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9   

•

 

  Specifications 

Vanquish Charged Aerosol Detectors Operating Manual 

Page 165 

Type 

Specification 

Control 

Chromeleon 7, Chromeleon 6.8 
The detector can be operated also with other data systems. For 
details, contact the Thermo Fisher Scientific sales organization. 
Keypad with 2 buttons for performing certain functions directly from 
the detector 

Materials in the flow path 

Stainless steel (type 316), Nitronic® 60 stainless steel, PEEK, SimRiz®, 
fused silica 

NOTICE

 For information about the chemical resistance of materials 

refer to the technical literature. 

Solvent and additive information 

See 

section 2.4, page 25

. 

Safety features 

•

 

Overpressure relief valve on gas inlet 

•

 

Liquid detection inside the detector and safe leak handling 

•

 

Detection of high evaporation temperatures 

•

 

Pump flow shutdown 

•

 

Leak detection and safe leak handling 

Good Laboratory Practice (GLP) 
features 

Predictive Performance functions for scheduling maintenance 
procedures based on the actual operating and usage conditions of 
the detector. 
This includes monitoring of the replacement interval for the gas filter 
assembly and the service interval. 
All system parameters are logged in the Chromeleon Audit Trail. 

 

Содержание Vanquish VF-D20

Страница 1: ...Vanquish Charged Aerosol Detectors VH D20 VF D20 Operating Manual 4820 8401 EN Revision 2 0a September 2017 thermoscientific...

Страница 2: ...manual is provided as is The contents of this manual are subject to being changed without notice in future revisions Thermo Fisher Scientific Inc makes no representations that this document is complet...

Страница 3: ...r sales support for HPLC products contact your local Thermo Fisher Scientific sales organization For contact information go to Contact Us on http www thermoscientific com Technical Assistance For tech...

Страница 4: ...Contacting Us Page 4 Vanquish Charged Aerosol Detectors Operating Manual...

Страница 5: ...Manual 17 2 1 3 Safety Symbols on the Detector 17 2 1 4 Rating Plate 17 2 2 Intended Use 18 2 3 Safety Precautions 19 2 3 1 General Safety Information 19 2 3 2 Qualification of the Personnel 20 2 3 3...

Страница 6: ...5 6 1 General Information and Guidelines 70 5 6 2 Guiding Capillaries and Tubing Through the System 71 5 6 3 Connecting Fittings Capillaries and Tubing 73 5 6 4 Connecting the Waste Line 75 5 6 5 Conn...

Страница 7: ...ice 115 7 1 Introduction to Maintenance and Service 116 7 2 Safety Guidelines for Maintenance and Service 117 7 3 General Rules for Maintenance and Service 119 7 4 Routine and Preventive Maintenance 1...

Страница 8: ...ng Flooding In the Detector 160 8 3 4 Additional Detector Operating Problems 161 9 Specifications 163 9 1 Performance Specifications 164 9 2 Physical Specifications 166 10 Accessories Consumables and...

Страница 9: ...d Aerosol Detectors Operating Manual Page 9 1 Using this Manual This chapter provides information about this manual the conventions used throughout the manual and the reference documentation that is a...

Страница 10: ...perly Note the following The detector configuration may vary therefore not all descriptions necessarily apply to your particular detector If some detail applies to only one model or variant the model...

Страница 11: ...ection or procedure appear in the section or procedure to which they apply They appear different from the main flow of text Safety messages are often preceded by an alert symbol and or alert word The...

Страница 12: ...hermo Chromeleon 7 Services Manager Start Instrument Controller References and Messages References to additional documentation appear italicized Messages that appear on the screen are identified by qu...

Страница 13: ...able as PDF Portable Document Format files To open and read the PDF files Adobe Reader or Adobe Acrobat is required Software Documentation Additional software documentation includes the following Chro...

Страница 14: ...ation TIP The Chromeleon Help and documents are included in the software shipment Third Party Documentation Refer also to the user documentation provided by the manufacturers of third party components...

Страница 15: ...2 Safety Vanquish Charged Aerosol Detectors Operating Manual Page 15 2 Safety This chapter provides general and specific safety information and informs about the intended use of the detector...

Страница 16: ...the detector The safety symbols and signal words in this manual include the following Always be aware of the safety information Do not proceed until you have fully understood the information and consi...

