 cm 74 82 in 189 58 cm 74 64 in 119 38 cm 47 00 in 162 42 cm 63 94 in 384 43 cm 151 35 in 259...

Page 163: ...40 C Inflation cover gas utility requirements Maximum inflation operation air pressure PCD 80 psi TSC 95 psi Temperature Ambient PCD inlet air connection 3 8 in OD push to connect tube TSC inlet air c...

Page 164: ...ront view Figure 8 15 Dimensions of 3 000 L imPULSE S U M with Touchscreen Console top view 413 39 cm 162 75 in 282 85 cm 111 36 in 276 58 cm 108 90 in 266 26 cm 104 83 in 142 46 cm 56 09 in 76 23 cm...

Page 165: ...C Inflation cover gas utility requirements Maximum inflation operation air pressure PCD 80 psi TSC 95 psi Temperature Ambient PCD inlet air connection 3 8 in OD push to connect tube TSC inlet air conn...

Page 166: ...n Console front and back views Figure 8 17 Dimensions of 5 000 L imPULSE S U M with Touchscreen Console top view 228 63 cm 90 01 in 227 47 cm 89 56 in 157 48 cm 62 0 in 201 00 cm 79 13 in 452 94 cm 17...

Page 167: ...30 C Noise level 70 dB at 1 5 m Relative humidity 15 80 IP rating IP54 RoHS 2011 65 EU CE compliant External components and data Pumps Supports various pumps with 4 20 mA signal control Load cells Met...

Page 168: ...1 0 Hz 0 05 Hz 1 5 Hz 0 08 Hz 2 0 Hz 0 10 Hz Sensor range 30 L 440 kg 1 4 kg 100 L 880 kg 3 1 kg 250 L 880 kg 3 1 kg 500 L 2 200 kg 7 7 kg 1 000 L 4 400 kg 15 4 kg 2 000 L 3 300 kg 11 5 kg 3 000 L 6...

Page 169: ...ECH Pressure Sensor 0 75 tri clover 0 5 x 0 75 in ID x OD Powder port 3 in tri clover Side probe ports 4 each 0 5 in AseptiQuik G Connector Outlet recirculation line 2 each MPX body with plug 0 5 x 0...

Page 170: ...dard SV61201 04 1 Clamp block door SV61201 05 1 Stainless steel small rolling diaphragm support SV61201 06 1 Turck speed sensor SV61201 07 1 Turck M12 3 wire chordset SV61201 08 1 Dayton VFD SV61201 0...

Page 171: ...l retrofit kit 100 L SV61312 543 1 Load cell retrofit kit 250 L SV61312 544 1 Load cell retrofit kit 500 L SV61312 545 1 Load cell retrofit kit 1 000 L SV61312 546 1 Load cell retrofit kit 2 000 L SV6...

Page 172: ...Conductivity probe Jumo SV51148 01 Conductivity probe Mettler Toledo SV51148 02 Pinch valve fill Line 30 1000 L SV61112 04 Pinch valve harvest line 250 1000 L SV61112 02 Pinch valve harvest line 30 10...

Page 173: ...U Lauda SV51142 101 Cable E Box to TCU Neslab SV51142 102 Cable Profibus SV51142 103 Cable RS485 Modbus RTU SV51142 104 Cable CANBus SV51142 106 Cable single RTD SV51142 200 Cable dual RTD Lemo connec...

Page 174: ...ature need to be controlled on the S U M Neslab ThermoFlex No Yes Is a pressure relief valve required Yes 150 psi pressure relief valve with indicator 75 psi pressure relief valve with indicator Will...

Page 175: ...Italy 16 A SV51142 705 Switzerland 16 A SV51142 707 Argentina 16 A SV51142 708 Israel 16 A SV51142 709 India 16 A SV51142 710 Japan 20 A SV51142 721 These 2 000 L systems with AC motors require a 240...

Page 176: ...0 09 170 mL min 108 240 VAC 50 60 Hz SV51151 03 Which pumps are needed Decide how many of each pump is needed Note One harvest fill and two titration pumps is a common configuration Figure 8 23 Pump...

Page 177: ...be used in the S U M simultaneously up to 2 Indicate total number of sensors and cables to be supplied with the new S U M pH VP6 Cable required SV51142 401 Figure 8 25 pH sensor options Will Conductiv...

Page 178: ...ole User s Guide 173 Chapter 8 Specifications and parts information Will pneumatic pinch valves be used on the S U M and controlled by the Touchscreen Console No Yes Choose the pinch valve location Ha...

Page 179: ...information Thermo Scientific General ordering information Chapter contents 9 1 Ordering instructions 9 2 Ordering and support contact information 9 3 Technical support 9 imPULSE S U M with Touchscree...

Page 180: ...3 1WA Great Britain Tel 44 1 670 734 093 Fax 44 1 670 732 537 Email customerservice bioprocessing thermofisher com 9 3 Technical support Technical support for imPULSE S U M s is available in a variety...

Page 181: ...t is available to assist in the initial setup and operation of each imPULSE S U M system If you require assistance in setting up and operating your imPULSE S U M system please inquire at the time of p...

Page 182: ...ng tables are recommended for the designated fasteners used in Thermo Scientific imPULSE mixers unless otherwise specified by Thermo Fisher Scientific technicians Should proper seating during componen...

Page 183: ...t lb 224 Nm 165 ft lb 1 8 700 Nm 515 ft lb 978 Nm 721 ft lb 542 Nm 400 ft lb Grade 5 per ASTM A449 only Stainless 316 per ASTM F593G or ASTM F593H only Figure A 2 Hex head cap screw Table A 3 Recommen...

Page 184: ...Toledo AG PowerFlex Allen Bradley and AB are trademarks of Rockwell Automation Inc SEW is a trademark of SEW EURODRIVE Swagelok is a trademark of Swagelok Company Burkert is a trademark of Burkert Fl...

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