2
CORN I NG ASCENT FBR PD SYSTEM
Figure 2-2.
Bottle compartment with bar code scanner (see Table 2-1).
Figure 2-1.
Corning Ascent FBR PD system
(see Table 2-1).
2.0 Introduction
The Corning® Ascent™ FBR PD System consists of a system controller and single-use, pre-sterilized components including a bioreactor, a
Media Conditioning Vessel (MCV), and other consumables, such as tubing, connectors, probes, in-line sensors, and bottles (Figure 2-1 and
Figure 2-2).
During cell culture, a recirculation pump circulates media from the MCV through the FBR. A separate pump aids in removing depleted media
and replacing the MCV with fresh media during media maintenance. Cell culture pH and nutrient levels are monitored and maintained
via feed and base pumps while temperature-controlled heated nests keep the MCV and bioreactor at a constant temperature. At harvest,
cells are released or lysed in situ from the bioreactor at the user’s discretion. A Human-Machine Interface (HMI) allows the user flexibility to
operate the system in manual or automated modes.