Страница 17: ...appear on the detector or on labels affixed to the detector Follow the safety notices in this manual to prevent the risk of operator injury or damage to the detector Symbol Description Indicates a po...

Страница 18: ...are intended for laboratory research use only They are not intended for use in diagnostic procedures Laboratory Practice Thermo Fisher Scientific recommends that the laboratory in which the Vanquish...

Страница 19: ...ponents options and peripherals specifically authorized and qualified for the detector by Thermo Fisher Scientific Perform only the procedures that are described in this operating manual and in suppor...

Страница 20: ...system General Operation The detector is designed to be operated only by trained and qualified personnel in a laboratory environment All users must know the hazards presented by the detector and the s...

Страница 21: ...vice High voltages are present inside the device that could cause an electric shock or damage to the device Do not make any changes to the electrical or grounding connections If you suspect any kind o...

Страница 22: ...he volume of substances to the minimum volume required for sample analysis Do not operate the detector in a potentially flammable environment Avoid accumulation of harmful substances Make sure that th...

Страница 23: ...le gases or fumes CAUTION Escape of Hazardous Substances from PEEK Capillaries In the Vanquish system capillaries made of PEEK may be used Swelling or attack by acids can cause PEEK capillaries to sta...

Страница 24: ...is particularly present with insulating capillaries and non conductive solvents for example pure acetonitrile Discharge of electrostatic energy might lead to sparking which could constitute a fire ha...

Страница 25: ...all parts in the flow path For details about the materials that are used in the flow path of the detector see the Specifications chapter For information about the materials that are used in the flow...

Страница 26: ...ol Detectors Operating Manual Follow any specific recommendations presented in other sections of this manual Refer also to the operating manuals for all modules in the Vanquish system They may provide...

Страница 27: ...etails see section 11 page 173 Changes that you make to the device may void compliance with one or more of these EMC and safety standards Changes to the device include replacing a part or adding compo...

Страница 28: ...2 Safety Page 28 Vanquish Charged Aerosol Detectors Operating Manual...

Страница 29: ...3 Detector Overview Vanquish Charged Aerosol Detectors Operating Manual Page 29 3 Detector Overview This chapter introduces you to the detector and the main components...

Страница 30: ...mparison to UV detection a chromophore is not required for detection and in comparison to mass spectrometry ionization of the analyte is not necessary Detection with great sub nanogram sensitivity and...

Страница 31: ...e interior components of the detector and illustrates how the detector operates Figure 1 Operating principle of the detector No Description No Description 1 Eluate from column 8 Mixing chamber 2 Nebul...

Страница 32: ...tream of ionized gas no 9 that has passed through a corona charger no 10 Each dried aerosol particle undergoes surface diffusional charging where the level of charge per particle is proportional to pa...

Страница 33: ...of the detector are located directly behind the front doors Figure 2 Interior view No Description 1 Keypad with status indicators 2 Gas filter assembly behind the protective cover 3 Leak tray 4 Nebuli...

Страница 34: ...nebulizer is the liquid flow inlet of the charged aerosol detector Eluate from the column flows into the nebulizer and merges with filtered gas that is supplied to the nebulizer Due to the concentric...

Страница 35: ...or The gas filters consist of a charcoal filter and a high efficiency particulate air HEPA filter Gas supplied through the gas inlet of the detector is first filtered in the charcoal gas filter bottom...

Страница 36: ...status indicators change to red and beeping starts to alert you The Chromeleon software automatically stops the pump flow and issues a message in the Audit Trail Follow the instructions in this manual...

Страница 37: ...and automated sample analysis with the Chromeleon software refer to the Vanquish System Operating Manual Details on control and operation of the detector are available in the Chromeleon Help TIP The d...

Страница 38: ...3 Detector Overview Page 38 Vanquish Charged Aerosol Detectors Operating Manual...

Страница 39: ...d Transport Vanquish Charged Aerosol Detectors Operating Manual Page 39 4 Unpacking and Transport This chapter provides information for unpacking and moving the detector and informs you about the scop...

Страница 40: ...ON Heavy Load Bulky Device The detector is too heavy or bulky for one person alone to handle safely To avoid personal injury or damage to the detector observe the following guidelines Physical handlin...

Страница 41: ...urface 6 Transport the detector by the carrying handles to the installation site if it is not already there and place it in the system stack see the System Arrangement section in this operating manual...

