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800581-2.11 NeurOne System User Manual.doc

MRI Information

Non-clinical testing has demonstrated the NeurOne Tesla amplifier,
battery pack, Bipolar Connection Box and MRI cap accessories are MR
conditional. MR Conditional system parts are labeled with MR
Conditional symbol.

MR Conditional system parts are for INVESTIGATIONAL USE ONLY!

Static Magnetic Field

Based on non-clinical testing the above devices can be scanned safely in a MR environment
under the following



Static magnetic field of 3 Tesla only



Spatial gradient field of 253 T/m (25.300 gauss/cm) and less



Spatial gradient field product of 684 T2/m and less



Theoretically estimated maximum whole body averaged (WBA) specific absorption

rate (SAR) of < 2 W/kg at 3 Tesla, (related to 2.3°C temperature increase) for 15
minutes of continuous MR scanning.

The following MRI scanner has been used in non-clinical testing:



Siemens Trio 3T



Siemens Prisma 3T



Philips Achieva 3.0 tx

Maximum duration of single scan based on non-clinical testing: 15 min of EPI

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Summary of Contents for NeurOne

Page 1: ...Page 1 of 191 800581 2 11 NeurOne System User Manual doc NeurOne User Manual Date of issue February 21st 2018...

Page 2: ...ion 23 3 3 4 NeurOne Database Conversion 26 3 4 INSTALLING NEURONE VIDEO OPTION 29 3 5 CONFIGURING THE ETHERNET ADDRESS FOR THE COMPUTER 29 3 5 1 NeurOne IP address 30 4 HARDWARE INSTALLATION 31 4 1 M...

Page 3: ...6 1 Audio Output Control 69 5 3 6 2 Data Writer 70 5 3 6 3 Impedance 70 5 3 6 4 Raw Signal Monitor 71 5 3 6 5 Response Monitor 72 5 3 6 6 Video Monitor 75 5 3 7 Finalizing the Protocol 75 5 4 MEASURE...

Page 4: ...ANALOG OUTPUT 150 APPENDIX 5 NEURONE DATA FORMAT 151 BINARY FILES 151 SIGNAL FILES 151 EVENT FILES 152 PROTOCOL XML 154 SESSION XML 155 SYSTEMINFO XML 155 HEADBOXVOLTAGES XML 156 APPENDIX 6 USE OF EXT...

Page 5: ...RESTATE PACKET 177 CLOCKSOURCESTATE PACKET 177 JOIN PACKET 178 EXAMPLES 179 GNU OCTAVE SCRIPT FOR RECEIVING UDP SAMPLE PACKETS 184 APPENDIX 12 RAW MONITOR CONTROL PARAMETERS 185 APPENDIX 13 RESPONSE M...

Page 6: ...0601 1 2 IEC60601 1 2 Medical electrical equipment General requirements for safety Electromagnetic compatibility Requirements and safety EN60601 2 26 IEC60601 2 26 Medical electrical equipment Particu...

Page 7: ...is not to be used with patients who have active implantable medical device like heart pacemaker etc Conductive parts of ELECTRODES and their connectors including the NEUTRAL ELECTRODE should not cont...

Page 8: ...tions regulatory and statutory requirements and appendices Please note that some maintenance and service procedures specified in this manual require the use of special tools or devices Some of these d...

Page 9: ...ctive 2002 96 EC on Waste Electrical and Electronic Equipment WEEE 1 3 User Responsibility This product shall be assembled operated maintained and repaired in accordance with the instructions provided...

Page 10: ...y date of the product Installation of additional equipment that is not specified or approved by Bittium or is such quality to render the unit inoperable may invalidate the warranty This warranty does...

Page 11: ...over 80 without proper protection Do not expose to temperatures under 0 C 32 F 273 K or above 35 C 95 F 308 K or relative humidity over 80 without proper isolation These include also storing and trans...

Page 12: ...Page 12 of 191 800581 2 11 NeurOne System User Manual doc 2 2 System Diagrams...

Page 13: ...Page 13 of 191 800581 2 11 NeurOne System User Manual doc Note SPI and COM port are not yet available and will be enabled by future updates...

Page 14: ...ta stream that s sent to the PC Incoming event triggers are fused to data stream in the Main unit Audio output from defined sources takes place in Main unit Tesla amplifiers are connected to the NeurO...

Page 15: ...alibration Do not try to open the device the Power Supply the cables or other sealed parts of the system Only technical personnel authorized by Bittium Biosignals Ltd are allowed to open these parts s...

Page 16: ...t RJ45 100 1000 Mb s USB One USB3 port for video option Operating System Windows 7 Professional 64 bit Recommended PC requirements Processor Intel i7 3 0 GHz or better Screen Resolution Full HD 1920x1...

Page 17: ...ion It uses the Microsoft NET Framework 4 0 Microsoft Visual C 2015 redistributable library and Microsoft SQL Server 2014 Express The installer will install or update these system parts automatically...

