cytiva 29038437 Operating Instructions Manual Download

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Part

Function

Air filter

Operator touchscreen

Upper drain valve

Retentate pressure sensor

Filter holder for Kvick Lab™ packet shown (optional)

Retentate pressure control valve

Feed pressure sensor

Pf and temperature sensor

Lower drain valve

Power switch

Feed pump

14, 15, and 16

Pinch clamps

3 System description

3.1 Illustrations of ÄKTA flux s

ÄKTA flux s Operating Instructions 29046893 AG

Summary of Contents for 29038437

Page 1: ...KTA flux s Operating Instructions Original instructions KTA flux cytiva com...

Page 2: ...ion 46 3 4 Optionalequipment 47 3 5 Filterdevices 48 3 5 1 Hollowfibercartridges 49 3 5 2 KvickLabpacketandholder 50 3 6 Flowchart 52 4 Flowlines 54 4 1 Recirculationloop 55 4 2 Permeateline 58 4 3 Tr...

Page 3: ...reAlarmsscreen 149 8 3 ConfigureSystemscreen 154 8 4 CalibrationSettingsscreen 157 8 5 SystemInformationscreen 158 8 6 Set points 161 9 Maintenance 164 9 1 Usermaintenanceschedule 166 9 2 Sanitization...

Page 4: ...11 6 7 Otherregulationsandstandards 203 11 7 Orderinginformation 204 11 8 HealthandSafetyDeclarationForm 205 Index 207 TableofContents 4 KTAfluxsOperatingInstructions29046893AG...

Page 5: ...u latoryinformation andintendeduseof KTA fluxs Inthischapter Section Seepage 1 1 Importantuserinformation 6 1 2 Aboutthismanual 7 1 3 Associateddocumentation 8 1 4 Additionaluserdocumentation addition...

Page 6: ...uchascellclarification harvesting orcassettes hollowfibersfor ultrafiltrationapplications suchasproteinconcentrationanddiafiltrationindown streamunitoperations KTAfluxsisnotintendedfordiagnosticpurpos...

Page 7: ...otheapplicablesoftwareversioninstructionmanualsprovidedbytherespectivesoft waresupplier Typographicalconventions Softwareitemsareidentifiedinthetextbybolditalictext Hardwareitemsareidentifiedinthetext...

Page 8: ...correctandsafeway Systemoverview siterequirements andinstructionsformovingthesystem withinthesamebuilding Instructionsforbasicmaintenanceand troubleshooting KTA flux s User Manual Additionalinformati...

Page 9: ...isplay software Tap toaccesstheInstrument Displayhelp KTAfluxsWorkstationsoftwareHelp Overviewanddetaileddescriptionsof menusandfunctionsintheWorkstation software Toaccessthesoftwarehelp select Helpfr...

Page 10: ...gram P ID Schematicoverviewoftheentire processflow allcomponentsand instrumentsandthecontrolsystem Declarationof Conformity DoC DeclarationofConformityforEUand or otherregions GeneralSpecification GS...

Page 11: ...ropylenedienemonomer ethylenepropylenedienemonomer HEPA highefficiencyparticulateair controlledvariablelowlimit PID proportionalintegralderivative APIDcontrollercalculatesanerror valueasthedifferenceb...

Page 12: ...theprocesscontrolinputs setpoint Thetargetvaluethatanautomatic controlsystem forexamplePID controller willattempttoreachby adjustingtheprocesscontrolinputs SPHL setpointhighlimit setpointhighlimit SPL...

Page 13: ...veryprocedures andprovidesrecyclinginformation Important WARNING Beforeinstalling operatingormaintainingtheproduct all usersmustreadandunderstandtheentirecontentsofthis chaptertobecomeawareofthehazard...

Page 14: ...aintenance on page 21 Definitions Thisuserdocumentationcontainssafetynotices WARNING CAUTION andNOTICE concerningthesafeuseoftheproduct Seedefinitionsbelow WARNING WARNINGindicatesahazardoussituationw...

Page 15: ...essesmayhaveontheclassi ficationofthehazardousarea Theprocessmightcausetheareato increaseorthezoneclassificationtochange Implementtherisk reductionmeasuresneeded includinguseofpersonalprotective equip...

Page 16: ...WARNING Usefumemaskduringtankopeningwhenprocessinghazardous liquids toavoidpossibleexposuretoaerosols CAUTION Riskofpinchingbymovingpartsinsidethetankorinsidethe pumps Donotinsertyourfingersorotherobj...

Page 17: ...rcord The powerswitchmustalwaysbeeasytoaccess Thepowercordwith plugmustalwaysbeeasytodisconnect WARNING Disconnectpowertotheproductbeforeinstallationoftheoptional pump WARNING Beforeconnectingthefilte...

Page 18: ...t KTAfluxs Liftonlyinthebottom partofthesystem CAUTION Makesurethatthesystemisplacedonastable levelbenchwith adequatespaceforventilation CAUTION Makesureyourfingersnotarepinchedunder KTAfluxswhenthe i...

Page 19: ...protectionanddisconnect devices Non compliancemayresultinpersonalinjuryand or equipmentdamage WARNING Allelectricalinstallationsmustbeperformedbyauthorized personnelonlyunlessstatedinthismanual WARNIN...

Page 20: ...Neverexceedtheoperatinglimitsstatedinthisdocumentandon thesystemlabel Operationoftheproductoutsidetheselimitscan damageequipmentandcausepersonalinjuryordeath WARNING Disconnectpowertotheproductbefore...

Page 21: ...scanbecomehotduringuse CAUTION Handlefluidswithcarewhenaddingfluidtothesystemor collectingfluidfromdrainvalves AlwaysuseappropriatePersonal ProtectiveEquipment PPE whenoperatingandinteractingwith KTAf...

Page 22: ...ybeusedformaintainingor servicingtheproduct WARNING Whenusinghazardouschemicals runSystemCIPand MembraneCIPtoflushtheentiresystem includingfilters with distilledwateruntilapHofapproximatelypH7 0isreac...

Page 23: ...eventexposuretoleakinghotfluids Donotusenon approvedtubingandcomponentstogetherwith orinsidethesystem Maintenanceandpumptubingreplacementofthe KTAfluxs mustbescheduledonregularbasiswithaCytivarepresen...

Page 24: ...below Labeltext Description Codeno Systemcodenumber Serialno Systemserialnumber MfgYear Manufacturingyearandmonth Voltage Supplyvoltage Frequency Supplyvoltagefrequency Maxpower Maxpowerconsumption Fu...

Page 25: ...Safetylabel Thewarninglabelonthepumpsindicatesthatthefingersmustbekeptawayfromthe movingrotor 2 Safetyinstructions 2 2 Labels KTAfluxsOperatingInstructions29046893AG 25...

Page 26: ...inspowersupplybypushingthepowerswitchtothe0position 1 or disconnectingthepowercord 2 Result Theentiresystembecomespowerless dataislostorcorrupt Restartafteremergencyshutdown orpowerfailure Followthein...