Страница 42: ...ilm during shipment Remove the protective film from all surfaces as applicable Moving the Detector after Installation If you have to move the detector after it has been set up and installed in the Van...

Страница 43: ...Aerosol Detectors Operating Manual Page 43 4 2 Scope of Delivery The following items are included in the delivery Detector with nebulizer Ship Kit For details about the kit content see section 10 2 Sh...

Страница 44: ...4 Unpacking and Transport Page 44 Vanquish Charged Aerosol Detectors Operating Manual...

Страница 45: ...l Detectors Operating Manual Page 45 5 Installation This chapter specifies the requirements for the installation site and describes how to set up install and configure the detector in the Vanquish sys...

Страница 46: ...avy or bulky for one person alone to handle safely To avoid personal injury or damage to the detector observe the following guidelines Physical handling of the detector including lifting or moving req...

Страница 47: ...System Operating Manual When another detector is installed in the system follow the instructions in this manual to install the charged aerosol detector in addition to the other detector 1 Pay attenti...

Страница 48: ...struments Installation Qualification Operating Instructions The manual provides information about the required materials and detailed instructions NOTICE If the detector is operated with another data...

Страница 49: ...ine voltage in the range specified for the device To avoid power fluctuations the use of an uninterruptible power supply UPS is recommended CAUTION Electric Shock or Damage to the Device Connecting th...

Страница 50: ...hat has a protective ground connection In case of emergency it must be possible to reach the power cord easily at any time to disconnect the device from the power line WARNING Electric Shock or Damage...

Страница 51: ...r nearby the gas supply and ventilation sources Ventilation must be at atmospheric pressure with no vacuum or negative pressure applied NOTICE A vacuum in the ventilation can cause a depressurization...

Страница 52: ...mum gas supply pressure If the overpressure relief valve is releasing gas as a result of an overpressure in the detector during operation turn off the detector immediately Remedy the situation as desc...

Страница 53: ...olatile substances it can impair the performance or even damage the detector Observe all requirements and specifications for the supply gas in this manual to avoid damage to the detector The gas suppl...

Страница 54: ...be a quick and easy source of nitrogen during installation However it is not recommended for routine operation The gas consumption of the detector is typically 4 L min The supply gas must be free fro...

Страница 55: ...Accessing the Interior Components To access the interior components in the detector open the front doors To allow easy access from the front the user accessible components and flow connections in the...

Страница 56: ...1 System Arrangement The detector is part of the Vanquish system The system modules are typically arranged in a system stack with the arrangement depending on the system configuration Figure 8 Vanqui...

Страница 57: ...install the solvent rack and the column compartment yet 2 To position the charged aerosol detector lift it by its carrying handles Place the detector on top of the stack approximately 5 cm before the...

Страница 58: ...nual 5 5 2 Connecting the Detector Detector Connectors The following connectors are provided on the detector Figure 9 Electrical and gas connectors on the right side of the detector No Description 1 2...

Страница 59: ...er modules in the Vanquish system or the computer on which the data management system is installed such as the Chromeleon software 7 Rating plate indicating part number module name line and fuse ratin...

Страница 60: ...erating Manual to connect the other modules in the system up to the diode array detector b Connect the B connector of a USB cable to the USB port on the charged aerosol detector and connect the A conn...

Страница 61: ...on the detector NOTICE Before connecting the detector to the power line be sure that no condensation is present in the device Condensation in the device can damage the electronics If you suspect that...

Страница 62: ...ive to contamination Even minute particles on the nebulizer can lead to contamination and poor detector performance Always wear clean room gloves when you install or remove the nebulizer The fused sil...

Страница 63: ...ilable when transporting the nebulizer Figure 11 Parts of the nebulizer No Description 1 Liquid flow inlet 2 Handle 3 Sealing bushing with sealing ring 4 Spray pipe 5 Nebulizer capillary on the tip of...

Страница 64: ...13 Dust seal plug installed in the nebulizer opening 2 Insert the nebulizer in the opening in the front panel of the detector Observe the following TIP To facilitate inserting the nebulizer in the ne...

Страница 65: ...zer for installation 3 Push the nebulizer into the opening until the spray pipe and sealing bushing are completely in the opening The nebulizer handle must lie flush against the nebulizer opening Figu...