Page 18: ...directory that the files will be installed is short For example you can 1 select the folder C temp and 2 press OK After extraction the installer automatically starts installation of a new database se...

Page 19: ...Page 19 of 191 800581 2 11 NeurOne System User Manual doc At Product updates click Next On the feature selection page make sure all features are selected and click Next...

Page 20: ...0581 2 11 NeurOne System User Manual doc On the Instance configuration page 1 ensure that the Named instance and Instance ID fields are set to value NEUROSQLEXPRESS and 2 click Next On Server Configur...

Page 21: ...Page 21 of 191 800581 2 11 NeurOne System User Manual doc In database engine configuration leave selection to default Click Next...

Page 22: ...ystem User Manual doc Click Close to exit SQL Server 2014 Setup 3 3 2 Visual C 2015 Redistributable Installation If the Visual C 2015 Redistributable x64 is not installed the installer will install it...

Page 23: ...ed on the PC and it is detected the setup program asks to choose 1 either existing or new database for installation and 2 Click Next If you re upgrading from an older version of NeurOne PC Software it...

Page 24: ...nnot be changed in application path selection controls are disabled If you ve selected a Session data path on a drive with less than 20 GiB free space the installer will show you a warning Then select...

Page 25: ...rOne program files are installed to the folder C Program Files Bittium Biosignals Ltd NeurOne During the installation the calibration files hbc of the amplifiers found on the installation media are co...

Page 26: ...eurOne database file so that it will work with new version of NeurOne First install SQL Server 2014 express with management studio to your computer This is not contained in the NeurOne installer You n...

Page 27: ...efault it is C ProgramData Mega Electronics Ltd NeurOne or C ProgramData Mega Electronics Ltd NeurOne64 Select the NeurOne database file NeurOneDB mdf Make sure that you make backup form the database...

Page 28: ...nd you need detach the database to be able to use it in NeurOne software Right click the attached database select task detach and click OK Database will disappear from under the system database and is...

Page 29: ...lect Network and Sharing Center and click on Change adapter settings Right click on Local Area Connection and select Properties In the Networking tab select Internet Protocol Version 4 TCP IPv4 and cl...

Page 30: ...and follow the above instructions 3 5 1 NeurOne IP address The following table defines the control IP address of NeurOne Main unit when used as Stand alone without SyncBox and as Master Slave Main uni...

Page 31: ...cs Model EXG amplifier or Tesla amplifier o Main Unit power cable with AC DC transformer o Amplifier power cables 1 4 pcs o Optical cables between Main Unit and Amplifier 1 4 pcs o Trigger cable for i...

Page 32: ...3 Display Display for measurement information and device diagnostic purposes 4 Power On Led ON Indicates that the Main Unit is operational 5 Power Indicator Led AC Indicates that the Main Unit is con...

Page 33: ...in 8 bit input 9 Amplifier power supply power connection to the amplifiers 10 Amplifier data transfer optical connection to the amplifiers SyncBox Digital OUT Connection for UDP transfer to other PC...

Page 34: ...igital OUT Connection for UDP transfer to other PC RJ45 7 Amplifier Data Transfer Optical connection to the Amplifiers SyncBox 8 Potential Equalization Connector for potential equalization cable that...

Page 35: ...ould be connected to the potential equalization rail in the measurement room It helps to reduce power line interference 50 60 hz 2 Power medical approved power supply 100 240 vac in 12 vdc out 3 Trigg...

Page 36: ...Amplifier front panel connections 1 Monopolar inputs Channels 1 32 with safety connectors 2 Bipolar inputs Channels 33 40 with safety connectors red signal black reference 3 Reference inputs REF The...

Page 37: ...plifier 2 is 2 etc With EXG amplifier you can also use 12 V Battery Pack 4 5 Tesla Amplifier A single NeurOne Tesla amplifier offers 32 monopolar channels and 8 bipolar channels allowing up to 40 avai...

Page 38: ...ovides inputs for two amplifier master and slave The master amplifier has inputs 1 40 and slave inputs 41 80 JackBox interface 1 Reference inputs REF Two reference inputs for all monopolar channels 2...

Page 39: ...fier is connected 11 Bipolar inputs 73 80 Safety connectors red signal black reference JackBox can be piled with two Tesla amplifiers as shown in the following picture 4 7 Bipolar Connection Box NeurO...

Page 40: ...connected to Tesla amplifier and power is turned on For each input there are two types of connectors safety connectors active and reference and 5 pole Binder connector Default labeling for input are...

Page 41: ...the instructions in chapter 4 14 5 Charging the Battery Pack 4 Connect each EXG amplifier power cable to the Amplifier power supply connector on the Main Unit Use the connector labeled Amplifier 1 fo...

Page 42: ...e Trigger cable which is connected to NeurOne Main unit Set the Input pulse trigger type to Video sync trigger 14 Connect Audio plug of Video trigger interface cable to MIC input of video camera 15 Op...

