Section G – Dissolution Testing
CD14 Tester & CD AutoPlus Autosampler User Guide—75-108-800 Rev. B—31 May 2021
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EAR99 technology subject to restrictions on cover page.
Manual Staggered Start with CD14 Tester
1.
On the tester, touch the temperature to bring up the
Temperature Setpoint screen. Enter the desired
bath temperature (+ 0.10 °C of the desired vessel
temperature is recommended) and touch OK.
2.
Raise the drive head to its highest point.
3.
Fill the vessels with media.
4.
Prepare the apparatus:
a. Baskets
i.
Raise the spindle shafts to their highest
point.
ii. Lower the drive head to the testing position.
iii. Cover the vessels
iv. Allow the media to stabilize.
b. Paddles
i.
Lower the paddles into the media to about 1
cm above the testing height. The CD14
Tester drive head should be lowered.
ii. Cover the vessels and allow the media to
stabilize.
c. Paddles with ADD Cover
i.
Close the chamber of the ADD cover by
pressing the hinged portion on the bottom of
the cover closed.
ii. Lower the paddles into the media to the
testing height. The CD14 Tester drive head
should be lowered.
iii. Cover the vessels and allow the media to
stabilize.
5.
Once the media has stabilized start the method
procedure described below.
