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Continuous Mononuclear Cell Collection (CMNC) Procedures
154
Spectra Optia Apheresis System Operator’s Manual
Collecting plasma
To collect the plasma, the system stops the collect pump, increases the centrifuge speed and decreases the inlet
pump flow rate to 60 mL/min, if necessary, to increase the packing factor to at least 14 and to reduce the number
of platelets flowing through the plasma port. Once the target packing factor is achieved, the system decreases the
plasma pump flow rate, which lowers the interface position. The system then increases the plasma pump flow rate
and once any remaining platelets have been cleared from the plasma line, the system moves the plasma valve into
the collect position and begins collecting plasma.
If you configured the procedure to collect plasma at the beginning of the run and you increase the target plasma
volume during the run, a screen appears with instructions for indicating whether the additional volume should be
collected immediately (now) or at the end of the run. Follow the instructions on the screen to indicate your
preference and resume the run.
Priority of collect volume and plasma volume
The system always prioritizes collection of the target collect volume over the target plasma volume when the plasma
collection is selected to occur at the end of the run. If you decrease a run target, make sure you thoroughly review
the values that have changed on the run values screen before you touch
Confirm
. If the decrease in the run target is
significant, the target plasma volume could be reduced to zero, and the collect volume could also decrease.
SpectraOptiaOpsManual.book Page 154 Thursday, May 17, 2018 11:24 AM