Page 43: ...ntrolled by the Power button of Main Unit NeurOne Main Unit Power button controls the following operations Power ON OFF Display mode change and FW upgrades to the amplifiers SyncBox and Digital out Th...

Page 44: ...file name syntax is TMS serial number date hbc MRI serial number date hbc EXG serial number date hbc 2 If the desired calibration file is not found please ask for the calibration file of desired ampli...

Page 45: ...Devices 4 12 1 Isolated Trigger In Out Trigger A Trigger B The NeurOne Main Unit provides two isolated trigger I O connectors Trigger A and Trigger B Both connectors have one Trigger In and one Trigg...

Page 46: ...be configured to emit digital measurement data via an optional add on Ethernet port called Digital OUT This is ideally suited for real time solutions that require data with minimal latency 4 12 4 1 S...

Page 47: ...mains power The Battery Pack can be used in any conditions but it is especially useful in restrictive measurement environments such as inside a magnetic resonance imaging scanner or where a stable ele...

Page 48: ...ates low output voltage below 12 V 4 Green Indicator Led Indicates high output voltage 4 14 3 Battery Pack 6 V for Tesla amplifier The side panel of the Battery Pack 6 V contains the following compone...

Page 49: ...oltage below 5 5 V 2 Power Switch 3 Power Out Charger Tesla amplifier or to Battery Charger for Battery Pack 7 2 V The battery type of Battery Pack 7 2 V is NiMH 4 14 5 Charging the Battery Pack 4 14...

Page 50: ...ely 5 hours Depending on the depth of discharge and operating temperature the Battery Pack 6 V provides 200 to 300 discharge charge cycles Please see YPC2A12 User Guide pdf for further instructions fo...

Page 51: ...ack EXG Amplifier 13 h Amplifier and 6 5 h 2 Amplifiers Tesla Amplifier 10 h Tesla Amplifier and 5 h 2 Tesla Amplifier Connect Battery Pack power cable only to the corresponding amplifier s Do not con...

Page 52: ...al Main Units connected to SyncBox The following features are available SyncBox distributes common clock pulse to each Main Units connected to SyncBox The main clock can be oscillator in SyncBox or cr...

Page 53: ...es that the SyncBox is operational If LED is ON there is connection between SyncBox and Main Unit If LED is blinking Main Unit connection does not exist 5 Power Indicator Led AC Indicates that the Syn...

Page 54: ...Main Unit to SyncBox using Optic connector 4 connector for Amplifier Ethernet connections by using switch Connect Ethernet cable from PC to port 1 of the switch Connect Ethernet cable from Main Unit M...

Page 55: ...ed at the bottom of the window displays Institute name of your user license SyncBox status SyncBox clock source information MHz and free disk space indicator when corresponding information is availabl...

Page 56: ...st A list of all persons entered into the NeurOne database The fields can be sorted by clicking the label of the wanted column Clicking a name selects a Person from the list and displays the Person de...

Page 57: ...selected according to previous application run If you don t want to group your measurements you can use the predefined Project called NeurOne You can manage the Projects with the following buttons New...

Page 58: ...abs on the right The protocol toolbar contains basic controls for creating and manipulating Protocols New The mode for creating a new protocol Enables editing the fields in the Protocol subtabs Confir...

Page 59: ...5 3 2 Main Properties Protocol subtab Name Input field for the name of the Protocol Protocol editor now appends a sequential number to protocol name if a protocol with given name already exists Sampl...

Page 60: ...ve white background color and the rows representing bipolar inputs are highlighted gray background color Some user configurable parameters e g the device filter affect the hardware and thus can affect...

Page 61: ...f the filter 80 kHz fundamental sampling frequency of hardware 10 kHz actual output sampling frequency defined in protocol Signal Type Type of the signal to be measured for example EEG EMG ECG Unit Un...

Page 62: ...r the calculator Functionality of calculation inputs have been disabled in current SW version Please use ONLY normal inputs Source Inputs Defines the physical inputs which is used as source for the ca...

Page 63: ...output channels Select either single channel or channel pair for desired analog or audio channel If channel pair is selected the channel difference of selected channels will control the output Data sa...

Page 64: ...hrough Digital OUT Inputs are added in order as they are defined in the input list Add all inputs from defined input list of the protocol to be the Digital OUT list Delete selected input from the Digi...

Page 65: ...sampling performed at regular intervals The chosen delivery rate i e how often UDP datagrams are emitted depends on measurement configuration User can request delivery rates of 100 Hz 250 Hz 500 Hz 1...

Page 66: ...measurement data samples triggers is emitted and also upon reception of a Join packet Note that this packet can contain different payloads which depend on the situation CheckBox Trigger delivery on ri...

Page 67: ...lternatives for trigger sending o Send Triggers as a Channel o Send Triggers as Packets o Do Not Send Triggers 5 3 5 Montage The Montage subtab is used to create the default Montage for the Protocol t...

