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Bauhs below). User manuals may contain an informative section that describes means for
conversion of the displayed CTDI
vol
or dose profile to an estimated phantom peripheral dose,
which may serve as an estimate for peak skin dose. A typical CT perfusion study should not
result in a console-displayed CTDI
vol
of more than 1,000 mGy. Care should be taken and
consideration given prior to rescanning a patient within a short time with a perfusion acquisition
for the same anatomy due to concerns about reaching a cumulative peak skin dose value
greater than the deterministic threshold for skin injury.
Sites should have a Quality Assurance (QA) program for oversight and review of any protocol
changes. As with other scan types, the CTDI
vol
for a CT perfusion acquisition is recorded in both
the DICOM screen capture and the DICOM CT dose structured report and should be used for
QA follow up for all scanning.
Additional information on CT perfusion may be obtained in the user manuals for the CT
perfusion post-processing software, from the ACR practice guide for CT perfusion, and from the
AAPM website that contains reference perfusion protocols as well as other perfusion related
information (please visit FDA website for documents related to radiation dose quality
assurance).
All the reference protocols provided within the software of this system, including those for CT
perfusion, are included in the Applications Protocol document supplied with the system. This
document provides a concise description of each scanning series within the protocol, technique
factors, and dose information for each.
2.2.2.8 Recommended reading
1. Ting Lee, “Functional CT: physiological models”, Trends in Biotechnology Vol. 20 No. 8
(Suppl.), 2002.
2. Jessica C. Tan, MD,1 William P. Dillon, MD,1 Songling Liu, MD,1 Felix Adler, MD,1 Wade S.
Smith, MD,2 and Max Wintermark, MD, “Systematic Comparison of Perfusion-CT and CT-
Angiography in Acute Stroke Patients”, Annals of Neurology Vol 61 No 6 June 2007.
3. Brix, G, ML Bahner, U Hoffman, A Horvath, and W Schreiber. 1999. “Regional blood flow,
capillary permeability, and compartmental volumes: Measurements with dynamic CT-Initial
Experience”, Radiology 210 : 269-276.
4. Cenic, A, DG Nabavi, RA Craen, AW Gelb, and TY Lee. 1999. “Dynamic CT measurement
of cerebral blood flow: A validation study”, American Journal of Neuroradiology 20 : 63-73.
5. Dillon, WP, and D Gress. 1999. “Intraarterial thrombolysis for cerebral infarction: To treat or
not to treat, and how?”, AJNR 20 : 1194-96.
6. Hunter GJ, Hamburg LM, Ponzo JA, Huang-Hellinger FR, Morris PP, Rabinov J, Farkas J,
Lev MH, Schaefer PW, Ogilvy CS, Schwamm L, Buonanno FS, Koroshetz WJ, Wolf GL,
Gonzalez RG. “Rapid assessment of cerebral perfusion and arterial anatomy in hyperacute
stroke with 3D functional computed tomography: early clinical results”, AJNR 19 (1):29-39,
1998.
7. Nabavi, DG, A Cenic, RA Craen, AW Gelb, JD Bennet, R Kozak, and T Lee. 1999. “CT
assessment of cerebral perfusion: Experimental validation and initial clinical experience”,
Radiology 213 : 141-149.
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2 Scan Theory