Page 27: ...sbeenlost switchonpowerto KTAfluxsbyturningonthe powerswitchtotheIposition Result Thesystemcomputerstartsautomatically 3 Restarttheprocess 2 Safetyinstructions 2 3 Emergencyprocedures KTAfluxsOperatin...

Page 28: ...fthetechnicalpropertiesof KTAfluxs Inthischapter Section Seepage 3 1 Illustrationsof KTAfluxs 29 3 2 Systemcontrol 32 3 3 Standardequipment 41 3 4 Optionalequipment 47 3 5 Filterdevices 48 3 6 Flowcha...

Page 29: ...of KTA flux s Frontviewwithalloptions Part Function 1 Transferpump optional 2 Tankholderwithtankbalanceandmotorformixer 3 Tank 3 Systemdescription 3 1 Illustrationsof KTAfluxs KTAfluxsOperatingInstruc...

Page 30: ...orPr 8 FilterholderforKvickLab packetshown optional 9 Retentatepressurecontrolvalve 10 FeedpressuresensorPfandtemperaturesensor 11 Lowerdrainvalve 12 Powerswitch 13 Feedpump 14 15 and16 Pinchclamps 3...

Page 31: ...eatepressuresensorPp optional 3 Permeatepump optional 4 USB connectorprotection 5 Ventilationholesforcabinetcoolingfan 6 Airinlet 7 Circuitbreakers 8 Powercordconnectionandfusedrawer 3 Systemdescripti...

Page 32: ...f needed adjusttheparametercausingthewarning Forfurtherinformationonwarningparameters seeSet system alarm parameters on page 152 Systemalarms Systemalarmscanappearonthetouchscreen Asystemalarmwillstop...

Page 33: ...pData Logging ThisfunctionisactivewhenaUSBdeviceis connected 4 Shutdownbutton Shutsdownthesystem Alwaysusethisbutton duringnormalshutdown 5 Controlpanel Startsandstopsfunctionsoperatedfromthis panel 6...

Page 34: ...alpumps installed Iftheoptionalpumpsnotareinstalled theyaregrayonthemainscreen TheLock buttononthetanklevelcontrolisdimmedandnotpossibletouse 3 Systemdescription 3 2 Systemcontrol 34 KTAfluxsOperating...

Page 35: ...playsrotationalspeedofthe mixer 4 Feed Adjuststhefeedpumpanddisplaysfeedpumpspeed flow rateorshearrate 5 Pauto Usedtosetretentate P PfminusPr tobekeptconstant bycontrollingfeedpumpspeed flowrateorshea...

Page 36: ...nwhenapump isstarted Pf Pf Start Stop Start AStartbuttonwithasurroundingredcircleindicatestheStopPumps buttonhasbeenpressed Pf Pf Start Stop Start TheLockbuttonindicatesanautomaticparameter ALockbutto...

Page 37: ...pump optional 2 Mixerandtank 3 Feedpump 4 Feedpressuresensor Pf 5 Temperaturesensor 6 Retentatepressuresensor Pr 7 Filter 8 Permeatepump optional 9 Permeatepressuresensor Pp optional 3 Systemdescripti...

Page 38: ...isnot running Agreencirclearoundthemotorsymbolindicatesthatthepumpis running Ayellowcirclearoundthemotorsymbolindicatesapumpwarning Aredcirclearoundthemotorsymbolindicatesapumpalarm Ayellowsensorindic...

Page 39: ...Displays pressure P Pf Pr 5 TMP Displaystransmembranepressure TMP Pf Pr 2 Pp 6 T Displayssystemtemperature 7 Qp Calculatedpermeateflow Stoppingtheprocess Button Function Pf Pf Start Stop Start Aruncan...

Page 40: ...xpectedoccur rence TheStopbuttonisrecommendedundernormaluse I O I O Shutdownofthewholesystemisdonewiththe Shutdownbuttononthemainscreen Alwaysuse thisbuttonduringnormalshutdown Poweroffthesystemintwos...

Page 41: ...erviewofthestandardcomponentsof KTAfluxs Inthissection Section Seepage 3 3 1 Feedpump pressuresensorsandpressurecontrolvalve 42 3 3 2 Tank 45 3 3 3 Communicationconnection 46 3 Systemdescription 3 3 S...

Page 42: ...e Thefeedpump Aperistalticfeedpumpusedinthefeedline Theoptionalpumpsusedinthetransfer andpermeatelinesareofthesametype 3 Systemdescription 3 3 Standardequipment 3 3 1 Feedpump pressuresensorsandpressu...

Page 43: ...lvesinstalledontheinstrument Theretentatepressurecontrolvalve usedintheretentateline enablesmanual regulationoftheliquidflowbyadjustingthepressureupstreamthefilter Theentire retentatelinecanbeshutoffb...

Page 44: ...3 Systemdescription 3 3 Standardequipment 3 3 1 Feedpump pressuresensorsandpressurecontrolvalve 44 KTAfluxsOperatingInstructions29046893AG...

Page 45: ...ansferinlet Description KTAfluxshasa0 5litertank Thetankhasafeedoutlet transferandretentateinlets Itisequippedwithacheckvalveandanairfilter Thevolumeinthetankiscalculatedonthebasisoftheweight Theweigh...

Page 46: ...nection TheUSBflashdriveisusedtosaveprocessdataandproduceasystemhealthreport A protectivecapisusedtocovertheUSBflashdrive 3 Systemdescription 3 3 Standardequipment 3 3 3 Communicationconnection 46 KTA...

Page 47: ...atepump Anoptionalpermeatepumpisavailabletocontrolthepermeateflow Whenusingthe permeatepumpitisrecommendedtoalsoincludetheoptionalpermeatepressure sensor Thepumptubingneedstobeorderedseparately Permea...

Page 48: ...ertypesthatcanbe installedwith KTAfluxs Thefollowingfiltertypescanbeused Hollowfibercartridges Filtercassettes Inthissection Section Seepage 3 5 1 Hollowfibercartridges 49 3 5 2 KvickLabpacketandholde...

Page 49: ...inedorfilteredoutwiththe permeate Thepermeatepenetratesthelumen swallinthefibersandflowsoutsidethefibersand iscollectedthroughoneofthesideconnectors AvailableHFcartridges KTAfluxscanbeusedwiththeCytiv...

Page 50: ...n 1 2 3 Part Function 1 KvickLabpacket 2 KvickLabpacketholder frontplate 3 KvickLabpacketholder backplate Description TheKvickLabpacketisintendedforconcentrationanddiafiltrationofsmallprocess volumes...

Page 51: ...mationregardingKvick Labpacketandholder ContactCytivaformoreinformationaboutotherfiltersolutionsthatcanbeused with KTAfluxsfiltrationsystems 3 Systemdescription 3 5 Filterdevices 3 5 2 KvickLabpacketa...

Page 52: ...17 Black standardcomponents Red optionalcomponents Processcomponents Thefollowingtableliststheprocesscomponentsthatareshownintheflowchart Tag Function 1 Feedpump 2 Lowerdrainvalve 3 Feedpressuresenso...