Page 68: ...ng the inputs of the input group Input groups are defined in Tools Input Group Pool Chapter 5 7 1 Name Channel name as seen in the monitor views Side Side information i e left or right optional Min Y...

Page 69: ...ing the measurement session are disabled for the rest of that session Each page has Add and Delete buttons for adding and removing corresponding plug in New plug in name appears on the list top of the...

Page 70: ...er it can be used only for monitoring purposes There can be only one Data Writer defined 5 3 6 3 Impedance This page defines the monitor for impedance test to be used in the measurement The Impedance...

Page 71: ...e threshold between good and acceptable impedance In impedance monitor and in EXG amplifier this is the threshold between green and orange indication color 5 3 6 4 Raw Signal Monitor This page defines...

Page 72: ...nt raw monitor 5 3 6 5 Response Monitor This page defines the response monitor s EP monitoring to be used in the Protocol There can be several response monitor definitions on this page The Response pa...

Page 73: ...by main record If set the main record button in raw monitor controls also the saving of responses Interactive average if set response monitor waits for the users action to proceed when the averaged c...

Page 74: ...unction is where a and b are slope coefficients these are the user settable coefficients fs is sampling frequency and 1 2 and 3 are fitting parameters determined by the fit for each TMS EEG response t...

Page 75: ...vailable Requested frame rate Video frame rate selection Audio device Sound controller selection for video option Average bitrate kbyte s Selection for average bit rate in MPEG 2 encoding of the captu...

Page 76: ...tab allows the user to fill in measurement related data before continuing with the actual measurement The fields are Exam code Exam code of the session data e g archiving number Technician The current...

Page 77: ...ecked in Settings see chapter 5 8 1 If checkbox Recording starts automatically is not checked the button Start Record must be clicked in order to start data recording Start Impedance test The third St...

Page 78: ...ing system configuration serials HBC files etc is now saved to the session folder of every measurement If any data is dropped recording is stopped and a new recording cannot be started without restart...

Page 79: ...itors of the measurement view can also be controlled using the buttons on the Toolbar of the monitor These buttons control the layout scaling sweep time triggers and Montage selection for the monitors...

Page 80: ...the label of the channel Grid On off selection if selected the grid is on the drawing area of the monitor Baseline Show all Sets baseline visible for all channels Hide all Removes baseline from all c...

Page 81: ...vidual channels Y axis max Sets Y axis maximal level of the channel Y axis min Sets Y axis minimum level of the channel S Increase vertical axis sensitivity of the channel for quick scale adjustment S...

Page 82: ...ta at the sampling frequency defined in the protocol Therefore display filters should be designed for the sampling rate defined in the protocol Mouse wheel Change window time base S Decrease vertical...

Page 83: ...annels Auto align Enable all Auto align enabled for all response curves Disable all Auto align disabled for all response curves Calculate from ms nn Definition of start time nn for align level calcula...

Page 84: ...n Record responses if set on responses are recorded to own data folder as reviewable data Single When set on button is highlighted the monitor shows n latest responses ch Number n of responses defined...

Page 85: ...he start of measurement Decay fit start ms See chapter 5 3 6 5 Coefficients 1 2 See chapter 5 3 6 5 In curve drawing area of response monitor right clicking on top of a single channel in a monitor ope...

Page 86: ...ment when the response monitor is selected F Fit curves vertically or keypad Increase decrease vertical scale PgUp or PgDn Switch montage M Toggle TMS Mute N Toggle TMS Decay 5 4 2 Impedance Test Impe...

Page 87: ...he indicator LEDs of the channels on the Amplifier only in EXG shows simultaneously the corresponding green orange red light during the impedance measurement If the viewing mode is selected to picture...

Page 88: ...ll electrodes are sufficient for proper measurement Use REF always when measuring impedance In EXG amplifiers also if only bipolar channels are used Use PGND when measuring impedance Do not use GND In...

Page 89: ...10 minutes the software gives the warning and possibility to cancel the choice o If Next session is chosen the file is left to person data folder primary location and will be moved to session folder a...

Page 90: ...nput Right Volume control Left Left Volume control Right Right Gain control Gain Increase Boost Decrease Boost Boost adjust by 1 dB steps Checkbox to lock volume controls Unchecked adjust left and rig...

Page 91: ...y double clicking the desired comment After the creation of new comment it is moved to the Session list on the left side of the dialog These comments are not saved to the database and therefore they a...

Page 92: ...which can be changed and saved during the Protocol session Latency markers are operational only in Default view The following picture shows an example of a monitor layout on the left there is a raw m...

Page 93: ...o find the latency after certain time instant In the middle response monitor the latency markers are set to find the latency after 230 ms and thus only the values after 230 ms are included Now looking...

Page 94: ...gers indicated with blue triangles in Raw Monitor Before stopping the recording first press the Trig button on the Video Trigger Unit and then stop the recording Stop video trigger output from Video T...

Page 95: ...ns for selected data It is possible to modify the results view Keep mouse pointer on the result list header Press mouse right button Select from pop up menu Column chooser Drag columns from to Customi...

