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GE Analytical Instruments ©2010

91 of 226

DLM 74001-04 Rev. A

Chapter 4: Basic Analyzer Operation

Specifying the Pharmacopeia

Because Pharmacopeia TOC and Conductivity Monographs diverge, the Analyzer allows you to specify which 
Pharmacopeia Monograph is applicable to your environment. To specify the Monograph you want the Analyzer 
to comply with, follow these steps:

1. Select the 

Maintenance

 tab.

2. Press the 

Advanced

 button.

3. Press the 

Advanced Setup

 button.

4. Press the 

Pharmacopeia

 button.

5. Press the one or more (in any combination) of the pharmacopeia options. (You can also use

 

the Analyzer 

without selecting a pharmacopeia option).

Pharmacopeia Options

You can select any combination or none of the following Pharmacopeia options:

•

USP WFI/PW

:

 

The analyzer meets the test requirements for the United States Pharmacopeia (USP) 

monographs; USP<643> 

Total Organic Carbon

 and USP<645> 

Conductivity

.  The water passes the 

USP<643> TOC test if its measured TOC (r

u

) is not more than the Limit Response, (r

s

 – r

w

). The water 

sample passes the Stage 1 conductivity test if the measured conductivity is not greater than the 
table value (at the first temperature in the chart that is not greater than the measured water 
temperature).  

•

EP WFI/HPW

: The analyzer meets the test requirements of the following European Pharmacopeia 

(EP) monographs; EP (2.2.44

) Total Organic Carbon in Water for Pharmaceutical Use

 and the 

Conductivity Requirements of the EP monographs “

Water for Injections

” (WFI) and “

Water, Highly 

Purified

” (HPW).  The TOC test passes if the measured TOC of the pharmaceutical water sample is not 

less than the lower of the Limit Response or 500 ppbC (per the requirements of the EP WFI and HPW 
monographs). The Stage 1 conductivity test passes if the measured non-temperature compensated 
conductivity value is not greater that the conductivity value in the table for WFI at the next lower 
temperature (in the table), than the measured temperature of the water (Stage 1 test in the WFI or 
HPW monographs). 

•

CP WFI

: The analyzer meets the test requirements of the following Chinese Pharmacopeial (CP) 

monographs; CP 

TOC Measurement in Pharmaceutical Water

- Appendix VIII R for Water for Injection 

and CP 

Conductivity

- Appendix VIII S for Water for Injection.  The TOC test passes if the sample of 

WFI has a measured TOC value not greater than (r

s

 – r

w

) or 0.50 g/L.  The conductivity test passes 

Step 1 if the measured non-temperature compensated conductivity is not greater than the table 
conductivity value at the next lower temperature value in the table that is not greater than the 
measured temperature. 

•

IP WFI

: The analyzer meets the test requirements of the India Pharmacopeia (IP) monographs for 

Water for Injection: IP 2.4.30 

Total Organic Carbon in Water

 and IP 2.4.9 

Conductivity

 for 

Water for 

Injections in Bulk

.  The TOC test is passed if the measured TOC of the sample (r

t

) is not greater than (r

s

 

Содержание Sievers 500 RL

Страница 1: ...Analyzer Operation and Maintenance Manual Firmware Version 2 10 or later GE Analytical Instruments 6060 Spine Road Boulder CO 80301 USA phone 800 255 6964 303 444 2009 fax 303 444 9543 DLM 74001 04 Rev A www geinstruments com Printed in USA 2010 ...

Страница 2: ...n Records Default Administrator User ID ADMIN Default Administrator Password GEAI Analyzer serial number _______________________ This is located on the side of the Analyzer Date of receipt and installation of Analyzer _______________________ This is the warranty start date ...

Страница 3: ...bilité 18 Beschränkte Ansprüche und Haftung 18 Limitazione di rimedi e responsabilità 19 赔偿与责任限制 20 Warnings 21 Chapter 1 Introduction 37 Chapter 2 System Description 39 System Specifications 39 System Overview 41 Sample Flow Path 42 Additional System Components 44 Microprocessor Controller and Electronics 44 Data Outputs 44 Chapter 3 Installation 45 Overview 45 Step 1 Unpack and Inspect the Analy...

Страница 4: ...ord Protection 59 Enabling DataGuard 60 Establishing a New Administrator Account for DataGuard 61 Setting the Clock and Time Zone 61 Naming the Analyzer Location Optional 62 Setting the Analyzer Mode 62 Setting Up the Data History 62 Setting Up the Printer Optional 63 Exporting and Printing System Settings 63 Set Up Data I O 64 Step 9 Rinsing the Analyzer 64 Step 10 Install DataShare 500 Software ...

Страница 5: ...r Printing the Warning and Error History 88 Saving System Settings 89 Printing the Constants Values 89 Adjusting Display Contrast Settings 90 Naming the Analyzer Location 90 Changing the Display Mode 90 Specifying the Pharmacopeia 91 Pharmacopeia Options 91 Pass Fail Reporting 92 Selecting the Program Language 93 Configuring the Flow Sensor 93 Specifying Auto Restart Settings 94 Programming the TO...

Страница 6: ...tion 115 Save System Settings 115 Perform Annual Maintenance Tasks 116 Handling Standards 116 Disable Daily Download and Binary Input 116 Performing a Single Point Calibration 117 Performing a Multi Point Calibration 120 Accuracy Precision and Calibration Verification 124 Performing Pharmacopeia Tests 127 System Suitability Verification 127 JP Protocol 129 Reviewing Calibration and Verification Hi...

Страница 7: ...Power On 160 No Flow Through the Analyzer 160 Checking the Sample Pump 160 Confirm Flow of Water to the Analyzer 160 Backflushing the Analyzer 160 Negative High or Erratic Measurements 163 Conductivity Autozero 163 Sample Conductivity Cell Calibration 163 Sample Cell Zero 164 TOC Autozero 164 TOC Offset 165 Problems Changing the Program Language 165 Problems with Vial Set Cartridges 166 Problems w...

Страница 8: ...GE Analytical Instruments 2010 8 of 226 DLM 74001 04 Rev A ...

Страница 9: ...ecord of User IDs 112 Table 8 Standards Required for Single Point Calibration 114 Table 9 Standards Required for Multi Point Calibration 114 Table 10 Standards Required for Accuracy Precision and Verification 115 Table 11 Standards Required for System Suitability Verification 115 Table 12 Maximum Stored Results by Protocol Type 132 Table 13 Replacement Schedule for Consumables 140 Table 14 Connect...

Страница 10: ...GE Analytical Instruments 2010 10 of 226 DLM 74001 04 Rev A ...

Страница 11: ... The I O Tab With Ethernet Port Installed 76 Figure 16 The Modbus Screen 83 Figure 17 The Maintenance Tab 86 Figure 18 The Advanced Menu with One Program Language Loaded 88 Figure 19 The Standard iOS System 97 Figure 20 The Super iOS System 98 Figure 21 The Sample Inlet Block 98 Figure 22 Menu Map Menu Lockout Off Requires Calibration Passwords 102 Figure 23 Menu Map DataGuard Optional Upgrade 103...

Страница 12: ...ecting the Tubing from the Front Solenoid Valve 161 Figure 41 The Inlet and Outlet Connections Inside the Analyzer 162 Figure 42 The Sample Pump Tubing Connections 162 Figure 43 The Sample Cell Calibration Results Screen 164 Figure 44 Removing the John Guest Fittings 169 Figure 45 Analyzer Dimensions with Standard iOS System 171 Figure 46 Right Side Analyzer Dimensions with Standard iOS System 172...

Страница 13: ...000 Rev B Editorial Corrections September 2005 DLM 74000 Rev C 1 01 October 2005 DLM 74000 Rev D 1 03 January 2006 DLM 74000 Rev E 1 10 Product Release February 2006 DLM 74001 01 Rev A 1 30 December 2007 DLM 74001 02 Rev A Editorial Corrections May 2008 DLM 74001 02 Rev B Editorial Corrections June 2008 DLM 74001 03 Rev A 2 0 April 2009 DLM 74001 04 Rev A 2 10 May 2010 ...

Страница 14: ...rademark of the Swagelok Company Windows and Excel are registered trademarks of Microsoft Corporation John Guest is a registered trademark of John Guest International Ltd The Analyzer described in this manual is covered by one or more patents issued to and owned or pending by General Electric Company including the following US 6 271 043 US 6 228 325 US 5 976 468 US 5 902 751 US 5 837 203 US 5 820 ...

Страница 15: ...shall not be used to manufacture construct or otherwise reproduce the goods disclosed herein The information disclosed herein shall not be disclosed to others or made public in any manner without the express written consent of GE Analytical Instruments Declaration of Conformity A copy of the Declaration of Conformity for this product is available on our Web site at http www geinstruments com Produ...