Page 53: ...fromtank 14 Tanktransferinlet 15 Transferpump optional 16 Externaltankconnection 17 Filterfeedinlet 18 Filterretentateoutlet 19 Filterpermeateoutlet 20 PermeatepressuresensorPp optional 21 Permeatepum...

Page 54: ...tthischapter Thischapterprovidesanoverviewoftheflowlinesin KTAfluxs Inthischapter Section Seepage 4 1 Recirculationloop 55 4 2 Permeateline 58 4 3 Transferline 60 4 Flowlines 54 KTAfluxsOperatingInstr...

Page 55: ...7 6 5 3 4 Part Function 1 Feedoutletfromtank 2 Feedpump 3 Lowerdrainvalve 4 FeedpressuresensorPfandtemperaturesensor 5 Feedinlettofilter 6 Retentateoutletfromfilter 7 RetentatepressuresensorPr 8 Rete...

Page 56: ...resensorPfprovidespressuredataforthefilterfeedinletpressureand protectsthesystemagainstoverpressure Ifthepressuresensorfails analarmwillbe triggeredinthecontrolsystem ThePfsensorhousingalsocontainsthe...

Page 57: ...irculation lineviatheretentatepressurecontrolvalveplacedafterthefilter Theprocessisnormallyoptimizedtominimizetheprocesstimewhichisdonebymaxi mizingtheflux permeateflow filterarea Tokeepthefluxatmaxpo...

Page 58: ...tepressurecontrolvalve placedonthepermeatesideoftheinstrument is usedtoshutoffthepermeatefilteroutletandtomanuallycontrolthepermeatepres sure Recycling Thepermeateoutletcanbecoupledtothetank Thisallow...

Page 59: ...The permeatepumpisusedtocontrolthepermeateflowrateandthepermeatepressure sensor Pp measurespermeatepressure Part Function 1 Permeatepressuresensorinlet 2 Permeatepressuresensor 3 Permeatepump 4 Tubing...

Page 60: ...n Thetransferlinetransfersliquidfromanexternaltanktothe KTAfluxstankviathe transferpump Constantretentatevolume Thetransferpumpsuppliesmaterialtothetankfromanexternalsource Asmaterialis separatedoutfr...

Page 61: ...he KTAfluxs 67 5 5 Installationtest 97 Precautions WARNING Beforeperforminganyoftheproceduresdescribedinthischapter youmustreadandunderstandallcontentsofthecorresponding sectionsinChapter 2 Safety ins...

Page 62: ...CAUTION Donottransport handleandstore KTAfluxsinanyotherway thandescribedinthismanual 5 Installation 62 KTAfluxsOperatingInstructions29046893AG...

Page 63: ...utlet Ambientenvi ronment Avoid Directsunlight Strongmagneticorelectricfields Vibrations Corrosivegas Dust Positioning Theplacementofthe KTAfluxsmustfulfillthefollowing requirements Aflat stableandcle...

Page 64: ...ure storage 25 Cto 50 C SeedetailedinformationinOperating limits on page 184 Relativehumidity Upto95 atmospherichumidityat40 Cfor48hrs Visualinspection Check thatallequipmentisenclosedinthecrateaccord...

Page 65: ...rtofthesystem CAUTION Makesurethatthesystemisplacedonastable levelbenchwith adequatespaceforventilation RefertoUnpacking Instructions 29056121 forafulldescriptionoftheunpacking procedure 5 Installatio...

Page 66: ...Parameter Allowedrange Ambienttemperature transport 25 Cto 60 C Temperaturegradientsof 1 C min SeedetailedinformationinOperating limits on page 184 Balanceshippingprotection NOTICE Ifthe KTAfluxsismo...

Page 67: ...section Section Seepage 5 4 1 PowersupplyandUSBconnection 68 5 4 2 Installandremovethetank 71 5 4 3 Tubing 72 5 4 4 Installthetransferpump 83 5 4 5 Installthepermeatepump 87 5 4 6 Installthepermeatepr...

Page 68: ...tem Theillustrationbelowshowsthelocationofthepowersupplyandfusesonthe KTAfluxs 1 2 3 Part Function 1 Fusedrawerwithtwomainsfuses Forspecificationofthefuses seeElectric power on page 184 2 Powerconnect...

Page 69: ...ctionsbelow Step Action 1 Connectthepowercordtotheinstrument 2 ConnectthepowercordtoagroundedpoweroutletspecifiedinSection 5 1 Site requirements on page 63 Built incircuitbreakers Allpumps theoperator...

Page 70: ...ecapfortheUSBflashdriveisplacedontherightsideof KTAfluxsseen fromthefront UnscrewtheprotectivecaptoinserttheUSBflashdrive Note The protective cap must always be used both with and without a USB flash...

Page 71: ...anyotherwaythan describedinthismanual NOTICE Blockedventscancauseoverpressureintank Installthetank Followtheinstructionsbelowtoinstallthetank Step Action 1 Fitthetanktothetankholder 2 Attachtheinletan...

Page 72: ...operatortoresidualfluidthatmight causecontaminationofskinandclothing Alwaysuseappropriate PersonalProtectiveEquipment PPE whenoperatingandinter actingwith KTAfluxs CAUTION UseonlytubingsuppliedbyCytiv...

Page 73: ...onthetagareexplainedinthetable PFB 1 2 3 Location Tag Description Dimension 1 P Pumptube N A 2 F Feedingpump tube N A 3 A TubingsizeA 1 6mmID 4 8 mmOD B TubingsizeB 3 2mmID 6 3 mmOD D TubingsizeD 6 4m...

Page 74: ...2 3 Loca tion Tag Description 1 T Transferline F Feedline R Retentateline P Permeateline 2 1 2 3 Orderintheline 3 L Linetube Pinchclamps Thetubingforthefeedline theretentatelineandthetransferlinearee...

Page 75: ...xs Tag Tubing Tubingsize ID Innerdiameter OD Outer diameter F1L Tubingfromtank outlettofeedpump 3 2mmID 6 4mmOD R1L Tubingfrompressure sensortodrainvalve 2 38mmID 5 56mmOD R2L Tubingfromdrain valvetot...

Page 76: ...ag Tubingsize Feedpump Transfer pump Permeate pump PA 1 6mmID 4 8mm OD X PB 3 2mmID 6 3mm OD X X PFA 1 6mmID 4 8mm OD X PFB 3 2mmID 6 3mm OD X PFD 6 4mmID 9 6mm OD X 5 Installation 5 4 Setupthe KTAflu...

Page 77: ...Part Tag Description Tubingsize 1 MM11 Tubingtopermeatepressure sensor 1 6mmID 4 8mm OD 2 MM12 Tubingtoretentatepressure sensor 2 38mmID 5 56mm OD 3 MM32 Tubingtofeedpressuresensor 2 38mmID 5 56mm OD...

Page 78: ...Upperdrainvalve Usetheexplodedviewasahelptoputtogethertheupperdrainvalve 5 Installation 5 4 Setupthe KTAfluxs 5 4 3 Tubing 78 KTAfluxsOperatingInstructions29046893AG...

