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June 9, 2016, 715004990 Rev. A

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Содержание Xevo TQ-XS Mass

Страница 1: ...Waters Xevo TQ XS Mass Spectrometry System Overview and Maintenance Guide 715004990 Revision A Copyright Waters Corporation 2016 All rights reserved...

Страница 2: ...this document consult the Waters Web site waters com Trademarks ACQUITY is a registered trademark of Waters Corporation ACQUITY UPLC is a registered trademark of Waters Corporation Alliance is a regi...

Страница 3: ...OSSIBLE is a registered trademark of Waters Corporation TRIZAIC is a registered trademark of Waters Corporation TargetLynxTM is a trademark of Waters Corporation UNIFI is a registered trademark of Wat...

Страница 4: ...ers contact information Contacting medium Information Internet The Waters Web site includes contact information for Waters locations worldwide Visit www waters com Telephone and fax From the USA or Ca...

Страница 5: ...ntact your local Waters distributor Solvent leakage hazard The source exhaust system is designed to be robust and leak tight Waters recommends you perform a hazard analysis assuming a maximum leak int...

Страница 6: ...fail device is installed to interrupt the flow of LC solvent should the nitrogen supply fail The nitrogen supply pressure does not fall below 400 kPa 4 bar 58 psi during an analysis requiring the use...

Страница 7: ...his procedure When you remove the instrument from use to repair or dispose of it you must decontaminate all of its vacuum areas These are the areas in which you can expect to encounter the highest lev...

Страница 8: ...so that it is difficult to disconnect the power cord Safety hazard symbol notice Documentation needs to be consulted in all cases where the symbol is used to find out the nature of the potential haza...

Страница 9: ...liance with the Waste Electrical and Electronic Equipment Directive WEEE 2012 19 EU contact Waters Corporation for the correct disposal and recycling instructions Serial number REF Part number catalog...

Страница 10: ...and above normal levels of a compound If sample trays are the same or very similar vary the location of the QC samples in the trays Ensure that QC sample results fall within an acceptable range and e...

Страница 11: ...low voltage power supply network supplying a building for domestic purposes There may be potential difficulties in ensuring electromagnetic compatibility in other environments due to conducted as wel...

Страница 12: ...e and purpose ix Intended use of the device ix Calibrating x Quality control x EMC considerations x FCC radiation emissions notice x Canada spectrum management emissions notice x ISM classification IS...

Страница 13: ...ponents 28 1 4 3 System operation 28 1 5 Ion optics 28 1 6 MS operating modes 29 1 7 MS MS operating modes 30 1 7 1 Product daughter ion mode 31 1 7 2 Precursor parent ion mode 31 1 7 3 MRM mode 32 1...

Страница 14: ...the Mode of Operation 46 3 2 ESI ESCi and APCI modes 46 3 2 1 ESI mode 46 3 2 2 ESCi mode 47 3 2 3 APCI mode 47 3 2 4 Configuring for ESI ESCi APCI modes 47 3 2 5 Installing the probe adaptor 50 3 2...

Страница 15: ...re the instrument for operations on or inside its source 95 4 6 Removing and refitting the source enclosure 96 4 6 1 Removing the source enclosure from the instrument 96 4 6 2 Fitting the source enclo...

Страница 16: ...8 Fitting the ion block support to the source 137 4 16 Replacing the probe assembly 137 4 16 1 Removing the probe assembly 137 4 17 Replacing the ESI probe tip and gasket 139 4 17 1 Removing the ESI...

Страница 17: ...buildup from electronic connectors 177 4 30 2 To clean the outside surfaces of the ionKey source 178 A Safety advisories 179 A 1 Warning symbols 179 A 1 1 Specific warnings 180 A 2 Notices 182 A 3 Bo...

Страница 18: ...tput signal connectors 205 B 11 Connecting to the electricity source 207 C Materials of Construction and Compatible Solvents 208 C 1 Preventing contamination 208 C 2 Items exposed to solvent 208 C 3 S...

Страница 19: ...UniSpray source Optional dual mode atmospheric pressure photoionization APPI APCI Optional low flow ESI Optional NanoFlow ESI Optional atmospheric solids analysis probe ASAP Optional atmospheric pres...

Страница 20: ...ectly to the MS probe from the LC column or from three integral reservoirs The integral reservoirs can also deliver sample through direct or combined infusion enabling you to optimize instrument perfo...

Страница 21: ...heater or column manager optional sample organizer one or more detectors a specialized ACQUITY UPLC column and software to control the system For additional information see the ACQUITY UPLC System Ope...

