3
Purpose and Overview
The TERUFUSION Syringe Pump Type SS3 OTCI is intended for the infusion of general and local anesthetics, vasodilators,
cardiotonics, parenteral feeding, anti-cancer drugs, labor-inducing drugs and blood transfusion at ICU, CCU, NICU, operating
rooms or general wards.
This equipment is intended to be used to inject a drug solution from a syringe constantly at a preset hourly flow rate.
Additionally, this product can be used in the TCI mode, which is equipped with predictive models of the drug action (PK/PD) with
three compartments.
* PK/PD Theory: To analyze the drug action by pharmacokinetics (PK) and/or pharmacodynamics (PD).
Model
Catalogue number
Communication function
Hereinafter referred to as
TE-SS830P
TE
*
SS835Pxx
Infrared communication (IrDA), Wireless LAN
TE-SS830P
Alphanumeric characters are entered for x in the catalogue number.
How the pump works in the TCI mode
In the TCI (Target Controlled Infusion) mode, the pump calculates and controls the flow rate to achieve and maintain the
predetermined (“target”) drug concentration in a patient’s body based on a mathematical model, called a compartment model,
which simulates drug absorption, distribution, and clearance (pharmacokinetics) and the drug effect on the site of action
(pharmacodynamics) in the human body.
This product analyzes the drug action by using the PK/PD models based on a three-compartment model as shown below:
Mô hình 3 buồng
Thuốc vào
k
12
k
13
k
21
k
31
k
1e
k
10
Vùng
ngoại vi
V2
Vùng
trung tâm
V1
Vùng
ngoại vi
V3
Vùng não
Giải phóng
k
e0
Vùng trung tâm
V1: A compartment where drug is input, principally plasma
Peripheral compartment V2: A vessel-rich rapidly distributing compartment such as muscle
Peripheral compartment V3: A vessel-poor slowly distributing compartment such as fatty tissue
Effect-site compartment:
A theoretical concept describing drug effect in the brain, considered to have no volume
Used for effect-site TCI
k
21
, k
31
:
Distribution (drug transfer) rate constant to the central compartment V1
k
12
:
Distribution rate constant to the peripheral compartment V2
k
13
:
Distribution rate constant to the peripheral compartment V3
k
10
:
Clearance (elimination) rate constant from the central compartment
k
e0
(~ k
1e
): Transport rate between the central compartment and the effect-site compartment
This product provides five TCI modes in combinations of drugs (Propofol and Remifentanil), PK/PD models (Marsh, Schnider, and
Minto), and targets (plasma targeting and effect-site targeting).
Purpose, Overview and Features of the Product