Page 79: ...Lowerdrainvalve Usetheexplodedviewasahelptoputtogetherthelowerdrainvalve 5 Installation 5 4 Setupthe KTAfluxs 5 4 3 Tubing KTAfluxsOperatingInstructions29046893AG 79...

Page 80: ...telinetubing TheP1Ltubingisusedonthepermeatesideafterthefilter whentheoptional permeatepressurepumpisnotinstalled 5 Installation 5 4 Setupthe KTAfluxs 5 4 3 Tubing 80 KTAfluxsOperatingInstructions2904...

Page 81: ...bing TheT1Ltubingisusedwhentheoptionaltransferpumpisinstalled Itisconnectedto thetankandtothepumptubinginthetransferpump 5 Installation 5 4 Setupthe KTAfluxs 5 4 3 Tubing KTAfluxsOperatingInstructions...

Page 82: ...aleFemaleLuertype FF FemaleFemaleLuer type 2 1 Tubelength1 115mmtubelength 2 Tubelength2 165mmtubelength 3 Tubelength3 230mmtubelength 4 Tubelength4 400mmtubelength 5 Tubelength5 600mmtubelength 3 1 S...

Page 83: ...wertotheproductbeforeinstallationoftheoptional pump CAUTION Takecarenottodroptheoptionalpumpassemblyduringinstalla tionasitcanresultindamagetotheunitorinjurytoyourself Toolsrequired Aflatscrewdriveris...

Page 84: ...rpump Step Action 1 Disconnectthepower 2 Unscrewthescrewsholdingthecasingforthetransferpumpconnections Removethecasing 3 Pulloutthepowerandcommunicationcables 5 Installation 5 4 Setupthe KTAfluxs 5 4...

Page 85: ...tioncabletothecorrespondingconnectiononthe transferpump 5 Connectthepowercabletothecorrespondingconnectiononthetransfer pump 5 Installation 5 4 Setupthe KTAfluxs 5 4 4 Installthetransferpump KTAfluxsO...

Page 86: ...performthefollowingactions Performamotorcontrol seeSection 6 4 5 Motor control on page 126 Installthepumptubing refertoInstall the pump tubing on page 94 Performacalibrationofthetransferpump seeSectio...

Page 87: ...kecarenottodroptheoptionalpumpassemblyduringinstalla tionasitcanresultindamagetotheunitorinjurytoyourself Toolsrequired Aflatscrewdriverisneededfortheinstallationofthepermeatepump Installthepermeatepu...

Page 88: ...2 Unscrewthescrewsholdingthecasingforthepermeatepumpconnections 3 Pulloutthepowerandcommunicationcables 5 Installation 5 4 Setupthe KTAfluxs 5 4 5 Installthepermeatepump 88 KTAfluxsOperatingInstructio...

Page 89: ...tioncabletothecorrespondingconnectiononthe permeatepump 5 Connectthepowercabletothecorrespondingconnectiononthepermeate pump 5 Installation 5 4 Setupthe KTAfluxs 5 4 5 Installthepermeatepump KTAfluxsO...

Page 90: ...formthefollowingactions Performamotorcontrol seeSection 6 4 5 Motor control on page 126 Installthepumptubing refertoInstall the pump tubing on page 94 Performacalibrationofthepermeatepump seeSection 6...

Page 91: ...orx screwdriverisneededfortheinstallationofthepermeatepressure sensor Installthepermeatepressuresensor Followtheinstructionsbelowtoinstallthepermeatepressuresensor Step Action 1 Disconnectthepower 2 R...

Page 92: ...ioncabletotheconnectiononthepres suresensor 4 Placethepressuresensoroverthefittingsforthescrewsonthechassisso thattheymatch 5 Installation 5 4 Setupthe KTAfluxs 5 4 6 Installthepermeatepressuresensor...

Page 93: ...Action 5 Fastenthescrews 6 Calibratethepressuresensorusingthesuppliedfactorysettings 5 Installation 5 4 Setupthe KTAfluxs 5 4 6 Installthepermeatepressuresensor KTAfluxsOperatingInstructions29046893A...

Page 94: ...connectpowertotheproductbeforeinstallingthepump tubing Followthestepsbelowtoinstallthepumptubing Step Action 1 Openthepumpheadbyrotatingthelevertotheleft 5 Installation 5 4 Setupthe KTAfluxs 5 4 7 Pum...

Page 95: ...betweenthe retainers NOTICE Makesurethetubingisstraightwhereitentersandexits thepump Twistingcancausedamagetothetubing 3 Lightlypullonthetubingdownwardstopre stretch 5 Installation 5 4 Setupthe KTAflu...

Page 96: ...ighttoclosethepumphead 5 Rotatethelevercompletelytoclosethepumphead NOTICE Makesurethetubingisfittedbetweentheretainersand checkthatthetubingisnottwisted 5 Installation 5 4 Setupthe KTAfluxs 5 4 7 Pum...

Page 97: ...ontrol on page 126 Tanklevelcalibration refertoCalibrate the tank level on page 127 Feedpumpcalibration seePerformance on page 97 Checkthatthepressuresensorsdisplay0barwhenconnectedtoatmospheric press...

Page 98: ...ance schedule on page 166 Inthischapter Section Seepage 6 1 Filterinstallation 99 6 2 InstallKvickLabpacketandholder 106 6 3 Testingfilters 108 6 4 Calibration 109 Precautions WARNING Beforeperforming...

Page 99: ...dexposingthefiltertoexcessivepressure makesurethatthepressurelimitissettothespecifiedmaximum pressureofthefilter Introduction Thissectioncontainsgeneralinformationonwhereandhowtoinstallthedifferent fi...

Page 100: ...gebelowshowswheretoattachdifferentfiltertypeson KTAfluxs Part Function 1 HolderforHFcartridgesorKvickStartcassette 2 HolderforKvickLabPacket optional 6 Runpreparations 6 1 Filterinstallation 6 1 1 Fil...

Page 101: ...utlet Thedescriptionsonthefollowingpagesrefertoinstallationswiththeoptional permeatepressuresensorandthepermeatepumpinstalled Eachfiltertypeusedin theseinstallationsrequiresitsownsetoffiltertubing 6 R...

Page 102: ...ed pressuresensor MM32 230mm MF32 230mm 2 Fromfiltertoreten tatepressuresensor MM42 400mm MF42 400mm 3 Fromfilterto permeatepressure sensor1 MM41 400mm MF41 400mm 1 Iftheoptionalpermeatepressuresensor...

Page 103: ...MF32 230mm 2 Fromfiltertoreten tatepressuresensor MM22 165mm MF22 165mm 3 Fromfilterto permeatepressure sensor1 MM11 115mm MF11 115mm 1 Iftheoptionalpermeatepressuresensorandpermeatepumpnotareinstall...

Page 104: ...nto KTAfluxs Step Action 1 PrepareandchecktheHFcartridgeaccordingtothemanufacturer s instructions 2 IftheinstalledHFcartridgeisnew itisstronglyrecommendedtoperforma filterintegritytesttoestablishitsch...

