GE AKTAprocess, Operating Instructions Manual

Page: 141 / 180

6.2.3 General procedure for CIP and sanitization
Introduction
The system can be cleaned using 1 M sodium hydroxide as outlined in the procedure
below.
The system owner must qualify a cleaning and sanitizing procedure that is
suitable for the required application. Note:
Preparations
•
All tubing including the sanitary fittings must resist sodium hydroxide.
• The filter may have to be removed from the filter housing when certain solutions are
used for CIP/Sanitizing. Refer to the documentation from the filter manufacturer to
determine if the filter should be removed or not.
If there is noticeable build-up of biofilm on the bottom plate of the filter
housing when the filter is removed, perform the following actions: Note:
1
Spray the surface with 70% ethanol
2
Wipe off the surface by hand
3 Re-mount the filter casing
4
Run the CIP method
•
The column (and medium) should be cleaned separately and is therefore removed
before system cleaning.
•
The pH electrode should be replaced with a pH CIP cap (pH plug) before system
cleaning. Refer to Install the pH electrode, on page 115.
•
To make sure that the system does not leak during CIP/Sanitization, perform a
combined method and leakage test by performing the CIP/Sanitization procedure
using water.
• The optional sample pump, if included in the system, shall always be cleaned first.
•
If a capsule filter is used, remove the filter and put the spool piece in place before
performing CIP.
ÄKTAprocess Operating Instructions 29-0252-49 AA 141
6 Maintenance
6.2 Cleaning
6.2.3 General procedure for CIP and sanitization