Страница 66: ...hat the protruding sides on the nebulizer arrest behind the two locks of the opening and lie against the alignment pin Figure 16 Locking the nebulizer in the detector No Description 1 Locks on the neb...

Страница 67: ...ional Preparations 1 Observe the site requirements for the gas supply and the ventilation see section 5 3 page 49 2 Check the gas tubes and elbow connectors Observe the following Use only the gas tube...

Страница 68: ...cut is at a right angle to the length of the gas tubes 4 Connect the gas tubes to the elbow connectors Mind the correct orientation of the elbow connectors see Figure 17 a Connect the gas inlet tubin...

Страница 69: ...he connection stem of the gas exhaust elbow connector no 4 into the port no 3 c Slightly pull on each elbow connector to check that they are properly locked in the ports If an elbow connector slips ou...

Страница 70: ...low path When you install devices or components to the system always flush them to waste before connecting them in the system flow path To flush the Vanquish modules follow the instructions in the Van...

Страница 71: ...en you remove the plugs to connect the detector in the system keep the plugs You may need them to close the connections again for example for future transport 5 6 2 Guiding Capillaries and Tubing Thro...

Страница 72: ...three solvent lines 3 Wash liquid tubing seal wash autosampler needle wash 4 Detector waste capillary Tubing brackets are available for holding the tubing in place Slip the bracket side onto the drain...

Страница 73: ...ontaminants Even minute particles may cause damage to the system or lead to invalid test results Do not install capillaries or tubing that is stressed nicked kinked or otherwise damaged Install capill...

Страница 74: ...ctions you can easily remove the knurls from neighboring capillaries through this slot and attach them again later 3 If the connection leaks a Tighten the connection a little more b If leakage continu...

Страница 75: ...etween waste outlet and waste container Tools required Tubing cutter optional Preparations 1 Route the waste line through the detector waste outlet in the system base to waste Follow the instructions...

Страница 76: ...e modules in your Vanquish system you can connect the inlet capillary to the nebulizer as follows Directly from the column or From the flow cell of a first detector such as the diode array detector in...

Страница 77: ...Connecting the Capillary Between Column and Nebulizer If the charged aerosol detector is the only detector in the Vanquish system flow path connect the inlet capillary between column and nebulizer Pre...

Страница 78: ...the LightPipe flow cell in the diode array detector Connect the capillary from the flow cell directly to the nebulizer Avoid connecting any additional components in the flow path between the two detec...

Страница 79: ...b Position the capillary behind the capillary clip c Carefully release the clip and take care not to clamp the capillary The capillary must be secured behind the clip Figure 24 Securing the capillary...

Страница 80: ...bulizer 3 Waste line from the charged aerosol detector to the system base 5 6 6 Guiding Liquid Leaks to Waste Leaking liquids of the detector are collected in the leak tray where they flow off through...

Страница 81: ...ystem base system power button is pressed in If the power button stands out press the power button to turn on the power on the system base 2 Turn on the detector with its main power switch Turn the de...

Страница 82: ...he chromatography software is already installed on the data system computer and a valid license is available For more information about setting up the Vanquish system in the software refer to the Vanq...

Страница 83: ...6 Operation Vanquish Charged Aerosol Detectors Operating Manual Page 83 6 Operation This chapter describes the elements for detector control provides information for routine operation and for shutdown...

Страница 84: ...tector has already been completed If this is not the case refer to the instructions in chapter 5 Installation before proceeding see page 45 For a basic description of instrument control and automated...

Страница 85: ...or from running the pump dry If there is evidence of leakage in the detector turn off the pump flow and remedy the situation immediately Verify that the detector gas flow is turned on always before y...

Страница 86: ...serve the requirements for gas supply and ventilation See section 5 3 Site Requirements page 49 Contamination of the mobile phase can damage the detector Avoid contamination of the mobile phase Follow...

Страница 87: ...he STATUS LED on the keypad provide a quick visual check of the operational status of the detector 6 3 1 Keypad The keypad inside the detector allows you to perform certain functions directly from the...

Страница 88: ...the button for turning off the drain pump will remain enabled for a short period longer to remove any remaining mobile phase The LED next to the button indicates the gas status LED Description Off dar...

Страница 89: ...are but is not equilibrated The detector gas flow and drain pump are turned off Green flashing The detector prepares for operation This comprises the following phases The detector performs the self te...