Page 105: ...tonthesystem Attacha stopplugtothelowerpermeateport Tip Keep connected tubing short to minimize holdup volume 7 Continuepreparation Moreinformation Formoreinformationseetheoperating handbook 18116530...

Page 106: ...Length 1 Fromfiltertofeedpres suresensor MM32 230mm 2 Fromfiltertoretentate pressuresensor MM12 165mm 3 Fromfiltertopermeate pressuresensor1 MM11 115mm 1 Iftheoptionalpermeatepressuresensorandpermeate...

Page 107: ...ontopofthefirstone Additionalgasketsare notrequired 4 Placethebackplateontopofthelastpacket 5 Placethespacersontothebolts IfmorethantwoKvickLabpacketsare installed donotusethespacers 6 Addthewashersan...

Page 108: ...rer sinstructions Leakagetest Followtheinstructionsbelowtoperformaleakagetest Step Action 1 Pressurizethesystemtothemaximumintendedprocesspressure a TapFeedonthemainscreen b Usethedisplayedkeypadtoset...

Page 109: ...sandmixer Allowedserviceperformedcalibrations Alluserallowedcalibration Fullrangecalibrationofinstalledpressuresensors Thepressureandtubingdimensionusedwhencalibratingthesystemshouldalways correspondt...

Page 110: ...thetankwithwater 3 3 Replacethefilterwithtubing 4 betweenthefeedpumppressuresensor andretentatepressuresensor 4 Opentheupperdrainvalvetocollecttheflow 5 inbeakerA 5 Setalowrpmvalueofthefeedpumpontheco...

Page 111: ...eakerAandputitinbeakerB Collectwater betweentimepoint0andtimepointT whereTisatleastoneminute MeasurethemassofthewaterinbeakerBwithanexternalbalanceand calculatetheflowrate weight time Assumingthatthed...

Page 112: ...eenthatappears 12 TapFeedpumpontheCalibrationSettingsscreen 13 Enterthelowrpmvalueofthefeedpumpandthecorrespondingcalculated flowvalueinthegrayfieldindicatedwith Assumingthatthedensityis1 themeasuredv...

Page 113: ...ecorrespondingcalculated flowvalueinthegrayfieldindicatedwith 15 EnterthesavedPffeedpressuresensorvaluemeasuredinthegrayfield markedwithPressure 6 Runpreparations 6 4 Calibration 6 4 1 Calibrationofth...

Page 114: ...librated 17 ToseetheflowinmL minonthemainscreenaftercalibration settheflow rateforthefeedpumptomL min seeSet units on page 154 Note When the pump tubing is changed the pump calibration needs to be rep...

Page 115: ...wforthetransferpumpat0 barbackpressure Thetransferpumpisoptional Step Action 1 Connecttubingtothetransferpumpinlet 1 andthetransferpumpoutlet 2 2 FillbeakerAwithprocessliquidandputthetubinginthebeaker...

Page 116: ...andstarttocollectflowatthetransferpump outlet 5 Collectfluidbetweentimepoint0andtimepointT Measurethemassofthe fluidinbeakerBwithanexternalbalanceandcalculatetheflowrate weight time 6 Runpreparations...

Page 117: ...tappears 9 TapTransferpumpontheCalibrationSettingsscreen 10 EnterthelowRPMvalueofthetransferpumpandthecorrespondingcalcu latedflowvalueinthegrayfieldindicatedwith Assumingthatthe densityis1 themeasure...

Page 118: ...ayfieldindicatedwith 12 Thetransferpumpiscalibratedat0barbackpressure 13 TapEnter Result ThesoftwarecalculatesthecorrelationbetweenusedRPMandachieved flowandthetransferpumpiscalibrated 6 Runpreparatio...

Page 119: ...flowinmL minonthemainscreenaftercalibration settheflow rateforthetransferpumptomL min seeSet units on page 154 6 Runpreparations 6 4 Calibration 6 4 2 Calibrationofthetransferpump KTAfluxsOperatingIns...

Page 120: ...uresensorinlet 1 andthepermeate pumpoutlet 2 2 FillbeakerAwithprocessliquidandputthetubinginthebeaker 3 SetalowRPMvalueofthepermeatepumponthecontrolpanelandtap Start Letthepumprunforacoupleofminutes F...

Page 121: ...ectedtothepermeatepumpoutlet frombeakerAto beakerB emptybeaker andstarttocollectflowatthepermeatepump outletinbeakerB 6 Runpreparations 6 4 Calibration 6 4 3 Calibrationofthepermeatepump KTAfluxsOpera...

Page 122: ...externalbalanceandcalculatetheflowrate weight time 6 Performthecorrespondingprocedure step2to6 atahighRPMvalueofthe permeatepump 7 TapSettingsonthemainscreen 8 TapCalibrationonthescreenthatappears 9 T...

Page 123: ...ndicatedwith Assumingthatthe densityis1 themeasuredvalueing minwillcorrespondtomL min 11 EnterthehighRPMvalueofthepermeatepumpandthecorresponding calculatedflowvalueinthegrayfieldindicatedwith 6 Runpr...

Page 124: ...ecalculatesthecorrelationbetweenusedRPMandachieved flowandthepermeatepumpiscalibrated 14 ToseetheflowinmL minonthemainscreenaftercalibration settheflow rateforthepermeatepumptomL min seeSet units on p...

Page 125: ...thepressureunitconnectedtothesystem in thegrayfields 2 markedZeroandSpan Foraninstructionhowtouseset points seeAdjust set points on page 161 5 TapEnter Result Thepermeatepressurefactorycalibrationsett...

Page 126: ...trol Step Action 1 TapSettingsonthemainscreen 2 TapCalibrationtoopenCalibrationSettingsscreen 3 TapMotorControl 1 1 2 4 Tap 2 theFeedPump PermeatePump Transferpump ortheMixer dependingonwhichofthemoto...

Page 127: ...ved oriftherehasbeenanyinterferencewiththebalance Note Do not interfere with the tank balance during the calibration procedure and filter run Calibratethetanklevel Step Action 1 TapSettingsonthemainsc...

Page 128: ...with inStep 2 panel Setthevalueusingthekeypad Foraninstructionhowtouseset points see Adjust set points on page 161 9 TapEnterinStep 2 panel Result Thesoftwarecalculatesthecalibrationandsavesthedata 10...

Page 129: ...ons WARNING Beforeperforminganyoftheproceduresdescribedinthischapter youmustreadandunderstandallcontentsofthecorresponding sectionsinChapter 2 Safety instructions on page 13 aslisted below WARNING Nev...

Page 130: ...fluids Donotusenon approvedtubingandcomponentstogetherwith orinsidethesystem Maintenanceandpumptubingreplacementofthe KTAfluxs mustbescheduledonregularbasiswithaCytivarepresentative andperformedbyprop...

Page 131: ...etsandoutletstothesystemareconnected closedorinappro priatestatedependingonthedesignedprocess Inletsandoutletsthatarenotin useshallbeclosed Checktheconditionofallconnectionsandgaskets Tightenconnectio...