Page 96: ...format export Brain Products Export Direct export to Brain Products raw data format to analyze it you need the Brain Products or BESA license purchased SDN SID Export Export to NeurOne simulation file...

Page 97: ...oducts SDN SID MegaWin ASCII Remove selected session from Export list Export selected sessions 5 5 1 Review window Review window provides data inspection tools with scaling zooming and panning as foll...

Page 98: ...mouse pointer to the right edge of the area to be zoomed Release the mouse button as default this operation is set on Mouse Pan Panning of the in the zoomed data as default this operation is set on M...

Page 99: ...alues constantly shown by setting the parameter Keep cursor values visible Statistic tab Shows general information about the recording montage and inputs Events tab Shows the information about the eve...

Page 100: ...ed curve On the right side of the window appear numeric values data curve of selected data area and spectrum of selected data of selected channel Event editor Editing tool for events This tool provide...

Page 101: ...cted channel exceeds or goes under defined threshold level Pressing Generate on NeurOne event editor opens Marker creator control with the following definition parameters Source channel defines the ch...

Page 102: ...the drawing area On off selection Millimeter grid for ECG Allows millimeter grid on the drawing area for ECG monitoring On off selection Anti aliased lines Curve smoothing On off selection Line width...

Page 103: ...e In addition this menu provides possibility also to set display filter for signal same type and add comment If the whole data is not shown on the drawing area there is the horizontal slider arrow lef...

Page 104: ...ion in the data is pointed with the tracking cursor in data review Pause Video monitor pauses the video play Stop Video monitor stops the video play Slider below video area controls manually video pla...

Page 105: ...sing new types of triggers in order to ease the further data analysis If single responses SR and average responses AR are stored the data structure is SR1 SR2 SR3 SRN AR1 SR1 SR2 SRN AR2 SR1 Where SR1...

Page 106: ...ters The Tools tab allows the user to create Input Groups Montages and Display Filters to be used during measurements On the left side of the tab is the Tool selector with the following selections Inp...

Page 107: ...put Group Description The description of the Input Group Add new Input Group to the list of Input Groups Remove selected Input Group from the list and from database Import new Input Group from XML fil...

Page 108: ...col button is active if some protocol is in edit mode If Shift key is pressed simultaneously input list of the protocol is appended 5 7 2 Montage pool On the left side of the Montage Pool page is the...

Page 109: ...e draw area Auto Align If checked the curve will be forced to stay on the drawing area by changing the Y scaling but keeping the user defined range Max Y Min Y Inverted Y axis If checked the channel i...

Page 110: ...ool The Display filter pool has two vertical tabs IIR Filters and FIR filters In both tab there are set of filter design parameters for filters to be used in the Protocol On the bottom of the subtab t...

Page 111: ...IIR Filters or FIR Filters tab Add new Display filter to the list of display filters Remove selected Display filter from the list and from database Import new Display filter from XML file Export sele...

Page 112: ...in dB Date created Creation date Date modified Modification date Note the limitations for raw monitor use Info button for the description about design method Updated automatically Design parameters fo...

Page 113: ...mpling frequency of the Protocol note the sampling rate limitations for raw monitor 5 8 Accessing settings The Settings tab is used for controlling all the settings related to the NeurOne Main Unit an...

Page 114: ...he Amplifiers update the firmware of the Main Unit and the Amplifiers and create new filters By pressing Shit key simultaneously with Manager button grid view style NeurOner manager is opened See more...

Page 115: ...y the Main Unit In case trigger type is Mute Output trigger will be sent when muting is complete set on On the Non isolated 8 bit trigger input tab there are the following control parameters Enabled I...

Page 116: ...e system NeurOne system without SyncBox If SyncBox system is selected NeurOne recording expects to find the Master Main Unit at address 192 168 200 101 If NeurOne system is selected NeurOne recording...

Page 117: ...amplifiers connected to the Main Unit as well as SyncBox if connected to Main Unit s Refresh and Setting buttons are on the left top corner of the window Make sure the all devices are properly connec...

Page 118: ...icon above Main Unit Press Update firmware button and browse to the folder location with the upgrade file for update exists and select the file Press open The Upgrade starts Main Unit display shows th...

Page 119: ...ng Main Unit display Press button for 2 s to start upgrading o Press Power button for 2 3 s o Display Now release button to start upgrading o Release the button o Display Press button for 2 s to confi...

Page 120: ...Impedance tab it is possible to set threshold levels for impedance measurement On the SyncBox tab if Ext Clock Marker compensation is checked all marker timestamps are re adjusted based on the extern...

Page 121: ...8 2 Remote Control NeurOne TCP Remote Control is a new feature introduced in NeurOne 1 4 1 39 It enables remote controlling start recording stop recording stop session of a running measurement and sup...

Page 122: ...sconnect any new clients trying to connect Apply Immediately applies the settings Remote control is restarted with the new settings Any previously connected clients will be disconnected The network in...