Страница 90: ...scription Off dark The power to the detector is turned off Green The detector is functioning properly Red A problem or error has occurred For the related message check the Chromeleon Audit Trail For r...

Страница 91: ...is pressed in When the power is off the system power button stands out If the main power switch on a device is off you cannot turn on the device with the system power button To turn off a device comp...

Страница 92: ...ns in the Vanquish System Operating Manual When the charged aerosol detector is connected in the system flow path Flush the detector only when the detector gas flow is turned on Deliver pump flow to t...

Страница 93: ...ysis Verify that the doors of the modules in the Vanquish system are closed Make sure that the chromatography system is properly equilibrated System equilibration should include the following operatio...

Страница 94: ...he drift and signal noise are within reasonable limits for the application Performing an autozero of the detector baseline TIP The Chromeleon software supports procedures for automatically starting a...

Страница 95: ...obile phases All constituents i e solvents and additives of the mobile phase should be sufficiently volatile to allow evaporation under the conditions used Non volatile solutes in the mobile phase eve...

Страница 96: ...olvents are miscible and that any buffer salts will not cause precipitation If required use an appropriate intermediate solvent TIP Keep this in mind particularly when switching pump flow from other d...

Страница 97: ...roacetic acid TFA 0 3 0 1 Formic acid 3 75 2 8 4 8 0 3 Ammonium formate 10 mM Acetic acid 4 76 3 8 5 8 0 05 1 Ammonium acetate 10 mM The stability of the mobile phase may decrease over time Prepare mo...

Страница 98: ...that is specified for your nebulizer The nebulizer gas pressure is defined on the gas pressure certificate that is shipped with the nebulizer 1 In Chromeleon open the Command window Navigate to the Ga...

Страница 99: ...an damage the detector Observe the respective order of steps When turning on detector gas flow and pump flow Turn on the detector gas flow first wait at least 5 minutes and only then turn on the pump...

Страница 100: ...tozero or filter constant applied As a standard the detector measures the current in pA For further information see section 6 7 4 Signal Channels page 106 Gas regulator pressure signal channel Records...

Страница 101: ...izer certificate As a standard the Analytical mode is set For VH detector only Two modes for regulating the nebulizer gas pressure in the detector are available Analytical mode and MicroLC mode For de...

Страница 102: ...perature page 107 Evaporator temperature Displays the actual temperature of the evaporation tube The actual temperature depends on several factors including mobile phase composition and temperature pu...

Страница 103: ...chanical shocks caused by external sources Stable backpressure and correct waste line setup Degas the solvent in the Vanquish pump Monitor the usage of specific detector components that are subject to...

Страница 104: ...parameters that influence the performance of the detector during data acquisition Parameter Affects Filter constant Sensitivity baseline noise Evaporation temperature Baseline noise background current...

Страница 105: ...f interest are less than a few seconds select a higher data collection rate 10 0 Hz for example If the data collection rate is too high data files may need more disk space and post run analyses may re...

Страница 106: ...Gas regulator pressure The signal channel records and monitors the nebulizer gas pressure during data acquisition It is recommended to record the signal channel for troubleshooting purposes For proper...

Страница 107: ...ee section 9 1 Performance Specifications page 164 Changes in the evaporation temperature affect the response of the detector When the temperature was changed the evaporation tube requires time to equ...

Страница 108: ...mperatures Typically 35 C and 40 C are appropriate if the temperature range is unknown If required perform additional tests in a maximum of 5 C increments With the VF detector use two evaporation temp...

Страница 109: ...llowed for the detector This mode is set as a default in Chromeleon MicroLC mode The nebulizer gas pressure setting is automatically reduced by a fixed fraction of the nebulizer pressure This mode opt...

Страница 110: ...alue depends primarily on the analysis conditions and the desired range of quantitation 6 7 8 Baseline Noise Baseline noise can originate from many factors To minimize the baseline noise observe the f...

Страница 111: ...system arrangement For your Vanquish detector note the following Charged aerosol detector Check that sufficient gas is available to continue gas flowing through the detector This is to prevent any bui...

Страница 112: ...the detector also observe the shutting down instructions for the other Vanquish system modules and take appropriate action refer to the Operating Manuals for the modules To interrupt operation for a...

Страница 113: ...en the gas flow a Turn off the pump flow to the detector Wait at least 5 minutes During the waiting period the detector drains any remaining mobile phase to waste b Turn off the gas flow on the detect...

