25
General guidelines for the UNGUATOR
®
Mixing System
2.3
Preparing the Mixing Process
Together with the UNGUATOR
®
Jar Lid, the UNGUATOR
®
MB should be loosely
screwed onto the UNGUATOR
®
Jar housing after the formulation constituents have
been weighed in. By pushing up the UNGUATOR
®
Jar bottom with a thumb or, for
large UNGUATOR
®
Jars, with the UNGUATOR
®
Spindle or the AirDynamic® System,
the air will escape between the UNGUATOR
®
Jar Lid and the UNGUATOR
®
Jar housing.
Then the UNGUATOR
®
Mixing System should be tightly screwed down. This process
is called air diminuation.
Air diminution will not only prevent ointment exudation at the sealing zones of the
UNGUATOR
®
Jar through reduction of any overpressure that may have developed.
The mixing result is also optimized since there is no trapped air. We recommend,
mainly in the case of intermingling large quantities of powder, that air diminuation be
repeated after 15 seconds of the mixing process.
When pregrinding by pasting the solids with some foundation in the UNGUATOR
®
Jar,
we recommend positioning the movable UNGUATOR
®
Jar Bottom as far downward as
possible. This will guarantee that the large surface area of the inside wall of the
UNGUATOR
®
Jar also including the lid and bottom can be used for dispersion between
the friction surfaces of the UNGUATOR
®
MB and the inside surface area of the
UNGUATOR
®
Jar housing. Consequently, no air diminuation need be carried out before
pegrinding.
At this point of the mixing process, device-specific settings will need to be implemented
and the UNGUATOR
®
Mixing System connected to the UNGUATOR
®
. These procedures
are exhaustively described in chapter 3.
2.4
The Mixing Process
Extending the mixing time and increasing the speed of the mixing motor will improve
the product quality of the ointment. Please see chapter 3 for more detailed information
and device-specific settings.
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