Страница 16: ...formance effective at the time of delivery All service interventions are to be reviewed and authorized as correct and complete at the completion of the service by a customer representative or designate GE Analytical Instruments warrants these services for 30 days after the authorization and will correct any qualifying deficiency in labor provided that the labor service deficiency is exactly relate...

Страница 17: ... and fitness for a particular purpose Limitación de remedios y responsabilidad La garantía anterior no se aplicará a los defectos que resulten de la realización incorrecta o inadecuada de la instalación el mantenimiento el ajuste la calibración o el manejo por parte del cliente La instalación el mantenimiento el ajuste la cal ibración o el manejo deberán llevarse a cabo de acuerdo con las instrucc...

Страница 18: ...xpresse écrite du groupe GE Analytical Instruments GE Analytical Instruments exclut tout particulièrement les garanties implicites de commerciali sation et d adaptabilité dans un but spécifique Beschränkte Ansprüche und Haftung Die vorangehende Garantie gilt nicht für Schäden die aus unsachgemäßer oder unzureichender Installation Wartung An passung Kalibrierung oder Betrieb durch den Kunden result...

Страница 19: ...Instruments sarà responsa bile per danni accidentali o consequenziali correlati o derivanti dall utilizzo del manuale e di altro materiale di supporto cor relato La garanzia è valida solo per l acquirente originale La presente garanzia limitata non è trasferibile dall acquirente originale a terzi senza l espresso consenso scritto da parte di GE Analytical Instruments GE Analytical Instruments decl...

Страница 20: ...和独占赔偿 在任何情况下 GE Analytical Instruments 不对任何 直接的 间接的 特殊的 偶发的或连带发生的损失 包括利润损失 负责 无论这些损害是依 据何种合同责任理论 侵权行为责任理论或其它法律理论进行推断的 操作与维护手册在出版时 被认为是准确的 GE Analytical Instruments 不对其中可能存在的任何错误负责 在任何情况 下 GE Analytical Instruments 均不对因使用该手册 或与其使用有关 或相关材料导致的偶发或 连带发生的损失负责 保证仅对原购买者有效 未经 GE Analytical Instruments明确书面同意 此有 限保证不可由原购买者转让给任何其他方 GEAnalyticalInstruments 特此声明不提供任何关于特殊 用途的适销性和适用性的暗示担保 ...

Страница 21: ... Water in the iOS System may be hot Before inserting a vial into the iOS System slide the door open and wait 30 seconds to allow sample to completely drain Inserting a vial before draining can result in potentially hot water spray projecting upward out of the iOS System Warning This symbol indicates the protective earth terminal ground for the Analyzer Warning This symbol indicates that to comply ...

Страница 22: ...id potentially dangerous shock turn off power and disconnect from the power supply before opening the Analyzer Warning The UV lamp and the display screen contain mercury and may be considered hazardous material in your local area Dispose of these items in accordance with federal state or local government regulations Warning Should the UV lamp become broken or damaged it should be handled in accord...

Страница 23: ...cartridge is full particularly when running samples with high TOC or high salt concentrations Always clean up the Analyzer by running low TOC DI water after running high TOC or salt samples Warning If this instrument is used in a manner not specified by GE Analytical Instruments the protection provided by the instrument may be impaired Warning The glass window in the UV reactor indicates proper la...

Страница 24: ...undos a que la muestra se vacíe por completo Si inserta un vial antes de que se vacíe es posible que agua potencialmente caliente se proyecte fuera del sistema iOS Advertencia Este símbolo indica el terminal de protección a tierra masa del analizador Advertencia Toda operación que requiera el acceso al interior del analizador incluida la instalación de los elementos de mantenimiento puede causar d...

Страница 25: ... la protección ofrecida por el instrumento puede verse reducida Advertencia Detenga siempre el análisis antes de apagar o desconectar el analizador Advertencia Asegúrese de que el depósito de agua DI está lleno en especial al procesar muestras con altas concentraciones de sal o carbono orgánico total TOC Limpie siempre el analizador procesando agua DI con bajos niveles de TOC después de procesar m...

Страница 26: ... 30 secondes que l eau s écoule complètement L insertion d une fiole avant le séchage complet peut entraîner une projection d eau chaude en dehors du système iOS Avertissement Ce symbole spécifie la borne de protection mise à la terre de l analyseur Avertissement Toute opération nécessitant d accéder à l intérieur de l analyseur y compris l installation d éléments de maintenance peut entraîner des...

Страница 27: ...t risque d être réduite Avertissement Arrêtez toujours l analyse avant de mettre l analyseur hors tension ou de le débrancher Avertissement Assurez vous que le réservoir d eau DI est plein tout particulièrement lors de l utilisation d échantillons comportant des concentrés fortement salés ou à TOC élevé Nettoyez toujours l analyseur à l aide d eau DI à faible TOC après avoir utilisé des concentrés...

Страница 28: ...it die Probe vollständig ablaufen kann Das Einsetzen eines Vial bevor das Wasser abgelaufen ist könnte dazu führen dass heißes Sprühwasser aus dem iOS System herausspritzt Warnung In Analyzers gibt dieses Symbol schützenden Erdungskontakt Boden für das Analysegerät an Warnung Jeder Betrieb der Zugriff auf das Innere des Analysegeräts erfordert einschließlich Installation von Wartungsteilen kann zu...

Страница 29: ...en Warnung Beenden Sie stets die Analyse bevor Sie das Analysegerät ausschalten oder den Stecker herausziehen Warnung Stellen Sie sicher dass der DI Wasserbehälter voll ist besonders wenn Proben mit hohem Gesamtkohlenstoffgehalt TOC oder hohen Salzkonzentrationen analysiert werden Reinigen Sie stets das Analysegerät indem Sie DI Wasser mit geringem Gesamtkohlenstoffgehalt durchlaufen lassen nachde...

Страница 30: ...fuoriuscita di uno spruzzo di acqua calda diretto verso l alto dal sistema Avvertenza Qualsiasi funzionamento che richieda accesso all interno dell analizzatore inclusa l installazione di componenti per la manutenzione può portare a lesioni Per evitare uno shock potenzialmente pericoloso spegnere l analizzatore e se possibile scollegarlo dall alimentazione prima di aprirlo Avvertenza La lampada UV...

Страница 31: ...gare l analizzatore Avvertenza Accertarsi che il serbatoio di acqua deionizzata sia pieno in particolare quando si utilizzano campioni con concentrazioni di TOC Total Organic Carbon Carbonio Organico Totale o di sale elevate Pulire sempre l analizzatore facendovi scorrere acqua deionizzata con basso livello di TOC dopo aver utilizzato campioni con contenuto elevato di sale o di TOC Avvertenza Ques...

Страница 32: ...ください 日本語 500 オンライン分析装置およびポータブル分析装置では iOS システム内の水が加熱してい る場合があります バイアルを iOS システムに挿入する前に ドアをスライドして開き 30 秒間待ち サンプルが完全に排水されるようにしてください 排水前にバイアルを挿入す ると iOS システムから熱水が噴出するおそれがあります 日本語 500 オンライン分析装置では この記号は分析装置用の保護アース端子 グランド を示し ます 日本語 保守部品を取り付ける際など 分析装置の内部にアクセスする操作では 負傷につながるおそれがあり ます 感電を避けるために 分析装置を開く前に電源を切り 可能であれば 電源コードを抜いてくだ さい 日本語 UV ランプおよび表示画面には水銀が含まれており 地域によっては危険物質と見なされる場合があり ます これらの部品は 連邦 州 または地方自治体の...

Страница 33: ...日本語 GE Analytical Instruments USA が指定した方法以外の方法でこの装置を使用すると 装備されている保 護機能が作動しないおそれがあります 日本語 分析装置の電源を切るか 電源コードを抜くときは 必ず分析を停止してください 日本語 DI 貯水槽が満杯になっていることを確認してください 特に TOC または塩分の濃度が高いサンプル を使用する場合に重要です TOC または塩分の濃度が高いサンプルを使用した後は TOC の濃度が低い DI 水で必ず分析装置を洗浄してください 日本語 これはクラス A 製品です 家庭環境では この製品によって電磁波干渉が発生するおそれがあります そのような場合は ユーザー自身で適切な対策を講じて干渉を回避する必要があります 日本語 TOC 値の誤った読み取りおよび分析装置の損傷を避けるために サンプル注入口が開いており DI 貯 水...

Страница 34: ...OS 系统或试剂瓶槽 中文 在 500 联机及便携式分析仪中 iOS 系统中的水为热水 在将试剂瓶插入 iOS 系统之前 请将 门滑开并等待 30 秒 以使试样完全流尽 若在未流尽时插入试剂瓶可能导致热水从 iOS 系 统上部溅出 中文 在 500 联机分析仪中 此符号表示分析仪的保护性接地端 地线 中文 任何需要接触分析仪内部的操作 包括安装维修件 均可能导致人身伤害 为避免可能的电击伤害 在 打开分析仪之前 请关闭电源开关并断开仪器与电源的连接 如果可能 中文 紫外线灯和显示屏含有水银 在您所在的地区可能被视为危险材料 处理这些材料时 请遵循国家 州 省或地方政府的相关规定 中文 如果紫外线灯破损或损坏 应根据您所在组织机构的有毒废料处理程序以及国家 州 省或地方政府的 相关规定进行处理 ...

