Gako Unguator e/s, Operating Instructions Manual

Page: 21 / 52

21
General guidelines for the UNGUATOR
®
Mixing System
1. Addition of hot water
2. Covering with cold water – heat up to 200 ml in the hot-water bath = 85 °C/
185 °F.
3. Covering with cold water – careful heating in the microwave.
To attain an even structure, heated emulsions should be stirred until they have cooled
to room temperature with a few intervalled strokes using a water jacket or by using
cooling phases at medium speed during which the UNGUATOR
®
Jars are placed in
the refrigerator, if necessary.
Emulsification can be more difficult when using refrigerated foundations. Adapted
emulsifiers can, after consultation with the physician, promote stability and the formation
of emulsion or reverse phase separation. For instance, liquor carbon. detergens in
vaseline emulsifies better containing a small portion of lanolin or wool fat ointment
(unguentum alcoholum lanae).
2.2.3 Normal
Mixing semisolid substances from low-viscous to paste state
Examples:
Ready-made pharmaceutical ointment with foundation(s), concentrated
active substances with foundation(s), liquid active ingredients in foundation(s).
First the foundation ointment should be weighed in into the UNGUATOR ® Jar. Then
the remaining constituents should be weighed.
2.2.4 Suspension < 2%
Mixing semisolid substances with a portion of microfine, agglomerated, optionally fine-
grained solid substances of less than 2 %.
Examples:
Cortisones, antibiotics, fungicides, metronidazole
We recommend using the UNGUATOR ® SMB.
If there is no concentrated active substance, we recommend a pregrinding process
e.g. by means of a pregrind program in the case of a suspension with a content of less
than 2 % active ingredients. For pregrinding, the solids with a low foundation content
are weighed into the UNGUATOR
®
Jars. The degree of dispersion reached by
pregrinding should be checked to ensure that no active substance particles or
agglomerates are too large, either microscopically or using a strong magnifying glass.