Waters Xevo TQ MS, Operator And Maintenance Manual, Page: 25 / 184

Ion optics 1-9
Ion optics
The mass spectrometer’s ion optics operate as follows:
1. Samples from the LC or instrument’s solvent delivery system are
introduced at atmospheric pressure into the ionization source.
2. The ions pass through the sample cone into the vacuum system.
3. The ions pass through the transfer optics to the first quadrupole where
they can be filtered according to their mass-to-charge ratio (m/z).
4. The mass-separated ions pass into the collision cell
(T-Wave™/ScanWave™) where they undergo collision-induced
dissociation (CID) or pass to the second quadrupole. Any fragment ions
can then be mass-analyzed by the second quadrupole.
5. The transmitted ions are detected by the photomultiplier detection
system.
6. The signal is amplified, digitized, and sent to the MassLynx mass
spectrometry software.
Ion optics
Sample cone
Isolation valve
T-Wave/ScanWave
collision cell
Z-Spray ion source Quadrupole 1
(MS1) Quadrupole 2
(MS2) Detector
Conversion dynode Sample inlet Transfer optics