Страница 114: ...ath before the detector before you connect the detector to the system flow path 3 Turn on the detector Observe the following If the detector remained in the system stack and all system modules were tu...

Страница 115: ...tenance and Service Vanquish Charged Aerosol Detectors Operating Manual Page 115 7 Maintenance and Service This chapter describes the routine maintenance and the service procedures that the user may p...

Страница 116: ...referred to as Thermo Fisher Scientific service personnel The detector is designed for easy maintenance and service The user serviceable parts of the detector can be accessed from the front If not st...

Страница 117: ...to do so in this manual WARNING Escape of Hazardous Substances from Flow Connections Flow and capillary connections can be filled with substances that can pose health risks Solvent can spray when capi...

Страница 118: ...solvent lines together with the caps from the reservoirs Empty the solvents lines Retighten the reservoir caps NOTICE Detector Gas Flow and Pump Flow Improper handling of detector gas flow and pump fl...

Страница 119: ...age 171 Follow all instructions step by step and use the tools recommended for the procedure Before opening the flow path to replace capillaries in the system turn off the pump flow and wait until the...

Страница 120: ...you should do Daily Inspect the flow connections for signs of leakage or blockage When using buffer solutions flush the detector thoroughly after use with an appropriate solvent that does not contain...

Страница 121: ...ect the detector from the system flow path first and flush the system to waste for example with 20 column volumes Then reconnect the detector to the system flow path turn on the gas flow and repeat th...

Страница 122: ...cleaning process Wipe the cleaned components thoroughly dry after cleaning Do not operate the detector before it is completely dry NOTICE Observe the following Only use cleaning detergents that will n...

Страница 123: ...tions which are called Predictive Performance allow you to schedule maintenance procedures based on the actual operating and usage conditions of the device On special wellness service and qualificatio...

Страница 124: ...important Predictive Performance counters for the detector Consider resetting these parameters after performing the related maintenance procedure FilterDone If you have replaced the gas filter assemb...

Страница 125: ...he gas flow path are properly connected and the protective cover of the gas filter assembly is installed Parts and tools required Only required if gas tubing is to be replaced For replacement of the g...

Страница 126: ...tinue d Turn off the gas supply to the detector 3 Turn off the detector with the main power switch Follow these steps On the gas port on the detector disconnect the elbow connectors of the gas tubes f...

Страница 127: ...off the pump flow and then the gas flow a Turn off the pump flow to the detector Wait at least 5 minutes During the waiting period the detector drains any remaining mobile phase to waste b Turn off th...

Страница 128: ...ose a health and safety risk Make sure that the detector gas flow and the gas supply are turned off before you remove the nebulizer disconnect the gas tubes or remove the gas filter assembly from the...

Страница 129: ...e detector 3 Turn off the detector with the main power switch 4 Disconnect the inlet capillary from the nebulizer Follow these steps 1 Turn the nebulizer by 90 degrees counter clockwise in the opening...

Страница 130: ...g to the opening for the nebulizer 4 If the nebulizer is to be transported Pack the nebulizer a Carefully install the protective tubing to the nebulizer spray pipe Do not to touch the nebulizer tip wi...

Страница 131: ...ilter assembly make sure that the gas supply and the detector gas flow are turned off CAUTION Escaping Gas Gas can escape from open gas connections when the detector gas flow and or the gas supply is...

Страница 132: ...le phase to waste b Turn off the gas flow on the detector c Wait until the system pressure is down to zero before you continue d Turn off the gas supply to the detector 3 Turn off the detector with th...

Страница 133: ...ve cover The gas filters are uncovered now Figure 32 Gas filter assembly No Description No Description 1 Charcoal gas filter 3 HEPA gas filter 2 Elbow fittings 4 Gas filter clamps 4 Disconnect the gas...

Страница 134: ...bow fitting with the multitool 5 Pull the gas filter assembly out of the clamps Figure 34 Pulling the gas filter assembly out of the clamps 6 With the new gas filter assembly mind the correct orientat...

Страница 135: ...he push in elbow fittings into the gas connectors on the detector Check that the connections are secure Slightly pull on the fittings If a fitting slides out repeat this step 9 Install the protective...

Страница 136: ...ARNING Electric Shock High voltages are present inside the detector that could cause an electric shock or damage to the device Turn off the detector with its main power switch Disconnect the power cor...

