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When contamination occurs, perform an initial routine cleaning. Clean up to and including the front of the orifice
plate. If routine cleaning does not resolve issues with sensitivity, then a full cleaning might be necessary. Contact
the local QMP or FSE.
This section provides instructions for performing routine cleaning without breaking vacuum.
Note:
Follow all of the applicable local regulations. For health and safety guidelines, refer to
Symptoms of Contamination
The system might be contaminated if any one of the following is observed:
• Significant loss in sensitivity
• Increased background noise
• Additional peaks that are not part of the sample are shown in full scan or survey scan methods
If any of these issues are observed, then clean the mass spectrometer front-end.
Required Materials
Note:
U.S. customers can call 877-740-2129 for ordering information and inquiries. International customers
.
• Powder-free gloves (nitrile or neoprene recommended)
• Safety glasses
• Laboratory coat
• Fresh, high-quality (pure) water (at least 18 MΩ de-ionized [DI] water or ultra-pure HPLC-grade water). Old
water can contain contaminants that can further contaminate the mass spectrometer.
• MS-grade methanol, isopropanol (2-propanol), or acetonitrile
• Cleaning solution. Use one of:
• 100% methanol
• 100% isopropanol
• 1:1 acetonitrile:water solution (freshly prepared)
• 1:1 acetonitrile:water with 0.1% acetic acid solution (freshly prepared)
• Clean 1 L or 500 mL glass beaker to prepare cleaning solutions
• 1 L beaker to catch used solvent
• Organic waste container
System User Guide
TripleTOF
®
5600/5600+ System
RUO-IDV-05-7040-B
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Service and Maintenance Information