Страница 35: ...品为 I 类安全产品 本产品必须连接具有接地端的电源 中文 如果本仪器未按照 GE Analytical Instruments USA 的规定使用 仪器提供的保护措施可能会失效 中文 在关闭或断开分析仪电源之前 必须停止分析 中文 请确保 DI 水容器中装满水 特别是在测试高 TOC 或高盐浓度的试样时尤其如此 在测试完高 TOC 或高盐 浓度的试样后 请务必使用低 TOC 的 DI 水清洗分析仪 中文 本产品为 A 类产品 在家庭环境中 本产品可能导致电磁干扰 用户可能需要采取适当措施以减少干扰 中文 为避免 TOC 读数错误或损坏分析仪 在开始分析前必须保证试样进口打开且 DI 水容器已满 ...

Страница 36: ...GE Analytical Instruments 2010 36 of 220 DLM 74001 04 Rev A ...

Страница 37: ... is measured using a sensitive selective membrane based conductometric detection technique as described by Godec et al R Godec et al Method and Apparatus for the Determination of Dissolved Carbon in Water U S Patent No 5 132 094 For each TOC measurement the concentration of inorganic carbon species CO2 HCO3 and CO3 2 is determined and after oxidation of the organic compounds the total carbon TC co...

Страница 38: ...ble for approximately one year For configurations with a Super iOS or Standard iOS recalibration and validation can be easily performed at the customer s site Note that on configurations with a Sample Inlet Block rather than an iOS System not all menu options may be relevant or available on your Analyzer This manual describes typical operational requirements and recommended procedures that are val...

Страница 39: ...me 6 minutes for continuous on line measurements Ozone Compatibility 50 ppb O3 continuous 200 ppb O3 for 2 hours daily Sample Flow Rate nominal Analysis mode 0 25 mL min Fast Flush between samples 0 5 mL min External Flow Rate Minimum 50 mL min Sample Temperature 1 C to 95 C 34 F to 203 F withstands short term steam exposure Sample Pressure Up to 100 psig Interferences Insensitive to organic heter...

Страница 40: ...7 546 ft Inputs One isolated binary input Outputs Serial RS 232 port USB parallel printer port three 4 20 mA ports four alarms ports one Ethernet port Installation Overvoltage Category II protects against transients present in Category II power Safety Certifications CE ETL listed Conforms to UL Std 61010 1 Certified to CSA C22 2 No 61010 1 Pollution Degree 2 normally only non conductive pollution ...

Страница 41: ...Sample inlet system and sample pump including the Integrated On Line Sampling iOS System or Super iOS System 2 Oxidation reactor 3 Measurement module comprising CO2 transfer manifold Sample conductivity cell 4 Fluidics module comprising DI Deionized water cartridge including resin bed DI water pump 5 Electronics subsystems comprising Microprocessors and circuit boards Data outputs ...

Страница 42: ...r is available in three primary configurations with the Super iOS offering four vial ports and on line monitoring with the standard iOS offering one vial port and on line monitoring and with the Sample Inlet Block offering on line monitoring only Discrete samples can be measured by the Sievers 500 RL On Line TOC Analyzer by inserting a filled 40 mL sample vial into the iOS System Continuous monito...

Страница 43: ...tented design utilizing a gas permeable membrane that allows the transfer of CO2 across the membrane The membrane separates the sample side of the Analyzer from the DI side The DI side of the Analyzer is a closed loop and consists of two conductivity cells one for the TC stream and one for the IC stream a DI water pump DI water reservoir and ion exchange resin resin bed CO2 from the sample passes ...

Страница 44: ...e memory for system specific coefficients I O board with interfaces to external devices via binary input four alarms and three 4 20 mA outputs Data Outputs The Analyzer has serial RS 232 USB and printer ports allowing flexibility for exporting and printing data Real time and historical data can be transferred from the Analyzer via the serial port to a computer using communication software such as ...

Страница 45: ...sistance contact GE Analytical Instruments Technical Support at 800 255 6964 Installation and training by a qualified service technician also can be provided Warning Original packing materials must be saved If for any reason the Analyzer must be returned it must be packed in the original carton to ensure that no damage occurs during shipment There will be a charge if the Analyzer must be repackage...

Страница 46: ...ple inlet tubing with in line filter 60 micron 25 32 clamp for 3 4 waste tubing 3 4 OD tubing for waste line Ferrite suppressor for use with 230 V configurations 9 16 open end wrench Double ended screwdriver John Guest tool Stainless steel metric tubing converter 1 4 in to 6 mm tube Water bottle 250 mL with nozzle for filling DI water reservoir Tray for draining DI water cartridge USB flash memory...

Страница 47: ...ted on a wall or support stand Allow a minimum of 5 cm clearance between the back of the Analyzer and the wall for heat dissipation allow 30 5 cm of clearance on the sides top and bottom of the analyzer for the plumbing and electrical connections Additionally this clearance provides for the proper circulation for temperature and humidity control When selecting the location mount the Analyzer so th...

Страница 48: ...nal strip see Figure with the line brown black wire connected to the left port and neutral blue white wire connected to the right port Connect the grounding conductor green and yellow wire to the ground stud A terminal ring for 16 14 AWG wire is provided in the accessories kit if you use wire of a different gauge you must provide an appropriate terminal ring Wire should be 18 12 AWG rated to 300 V...

Страница 49: ...he wing nut that secures the cover from inside the Analyzer Secure the PVC conduit connector strain relief hub and washer to the conduit and the Analyzer bulkhead in the normal manner Wire should be 22 12 AWG rated to 300 Volts Strip length should be 8 9 mm 33 in To attach the output connections first remove the terminal block from the I O board by firmly grasping the terminal block and pulling it...

Страница 50: ...imum load for the alarm ports is 30 VDC at 1 0 A The maximum 4 20 mA load is 600 ohms NC normally closed NO normally open NC normally closed NO normally open Table 1 Alarm Outputs TB2 Pin Number Output 10 24 V ground for binary input 9 24 V output for binary input 8 Remote 7 Remote 6 Alarm 2 NO 5 Alarm 2 NC 4 Alarm 2 Common 3 Alarm 1 NO 2 Alarm 1 NC 1 Alarm 1 Common Table 2 Alarm Outputs TB1 Pin N...

Страница 51: ...ctions are shown in Figure Figure 3 Wiring Diagram for the 4 20 mA Connection Table 3 Serial and 4 20 mA Outputs TB3 Pin Number Output 12 4 20 mA 1 Output 11 4 20 mA 1 Output 10 4 20 mA 2 Output 9 4 20 mA 2 Output 8 Reserved 7 Reserved 6 Reserved 5 4 20 mA 3 Output 4 Serial In 3 Serial Out 2 Serial ground 1 4 20 mA 3 Output TB3 Internal to Analyzer 4 20 mA Output Isolated self power Voltage compli...

Страница 52: ... Figure 4 and Figure 5 Note that binary input must be activated in the Analyzer firmware later It is important to confirm the correct signal strength before setting binary input to On to avoid unexpectedly starting or stopping analysis For more information on activating binary input see Activating Binary Input on page 81 Figure 4 Wiring Option for Binary Input Using Analyzer s Internal Supply 10 2...

Страница 53: ...set screws with a Phillips screwdriver Then close and latch the Analyzer front panel Before installing the printer cable USB flash drive or serial cable you must first remove the cover plate from the Analyzer Loosen the two thumb screws on the cover plate and remove the plate Figure 6 Input and Output Connectors 10 24 V gnd 9 24 V 8 7 TB2 Internal to Analyzer Local Control External to Analyzer K1 ...

Страница 54: ...ash memory drive The flash memory drive can then be used with your computer s USB port to transfer exported data for import into a spreadsheet or database program The Analyzer cannot be directly connected to a computer via the USB port Due to significant variance among USB devices not all USB flash memory devices are compatible with the Analyzer To attach the USB flash memory drive simply slide it...

Страница 55: ...4 Teflon tubing with the in line filter to the sample inlet on the iOS or Super iOS System or the Sample Inlet Block depending on your Analyzer configuration Tighten 1 4 turn past finger tight with a 9 16 open end wrench Do not over tighten the nut 2 Connect the 3 4 OD waste line tubing to the waste outlet on the sample inlet system or the Sample Inlet Block by sliding the tubing over the barb fit...

