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nanoACQUITY UPLC system information
Intended use
Use the Waters
®
nanoACQUITY UPLC system for analyzing compounds and
introducing separated sample components into a mass spectrometer.
The Waters nanoACQUITY UPLC system is not intended for use in
diagnostic procedures.
When you develop methods, follow the “Protocol for the Adoption of Analytical
Methods in the Clinical Chemistry Laboratory,” American Journal of Medical
Technology, 44, 1, pages 30–37 (1978). This protocol covers good operating
procedures and techniques necessary to validate system and method
performance.
Biological hazard
When you analyze physiological fluids, take all necessary precautions and
treat all specimens as potentially infectious. Precautions are outlined in “CDC
Guidelines on Specimen Handling,” CDC – NIH Manual, 1984.
Calibration
Follow acceptable methods of calibration with pure standards to calibrate
methods. Use a minimum of five standards to generate a standard curve. The
concentration range should cover the entire range of quality-control samples,
typical specimens, and atypical specimens.
Quality control
It is recommended that you routinely run three quality-control samples.
Quality-control samples should represent subnormal, normal, and
above-normal levels of a compound. Ensure that quality-control sample
results are within an acceptable range, and evaluate precision from day to day
and run to run. Data collected when quality-control samples are out of range
might not be valid. Do not report this data until you ensure that
chromatographic system performance is acceptable.
Summary of Contents for nanoACQUITY UPLC
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