Страница 22: ...stem components are optimized for use with sub 2 m particle liquid chromatography and use reduced fluid volumes The supported flow rate for a gradient elution ranges from 200 nL min to 100 L min at 15...

Страница 23: ...ve light scattering ELS and analog data OpenLynx and TargetLynx XS application managers are included with MassLynx software See the MassLynx software user documentation and online Help for information...

Страница 24: ...d as standard equipment on the mass spectrometer In ESCi the standard ESI probe adaptor is used in conjunction with a corona pin to allow alternating acquisition of ESI and APCI ionization data which...

Страница 25: ...electrospray However for similar experiments NanoFlow s significant reduction in sample consumption accompanies significant increases in sensitivity The following options are available for the sprayin...

Страница 26: ...lifies the implementation of capillary scale chromatography and analysis of limited volume samples See the TRIZAIC UPLC System Guide for further details 1 3 11 ionKey source The ionKey source integrat...

Страница 27: ...s solvent delivery system For further information on the IntelliStart fluidics system see IntelliStart Fluidics Plumbing and the diagram located on the inside of the fluidics access door see Waters AC...

Страница 28: ...at atmospheric pressure into the ionization source where they are ionized 2 The ions pass through the sample cone into the vacuum system 3 The resulting ion beam passes through the source sampling ori...

Страница 29: ...de Detector assembly Photomultiplier tube Source sampling orifice Isolation valve Z Spray ion source Sample inlet Sample cone Conjoined ion guide StepWave T Wave ion guide 1 6 MS operating modes The f...

Страница 30: ...scanned therefore no spectrum intensity versus mass is produced The data obtained from SIR or MRM analyses derive from the chromatogram plot specified mass intensity versus time 1 7 MS MS operating mo...

Страница 31: ...information Figure 1 4 Product ion mode MS1 Static at precursor mass Collision cell Fragment precursor ions and pass all masses MS2 Scanning 1 7 1 1 Typical applications You typically use product ion...

Страница 32: ...the most commonly used acquisition mode for quantitative analysis allowing the compound of interest to be isolated from the chemical background noise Figure 1 6 MRM mode MS1 Static at precursor mass...

Страница 33: ...onstant neutral loss mode to screen mixtures for a specific class of compound that is characterized by a common fragmentation pathway indicating the presence of compounds containing a common functiona...

Страница 34: ...example peptide sequencing 1 8 Leak sensors Leak sensors in the instrument s drip trays continuously monitor for liquid leaks A leak sensor stops system flow when its optical sensor detects about 1 5...

Страница 35: ...devices For further details see External connections Figure 1 9 Mass spectrometer rear panel Auxiliary 10MB 100MB Activity External Connections 2 10 1 External Connections 1 10 1 LA N EPC Com Port Vi...

Страница 36: ...Source vent Nitrogen inlet Pilot valve port Turbo vacuum Source vacuum Collision cell gas inlet June 9 2016 715004990 Rev A Page 36...

Страница 37: ...s To prepare the mass spectrometer 1 On the rear panel ensure that the nitrogen supply is connected to the instrument s nitrogen inlet connection see the figure Connecting the nitrogen gas supply Requ...

Страница 38: ...system instrument runs a series of startup tests 3 Wait three minutes for the embedded PC to initialize as indicated by an audible alert Tip The power and operate LEDs change as follows During initial...

Страница 39: ...analysis requiring the use of flammable solvents 6 Start the nitrogen gas flowing through the source by clicking API 7 Click Operate Result When the mass spectrometer is in good operating condition In...

Страница 40: ...ensitivity run the ACQUITY Xevo TQ XS system at appropriate gas flows and desolvation temperatures When you specify a flow rate IntelliStart software automatically specifies the settings shown in the...

Страница 41: ...o infuse smaller volumes The low volume vials have a volume of 1 5 mL Required materials Chemical resistant powder free gloves To install the reservoir bottles Warning To avoid personal contamination...

Страница 42: ...caused by the shattering of fragile low volume glass vials take care when screwing them in and never use force 3 Screw the low volume vials into the adaptors 4 For each low volume vial ensure that the...

Страница 43: ...ss door 2 8 Purging the fluidics Whenever you replace a solution bottle purge the fluidics with the solution that you are going to use next See the mass spectrometer s online Help for details Requirem...

Страница 44: ...Remove the PEEK tubing from the reset button aperture 5 Close the mass spectrometer s door 6 Wait until the reboot sequence completes before starting the mass spectrometer software Tip An audible ale...