Страница 56: ...ssories kit to open the bottom latch 3 Locate the DI water cartridge at the center of the Analyzer see Figure 7 Figure 7 Locating The DI Water Cartridge 4 Lift the spring clip see Figure 8 on page 57 at the top of the DI water cartridge and rotate the cartridge clockwise as viewed from the top so it slides out of the retaining hooks Note Setting a water flow rate that exceeds 300 mL min may result...

Страница 57: ... the bottom ring on the fitting so that the ring moves toward the fitting see Figure 9 Note that the tool is not used like a wrench to turn the fitting but rather is only used to press in on the bottom ring of the fitting You may want to rest the tool on the small post when you release the fitting as shown in see Figure 9 Warning To avoid scratches do not use a metal tool to remove the John Guest ...

Страница 58: ...ttom of the cartridge must be perpendicular to the bracket 10 Visually check for leaks from the reservoir after the DI water cartridge has been filled 11 Turn on the Analyzer using the main power switch This will start the DI pump Check for large air bubbles in all the tubing that connects to the DI water cartridge If large air bubbles are present tap or manipulate the tubing to work the air bubbl...

Страница 59: ...ronment Enabling DataGuard or Password Protection Optional The Sievers 500 RL On Line TOC Analyzer offers two levels of security one included with the Analyzer and the other available for purchase as an upgrade from GE Analytical Instruments The Password Protection feature is included with the Analyzer and provides a basic level of security DataGuard is available as an upgrade directly from GE Ana...

Страница 60: ...log in information to access the Analyzer s menus Enabling DataGuard If you are enabling DataGuard follow these steps 1 Insert the USB flash drive containing the DataGuard activation into the Analyzer s USB port 1 Press the Menu button select the Maintenance tab and press the Advanced button 2 Press the Activate Options button 3 Press the OK button and wait for the Analyzer to detect the USB flash...

Страница 61: ... enter the new User ID and Password you just created 11 Press the Menu button and select the DataGuard tab 12 Press the Edit User button 13 Use the arrow buttons to highlight the default administrator account and press OK 14 Press the User Status button and select Inactive 15 Press the Back button to return to the Menu screen Setting the Clock and Time Zone Set the Analyzer clock to ensure that al...

Страница 62: ...rn to the Maintenance tab Setting the Analyzer Mode Before starting normal Analyzer operation confirm that the mode settings match your configuration s needs 1 Select the Setup tab Confirm that the correct mode is selected In On Line mode the Analyzer measures TOC continuously and returns measurement results every 6 minutes In On Line Timed mode the Analyzer returns a single TOC measurement at spe...

Страница 63: ...ge of output or select All Pages to print a header on all pages of output 4 Press the Print Freq button and select how often you would like to print TOC data information Exporting and Printing System Settings Calibration constants and other key parameters are stored in the Analyzer s memory You should export and print the factory settings for future reference To export the system to a configured f...

Страница 64: ...tup button 3 Press the Auto Restart button Make sure Rinse Down is set to On If it is set to Off press the Rinse Down button and then press the On button 4 Press the Back button then press the Rinse button 5 The Analyzer will run in Rinse mode and then will automatically switch into On Line mode Let the Analyzer run for 12 hours No data will be reported for the Rinse mode 6 After 12 hours press th...

Страница 65: ...ation Step 10 Install DataShare 500 Software If you have DataShare 500 software to manage from your Analyzer install it now Consult the DataShare 500 Operation and Maintenance Manual located on the software CD or at www geinstsruments com in The Library Manuals for instructions ...

Страница 66: ...GE Analytical Instruments 2010 66 of 226 DLM 74001 04 Rev A Chapter 3 Installation ...

Страница 67: ...ion number The Analyzer then begins initialization to check the status of consumables and prepare for taking measurements When the Analyzer is done with initialization the Main screen automatically displays If Password protection is enabled you may be required to log in before starting analysis or proceeding to the Menu screen If DataGuard is enabled you will be required to log in before starting ...

Страница 68: ...dicators for the status of the Analyzer s primary consumables see Displaying Consumables Status on page 86 for more information Information about TOC measurements also displays depending on which mode the Analyzer is in In the On Line modes a trend graph displays on the Main screen to change the scale and specify which readings display on the graph see Graphing Data History on page 74 In Grab mode...

Страница 69: ...ings The Menu screen contains the five main configuration categories press a tab to display the available options Setup Set the Analyzer mode and change parameters such as the number of repetitions and the number of rejects Data Display and export historical data stored in RAM I O Configure the input and output of data from the Analyzer Maintenance Display information about the Analyzer s consumab...

Страница 70: ...ute for the first measurement then specify the time interval At each specified interval the Analyzer displays data reflecting the average TOC value since the last specified interval Also press the Threshold button to specify a TOC level above which the Analyzer will switch to On Line mode for the remainder of the interval When the threshold is exceeded the Analyzer gives the average value for the ...

Страница 71: ...ost cases this first measurement will be close to the actual TOC but may be an outlier It is best to set the number of rejections to 1 or more to ensure an accurate TOC value Using at least 4 repetitions allows rejection of the first value and calculation of a standard deviation using the remaining values If your Analyzer has a Super iOS the vial must be in Port 1 When measuring in Grab mode if yo...

Страница 72: ...sage is issued and the Analyzer stops taking TOC measurement until you archive the data To archive your data follow these steps 1 Select the Data tab Press the Print Archive button if you wish to print the data history archive Press the Export Archive button to export the data history archive to a file You will be prompted to verify that the export device is ready to capture the data The archive c...

Страница 73: ...down through the Data History list with the arrow keys and move to the start or end of the list with the Start or End buttons Figure 13 Specifying a Start Date on the View Data Screen To display a specific portion of the data history press the Go To button use the number pad to enter the appropriate date and time settings and then press the Back button The first measurement for the date you entere...

Страница 74: ...le Temp 5 Press the X Scale button and select a time range for the X axis of the graph 1 Hour 2 Hour 4 Hour 8 Hour 1 Day 2 Days 1 Week 6 Press the Y Scale button to select a range for the Y axis Select Auto to have the Analyzer automatically calculate the appropriate range Select Manual to enter specific TOC values in ppb or conductivity values in µS Press the Min button to enter the minimum value...

Страница 75: ...ay 1 Week All or Custom If you select a Custom range press the To Date and From Date buttons and enter the desired time range values 4 Press the Values button to specify which data will print TOC tCond Mode Prints TOC and temperature corrected conductivity data and and the mode in which the data was measured TOC rCond Temp Prints TOC raw conductivity and temperature data TOC Mode Displays TOC data...

Страница 76: ...l cable is attached to the Analyzer prior to pressing the Export button 5 Indicate the destination port by pressing the USB or Serial button to start the data export The data is exported in two formats comma separated format csv and an encrypted format for use with Sievers DataShare 500 software In addition the Audit Trail is exported The files contain the following fields Analysis mode Date Time ...

Страница 77: ... 22 mA or LAST The initial default value is 1 mA Press the Warning button and then press a button on the right to indicate the value for a warning condition either 1 mA 2 5 mA 4 mA 20 mA 22 mA or LAST The initial default value is LAST 4 Press the Back button 5 Press one of the Analog Out buttons either Analog Out 1 Analog Out 2 or Analog Out 3 Set the values for the following Press the Value butto...

Страница 78: ...d press the Enter button 11 Check the value that is output to the multimeter If the reading is not 20 mA 0 01 mA go back to Step 9 and adjust the value Repeat until the multimeter measures 20 mA 0 01 mA 12 Disconnect the multimeter wires from TB3 and close the Analyzer door Setting Up Serial Output To download data from the Analyzer directly to a computer you must set the Baud Rate for the serial ...

Страница 79: ... 8 Parity None Stop Bits 1 Flow Control Hardware Interpreting Serial Output If configured to output 500 RL format the Analyzer outputs the data shown in Table 4 to the Serial RS 232 Port for every measurement On configurations without conductivity measurement Field 7 is not available Note For long distance connections up to 1 000 feet or 305 meters GE Analytical Instruments recommends use of eithe...

Страница 80: ...ng a connection consult Using HyperTerminal on page 179 in the Appendix The Analyzer accepts the following serial commands RUN Start analysis STP Stop analysis When the Analyzer receives one of these commands successfully it returns ACK to the communications program on the PC If the command fails or if a bad command is sent the Analyzer returns NAK Configuring Printer Settings You can change the w...

Страница 81: ... Alarm Values The Analyzer has four customizable alarm outputs that can be triggered if the measured data exceeds a set value or if a warning or error occurs By default the alarms are disabled When external alarms are connected to the Analyzer you can set the alarm levels by following the steps below Instructions for wiring the alarms can be found in the Installation chapter on page 49 On configur...

Страница 82: ...ormation 5 Press the Menu button when you are done While the Analyzer is running system protocols such as calibration only the alarms for Error Warning Power Fail and Break In are in an active monitoring state Using the Ethernet Connection and Modbus When exporting data to the Ethernet port the Analyzer uses the Modbus communication protocol port 502 Before data can be exported via Ethernet you mu...