Page 132: ...rtthesystem Step Action 1 SwitchonthepowerbyturningonthepowerswitchtotheIposition 1 2 Agreenlamp 2 lightsup 3 Thesystemstartsautomaticallyandthemainscreenappears 3 7 Operation 7 1 Startthesystem 132 K...

Page 133: ...ingfluidtothesystemor collectingfluidfromdrainvalves AlwaysuseappropriatePersonal ProtectiveEquipment PPE whenoperatingandinteractingwith KTAfluxs NOTICE MakesurethattheLUERlockcannotbeopenedbyinadver...

Page 134: ...thestartofthefiltering process Inthissection Section Seepage 7 2 1 Basicfiltration 135 7 2 2 Automatedfeatures 136 7 2 3 Datalogging 140 7 2 4 Shutdown KTAfluxs 142 7 Operation 7 2 Performarun 134 KTA...

Page 135: ...hattheretentatepressurecontrolvalveisfullyopenandthatthe recirculationpath fromtankandbacktotankagain iscompletelyopen 6 TapFeed 3 7 Usethedisplayedkeypadtosetthedesiredfeedpumpspeed rpm andtap OK 8 T...

Page 136: ...ume CRV inthetank Todothis followthestepsbelow Step Action 1 TapLockbutton 1 onLevelonthecontrolpanel 1 2 2 Usethedisplayedkeypadtoinsertset pointsfortheconstantretentate volumeandtapActivate 3 TapSta...

Page 137: ...CRV mode the tank low level alarm should be activated Pfcontrol Thefeedpressurecanbeusedtocontrolthefeedflowrate Todothis followthesteps below Step Action 1 Performabasicfiltration refertostep1to5inSe...

Page 138: ...ge 135 2 TapLockbuttonnext Pautopressureonthecontrolpanel setthevalue onthekeypadthatappearsandpressActivate 3 Tostopthefunction taptheLockbuttonandtapDeactivateonthe displayedkeypad Note When using d...

Page 139: ...tion 1 TapPermeate 1 onthecontrolpanel 4 GE Title or job number 2 8 2013 2 1 2 Usethedisplayedkeypadtosetthedesiredpermeatepumpspeed rpm andtapOK Foraninstructionhowtouseset points seeAdjust set point...

Page 140: ...1 ConnectaUSBflashdriveto KTAfluxs forlocationseeUSB connection on page 46 2 TapStartDataLoggingonthemainscreen Result Dataiscapturedfromthecurrentrun Note It is not possible to generate data after t...

Page 141: ...Tosavetheresultfile followthestepsbelow Step Action 1 InserttheUSBflashdriveinthecomputer 2 Openthe csvfileinExcel 3 SelectthefirstcolumnandthenData TexttoColumns ClickNext 4 SelectCommaasdelimiter C...

Page 142: ...stopowerofftheinstrument Note If a restart of the system is required tap Restart and do not proceed to step 3 3 Turnofftheinstrumentbypushingthepowerswitchtothe0positionwhen theblinkingcursorhasdisapp...

Page 143: ...easedwhenthereisnoactive filtration Emptythesystem Emptythesystemby Opentheupperandlowerdrainvalve Runfeedpumpatlowvelocityuntilthesystemisempty Shutdownthepump Openthepressurecontrolvalves NOTICE Mak...

Page 144: ...Prepareforstorage Ifneeded preparethesystemforstorageasdescribedinSection 9 3 Storage on page 174 7 Operation 7 3 Proceduresaftertherun 144 KTAfluxsOperatingInstructions29046893AG...

Page 145: ...ethesettingsoftheparameters Inthischapter Section Seepage 8 1 USBDeviceManagementscreenandsoftwareupdate 146 8 2 ConfigureAlarmsscreen 149 8 3 ConfigureSystemscreen 154 8 4 CalibrationSettingsscreen 1...

Page 146: ...e on page 140 Systemhealthreport AsystemhealthreportisasystemstatusreportthatcanbegeneratedifaUSBflash driveisconnectedtothesystem Followtheinstructionsbelowtogenerateasystemhealthreportandsendtheinfo...

Page 147: ...04 X xxxxxx_x86_ release opk tothe root directoryontheUSBdrive 3 Removeallotherversionsfromroot directoryifpresentintheUSB Thisstep isrequiredifUSBisnot formattedandoldversionofsoftwareispresentinthe...

Page 148: ...t 9 NavigatetoSettings USBDevice USBDeviceManagement 10 SelectEjectUSB 11 Togetthenewdefaultvaluesforupgradation resetthesystemwiththe Restoredefault optionalstep 8 Settings 8 1 USBDeviceManagementscr...

Page 149: ...topthesystem s feedpump andtransferandpermeate pumps ifapplicable andtherebypause theprocessuntilmanualinteraction Systemrelatedwarning Thewarningmessageconcernsan internalerrorinthesystem Thetriggere...

Page 150: ...X X X X Note The AlarmHighsettings for FeedPressure RetentatePressure and PermeatePressure can be adjusted but can never be set to a value higher than the highest system pressure 4 bar bar and cannot...

Page 151: ...goralarmissetforthe parameter Agreenindicatorshowsthatatleastonehighorlowwarningor alarmhasbeensetfortheparameter Aredindicatorshowsthatanalarmorawarningistriggered 8 Settings 8 2 ConfigureAlarmsscree...

Page 152: ...rmstoopenConfigureAlarmsscreen 3 TapFeedPressureontherighthandofthescreen 4 TaptheAlarmHighbuttonandusethe or tosetthepreferredvaluesfor AlarmHigh orusethedisplayedkeypadtosetpoints Foraninstructionho...

Page 153: ...atorturnsgreenshowingthatanalarmhighistrig gered Note To deactivate an alarm or warning tap the activated alarm and check that the indicator turns white 8 Settings 8 2 ConfigureAlarmsscreen KTAfluxsOp...

Page 154: ...ar psi Temperature Celsius Fahrenheit FeedPump RPM mL min ShearRate PermeateFlux g min LMH Transfer PermeatePump RPM mL min Setunits Followtheinstructionsbelowtosettheunits Step Action 1 TapSettingson...

Page 155: ...arRate values providedbythehollowfibermanufacturer 5 TaptheFlowRate mL min fieldandtheShearRatefieldtosetthe preferredvalueswiththedisplayedkeypad Digitscanbedeletedusingthe arrowsignbuttonintheupperr...

Page 156: ...80 1 25 50 100 200 H42LA 0 5 4 8 5 17 33 1 25 50 100 200 AXHor H24LA 0 5 8 5 17 33 66 AXM 0 5 25 50 100 200 0 75 40 80 160 320 1 70 140 280 560 6 TapOKtosavethesettings 7 TapCanceltoclosethedisplayed...

Page 157: ...anbecalibratedfromtheCali brationSettingsscreen Forinformationonhowtoperformcalibrationin KTAfluxs seeSection 6 4 Calibration on page 109 Theillustrationbelowisjustanexampleofacalibrationscreen 8 Sett...

Page 158: ...Providesinformation aboutinstalledsoftware andtheserialnumberof thesystem 2 Pump MixerRunning Hours Overviewoftherunning hoursofpumpsand mixer 3 OptionalComponents panel Providesinformationof thefollo...