Страница 137: ...rol Fuse holder Power inlet connector 1 Use the screwdriver to remove the fuse holder 2 Replace the two fuses with new fuses of the specified type and current rating Always replace both fuses 3 Reinst...

Страница 138: ...ed automatically to the device when you install the Chromeleon Service Release Preparations Read the release notes provided with the firmware and or Chromeleon Service release Verify the following The...

Страница 139: ...e update process a message appears showing the firmware version currently installed in the detector and the version that will be transferred from the Chromeleon software If the firmware installed in t...

Страница 140: ...n performing the following sequence of steps and do not apply force 1 To remove a door push the door upward while opening Open the door to a position in which the two hinges on the housing are aligned...

Страница 141: ...Charged Aerosol Detectors Operating Manual Page 141 4 Insert the hinges in the groove by pushing up and slightly turning the door 5 Push the door downward to lock it in place You can close the door o...

Страница 142: ...m effort of two persons A team effort is in particular required when lifting the detector into the system stack or when removing it Use the carrying handles that were shipped with the detector to move...

Страница 143: ...em stack Follow the instructions on mounting the system stack in the Vanquish System Operating Manual 4 Set up the detector a To connect the detector and to set up flow connections follow the instruct...

Страница 144: ...d that it is free of hazardous substances Thermo Fisher Scientific refuses to accept devices for repair if the Decontamination Certificate is missing Restarting the Detector after Shipping To restart...

Страница 145: ...slide in module from the enclosure CAUTION Heavy Load Bulky Device The detector is too heavy or bulky for one person alone to handle safely To avoid personal injury or damage to the detector observe...

Страница 146: ...ng chase of the Vanquish system modules into the tubing chase Otherwise you will not be able to remove the slide in module properly from the enclosure in the next step 3 Grasp the slide in module by t...

Страница 147: ...The packaging for the slide in module differs from the packaging for the complete module Shipping the slide in module or the detector incorrectly leads to damage on the device Always pack and ship the...

Страница 148: ...that the enclosure is placed correctly in the stack 3 Open the doors of the enclosure Follow these steps 1 Unpack the slide in module Remove any foam spacers from the module 2 Push all tubing and cap...

Страница 149: ...ot move the slide in module is installed properly If the screws move tighten the screws further 5 Set up the slide in module a To connect the slide in module and to set up flow connections follow the...

Страница 150: ...7 Maintenance and Service Page 150 Vanquish Charged Aerosol Detectors Operating Manual...

Страница 151: ...8 Troubleshooting Vanquish Charged Aerosol Detectors Operating Manual Page 151 8 Troubleshooting This chapter is a guide to troubleshooting issues that may arise during operation of the detector...

Страница 152: ...side of the detector and the STATUS LED on the keypad inside provide quick visual feedback on the operational status of the device If the detector firmware detects a problem the status indicators are...

Страница 153: ...started The current run is not interrupted Nevertheless Thermo Fisher Scientific recommends taking appropriate remedial action to resolve the problem Error The software attempts to correct the proble...

Страница 154: ...le to charge the secondary ion gas stream Typical value ranges from 2 0 3 0 kV If the value is outside of this range contact Technical Support Charger current Displays the current that is required to...

Страница 155: ...umber When the message appears write down the message code and turn off the module Wait for 5 seconds and turn on the module again If the message appears again contact Technical Support Module malfunc...

Страница 156: ...gas is still supplied to the detector Check that the gas supply pressure is within the allowed range See the Gas specifications in section 9 1 page 164 Check that the nebulizer gas pressure is set as...

Страница 157: ...he nebulizer gas pressure is set as specified on the nebulizer gas pressure certificate Check the gas inlet tubing and gas filter assembly for proper connection to the detector Turn the detector off a...

Страница 158: ...ce of the leak As leakage usually occurs at a connection visually inspect all components and connections in the flow path If liquid is visible on the nebulizer leakage may have occurred in the nebuliz...

Страница 159: ...as Supply Overpressure section in this manual When The gas supply pressure has exceeded 620 kPa 6 2 bar 90 psi The detector cannot pressurize properly The overpressure relief valve on the gas inlet in...

Страница 160: ...detector A related message appears in the Audit Trail See section 8 2 Messages page 155 Follow these steps 1 Leave the detector gas flow turned on to dry the excess liquid If there is only a small amo...