Страница 83: ...Bit Discrete Inputs read Status 2 1000 New Data 0 Error 1 Standby 2 Alarm 1 3 Alarm 2 4 Alarm 3 5 Alarm 4 6 Activations 2 1002 Feature 1 0 Feature 2 1 Feature 3 2 Feature 4 3 Coils read State 1 2000 Run 0 Stop 1 Coils write Run 5 2000 Stop 5 2001 Input Registers read Instrument Family 4 3010 Instrument Model 4 3011 Serial Number 4 3012 Firmware Version Major 4 3015 Firmware Version Minor 4 3016 ...

Страница 84: ...rror Time Day 4 3203 Error Time Hour 4 3204 Error Time Minute 4 3205 Error Time Second 4 3206 TOC Value Low Word 4 3300 TOC Value High Word 4 3301 TOC Units 4 3302 TC Value Low Word 4 3310 TC Value High Word 4 3311 TC Units 4 3312 IC Value Low Word 4 3320 IC Value High Word 4 3321 IC Units 4 3322 Sample Temp Cond Value Low Word 4 3500 Sample Temp Cond Value High Word 4 3501 Sample Temp Conductivit...

Страница 85: ...zz Firmware Minor is yy in xx yy zzz Firmware Engineering is zzz in xx yy zzz Measurement Mode IC 10 TC 20 TOC 30 NPOC 40 Possible Mode values are as follows On Line Mode 0 Grab Mode 1 Cell Calibration Mode 2 Conductivity Autozero Mode 3 TOC Autozero Mode 4 TOC Calibration Mode 5 TOC Verification Mode 7 System Suitability Mode 15 Linearity Mode 16 On Line Timed Mode 17 On Line Averaged Mode 18 Sam...

Страница 86: ...b 2 Press the Consumables button The status of each of the consumables is displayed with an estimate of remaining life If you need to install new consumables follow the instructions in Chapter 7 Maintenance for each consumable you install also be sure to follow the instructions in the section called Setting the Installation or Date for New Consumables on page 149 Setting the Analyzer Clock and Tim...

Страница 87: ...or to protect the Analyzer from damage Corrective action should be taken before the Analyzer can resume normal operation Warnings and errors issued by the Analyzer collect in the Warnings Errors list after their initial display The W icon displays in the Menu screen header when a warning has been issued and the E icon displays when an error has been issued if both a warning and an error have been ...

Страница 88: ...rial number GE Analytical Instruments phone numbers and Web site information Advanced Analyzer Settings Analyzer settings are considered to be advanced if they will not be regularly changed in the course of normal Analyzer operations If Password Protection or DataGuard is enabled logging in with a User ID that has a User Level of Quality or Administrator is required in order to change these settin...

Страница 89: ...port repeat Steps 1 through 3 above and select Restore System Printing the Constants Values Calibration constants and other key parameters are stored in non volatile memory If you have a printer attached to the Analyzer you can print these settings for future reference by following these steps 1 Select the Maintenance tab 2 Press the Advanced button 3 Press the Print Constants button and then sele...

Страница 90: ...ave multiple Analyzers at your facility and want to easily distinguish data collected from each instrument To assign a name follow these steps 1 Select the Maintenance tab 2 Press the Advanced button 3 Press the Advanced Setup button 4 Press the Location button 5 Use the keypad to specify a name for the Analyzer and press Enter Changing the Display Mode By default the Analyzer displays the TOC and...

Страница 91: ... Organic Carbon in Water for Pharmaceutical Use and the Conductivity Requirements of the EP monographs Water for Injections WFI and Water Highly Purified HPW The TOC test passes if the measured TOC of the pharmaceutical water sample is not less than the lower of the Limit Response or 500 ppbC per the requirements of the EP WFI and HPW monographs The Stage 1 conductivity test passes if the measured...

Страница 92: ... in Pharmaceutical Water Appendix VIII R for Water for Injection and CP Conductivity Appendix VIII S for Water for Injection The TOC test passes if the sample of WFI has a measured TOC value not greater than rs rw or 0 50 g L The conductivity test passes if the measured conductivity not the temperature compensated conductivity is not greater that the value in the Temperature and Conductivity requi...

Страница 93: ...th an iOS or Super iOS the Analyzer automatically detects the presence of the sample stream when it is working in On Line mode When the water flow is interrupted the Analyzer issues an error and stops analysis To change the Flow Sensor setting follow these steps 1 Select the Maintenance tab 2 Press the Advanced button 3 Press the Advanced Setup button 4 Press the Flow Sensor button 5 By default th...

Страница 94: ...tability and Linearity For verification system suitability and linearity functions analysis only restarts only when the protocol is completed successfully If any of these protocols fail analysis does not restart Programming the TOC Autozero If your application requires you to perform on line TOC measurements you may want to set the Analyzer to automatically perform a TOC Autozero at a specific int...

Страница 95: ... button 4 Follow the prompts on screen You will need to stop sample flow to the Analyzer before the iOS System can drain properly Activating Additional Features If you purchased a 500 RL TOC Analyzer with a Sample Inlet Block it is possible to activate additional features available by default on other 500 RL configurations If you purchased a feature upgrade follow these steps to activate the featu...

Страница 96: ...a quarter VGA color LCD The operator s finger is optimal for interacting with the display To avoid scratching the display do not use pens or pencils to press buttons Recommended Operational State To assure optimal performance across the operating range the Analyzer should remain powered On in the idle state when not in use This will allow the measurement components and other subsystems to maintain...

Страница 97: ...generating erroneous measurement data If the flow sensor is On opening the iOS System door while analysis is taking place causes the flow sensor to activate and halt analysis If the flow sensor is Off opening the iOS System door while analysis is taking place results in air being drawn into the Analyzer Warning The iOS System contains two sharp needles designed to pierce the septa of sample vials ...

Страница 98: ...stem The Sample Inlet Block The Sample Inlet Block see Figure 21 is designed to for on line sampling only Sampling from a vial is not possible with this configuration Figure 21 The Sample Inlet Block Warning The Sample Inlet Block may be hot If the sample water is hot be careful to avoiding touching the Sample Inlet Block ...

Страница 99: ... set expiration date Vial set name Vial name Vial part number Vial lot number Vial expiration date Steam Exposure The iOS and Super iOS are rated at IP 45 and can withstand short term steam exposure of up to 40 psi steam for 30 minutes When exposed to steam the Analyzer should be powered off or in standby mode and not in analysis mode After exposure to steam allow the Analyzer to cool before retur...

Страница 100: ...GE Analytical Instruments 2010 100 of 226 DLM 74001 04 Rev A Chapter 4 Basic Analyzer Operation Ambient Temperature Time Interval Below 20 C 15 minutes 20 30 C 30 minutes 30 40 C 90 minutes ...

Страница 101: ...hat run and stop analysis or display sampling data without the need to enter the user name and password Users are ONLY required to enter a user name and password in order to change parameters that affect calibration and analysis To view which menus and sub menus require a password see Figure 22 Menu Map Menu Lockout Off Requires Calibration Passwords on page 102 The DataGuard security feature is a...

Страница 102: ...GE Analytical Instruments 2010 102 of 226 DLM 74001 04 Rev A Chapter 5 Password Protection and DataGuard Figure 22 Menu Map Menu Lockout Off Requires Calibration Passwords ...

Страница 103: ...fault User ID and Password i e there is ONLY one User ID and one password Setup DataGuard Maintenance I O Data Setup History Q View O Grab Q On Line Averaged Q On Line Timed Q On Line Q Export O Print O Graph O Printer Q Serial Q Clock Q Cal Ver Validate M Consumables O M Export AuditTrail A View Audit Trail A Change Password O Warnings Errors O M Advanced Q Add User A Setup A Print Audit Trail A ...

Страница 104: ...and press the Enter button The new Password is immediately activated To configure password settings After enabling Password Protection you can specify the password preferences as follows 1 Press the Menu button and select the DataGuard tab 2 Press the Setup button Password Expires Specifies how long the Password is valid before it must be changed The default is 90 days You can enter a value in the...

Страница 105: ...lytical Instruments Once it is enabled it cannot be disabled Enabling DataGuard DataGuard is locked until it is activated by following the steps below When activating DataGuard to ensure system security we strongly recommend that you create a new administrator level account and inactivate the default administrator account Steps 7 through 21 below 1 Insert the USB flash drive containing the DataGua...

Страница 106: ...7 Select the DataGuard tab 18 Press the Edit User button 19 Use the arrow buttons to highlight the default administrator account and press OK 20 Press the User Status button and select Inactive 21 Press the Menu button to return to the Menu screen Adding User IDs After DataGuard has been enabled you can add a User ID by following these steps 1 Select the DataGuard tab 2 Press the Add User button 3...