Страница 45: ...nstrument from the main power supply The instrument s power switch does not isolate it from the main power supply Notice To avoid losing data use the following procedure only in an emergency To reboot...

Страница 46: ...flow ESI UniSpray NanoFlow ESI ionKey source For details about other Waters and third party source options refer to the documentation supplied with the source 3 2 ESI ESCi and APCI modes ESI ESCi and...

Страница 47: ...nverted to an aerosol rapidly heated and vaporized or gasified at the probe tip Figure 3 1 APCI mode APCI probe Corona pin Sample cone Hot gas from the APCI probe passes between the sample cone and th...

Страница 48: ...Figure 3 2 Probe adaptor types APCI probe adaptor APCI label APCI probe heater ESI probe tip ESI label ESI probe adaptor June 9 2016 715004990 Rev A Page 48...

Страница 49: ...for ESI ESCi APCI modes Mode Probe adaptor Install corona pin ESI ESI No ESCi ESI Yes APCI APCI Yes For more information on using each mode see the Xevo TQ XS system online Help The following section...

Страница 50: ...adaptor cap release buttons Required materials Chemical resistant powder free gloves To install the probe adaptor Warning To avoid personal contamination with biohazards or compounds that are toxic we...

Страница 51: ...gure 3 5 Probe adaptor cap release 2 For ESI probe adaptors remove the protective cap if fitted from the probe tip Figure 3 6 ESI probe protective cap Protective cap 3 Carefully slide the probe adapto...

Страница 52: ...for probe location dowel Probe adjuster assembly Figure 3 9 Locating the APCI probe adaptor Location hole for probe location dowel Probe adjuster assembly 4 Rotate the probe adaptor locking ring clock...

Страница 53: ...High voltage connector ESI probe adaptor cable ESI probe adaptor only Probe adaptor locking ring 5 For ESI probe adaptors connect the ESI probe adaptor s cable to the high voltage connector 6 Install...

Страница 54: ...so minimizes delays and dispersion Recommendation To connect the probe assembly directly to the fluidics valve use the 500 mm ESI or APCI probe assembly Notice Do not adjust the length of the probe a...

Страница 55: ...ometer is in Standby mode before you touch any of its external surfaces that are marked with this high voltage warning symbol 1 Carefully insert the probe assembly capillary into the probe adaptor Tip...

Страница 56: ...ssembly 3 Tilt the probe adaptor cap so that the ball bearing is located in the recess at the bottom of the aperture and insert the probe assembly tubing through the aperture Figure 3 14 Probe adaptor...

Страница 57: ...robe adaptor PEEK fitting 5 Push the probe adaptor cap on to the probe adaptor until it clicks Tips Do not squeeze the probe adaptor cap release buttons when fitting the probe adaptor cap Ensure that...

Страница 58: ...gn with the edge of the probe adaptor Probe adaptor cap seated correctly edge aligns with the edge of the probe adaptor 6 If you are not immediately connecting the probe assembly to the fluidics inser...

Страница 59: ...aters equipment ensure that the liquid outlet connection is grounded 7 To connect the probe inlet PEEK fitting to the IntelliStart Fluidics system a Open the access door to the IntelliStart Fluidics s...

Страница 60: ...he IntelliStart Fluidics system Tip If fluid collects in the leak tray inspect the connection at the diverter valve 3 2 7 Removing the probe adaptor Remove the probe adaptor before performing any of t...

Страница 61: ...he source see Preparing the instrument for working on the source Warning To avoid electric shock or solvent ignition when connecting ESI or UPC2 source probes directly to non Waters equipment ensure t...

Страница 62: ...marked with this high voltage warning symbol 1 Prepare the instrument for working on the source see Preparing the instrument for working on the source Warning To avoid burn injuries take great care wh...

Страница 63: ...securely mounted and that its tip aligns with the sample cone orifice Figure 3 20 Corona pin Corona pin 5 Close the source enclosure 6 Look through the source window and use the vernier probe adjuste...

Страница 64: ...es To remove the corona pin from the source Warning To avoid personal contamination with biohazards toxic materials and corrosive materials wear chemical resistant gloves when performing this procedur...

Страница 65: ...the figure in Installing the corona pin in the source Tip Store the corona pin in a safe location 4 Fit the blanking plug to the corona pin mounting contact see the figure in Installing the corona pi...

