Peak Splitting
This parameter controls whether a potentially noisy peak is found as one single peak or as two (or more) separate
peaks. If the dip between two potential peaks is less than the specified value, then a single peak is found. Otherwise,
two peaks are found.
Setting this parameter to a large value will prevent noisy peaks from being split and found as two separate peaks.
However, a smaller value needs to be used if there are two closely eluting (overlapping) distinct peaks.
In
, the graph on the left shows Peak Splitting set to two points. The graph on the right shows Peak
Splitting set to three points.
Figure 6-61 Peak Splitting
AutoPeak Integration Algorithm Parameters
The following parameters are used to identify and report the peak of interest.
For more information, refer to the Help system.
•
Local peak baseline:
The software assesses changes to the baseline locally around the peak as opposed
to calculating the baseline with respect to the entire chromatogram.
•
Linear peak baseline:
The software fits a line between the points at the beginning and at the end of that
specific group of peaks as opposed to the possibility of having a non-linear as the baseline below the peak.
Saturation correction:
When the algorithm detects that a peak is saturated, it uses the model to predict how
the peak might look if the detector had not saturated. This causes the profile to extend above the top of the peak
to approximate the response that would have been obtained if the detector had not saturated. This can extend
the linear dynamic range of calibration curves. This option is only available when setting the overall algorithm
default values and not during processing method creation or individual peak review, because it is not useful to
use this setting for only some peaks.
System User Guide
SCIEX X500 QTOF System
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Operating Instructions—Software