Page 123: ...ntial input of the amplifier reference selection none the reference input field in montage is empty but the corresponding text in curve name is defined here As default Empty source text is REF In the...

Page 124: ...titute information placed into reports created with the NeurOne system Edited information will be stored automatically to the database Besides information you can also select a logo to be placed on th...

Page 125: ...alibration Offset Calibration Adapter for Tesla amplifier Offset Calibration Adapter for EXG Amplifier Internal gain calibration No adapter needed for Tesla amplifier Calibration Adapter for EXG Ampli...

Page 126: ...G Amplifier and press Calibrate 7 Amplifier calibration window shows the list of available Amplifier calibration files hbc For new calibration press New HBC button 8 New calibration file to be used in...

Page 127: ...In Calibration options window set AC and DC signal path set Calibration type Offset Uncheck Use internal test signal Run the offset calibration with setting shown below 14 The reminder message shown...

Page 128: ...alibration progress window shows the progress all calibration steps defined to be executed 17 When AC and DC offset calibration is completed close the window 18 The calibration values of Offset DC and...

Page 129: ...in calibration 20 Press Select all button to select all channels for calibration or select desired channels 21 Press Calibrate 22 In Calibration options window set AC and DC signal path set Calibratio...

Page 130: ...en set active for the amplifier In above Amplifier calibration window example new calibration file is saved and set active for the Tesla amplifier As the result of improper calibration the calibration...

Page 131: ...r installed ask Bittium Biosignals for more information and information on the software The User manual can be opened by clicking the User manual button Release notes opens the file ReleaseNotes txt A...

Page 132: ...e Protocol tool tab The fields on the right of the screen will activate and enable you to fill in and select values in the text boxes and drop down menus Name the Protocol as you wish Set the sampling...

Page 133: ...tional options to be selected in creating the display channels Note that information from all sensors will be recorded regardless of what display channels are created Choose the active and reference e...

Page 134: ...or is named to be P300 standard and the second P300 target Other settings except Accepted 8 bit Trigger Values will be similar and the following settings are set Window Pre stim time ms 50 Post stim t...

Page 135: ...three curves As a default the reference is set to be reference and now this must be changed to A1 A2 that was made in the input group pool Select Reference source and choose the A1 A1 on the drop dow...

Page 136: ...ove size the windows the way you like If you have several display monitors drag windows to other monitors to get a clear view of all the monitors at the same time Using the Settings magnet you can att...

Page 137: ...he protocol 2 No monitor is defined in the protocol Solution 1 Define curves for default montage 2 Define raw monitor s for the protocol Problem Recording START button is not active during the measure...

Page 138: ...Current consumption Max 3 0 A Connectors Analog Out 16 ch Centronics 24 pin Audio Out 3 5mm connector for headphones external audio amplifier Isolated trigger A Out In Isolated trigger B Out In 8 bit...

Page 139: ...ions 33 x 7 x 27 cm Weight 2 9 kg 8 3 Main unit model Black High Intended use Electroencephalograph Storage methods Online to PC Raw Amplifiers EXG Max 4 pcs 40 channel amplifier boxes EXG or Amplifie...

Page 140: ...on 24 bit ADC range 2 5 v 2 5 V System Gain AC mode 1000 System Gain DC mode 10 Full Scale Input Range AC mode 4 3 mV DC mode 430 mV Sensitivity AC mode 0 51nV bit DC mode 51 nV bit RMS noise 0 8 uV R...

Page 141: ...ltaneously Sampling rate Hz 250 500 1000 2000 5000 10000 160 ch 20000 120 ch 40000 40 ch 80000 20 ch Sampling rate per channel 80kHz up to 20ch 40kHz up to 40ch 20kHz up to 80 ch 10kHz up to 160 ch A...

Page 142: ...Inputs 1 32 Unipolar Inputs 33 40 Bipolar Inputs 41 72 Unipolar Inputs 73 80 Bipolar 2 x REF 2 x GND 1 x PGND KEL connectors 2 x Inputs 1 40 for Master 2 x Inputs 41 80 for Slave Indicator LEDs Master...

Page 143: ...ber of cells 2 LoBatt level 5 5 V Charger type YPC2A6 Yu Power Charger connector RPC2 12P 7S Charging current max 2 A 8 9 Battery Pack 7 2V Dimensions 35 x 165 x 225 mm Weight 2 0 kg Box type G747 Mul...

Page 144: ...01 2 26 EC Declaration of Conformity We hereby declare under our sole responsibility that the products mentioned below comply with the European Medical Directive 93 42 EEC as amended by the Directive...

Page 145: ...ood concrete or ceramic tiles If the floor is tiled with synthetic material the relative air humidity must have 30 at least Fast transient electric disturbances bursts acc to IEC 61000 4 4 2 kV for po...

Page 146: ...in regard to stationary transmitters a study of the location should be considered If the measured field strength at the location where the device is being used exceeds the accordance level above the...

