Thermo Scientific thermoscientific Vanquish UHPLC System, Operating Manual

Page: 23 / 148

2 • Safety
UHPLC System
Operating Manual Page 23
WARNING—Self-Ignition of Solvents
Solvents with a self-ignition temperature below 150 °C might ignite
when in contact with a hot surface (for example, due to leakage in the
chromatography system).
Avoid the use of these solvents.
WARNING—Hazardous Vapors
Mobile phases and samples might contain volatile or flammable
solvents. The handling of these substances can pose health and safety
risks.
• Avoid accumulation of these substances. Make sure that the
installation site is well ventilated.
• Avoid open flames and sparks.
• Do not operate the system in the presence of flammable gases or
fumes.
CAUTION—Escape of Hazardous Substances from PEEK Capillaries
In the Vanquish system, capillaries made of PEEK may be used. Swelling
or attack by acids can cause PEEK capillaries to start leaking or to burst.
Certain chemicals, for example, trichlormethane (CHCl
3
), dimethyl
sulfoxide (DMSO), or tetrahydrofuran (THF) can cause PEEK to swell.
Concentrated acids, such as sulfuric acid and nitric acid, or a mixture of
hexane, ethyl acetate, and methanol, can attack PEEK.
• Swelling or attack is not a problem with brief flushing procedures.
• For more information, refer to the technical literature on the
chemical resistance of PEEK.
CAUTION—Allergic Reaction
Some capillaries in the Vanquish system are made of MP35N™, a nickel/
cobalt-based alloy. Individuals with sensitivity to nickel/cobalt may show
an allergic reaction from skin contact.