Page 159: ...e 6 SetSystemTime button Sub menutosetthe systemdateandtime seeinstructionsbelow Setsystemdateandtime Followtheinstructionsbelowtosetthesystemtimeanddate Step Action 1 TapSettingsonthemainscreen 2 Tap...

Page 160: ...dshourandminutestosetthetime 5 Usethekeypadthatappearstoenternewvalues Digitscanbedeletedusing thearrowsignbuttonintheupperrightcornerofthekeypad 6 TapOK 7 TapCanceltoclosethekeypadsetwithoutsaving 8...

Page 161: ...djusttheset points Step Action 1 Onthemainscreen taptheparameteryouwanttoset forinstance Transfer Ifthebuttoncontainsalocksymbol i e forLevel Pfautoand P auto tapthelocksymbolinsteadoftheparametername...

Page 162: ...uttoninthe upperrightcornerofthekeypad 3 TapOKtosavethesettings 4 TapCanceltoclosethekeypadwithoutsaving ConfigureLogInterval Tologthecontentintervalfollowthestepsbelow Step Action 1 Toconfigurethecon...

Page 163: ...Step Action 2 EnterthetimeintervalandtapOK 3 Arunreportwillbeofrecordedattheselectedloginterval 8 Settings 8 6 Set points KTAfluxsOperatingInstructions29046893AG 163...

Page 164: ...sfuse 177 Precautions WARNING Beforeperforminganyoftheproceduresdescribedinthischapter youmustreadandunderstandallcontentsofthecorresponding sectionsinChapter 2 Safety instructions on page 13 aslisted...

Page 165: ...nddamagetopreventleaksandtherelease ofpotentiallyhazardousfluids WARNING Beforemaintenance serviceisperformed thesystemownermust firstcleanthesystemandcompleteaHealth SafetyDeclaration Form ContactCyt...

Page 166: ...uppliedbyCytivamaybeusedformaintainingor servicingtheproduct Foreachrun Thissectioncoversmaintenanceactionsrequiredforeachrunorweekly depending onwhichhappensfirst Component Action Completesystem Clea...

Page 167: ...alvesshouldbeperformedannuallyby trainedandcertifiedpersonnel ContactyourlocalCytiva representative Replaceallgaskets O rings andvalveorpres suresensordiaphragms Pumpofperi staltictype Replaceallweara...

Page 168: ...movalofeverykindofcontaminant protein lipid otherparticlesand microorganisms Precautions WARNING NaOHiscorrosiveandthereforedangeroustohealth Whenusing hazardouschemicals avoidspillageandwearprotectiv...

Page 169: ...andNaOH Followthestepsbelowtoclean KTAfluxs Thestepsaredescribedinmoredetailon thefollowingpages A Drainthesystem B Rinsewithwater C Rinsewithwaterunderpressure D Rinseagainwithwaterunderpressure E Ri...

Page 170: ...hesystem Todrainthesystem followthestepsbelow Step Action 1 Ifanyoptionalpumpsareinstalled disconnectthetransferpumptubing and orthepermeatepumptubingfromthepumps 2 Runthefeedpumpatlowspeed Drainthesy...

Page 171: ...pumptubing 1 withthepermeatepumptubing 2 4 Recirculatetherinsingwaterfor5minutesbyrunningthefeedpumpat75 ofmaximumspeed Increasethefeedpressureto2barwithhelpofthe retentateandpermeatecontrolvalves 5 D...

Page 172: ...ateandpermeatecontrolvalves 5 Drainthesystem G Recirculatewith0 5MNaOHfor twohours Torecirculatewith0 5MNaOH followthestepsbelow Step Action 1 Fillthetankwith0 5MNaOH 2 Iftheoptionalpumpsareinstalled...

Page 173: ...ercleaningproceduresareprovidedinData File 18117157 Hollowfibercartridgescleaningproceduresareprovidedintheoperating handbook 18116530 Filterunitsprovidedbyothermanufacturersshallbecleanedaccordingtot...

Page 174: ...ure storage 25 Cto 50 C Temperaturegradientsof 1 C min SeedetailedinformationinOperating limits on page 184 Shorttermstorage Theproceduredescribedbelowisapplicableforstoragedurationsuptoonemonth Step...

Page 175: ...nthefeedpumpatlowvelocityuntilthesystemisempty c Clearanddrylineswithcompressedgas d Shutdownthepump e Releasethepumptubingfromthepumpheadbymovingthetoplever fromrighttoleft f Closethevalves g Coveral...

Page 176: ...Cytivarepresentative WARNING Donotattempttoperformanyactionsnotdescribedinthisdocu ment AlwayscontactyourCytivarepresentativeforadviceifsuchaneed shouldarise Filterintegritytest Thismethodcanbeusedtoc...

Page 177: ...s WARNING Alwaysdisconnectpowerto KTAfluxsbeforereplacingfuses Replacethemainsfuse Note A small screwdriver is used to remove the mains fuses Followthestepsbelowtoreplacethemainsfuse Themainsfusesarep...

Page 178: ...edrawerandloosenit 3 Foldthedrawerlidtolocatethemainsfuses Removetheoldfusewithhelpofasmallscrewdriverthatisinsertedinthe holeunderthefusedrawer 9 Maintenance 9 5 Replacemainsfuse 178 KTAfluxsOperatin...

Page 179: ...Step Action 4 Insertthenewfuses Forspecificationofthefuses seeElectric power on page 184 5 Pushthefusedrawerinitsholder 9 Maintenance 9 5 Replacemainsfuse KTAfluxsOperatingInstructions29046893AG 179...

Page 180: ...lemisnot coveredbythisguidethencontactCytivaforadvice Precautions WARNING Beforeperforminganyoftheproceduresdescribedinthischapter youmustreadandunderstandallcontentsofthecorresponding sectionsinChapt...

Page 181: ...yused Checkifliquidissuppliedtothesystem Checkinlet containers Checkifpressurecontrolvalveisopen Checkiftubingfrominletcontainercausespressureorflow loss Reasonsmightbetoolongtubing toosmallinternal d...

Page 182: ...hooting KTAfluxs Inthischapter Section Seepage 11 1 Specifications 183 11 2 Softwarelicense 187 11 3 Wettedmaterials 188 11 4 Chemicalresistance 190 11 5 Recyclinginformation 193 11 6 Regulatoryinform...

Page 183: ...resentedincm Weightandvolume Data Value Weight 28kg Tankvolume 0 5L Systemsoundlevels Properties Value Max 70dBA Typicalvalueundernormalrunning conditions 65dBA 11 Referenceinformation 11 1 Specificat...

Page 184: ...mpera ture 2 Cto50 C Inletpressure Max1bar Outletpressure Max1bar Environmentalranges Ambienttemperature 2 Cto35 C Temperature trans port 25 Cto 60 C Temperaturegradientsof 1 C min Dryinstrument drain...