Страница 107: ...ds on page 102 for a menu map that indicates the minimum User Level required to access each menu User Status Indicates whether the User ID is Active default for all new User IDs or Inactive When you set a User ID to Inactive the user will not be able to log in to the Analyzer and the User ID will be deleted from memory the next time you archive see Archiving User Accounts on page 109 for more info...

Страница 108: ...Analyzer Select either Cal Lockout or Menu Lockout When the Analyzer is set to Cal Lockout only operations that can affect measurements are password protected When the Analyzer is set to Menu Lockout all menus are password protected Changing User Passwords All users can change their own Passwords by following these steps 1 Log in with a valid User ID and Password 2 Select the DataGuard tab 3 Press...

Страница 109: ...he User Status button and select Active 6 If the user has forgotten the Password you can assign a new Password now Press the Password button specify and confirm the new Password and press Enter 7 Press the Menu button to save and return to the DataGuard screen Archiving User Accounts If you want to remove User IDs from the user list you must first set the unwanted User IDs to Inactive and then arc...

Страница 110: ... to display the audit trail entries on screen Press the Export Audit button to export the current audit trail to the serial RS 232 port or the USB port as a comma separated text file csv Make sure a USB device or serial cable is attached to the Analyzer Press the Print Audit button to print the current audit trail Printing the audit trail can be time consuming To save time first export the audit t...

Страница 111: ...egrity of the audit trail Logging out also minimizes the risk of unauthorized access by other personnel To log out press the Logout button on any display screen If the Logout button is not displayed on the current screen press the Back or Menu button until any of the main tabs Setup Data I O Maintenance or DataGuard display and then press the Logout button 6 New Value Alpha numeric characters colu...

Страница 112: ...GE Analytical Instruments 2010 112 of 226 DLM 74001 04 Rev A Chapter 5 Password Protection and DataGuard Table 7 Record of User IDs User ID User s Name Date Created Date Archived ...

Страница 113: ...ne TOC Analyzer facilitates the calibration and verification process by handling the necessary calculations internally you will have the opportunity to accept or reject the calibration during the procedure Calibration and verification are accomplished using Sievers Standards in 40 mL and 30 mL vials sampled via the Analyzer s iOS System If your Analyzer has a standard iOS System one vial port you ...

Страница 114: ...y Precision Linearity Robustness Specificity and JP Protocol can be purchased individually or as a combined Validation Set To purchase standards in North America or Canada contact GE Analytical Instruments by phone at 800 255 6964 or 303 444 2009 To purchase standards in the United Kingdom contact GE Analytical Instruments at 44 0 161866 9337 instruments com To purchase standards in Europe Asia an...

Страница 115: ...ress the Advanced button Table 10 Standards Required for Accuracy Precision and Verification Verification Blank 500 ppb TOC as NIST sucrose 25 µS cm Conductivity as HCl Table 11 Standards Required for System Suitability Verification Reagent Water Blank Rw 500 ppb TOC as sucrose Rs 500 ppb TOC as benzoquinone Rss Rinse Water Warning Consult the MSDS that accompanies each standards set to identify p...

Страница 116: ...rom light in a box or solid door refrigerator Warm standards to ambient temperature prior to starting analysis Avoid touching the top of the vials to protect against introducing foreign particles TOC and conductivity After following these steps proceed either to Performing a Single Point Calibration below or to Performing a Multi Point Calibration on page 120 Disable Daily Download and Binary Inpu...

Страница 117: ...remove them now Press Next to continue Wait for the Analyzer to drain each of the Super iOS vial chambers about 2 minutes 7 If you have selected to run a rinse the Analyzer will prompt you to do one of the following Insert the Super iOS Rinse vial set into the Super iOS Or if using individual rinse vials press Next for additional instructions Insert the individual vials in the Super iOS and then p...

Страница 118: ...he Next button 11 Part 2 of the summary displays the data for the conductivity standard see Figure 25 12 Press the Print button if you want to print the Calibration results 13 The Analyzer indicates if the calibration passed If the calibration passed press the Apply button to accept the calibration and continue If the calibration failed press the Cancel button to reject the calibration You may nee...

Страница 119: ... System Protocols 17 You should now verify the calibration Proceed to Accuracy Precision and Calibration Verification on page 124 for instructions Figure 24 Reviewing TC and IC Values from a Single Point Calibration Figure 25 Reviewing Conductivity Values from a Single Point Calibration ...

Страница 120: ...move them now Press Next to continue Wait for the Analyzer to drain each of the Super iOS vial chambers about 2 minutes 7 If you have selected to run a rinse the Analyzer will prompt you to do one of the following Insert the Super iOS Rinse vial set into the Super iOS Or if using individual rinse vials press Next for additional instructions Insert the individual vials in the Super iOS and then pre...

Страница 121: ...firm the value of the Conductivity Standard and insert the vial into the iOS System If the label shows a value of 25 µS cm HCl press Next to continue If the label shows a different value press Edit enter the value press Enter and then press Next If your configuration does not measure conductivity you will not be prompted to enter a conductivity value and you can skip this step When prompted remove...

Страница 122: ...e for RW2 TOC plus 1 5 ppm For 1 00ppm TOC and 500 ppb TOC TOC Calibration Standards this is the expected value for RW3 plus 1 00 ppm or 500 ppb respectively For 25 00 S cm tCond Conductivity Standard this is the certified value of the standard as shown on the vial label Diff is percent difference between the average and expected value Adj is the adjusted value with the new calibration applied 15 ...

Страница 123: ...nstruments 2010 123 of 226 DLM 74001 04 Rev A Chapter 6 Calibration and System Protocols Figure 27 The Second Summary Screen in a Multi Point Calibration Figure 28 The Third Summary Screen in a Multi Point Calibration ...

Страница 124: ...rs Otherwise go to step 10 3 Select one of the following rinse options and then press the Next button No Rinse Before After Before and After 4 If you have selected No Rinse or After and there are vials in the Super iOS remove them now Press Next to continue Wait for the Analyzer to drain each of the Super iOS vial chambers about 2 minutes 5 If you have selected to run a rinse the Analyzer will pro...

Страница 125: ...rom the iOS System Confirm the value of the Conductivity Standard and insert the vial into the iOS System If the label shows a value of 25 µS cm HCl press Next to continue If the label shows a different value press Edit enter the value press Enter and then press Next 8 After the last standard has been analyzed the summary screen is displayed Part 1 of the summary screen displays the data for the s...

Страница 126: ...nd to insert the rinse cartridge or vials into the Super iOS system to continue the Rinse activity Take out the rinse cartridge or vials when completed 13 If you have a standard iOS System remove the standards and slide the iOS door closed Figure 29 The Accuracy Precision and Verification Summary Screen Part 1 Figure 30 The Accuracy Precision and Verification Summary Screen Part 2 Relative Standar...

Страница 127: ...hese Pharmacopeias please refer to Specifying the Pharmacopeia on page 91 System Suitability Verification To perform the system suitability verification follow this procedure 1 If the Analyzer is taking measurements press the Stop Analysis button 2 Press the Menu button select the Maintenance tab press the Cal Ver Validate button and press the Suitability button 1 If the Analyzer is taking measure...

Страница 128: ...ert the 500 ppb Sucrose Standard Rs and press Next When prompted remove the 500 ppb Sucrose Standard Rs from the iOS System insert the 500 ppb Benzoquinone Standard Rss and press Next When prompted remove the 500 ppb Benzoquinone Standard Rss from the iOS System insert the Rinse Water standard and press Next Press the Print button if you want to print the Calibration results 8 After the last stand...

Страница 129: ... TOC for Water Injection and Purified Water and JP 2 51 Conductivity COND 1 Optional If DataGuard is enabled log in to the Analyzer with a UserID that has a User Level of Quality Assurance or Administrator and the appropriate Password If Password protection is enabled log in to the Analyzer with the UserID and Password NOTE Before you begin this protocol ensure that you have selected the appropria...

Страница 130: ...vidual vials in the Super iOS and then press No Set to proceed 7 Do one of the following If you have a purchased vial set insert the JP Protocol standards cartridge into the Super iOS System with the label facing away from the Analyzer and press Next Proceed to Step 11 Insert the individual vials into the Super iOS system in the following order Port 1 Leave empty Port 2 Reagent Water Rw Blank Stan...

Страница 131: ...rrected Average The Analyzer will also report separately only if JP Conductivity pharmacopeia is active whether the JP TOC and Conductivity Protocol passed or failed based on the following criteria TOC Blank Average 250 ppb Blank Corrected Average 450 ppb Conductivity Difference RSD 2 Sample temperature is between15 C to 30 C 10 Complete the JP Protocol Worksheet with the pass or fail information ...

Страница 132: ...ts TC Cal and IC Cal for calibration results TC Ver and IC Ver for verification results Sys Suit for system suitability results and Linearity for Linearity results These results also are included when you export the data history The Analyzer s Cal Ver History is divided by protocol type and a finite number of result summaries for each type will be stored see Table 12 Once the maximum number of sto...

