ABX Pentra 80 RAB108EA, User Manual

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Pentra 80
8–16
Pentra 80 - User Manual - RAB108EA
MCV (Mean Corpuscular Volume) :
◆ Red blood cell agglutination - May produce an inaccurate MCV value. Red blood cell ag-
glutination may be detected by observing abnormal MCH and MCHC values, as well as by
examination of the stained blood film. In such cases, manual methods may be required to
obtain an accurate MCV value.
◆ Excessive numbers of large platelets and/or the presence of an excessively high WBC
count may interfere with the accurate determination of the MCV value. In such cases, care-
ful examination of the stained blood film may reveal the error.
MCH (Mean Corpuscular Hemoglobin) :
◆ The MCH is determined according to HGB value and the RBC count. The limitations listed
for the HGB and RBC will have an effect on the MCH and may cause inaccurate values.
MCHC (Mean Corpuscular Hemoglobin Concentration) :
◆ The MCHC is determined according to the HGB and HCT values. The limitations listed for
the HGB and HCT will have an effect on the MCHC and may cause inaccurate values.
RDW (Red blood cell Distribution Width) :
◆ The red blood cell distribution width is determined according to the RBC count.
◆ Nutritional deficiency or blood transfusion - May cause high RDW results due to iron
and/or cobalamin and /or folate deficiency.
PLT (Platelets) :
◆
Very small erythrocytes (microcytes), erythrocyte fragments (schizocytes) and WBC frag-
ments may interfere with the proper counting of platelets and cause elevated PLT counts.
◆ Agglutinated erythrocytes - May trap platelets, causing an erroneously low platelet count.
The presence of agglutinated erythrocytes may be detected by observation of abnormal
MCH and MCHC values and by careful examination of the stained blood film.
◆ Giant platelets in excessive numbers - may cause a low inaccurate platelet count as these
large platelets may exceed the upper threshold for the platelet parameter and are not
counted.
◆ Chemotherapy - Cytotoxic and immunosuppressive drugs may increase the fragility of
these cells which may cause low PLT counts. Reference (manual) methods may be necessary
to obtain an accurate platelet count.
◆ Hemolysis - Hemolysed specimens contain red cell stroma which may increase platelet
counts.
◆ A.C.D. blood - Blood anticoagulated with acid-citrate-dextrose may contain clumped
platelet which could decrease the platelet count.
◆ Elevated triglycerides and/or cholesterol : may interfere with correct platelet counting.
◆ Platelet agglutination - Clumped platelets may cause a decreased platelet count and/or
a high WBC count. The specimen should be recollected in sodium citrate anticoagulant to