Page 147: ...age 147 of 191 800581 2 11 NeurOne System User Manual doc A AP PP PE EN ND DI IX X 1 1 P PI IN NO OU UT TS S O OF F T TE ES SL LA A A AM MP PL LI IF FI IE ER R K KE EL L C CO ON NN NE EC CT TO OR RS S...

Page 148: ...M MP PL LI IF FI IE ER R D D C CO ON NN NE EC CT TO OR RS S 35 40 34 33 33 VA VA VA GND GND GND GND GND VA 34 37 38 39 36 35 40 37 38 39 36 Pin 1 Bipolar Module connector outside view 15 13 11 9 7 5 3...

Page 149: ...1 2 11 NeurOne System User Manual doc A AP PP PE EN ND DI IX X 3 3 P PI IN NO OU UT T O OF F N NO ON N I IS SO OL LA AT TE ED D 8 8 B BI IT T T TR RI IG GG GE ER R IN1 GND NC GND NC GND GND IN2 IN3 IN...

Page 150: ...rOne System User Manual doc A AP PP PE EN ND DI IX X 4 4 P PI IN NO OU UT T O OF F A AN NA AL LO OG G O OU UT TP PU UT T GND GND GND GND GND GND GND GND AO1 AO2 AO3 AO5 AO6 AO7 AO8 AO12 AO13 AO15 AO14...

Page 151: ...For NeurOne software internal use subject to change Protocol xml Limited collection of protocol information that can be used when reading the measurement data into an analysis program Session xml Lim...

Page 152: ...ce port 4 12 See EventSourcePort table below Channel number 4 16 Number of the input corresponding to the amplifier pinout such that input 41 is the first input of amp 2 Code 4 20 Value of 8 bit trigg...

Page 153: ...h description the file size and Description length in event bin are zero Length of event description is not limited and each event s description is read using Description length and Description offset...

Page 154: ...AsCalibratedMaximum True max level Calibrated value e g temperature high RangeAsCalibratedMinimum True min level Calibrated value e g temperature low RangeMaximum Maximum raw signal level correspondin...

Page 155: ...st name of the Person DateOfBirth Date of birth in format YYYY MM SSThh mm ssZ as defined in ISO 8601 PersonID Identification field given to the person in NeurOne PC Software TableSession ProtocolName...

Page 156: ...es xml This file contains a log of battery voltages measured at each amplifier during measurement Please note that only Tesla amplifiers support battery voltage measurement Each line in the session lo...

Page 157: ...rs for the sensor in Input tab of the Protocol o Use Inputs 33 40 for external sensors o Check the further information how into which input sensors are connected Range min max parameters corresponding...

Page 158: ...ouse button and when defined release the button Move area borders in order to finalize the area definition Click the data curve under calibration On the right side of the window FFT calculation result...

Page 159: ...e System User Manual doc Example 1 Accelerometer 3D During the calibration measurement adjust the known actual levels 0g and 1g acceleration levels as described in the figure above Range As Calibrated...

Page 160: ...Range As Calibrated min o Higher level 150 BPM Range As Calibrated max In this example measured min 44225 max 159250 Example 3 GSR Use resistors in calibration in order to simulate conductance Connect...

Page 161: ...lug ins folder Restart Matlab if it was running during the installation Usage After installation you can see a new menu item in the EEGLAB menu bar File Import data From a NeurOne file ses The NeurOne...

Page 162: ...eived the server terminates the client connection immediately For most commands the server immediately responds by sending OK commandText r n where commandText is the command initially sent by the cli...

Page 163: ...ng data Nothing is being recorded yet Recording The measurement hardware is running and PC software is recording data ImpedanceTest Measurement is running in impedance test mode Error identifier Descr...

Page 164: ...oring r n Command example 3 Status query Client requests current state information Client STATUS r n Server responds that it s currently idle Client STATUS Idle r n Command example 4 Recording start f...

Page 165: ...fault Bipolar Connection Box is configured for Bipolar ExG use EMG EEG and ECG configuration 2 Then the DIP switches are set OFF i e switches are open Inputs have 9 1 kOhm protective resistors no sign...

Page 166: ...Configurations of Bipolar Connection Box in NeurOne System Ch n indicates the bipolar channel to be configured n is in bipolar channel range It s possible to use configuration 1 in standard ERP labor...

Page 167: ...d or the official local distributor of Bittium Biosignals Ltd 2 Disconnect Bipolar Connection Box from the NeurOne system and reserve small screwdriver one Bipolar Connection Box Adhesive Configuratio...

Page 168: ...e Configuration Template sticker If configuration 1 is set the MRI use of Bipolar Connection Box is prohibited If configuration 5 is set to certain channel no signal connection is allowed to that chan...

Page 169: ...tions of this subchapter If Adhesive Configuration Template sticker is missing check the configuration according to the subchapter Configuration change check of this Appendix If any NO MRI USE checkbo...