Страница 66: ...the photon energy exceeds the ionization potential of the sample molecule A repeller electrode mounted on the APPI lamp drive assembly deflects and focuses the sample ions toward the sample cone 3 3...

Страница 67: ...l mode operation enables rapid switching between APPI and APCI ionization modes and allows high throughput operations for example for sample screening You replace the standard corona pin with a specia...

Страница 68: ...tons from the UV lamp Sample cone APCI probe 3 3 4 The combined APPI APCI source components The combined APPI APCI source comprises the APCI probe adaptor and a source enclosure with an APPI lamp driv...

Страница 69: ...pon the sample molecules by adjusting the distance between the UV lamp and probe tip Figure 3 27 APPI lamp drive assembly inside the source enclosure UV lamp and repeller electrode Desolvation heater...

Страница 70: ...erface door see the figure on Waters ACQUITY Xevo TQ S UPLC MS system 7 Connect the APPI drive cable to the instrument s front panel connector Tip The front panel connectors and cables are color coded...

Страница 71: ...strument for working on the source see Preparing the instrument for working on the source 2 Remove the APCI probe adaptor see Removing the probe adaptor 3 Disconnect the source enclosure cable from th...

Страница 72: ...Figure 3 28 UniSpray source front and rear view June 9 2016 715004990 Rev A Page 72...

Страница 73: ...procedure To install the UniSpray source 1 Prepare the instrument for working on the source see Preparing the instrument for working on the source Warning To avoid electric shock ensure that the inst...

Страница 74: ...be inlet See Fitting the UniSpray probe assembly 4 Using two hands fit the UniSpray source enclosure to the two supporting studs on the adaptor housing Figure 3 29 Fitting the source Supporting studs...

Страница 75: ...source connections Probe adjuster cable yellow High voltage connector 6 Slide open the instrument s source interface door Figure 3 31 UniSpray Source connections to mass spectrometer June 9 2016 7150...

Страница 76: ...wear chemical resistant gloves when performing this procedure Warning To avoid electric shock ensure that the instrument is prepared for working on the source before commencing this procedure To remov...

Страница 77: ...ich slides on a pair of guide rails that allow its withdrawal from the source enclosure for maintenance and changes A light within the source provides illumination for the spray which you can observe...

Страница 78: ...nstrument for working on the source see Preparing the instrument for working on the source Warning To avoid burn injuries exercise care when handling the components of the source enclosure heated to h...

Страница 79: ...apillary nanovial Capillary Electrophoresis and Capillary Electrochromatography Sprayer Operator s Guide part number 6666522 7 Open the instrument s source interface door see Waters ACQUITY Xevo TQ XS...

Страница 80: ...To avoid damaging capillaries take great care when handling them they are extremely fragile Always hold the blunt end never the sharp end Warning To avoid electric shock ensure that the NanoFlow stage...

Страница 81: ...y using a fused silica syringe needle or a GELoader tip minimizing any bubbles between the capillary tip and the sample Recommendation When using a GELoader tip break the glass capillary in half scori...

Страница 82: ...r back into the assembly 13 Replace the sprayer cover 14 On the MassLynx MS Tune window ensure that the Capillary parameter on the ES Source tab is set to 0 kV Notice To avoid damage to the capillary...

Страница 83: ...pray Should the spray stop you can restart it To do so in the Tune window set Capillary to 0 kV Then adjust the three axis manipulator so that viewed under magnification the capillary tip touches the...

Страница 84: ...e camera Handle for locking and unlocking the iKey separation device Front cover Docking port for the iKey separation device Required materials Chemical resistant powder free gloves Flat blade screwdr...

Страница 85: ...tor housing 4 Swing the source enclosure to the closed position ensuring that it locks into place Notice To avoid damaging the Sample manager or mass spectrometer ensure the Sample manager s power is...

Страница 86: ...e cable white to the high voltage supply outlet on the mass spectrometer 7 Connect the options cable blue to the options port on the mass spectrometer 8 Identify the three fluid lines by the part numb...

Страница 87: ...e Figure 3 43 Sample manager injection valve Fluid inlet line connected to injection valve port 6 9 Connect the fluid inlet line to port 6 on the injection valve of the Sample manager 10 Connect the f...

Страница 88: ...rter box Notice To avoid damaging the video converter make sure the workstation is powered off before connecting the converter to the workstation in the next step 2 Connect the video to USB converter...

Страница 89: ...tant powder free gloves 1 4 inch open end wrench Warning To avoid personal contamination with biohazards toxic materials and corrosive materials wear chemical resistant gloves when performing this pro...