Страница 133: ... the Analyzer will cancel an auto restart The Analyzer will report an error for all system protocols at the end of of the Blank vial measurement if the average TOC of the blank vial is higher than 150 ppb except for the JP Protocol where the limit is 250 ppb If this error occurs the Analyzer will abort the analysis and cancel an auto restart To disable the reporting of high Blank TOC warnings and ...

Страница 134: ...______ Standards Expiration Date _______ Standards Set Lot No optional ________________ Standards Vials Lot Nos _________ Enter data for the Calibration Rep RW IC RW2 TOC 1 50 ppm TOC 25 00 µS cm tCond 1 ________ ________ ________ ________ 2 ________ ________ ________ ________ 3 ________ ________ ________ ________ Avg ________ ________ ________ ________ Exp ________ ________ ________ Diff ________...

Страница 135: ...als Lot Nos _________ Rep RW IC RW2 TOC 1 50 ppm TOC 25 00 µS cm tCond 1 ________ ________ ________ ________ 2 ________ ________ ________ ________ 3 ________ ________ ________ ________ Avg ________ ________ ________ ________ Exp ________ ________ ________ Diff ________ ________ ________ Adj ________ ________ ________ ________ Rep RW3 TOC 1 00 ppm TOC 500 ppb TOC 1 ________ ________ ________ 2 ____...

Страница 136: ...__ Rep RW TOC 500 ppb TOC 25 00 µS cm tCond 1 ________ ________ ________ 2 ________ ________ ________ 3 ________ ________ ________ Avg ________ ________ ________ RW TOC Conductivity Avg ________ ________ ________ Adj Standard Concentration ________ N A N A SD N A ________ ________ RSD verification N A ________ ________ Pass Fail Accuracy N A ________ ________ Pass Fail Pass criteria TOC Precision ...

Страница 137: ... Date _______ Standards Set Lot No optional ________________ Standards Vials Lot Nos _________ Average TOC of Reagent Water Rw ____________________ Line 1 Average TOC of 500 ppb Sucrose Standard Rs ____________________ Line 2 Average TOC of 500 ppb Benzoquinone Standard Rss ____________________ Line 3 Response Efficiency ____________________ Line 4 Response Limit ____________________ Line 5 Respon...

Страница 138: ...ected Average ___________________________ Line 3 SDBS Average Line 2 TOC Blank Average Line 1 SDBS Blank Corrected Average Line 3 Average Temperature Corrected Conductivity of 29 4 μS cm __________________ Line 4 Temperature __________________________________________________________ Line 4 RSD__________________________________________________________________ Line 5 Difference _____________________...

Страница 139: ... heads must be purchased from GE Analytical Instruments If you need additional assistance contact GE Analytical Instruments Technical Support at 800 255 6964 Training is also available from GE Analytical Instruments Note that this chapter covers replacement instructions for all routine maintenance items that are replaced on a regular schedule instructions for non routine maintenance items are prov...

Страница 140: ...the DI water cartridge 1 If the Analyzer is taking measurements press the Stop Analysis button 2 Turn off power to the Analyzer with the main power switch 3 Open the Analyzer front panel 4 Locate the DI water cartridge at the center of the Analyzer see Figure 32 on page 140 Table 13 Replacement Schedule for Consumables Description Typical Operating Life DI Water Level Refill as needed check when r...

Страница 141: ... gently pushing it back into place on the cartridge 9 If you need to replace other consumables follow the procedures listed in the appropriate sections of this chapter Otherwise close and latch the Analyzer door 10 Restore power to the Analyzer 11 Press the Start Analysis button After five minutes open the Analyzer front panel and check the water level in the DI water cartridge to make sure it is ...

Страница 142: ...rtz window of the lamp Remove the new lamp from the packet and the nut and ferrules from the zip top bag Warning The UV lamp contains mercury and may be considered hazardous material in your local area Dispose of the UV lamp in accordance with federal state or local government regulations Warning Installation of the UV lamp requires access to the inside of the Analyzer To avoid potentially dangero...

Страница 143: ...ten the brass colored nut finger tight While tightening the nut make sure the heat shrink tubing remains flush against the nut Figure 34 Do not use a wrench 12 Connect the power connector to the power supply by aligning the slot on the connector with the slot on the power supply Tighten the connector screw Gently pull on the power connector to make sure it is securely attached to the power supply ...

Страница 144: ...ress the Stop Analysis button 2 Turn off the Analyzer by using the main power switch 3 Stop the flow of sample water to the Analyzer 4 Open the Analyzer front panel 5 Locate the sample pump heads see Figure 32 on page 140 6 Remove the masterflex tubing from the four barbs 7 Use a small Phillips screwdriver from the accessories kit to loosen the two screws that secure the pump heads Remove the scre...

Страница 145: ...n Setting the Installation or Date for New Consumables on page 149 Figure 36 Replacing the Sample Pump Heads Replacing the DI Water Cartridge The ion exchange resin resin bed within the DI water cartridge depletes over time With typical Analyzer use the DI water cartridge should be replaced after every 24 months of operation To replace the DI water cartridge you will need the new cartridge paper t...

Страница 146: ...pose of the old DI water cartridge in compliance with local state and federal regulations 13 Carefully remove the tray and discard the collected water 14 Remove the new DI water cartridge from the packaging and remove the caps from each of the barbs 15 Remove the rubber inlet cover from the new cartridge and set it aside 16 Attach the John Guest fittings to the barbs on the bottom of the new DI wa...

Страница 147: ... it snaps into place 29 Replace the rubber inlet cover 30 Close and latch the Analyzer door 31 Restore power to the Analyzer 32 Check the level of the DI water cartridge If the water level has dropped below the Full line remove the rubber inlet cover from the top of the cartridge add more water and replace the inlet cover 33 Let the Analyzer run for two hours 34 After two hours open the Analyzer f...

Страница 148: ...to decrease It is desirable to replace the filter element on a routine basis to prevent clogging For this procedure two 3 4 wrenches are needed To replace the filter element follow these steps 1 Stop the Analyzer by pressing the Stop Analysis button 2 Turn off the Analyzer using the main power switch 3 Shut off the water to the sample inlet system 4 Remove the filter by loosening the Swagelok nuts...

Страница 149: ...s When you replace a consumable you must enter the date of installation ensure that the Analyzer keeps an accurate record of usage and that the indicators on the Main screen remain accurate 1 Press the Menu button and select the Maintenance tab 2 Press the Consumables button 3 Press the New button that corresponds to the consumable you are installing Choose New Lamp New Tube or New RBed press the ...

Страница 150: ...pe dry with a clean soft cloth The touch screen may be cleaned with a soft cloth or cotton pad Isopropyl Alcohol may be used but insure that all solvent residue is removed Water may cause damage or discoloration of the polarizer Clean any condensation or moisture from any source immediately Before cleaning the screen you can temporarily deactivate touch screen sensitivity for 30 seconds by selecti...

Страница 151: ...rksheet from __________to __________ Table 15 Sievers 500 RL On Line TOC Analyzer 3 Year Maintenance Worksheet Item Period Installation Date Notes UV Lamp 6 months DI Water Filled 6 months Pump Heads 12 months UV Lamp 12 months DI Water Filled 12 months UV Lamp 18 months DI Water Filled 18 months Pump Heads 24 months UV Lamp 24 months DI Water Cartridge 24 months DI Water Filled 24 months UV Lamp ...

Страница 152: ...GE Analytical Instruments 2010 152 of 226 DLM 74001 04 Rev A Chapter 7 Maintenance ...

Страница 153: ...bleshooting erratic readings poor reproducibility 3 or other operational problems is to review and print the Warnings Errors list To display and print the Warnings Errors list follow these steps 1 Select the Maintenance tab 2 Press the Warnings Errors button 3 Use the scroll buttons to browse the warnings and errors Note For Analyzer firmware with the DataGuard feature a Maintenance level or highe...

Страница 154: ...tory of usage the Analyzer estimates that only 10 of the sample pump tubing life remains Order new pump tubing from GE Analytical Instruments now to avoid down time when the tubing expires 7 Resin Bed Warning Message The resin bed life is less than 15 days Order a new resin bed Explanation Based on the history of usage the Analyzer estimates that only 10 of the resin bed life remains Order a new r...

Страница 155: ...on Based on the history of usage the Analyzer estimates that the sample pump tubing has expired Order new pump tubing from GE Analytical Instruments now 22 Resin Bed Warning Message The resin bed needs to be replaced Explanation Based on the history of usage the Analyzer estimates that the resin bed has expired Order a new resin bed from GE Analytical Instruments now 23 Autozero Warning Message TO...