Страница 161: ...re or if you experience problems that are not covered in this section contact Thermo Fisher Scientific Technical Support for assistance Symptom Possible Cause Remedial Action Baseline noise and or poo...

Страница 162: ...l Support Loss of response Change in parameters Check that the detector is turned on and the data acquisition is on Check the parameter settings Drain pump failed Check that the drain pump is turned o...

Страница 163: ...quish Charged Aerosol Detectors Operating Manual Page 163 9 Specifications This chapter provides the physical and performance specifications including information about the materials used in the flow...

Страница 164: ...Adjustable 2 0 Hz 100 Hz Filter response time Digital filter selectable in numerical sequence 1 2 5 increments Digital filter constants Selectable between 0 1 0 2 0 5 1 0 2 0 3 6 5 0 10 0 seconds Dyn...

Страница 165: ...emical resistance of materials refer to the technical literature Solvent and additive information See section 2 4 page 25 Safety features Overpressure relief valve on gas inlet Liquid detection inside...

Страница 166: ...s follows Type Specification Range of use Indoor use only Ambient temperature 5 35 C Ambient humidity 20 80 relative humidity non condensing Pollution degree 2 Power requirements 100 240 V AC 50 60 Hz...

Страница 167: ...ng Manual Page 167 10 Accessories Consumables and Replacement Parts This chapter describes the standard accessories that are shipped with the detector and the accessories that are available as an opti...

Страница 168: ...th the replacement parts and additional components options and peripherals specifically authorized and qualified by Thermo Fisher Scientific Accessories consumables and replacement parts are always ma...

Страница 169: ...at the time when the detector is shipped Ship kit Item Quantity in shipment Screwdriver Torx T10 1 Tubing adapter inch to metric OD 1 4 1 Tubing cutter 1 Multitool 1 Tubing kit including Gas inlet el...

Страница 170: ...compressed air source Corona air compressor 230 V 6295 0300 Supplies the required amount of air pressure for operation of the detector Corona air compressor 110 V 6295 0350 Supplies the required amou...

Страница 171: ...filter assembly kit consisting of charcoal gas filter and HEPA gas filter 6081 7062 Miscellaneous Description Part No Front door kit including right door and left door 6036 1920 Slide in charged aeros...

Страница 172: ...t No System interlink cable 6036 0004 Power cords Description Part No Power cord Australia China 6000 1060 Power cord Denmark 6000 1070 Power cord EU 6000 1000 Power cord India SA 6000 1090 Power cord...

Страница 173: ...11 Compliance Information Vanquish Charged Aerosol Detectors Operating Manual Page 173 11 Compliance Information This chapter provides additional information about compliance...

Страница 174: ...formity The device has satisfied the requirements for the CE mark and is compliant with the applicable requirements cTUVus Compliance The cTUVus label on the device indicates that the device has satis...

Страница 175: ...aste Electrical Electronic Equipment WEEE Directive 2002 96 EC It is marked with the following symbol Figure 41 WEEE symbol Thermo Fisher Scientific has contracted with one or more recycling or dispos...

Страница 176: ...ide reasonable protection against harmful interference when the equipment is operated in a commercial environment This equipment generates uses and can radiate radio frequency energy and if not instal...

Страница 177: ...12 Index Vanquish Charged Aerosol Detectors Operating Manual Page 177 12 Index...

Страница 178: ...flow 99 door 55 open 55 replacement 140 unhinge 116 140 drain system 80 drainage 80 E equilibration 93 evaporation temperature actual temperature 102 control 102 guidelines 107 nominal temperature 10...

Страница 179: ...ncing 100 O operating principle 31 operation 37 83 interrupt 111 optimization guidelines 103 parameters overview 104 overview functional 29 P peak width 101 pH range 25 power considerations 49 power c...

Страница 180: ...111 Smart Startup 94 solvent buffer concentration 25 chloride concentration 25 information 25 pH range 25 specifications 163 performance 164 physical 166 startup 93 status indicator LED bar 87 89 152...

Страница 181: ...12 Index Vanquish Charged Aerosol Detectors Operating Manual Page 181...

Страница 182: ...Thermo Fisher Scientific Inc 168 Third Avenue Waltham Massachusetts 02451 USA www thermofisher com...

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