Page 170: ...f 191 800581 2 11 NeurOne System User Manual doc A AP PP PE EN ND DI IX X 1 10 0 P PI IN NO OU UT TS S O OF F C CO ON NN NE EC CT TO OR RS S O ON N B BI IP PO OL LA AR R C CO ON NN NE EC CT TI IO ON N...

Page 171: ...x master 192 168 200 101 192 168 200 121 SyncBox slave1 192 168 200 102 192 168 200 122 SyncBox slave2 192 168 200 103 192 168 200 123 SyncBox slave 9 192 168 200 110 192 168 200 130 Triggering inform...

Page 172: ...ariable length MeasurementStartPacket This packet is sent by NeurOne when it starts measuring before any measurement data samples triggers is emitted and also upon receival of Join packet The emission...

Page 173: ...hannelTypes Variable length array of input channel metadata N NumChannels Each 8 bit entry is as follows Bits Meaning 0 2 Channel type AC DC 000 AC 001 DC Rest of the values are reserved 3 4 Amplifier...

Page 174: ...t should be noted that the sample values may need to be scaled by the receiver The sample scaling factor depends on the amplifier hardware amplifier type input type AC DC This information is supplied...

Page 175: ...h is satisfied on taccept see Figure 1 Figure 1 Trigger signal rising edge and accept timing Each trigger sample has the following information Bits Name Description 0 Res Reserved for future use 1 2 A...

Page 176: ...denote the physical channel the trigger came from The lower 4 bits indicate the mode the trigger hardware was configured for Source id upper 4 Description Mode lower 4 Description 1 Isolated port A 1...

Page 177: ...acket is coming from see MainUnitNum field in Samples packet uint8 StateType Type of the payload 1 ClockSourceState uint8 Reserved Reserved for future use uint8 StatePayload Payload depending on State...

Page 178: ...nds to Join only if it originates from that same address b If digital out is sending to a broadcast address NeurOne responds to Join only if it originates from the same subnet 255 255 255 0 The Measur...

Page 179: ...SampleBundles 5 FirstSampleIndex 5 MicroTime 1 000 3 0 Samples Samples 10 14 for each output channel PacketSeqNo 2 NumSampleBundles 5 FirstSampleIndex 10 MicroTime 2 000 Measurement is stopped Case 2...

Page 180: ...qNo 0 NumSampleBundles 10 FirstSampleIndex 0 MicroTime 0 2 0 Samples Samples 10 19 for each output channel PacketSeqNo 1 NumSampleBundles 10 FirstSampleIndex 10 MicroTime 1 000 2 2 Triggers One or mor...

Page 181: ...mpling rate and packet delivery frequency are set to be 500 Hz Byte 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Value uint8 2 0 0 0 0 0 0 24 0 1 0 1 0 0 0 0 Byte 17 18 19 20 21 22 23 24 25 26 27 28 29 30 3...

Page 182: ...33 34 Value uint8 0 0 0 30 0 0 0 0 0 234 96 248 231 55 248 232 51 Type Description Value uint8 Value uint8 Sample packet identifier 2 2 uint8 Main unit indication 0 0 uint8 Not in use 0 0 uint8 Not in...

Page 183: ...218 135 249 210 6 249 205 203 Type Description Value uint8 Value uint8 Sample packet identifier 2 2 uint8 Main unit indication 0 0 uint8 Not in use 0 0 uint8 Not in use 0 0 uint32 Packet sequency numb...

Page 184: ...e must be greater than the packet size rcv_port 50000 target port number rcv_sck socket AF_INET SOCK_DGRAM 0 bind rcv_sck rcv_port str len_s recv rcv_sck buff_size the first packet is empty packet for...

Page 185: ...yes no Display Curve Labels no yes no no Display Last Values no yes no no Use Notch Filter no yes no no Modify Curve Polarity inversion no yes no no Show Baseline no yes no no Fit by signal type no y...

Page 186: ...stim time yes no no no Display single responses yes yes yes no Number of displayed single responses yes yes no no Display average responses yes yes yes no Number of responses in average yes yes no no...

Page 187: ...Curve Y axis Min yes default montage yes yes yes Curve Y axis Max yes default montage yes yes yes Curve Auto align Enabled yes default montage yes yes yes Curve Auto align bound to single response no...

Page 188: ...g has based on the standards ASTM F2182 Standard Test Method for Measurement of Radio Frequency Induced Heating On or Near Passive Implants During Magnetic Resonance Imaging ASTM F2213 Standard Test M...

Page 189: ...bove devices can be scanned safely in a MR environment under the following Static magnetic field of 3 Tesla only Spatial gradient field of 253 T m 25 300 gauss cm and less Spatial gradient field produ...

Page 190: ...flux of RF energy it does not take much for this to be a positive heating cooling ratio which in process of the time causes the hazardous heating on the brain tissue of test subject It is essential to...

Page 191: ...slice multi band sequence classes For safe use Based on non clinical tests image artefacts based on Tesla amplifier and battery pack are not significant Electrodes on EEG cap and other test arrangemen...

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