Страница 90: ...Disconnect the reference probe power cable green from the reference probe power inlet on the mass spectrometer 11 Disconnect the options cable blue from the options port on the mass spectrometer 12 Di...

Страница 91: ...nitrogen exhaust trap bottle Clean the source components When source components are visibly fouled the background or high peak contaminants are unacceptably high or sensitivity decreases to unaccepta...

Страница 92: ...eater fails to heat when the instrument is pumped down evacuated See Replacing the ion block source heater Replace the source assembly seals Annually See Replacing the source assembly seals Replace th...

Страница 93: ...n manually submit a Connections INSIGHT request to Waters customer support Alternatively you can use Remote Desktop a real time collaboration option that controls the two way connection with the ACQUI...

Страница 94: ...tective panels The components they cover are not user serviceable When the instrument is in Operate mode avoid touching the areas marked with the high voltage warning symbol To touch external areas ma...

Страница 95: ...can erode the emitter over time Do not touch the electrospray emitter for it can bend Decompress the iKey before you remove it from the source See Safety advisories for safety advisory information 4 5...

Страница 96: ...following procedures apply to both the standard and optional source enclosures 4 6 1 Removing the source enclosure from the instrument Required materials Chemical resistant powder free gloves To remov...

Страница 97: ...rce enclosure before you open the enclosure 5 Pull the source enclosure release located at the bottom right hand side outwards and swing open the enclosure 6 Using both hands grasp the source enclosur...

Страница 98: ...oid damaging the sample inlet when removing a NanoLockSpray source enclosure you must slide the sprayer platform out of the source enclosure before you open the enclosure 2 Close the source enclosure...

Страница 99: ...burn injuries take great care while working with the source enclosure open Warning To avoid puncture wounds take great care working with the source enclosure open if one or both of these conditions ap...

Страница 100: ...nclosure open if one or both of these conditions apply An ESI probe is fitted the probe s tip is sharp A corona pin is fitted the pin s tip is sharp 1 Open the source isolation valve by moving its han...

Страница 101: ...e the forked end of tool 2 to impale the O ring or seal aiding its removal 4 9 Cleaning the instrument case Notice To avoid abrading the surfaces of the instrument do not use abrasives or solvents whe...

Страница 102: ...tle From instrument exhaust connection One way valve Required materials Chemical resistant powder free gloves To empty the nitrogen exhaust trap bottle 1 In the instrument console click Stop Flow 2 Pu...

Страница 103: ...11 Maintaining the roughing pump There are no user maintenance procedures for the EBARA EV SA30 pump To replace the pump contact Waters Technical Support 4 12 Cleaning the source components Clean the...

Страница 104: ...source enclosure open if one or both of these conditions apply An ESI probe is fitted the probe s tip is sharp A corona pin is fitted the pin s tip is sharp Warning To avoid burn injuries take great c...

Страница 105: ...embling the sampling cone assembly Required materials Chemical resistant powder free gloves Combined 2 5 mm hex wrench and cone extraction tool To disassemble the sampling cone assembly Warning To avo...

Страница 106: ...d of the tool Figure 4 9 Cone extraction tool Collar 3 Insert the collar in the sample cone Figure 4 10 Inserting the cone extraction tool Insert the collar Notice To avoid damaging the sampling cone...

Страница 107: ...one gas nozzle Figure 4 11 Removing the sample cone Rotate the tool Remove the sample cone 5 Remove the O ring from the sample cone Figure 4 12 O ring removed from the sample cone Sample cone O ring C...

Страница 108: ...bottle containing HPLC grade or better 1 1 methanol water Large beaker To clean the sample cone and cone gas nozzle Warning To avoid personal contamination with biohazards toxic materials and corrosi...

Страница 109: ...the wash bottle containing 1 1 methanol water to rinse the component over the large beaker b Blow dry the component with inert oil free gas Warning To avoid spreading contamination dispose of all wast...

Страница 110: ...one assembly to the source Required materials Chemical resistant powder free gloves To fit the sampling cone assembly to the source Warning To avoid personal contamination with biohazards toxic materi...

Страница 111: ...to rotate the sampling cone assembly 90 degrees moving the handle downward from the horizontal to the vertical position 4 Open the source isolation valve see Opening the source isolation valve 5 Clos...

Страница 112: ...urn injuries exercise care when handling the column or other components heated to high temperatures Wait until the hot components have sufficiently cooled before you handle them Warning To avoid punct...

