GE AKTAprocess, Operating Instructions Manual

Page: 142 / 180

Inlets
If the system has optional CIP valves and CIP manifolds:
• Connect tubing between the CIP valves and tanks filled with suitable solutions for
system CIP. For example 1 M sodium hydroxide in CIP 1, water in CIP 2 and 20%
ethanol in CIP3.
•
Connect the manifold(s) to the inlet(s).
•
Connect flexible tubing (supplied with the CIP manifolds) between the manifolds and
the side inlet of the CIP valve set. If the system contains more than one set of inlet
valves, the flexible tubing from each valve set is connected to a manifold on the side
inlet of the CIP valve set. Refer to the figure in Using the CIP/AxiChrom manifold option,
on page 139 for the complete set-up.
If the system does not contain the optional CIP valves, connect tubing to each
inlet valve. The tubing from each system inlet then has to be moved manually
between tanks filled with the different CIP solutions.
Note:
Column valves
With the column removed, connect the column manifold between the Column top and
Column bottom system valves.
If the system does not have the CIP valves option, connect tubing with sanitary
fittings between the Column top and Column bottom system valves. Note:
Outlets
• Connect the manifold to the outlet (to Outlet 1-10 in the example below)
•
Connect tubing from the manifold and lead to waste.
If the system does not contain the CIP valves, connect tubing to each outlet
valve and lead to waste.
Note:
Method
Action Step
Use for example 75% of the max flow of the system and design a method
with which each outlet and component pathway is flushed with CIP/Saniti-
zation liquid for at least 30 seconds. 1
142 ÄKTAprocess Operating Instructions 29-0252-49 AA
6 Maintenance
6.2 Cleaning
6.2.3 General procedure for CIP and sanitization