Страница 156: ...e no air bubbles in any tubing inside the Analyzer and make sure the water level in the DI water cartridge is sufficient Also confirm that sample water is flowing to the Analyzer If necessary turn the Analyzer off and on and restart analysis If the warning persists contact Technical Support 44 Analog Error Sample Cell Conductivity Message Measurement is out of range Please refer to the Oper and Ma...

Страница 157: ...ou must either Export DataGuard tab Export AuditTrail or Print DataGuard tab Print Audit Trail the audit trail before proceeding 55 Linearity Vial Error Message The Linearity vials appear to be in the wrong order Check the vials to assure they are in the correct order Explanation This error generally displays when the vials in a Linearity protocol are not inserted into the Super iOS System in the ...

Страница 158: ...cal Support 62 iOS Comm Error Message Unable to communicate with iOS Please refer to the Oper and Maint manual for info Explanation The Analyzer is not able to establish communication with the iOS System due to a hardware issue Contact GE Analytical Instruments Technical Support 65 Main Board Error Message An error has been detected on the Main Board Please refer to the 500 Oper and Maint Manual C...

Страница 159: ...eaks throughout the Analyzer there should not be moisture on the inside floor of the Analyzer case Confirm that the sample pump is turning Check to make sure there are no leaks from tubing in the DI water system Confirm that the DI water cartridge is full If necessary add water up to the Full line If maintenance work has recently been performed on the Analyzer confirm that electronics cables such ...

Страница 160: ...ng the display screen indicates that analysis is taking place contact GE Analytical Instruments Technical Support for instructions Confirm Flow of Water to the Analyzer Make sure the flow of sample water to the Analyzer is enabled from your water system Also confirm that the iOS System or Super iOS System inlet valve is open Inlet to the iOS System is controlled by a needle valve which is adjusted...

Страница 161: ...Replace the Masterflex tubing so it connects to the stainless steel tubing 6 Remove the Masterflex tubing from the front solenoid valve and check to see if water is flowing through the restrictor tubing see Figure 40 If there is water flowing from the restrictor tubing reconnect the tubing to the solenoid valve If there is no water flowing through the restrictor tubing you may need to replace the ...

Страница 162: ...ions leading to the sample pump tubing at the plastic barbs see Figure 42 The first pair of tubes on the left should be connected to the barbs that normally connect to the second pair of tubes on the right The second pair of tubes on the right should be connected to the barbs that normally connect to the first pair of tubes on the left Figure 42 The Sample Pump Tubing Connections ...

Страница 163: ...y Autozero If the Analyzer is returning unusually high IC or conductivity values a sample conductivity cell autozero may be necessary If you have recently run a system protocol let the Analyzer run for at least five hours before performing a conductivity autozero 1 Make sure the Analyzer is not taking measurements 2 Press the Menu button and select the Maintenance tab 3 Press the Advanced button 4...

Страница 164: ...ion before performing the sample cell zero 1 Make sure the Analyzer is not taking measurements 2 Press the Menu button and select the Maintenance tab 3 Press the Cal Ver Validate button 4 Press the Sample Cell Zero button 5 Follow the prompts on the screen TOC Autozero The TOC Autozero corrects for minor differences in the response of the two CO2 sensors This adjustment may help when the Analyzer ...

Страница 165: ...the TOC Offset follow these steps 1 If the Analyzer is taking measurements press the Stop Analysis button 2 Press the Menu button select the Maintenance tab and press the Cal Ver Validate button 3 Press the Program Autozero button 4 Press the Offset button 5 Use the number keypad to enter a positive or negative number for the offset 6 Press the Enter button Problems Changing the Program Language W...

Страница 166: ... and the B connection on the DI water cartridge was not removed prior to adding DI water If the pump begins emitting a noise try the following 1 Turn off power to the Analyzer and wait 15 seconds 2 Restore power to the Analyzer Cycling power causes the DI pump to stop and start potentially freeing a trapped air bubble If the noise persists turn off power to the Analyzer again 3 Open the Analyzer f...

Страница 167: ...ed contact GE Analytical Instruments at 1 800 255 6964 or 303 444 2009 to order shipping supplies Under no circumstances should you try to pack the Analyzer in anything other than the original shipping container Before repackaging water must be drained from the Analyzer 1 If the Analyzer is taking measurements press the Stop Analysis button 2 Press the Menu button and select the Maintenance tab 3 ...

Страница 168: ...otate it into the retaining clip until it snaps into place The cartridge must be level as you rotate it inward and the bottom of the cartridge must be perpendicular to the bracket 16 Replace the John Guest connections to the DI water cartridge 17 Replace the rubber inlet cover on the DI water cartridge 18 Disconnect the waste tubing and sample inlet tubing from the Analyzer 19 Remove any printer a...

Страница 169: ...GE Analytical Instruments 2010 169 of 226 DLM 74001 04 Rev A Chapter 8 Troubleshooting Figure 44 Removing the John Guest Fittings ...

Страница 170: ...GE Analytical Instruments 2010 170 of 226 DLM 74001 04 Rev A Chapter 8 Troubleshooting ...

Страница 171: ...ments 2010 171 of 186 DLM 74001 04 Rev A Appendix A Analyzer Dimension Diagrams Diagrams show Analyzer dimensions and required clearances as follows inches millimeters Figure 45 Analyzer Dimensions with Standard iOS System ...

Страница 172: ...Appendix A GE Analytical Instruments 2010 172 of 186 DLM 74001 04 Rev A Figure 46 Right Side Analyzer Dimensions with Standard iOS System ...

Страница 173: ...Appendix A GE Analytical Instruments 2010 173 of 186 DLM 74001 04 Rev A Figure 47 Analyzer Dimensions with Super iOS System ...

Страница 174: ...Appendix A GE Analytical Instruments 2010 174 of 186 DLM 74001 04 Rev A Figure 48 Right Side Analyzer Dimensions with Super iOS System ...

Страница 175: ...Appendix A GE Analytical Instruments 2010 175 of 186 DLM 74001 04 Rev A Figure 49 Analyzer Dimensions with Sample Inlet Block ...

Страница 176: ...Appendix A GE Analytical Instruments 2010 176 of 186 DLM 74001 04 Rev A Figure 50 Right Side Analyzer Dimensions with Sample Inlet Block ...

Страница 177: ...Appendix A GE Analytical Instruments 2010 177 of 186 DLM 74001 04 Rev A Figure 51 Left Side Analyzer Dimensions ...

Страница 178: ...Appendix A GE Analytical Instruments 2010 178 of 186 DLM 74001 04 Rev A ...

Страница 179: ...minal Select Start Run type Hypertrm in the Open field and click OK 3 When HyperTerminal launches the Connection Description window displays Enter a name in the Name field such as Sievers 500 TOC Analyzer and click OK 4 If you are using an Ethernet connection when the Connect To window displays select TCP IP from the Connect Using drop down menu Click OK For the Host address enter the Analyzer s I...

Страница 180: ...ou specified in Step 6 When you open the file in a spreadsheet or database program you will need to browse to this folder in the program s Open dialog box 11 Exit out of HyperTerminal You will be prompted to save the connection information Saving the information makes it easier to connect to the Analyzer the next time you want to capture data Determining Your Communications Port Number If your com...

Страница 181: ... single point 117 single point worksheet 134 verification procedure 124 Clock setting 86 Conductivity out of range 73 viewing data 73 Conductivity Autozero for troubleshooting 163 Configuration setting the Analyzer mode 69 Constants exporting 89 printing 89 Consumables DI water cartridge 140 145 displaying status 68 86 replacing 139 sample pump tubing and pump heads 144 setting installation dates ...

Страница 182: ... start binary input 52 selecting a location 47 serial RS 232 connection 54 USB device 54 Ion Exchange Resin See Resin Bed iOS System draining 95 overview 96 proper use 96 IP Address setting 82 J JP 16 Protocol 132 L Linearity Verification procedure 132 Location naming 93 Logging Out 111 M Main Screen 67 Maintenance cleaning the Analyzer touch screen 150 DI Water Cartridge 145 DI water cartridge 14...

Страница 183: ...int calibration set 114 single point calibration set 114 system suitability set 115 Super iOS System cartridge data 99 draining 95 overview 96 System Information Displaying 88 System Settings saving and restoring 89 System Specifications 39 System Suitability system suitability worksheet 137 T Tabs Setup 69 Terminal Blocks connecting to 49 overview tables 50 Theory of Operation 37 Time Zone Settin...

Страница 184: ...struments 2010 184 of 186 DLM 74001 04 Rev A V Verification accuracy precision and verification work sheet 136 history printing 132 reviewing history 132 Vial Sets cartridges 99 W Warnings and Errors list of 154 reviewing 87 ...

Страница 185: ...Notes GE Analytical Instruments 2010 185 of 186 DLM 74001 04 Rev A 186 ...

Страница 186: ...Notes GE Analytical Instruments 2010 186 of 186 DLM 74001 04 Rev A 186 ...

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