Micromass Quattro Ultima, User Manual

Page: 154 / 227

Megaflow Hints
With this high flow rate technique the setup procedure involves making the following
adjustments:
•
increase Drying Gas flow to approximately 750 litres/hour.
•
increase Desolvation Temp to 400°C.
•
increase Source Temp to 150°C.
•
move the probe further away from the sample cone.
When changing from electrospray to megaflow operation it is not necessary to
adjust any source voltages.
Cluster ions are rarely observed with Z-spray. However solvent droplets may form
within the source enclosure if the source and desolvation temperatures are too low.
Refer to the previous section on operating parameters for typical desolvation gas flow
rates.
If the sample is contained within a ‘dirty matrix’ the probe may be moved away from
the sample cone to extend time between source cleaning operations. This may incur a
small loss in sensitivity.
Warning: It is normal for the source enclosure, the glass tube and parts of the
probe mounting flange, to get hot during prolonged megaflow operation. Care
should be taken when handling source components during and immediately after
operation.
The source enclosure runs cooler if purge gas is used.
Warning: For health and safety reasons always ensure the exhaust line is vented
outside the building or to a fume hood.
Warning: Ensure that a plastic bottle is connected in the exhaust line to collect
any condensed solvents.
Removing the Probe
To remove the probe from the source proceed as follows:
On the tune page deselect .
Switch off the liquid flow and disconnect from the probe.
Select
Gas
,
Gas
to turn off the nitrogen.
Disconnect the probe cable from the instrument.
Disconnect the nebulising gas supply from the instrument.
Electrospray
Page 154
Quattro Ultima
User's Guide