1 Specifications and Operating Modes
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Constant neutral loss mode
Constant neutral loss mode detects the loss of a specific neutral fragment or
functional group from an unspecified precursor(s).
The scans of MS1 and MS2 are synchronized. When MS1 transmits a specific
precursor ion, MS2 “looks” to see whether that precursor loses a fragment of a
certain mass. If it does, the loss registers at the detector.
In constant neutral loss mode, the spectrum shows the masses of all
precursors that actually lost a fragment of a certain mass.
Constant neutral loss mode:
Typical application
You typically use constant neutral loss mode to screen mixtures for a specific
class of compound that is characterized by a common fragmentation pathway,
indicating the presence of compounds containing a common functional group.
MS1
Scanning
(synchronized with MS2)
Collision cell
Fragmenting
precursor ions and
passing all masses
MS2
Scanning
(synchronized with MS1)
Summary of Contents for Xevo TQD
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Page 56: ...2 Preparing for Operation 56 March 14 2014 715004387 Rev B...
Page 200: ...4 Maintenance Procedures 200 March 14 2014 715004387 Rev B...
Page 216: ...A Safety Advisories 216 March 14 2014 715004387 Rev B...
Page 242: ...B External Connections 242 March 14 2014 715004387 Rev B...
Page 246: ...C Materials of Construction and Compliant Solvents 246 March 14 2014 715004387 Rev B...