Page 185: ...ted 4 4mL 4 4mL Minimumworkingvolume 15mL2 21mL 1 Toachieverequireddynamicranges tubesizechangesmayberequired iftubesizechangesareused thenpump flowwillbelimitedtoagivenrangeforafittedtubesize 2 Minim...

Page 186: ...1 16inch 600mm FF51 TubeSet1 16inch 600mm Custommaletofemaleluerconnectionblue 6 Gasket 6 Tygon tubing1 16 50feet Filtercassettes Holdertype Cassettetype Cassettesize Numberof cassettes Nuttorque Fitt...

Page 187: ...distribution org QTLibraries QTLibrariesarereleasedunderGNULGPLv2 1 seebelow Licenseagreements GNUGPLv2 GNUGENERALPUBLICLICENSE Version2 June1991 Copyright C 1989 1991FreeSoftwareFoundation Inc 51Fran...

Page 188: ...curedsilicone Platinumcuredsilicone PP PolyPropylene PTFE PolyTetraFluoroEthylene PVDF PolyVinylDeneFluoride Silicone Curedsiliconepolymer Tygon Tygon Standardcomponents Thetablebelowliststhematerials...

Page 189: ...using Whatmanfiltermembrane PTFE Pressuresensor Fronthousing PP Disposablegasket Silicone FemaleLuerto1 4 24bottomseal PP Tubing Pumptubing Platinum curedsilicone ExpandedPTFE Linetubing Tygon Tubingc...

Page 190: ...wlistallowedexposureconcentrationsandtimesforvariouschemicals thatcanbeusedfor KTAfluxs WARNING Flammableliquids KTAfluxsisnotapprovedtohandleflam mableliquids 11 Referenceinformation 11 4 Chemicalres...

Page 191: ...nol 30 1h 1000h CIP Sodiumchloride 0to3M 3h 3000h Purification CIP Sodium hydroxide 1MatpH14 0 5M 0 1MatpH13 24hattemp 40 C 3hattemp 50 C 12months 1000days 3000h Unlimited CIP CIP Storage Sodiumhypo c...

Page 192: ...sterilantsolution fogging 4 5 per aceticacidand22 hydrogenperoxide Minncarecoldsterilantsolution Wiping 3 Minncaresolution Phosphoricacid 5 2 propanol 70 Sodiumchloride 0to3M Sodiumhydroxide 1MatpH14...

Page 193: ...ppingoftheequipment Disposaloftheproduct Whentakingtheproductoutofservice thedifferentmaterialsmustbeseparatedand recycledaccordingtonationalandlocalenvironmentalregulations Disposalofelectricalcompon...

Page 194: ...ctinformation 195 11 6 2 EuropeanUnionandEuropeanEconomicArea 196 11 6 3 EurasianEconomicUnion 197 11 6 4 RegulationsforNorthAmerica 199 11 6 5 Regulatorystatements 200 11 6 6 DeclarationofHazardousSu...

Page 195: ...t Manufacturinginformation Thetablebelowsummarizestherequiredmanufacturinginformation Requirement Information Nameandaddressofmanufacturer CytivaSwedenAB Bj rkgatan30 SE75184Uppsala Sweden Telephonenu...

Page 196: ...yisavailable onrequest CEmarking TheCEmarkingandthecorrespondingEUDeclarationofConformityisvalidforthe instrumentwhenitis usedaccordingtotheOperating Instructionsorusermanuals and usedinthesamestateas...

Page 197: ...rovidessummaryinformationaboutthemanufacturerand importer inaccordancewiththerequirementsoftheTechnicalRegulationsofthe CustomsUnionand or theEurasianEconomicUnion Requirement Information Name address...

Page 198: ...109004 21 3 I 57 74996091550 rucis cytiva com 11 Referenceinformation 11 6 Regulatoryinformation 11 6 3 EurasianEconomicUnion 198 KTAfluxsOperatingInstructions29046893AG...

Page 199: ...ndfoundtocomplywiththelimitsforaClassAdigital device pursuanttopart15oftheFCCRules Theselimitsaredesignedtoprovide reasonableprotectionagainstharmfulinterferencewhentheequipmentisoperatedin acommercia...

Page 200: ...ulatoryinformationtocomplywiththeKoreantechnicalregulations NOTICE ClassAequipment equipmentforbusinessuse Thisequipmenthasbeenevaluatedforitssuitabilityforuseina businessenvironment Whenusedinareside...

Page 201: ...otleakormutateundernormal operatingconditionssothattheuseofsuchelectricalandelectronicproductswillnotresultin anysevereenvironmentalpollution anybodilyinjuryordamagetoanyassets Theunitofthe periodis Y...

Page 202: ...nedinallofthehomogeneous materialsforthispartisbelowthelimitrequirementinGB T26572 X Indicatesthatthishazardoussubstancecontainedinatleastoneofthe homogeneousmaterialsusedforthispartisabovethelimitreq...

Page 203: ...torycomplianceofconnected equipment Anyequipmentconnectedto KTAfluxsmustmeetthesafetyrequirementsofEN IEC 61010 1 orrelevantharmonizedstandards WithintheEU connectedequipment mustbeCEmarked 11 Referen...

Page 204: ...ringinformation visitcytiva com aktaflux KTAfluxssparepartsand accessories Forcorrectuptodateinformationonsparepartsandaccessories visitcytiva com aktaflux 11 Referenceinformation 11 7 Orderinginforma...

Page 205: ...n some cases this may require customer to move equipment from normal operating location prior to Cytiva arrival Consumables such as columns or gels have been removed or isolated from the instrument an...

Page 206: ...t must be decontaminatedprior to service return Provide a telephone number where Cytiva can contact you for additional information concerning the system equipment Telephone No Liquid and or gas in equ...

Page 207: ...e 140 Connections 69 powersupply 69 Constantpermeateflow 139 Constantretentatevolume 60 136 Crossflowfiltration 6 CRV 136 CSV 140 146 D DeltaP 35 39 56 Diafiltration 50 Drainvalve 30 53 55 E Emergency...

Page 208: ...tion 195 Mixer 29 53 Motorcontrol 126 calibrate 126 N Notesandtips 6 7 O Onsiteservice 205 Operation 6 prerequisites 6 Operatortouchscreen 32 Orderinginformation 204 P Parameters 152 154 alarms 152 sy...

Page 209: ...161 Shearrate 155 Shutdown 142 Spareparts 204 Startthesystem 132 Startup 132 Storage 64 144 174 175 longterm 175 requirements 174 shortterm 174 Systemalarm 32 Systemlabel 24 Systemtime 159 set 159 Sy...

Page 210: ...calconventions 7 U Unpacking 64 USB 31 146 protection 31 Storagedevicepanel 146 Systemhealthreport 146 USBflashdrive 46 70 140 W Warnings 32 Wettedmaterials 188 Index 210 KTAfluxsOperatingInstructions...

Page 211: ...Pageintentionallyleftblank...

Page 212: ...eisatrademarkofAlconox Inc TorxisatrademarkofAcumentIntellectual Properties LLCTweenisatrademarkofCrodaGroupofCompanies TygonisatrademarkofSaint GobainPerformancePlastics Allotherthird partytrademarks...

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