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PROPRIETARY INFORMATION
CONFIDENTIAL MATERIAL
Not for Customer Distribution
Assays/Reagents
AEROSET
®
System Troubleshooting Guide
139
94816-107—November 2004
Interference Information
Any condition that shortens RBC survival,
e.g.
, hemolytic
anemia or hemolytic diseases, pregnancy, and recent
significant blood loss, results in decreased HbA
1c
.
Samples containing hemoglobin variants S and C may result in
up to a 40% increase in apparent HbA
1c
result.
Samples containing > 10% HbF may give lower results.
Samples containing HbE were shown to not interfere.
The following table was obtained from the National
Glycohemoglobin Standardization Program (NGSP) website; it
lists effects of frequently encountered hemoglobin variants
and derivatives on HbA
1c
(GHB) measurement. A list of
references can be found on the website,
http://web.missouri.edu/~diabetes/ngsp.html. All of these
methods, with the exception of Beckman Diatrac and Helena
Glyco-Tek, were NGSP certified as of March 2002.
Method
Interference (Yes/No)
HbC
Trait
HbS
Trait
HbE
Trait
Elevated
HbF
Carbamyl-
Hb
Axis-Shield Nycocard
(Primus Nycocard)
No
No
—
—
—
Bayer DCA 2000
No
No
No
—
No
Beckman Diatrac
Yes
Yes
—
Yes
Yes
Beckman Synchron CX7
No
No
—
—
—
Bio-Rad Variant A
1c
No
Yes
No
—
Yes
Bio-Rad Variant GHb
No
No
—
—
—
Bio-Rad Variant II A
1c
No
Yes/No
Conflicting
data in
literature
—
No
울
24%
HbF
No
Helena Glyco-Tek
Yes
No
—
—
—
Menarini HA8140
No
Yes
Yes
No
Yes/No
Conflicting
data in
literature
Primus CLC 330/385
No
No
No
—
No