Waters Xevo TQD, Overview And Maintenance Manual

Page: 36 / 250

1 Specifications and Operating Modes
36 March 14, 2014, 715004387 Rev. B
Ion optics
The mass spectrometer’s ion optics operate as follows:
1. Samples from the LC or Intellistart fluidics system are introduced at
atmospheric pressure into the ionization source.
2. The ions pass through the sample cone into the vacuum system.
3. The ions pass through the transfer optics (the ion guide) to the first
quadrupole, where they can be filtered according to their mass-to-charge
ratios.
4. The mass-separated ions pass into the T-Wave™ collision cell where
they either undergo collision-induced dissociation (CID) or pass to the
second quadrupole. Any fragment ions are then mass-analyzed by the
second quadrupole.
5. The transmitted ions are detected by the photomultiplier detection
system.
6. The signal is amplified, digitized, and sent to the mass spectrometry
software.
Ion optics overview:
Sample cone
Isolation valve
T-Wave collision
cell
Z-Spray ion source Quadrupole 1
(MS1) Quadrupole 2
(MS2) Detector
Conversion dynode Sample inlet Transfer optics