Страница 113: ...igure 4 15 Ion block assembly securing screws 6 Remove the ion block assembly from the PEEK ion block support Figure 4 16 PEEK ion block support Ion block assembly June 9 2016 715004990 Rev A Page 113...

Страница 114: ...rce isolation valve is closed Figure 4 17 Source ion block assembly Source isolation valve handle in closed position Sampling cone assembly retaining blocks Cone gas nozzle handle 2 Grasp the cone gas...

Страница 115: ...n block cover plate securing screw Ion block cover plate 5 Remove the ion block cover plate 6 Grasp the isolation valve and pull it out of the ion block Figure 4 19 Removing the isolation valve from t...

Страница 116: ...ck securing screw Figure 4 20 Loosening the PEEK terminal block securing screw PEEK terminal block securing screw Heater cartridge assembly wires Notice To avoid damaging the heater cartridge assembly...

Страница 117: ...11 Use the O ring removal kit to carefully remove the cover seal from the ion block see also Removing O rings and seals Figure 4 22 Removing the cover seal from the ion block Cover seal Cone gas O ri...

Страница 118: ...rying air drying optional Wash bottle containing HPLC grade or better 1 1 methanol water Large beaker To clean the ion block components Warning To avoid personal contamination with biohazards toxic ma...

Страница 119: ...r b Blow dry the component using inert oil free gas Warning To avoid spreading contamination dispose of all waste materials according to local environmental regulations 6 Inspect each component for pe...

Страница 120: ...ohol so that it better fits the isolation valve 7 Fit the isolation valve to the ion block assembly so that it is in the closed position 8 Fit the ion block cover plate to the ion block assembly and t...

Страница 121: ...rce enclosure see Fitting the source enclosure to the instrument 5 Close the source enclosure 6 Connect the power cords for the mass spectrometer and the roughing pump to the main power source 4 15 Cl...

Страница 122: ...ment see Removing the source enclosure from the instrument 2 Remove the ion block assembly from the PEEK ion block support see Removing the ion block assembly from the source assembly 3 Use the 3 mm h...

Страница 123: ...ool Recommendation When not in use store the seal breaker and locator tool on the end of the StepWave assembly removal and insertion tool To remove the StepWave assembly from the source assembly Warni...

Страница 124: ...Figure 4 24 Seal breaker and locator tool Lip Pin Handle June 9 2016 715004990 Rev A Page 124...

Страница 125: ...le to lever the StepWave assembly slightly out of the adaptor housing Rationale Moving the assembly in this manner releases it from a seal located inside the instrument 3 With the StepWave removal and...

Страница 126: ...l and insertion tool pull the StepWave ion guide assembly from the pumping block assembly and into the StepWave removal and insertion tool Notice To avoid damaging the StepWave ion guide assembly hand...

Страница 127: ...ersonal contamination with biohazards toxic materials and corrosive materials wear chemical resistant gloves when performing this procedure Required materials Chemical resistant powder free gloves Com...

Страница 128: ...t and second ion guide assemblies Figure 4 28 StepWave ion guide assembly separated Second ion guide assembly First ion guide assembly 3 Remove the brown PEEK gasket from the second ion guide assembly...

Страница 129: ...perture O ring Warning To avoid spreading contamination dispose of all waste materials according to local environmental regulations 5 If the O ring shows signs of deterioration or damage dispose of it...

Страница 130: ...which to completely immerse components when cleaning Use only glassware not previously cleaned with surfactants Two lengths of PEEK PTFE or stainless steel tubing appropriately sized for suspending th...

Страница 131: ...sed completely 4 Repeat step 1 through step 3 for the second ion guide PCB assembly placing the hook through one of the support rod holes Figure 4 32 Cleaning the second ion guide PCB assembly Hook Se...

Страница 132: ...s containing the first ion guide and second ion guide PCB assemblies in the ultrasonic bath for 20 minutes 12 Carefully pour out and discard the deionized water from both vessels retaining the ion gui...

Страница 133: ...g the wiring on assemblies fitted with an externally wired printed circuit board PCB do not touch the wiring 1 Fit the new O ring to the differential pumping aperture on the second ion guide assembly...

Страница 134: ...quired materials Chemical resistant powder free gloves Seal breaker and locator tool StepWave assembly removal and insertion tool To fit the StepWave assembly to the source assembly Warning To avoid p...

Страница 135: ...ct orientation in the StepWave removal and insertion tool Figure 4 35 Sliding the StepWave assembly into the StepWave removal and insertion tool StepWave assembly Pins 2 StepWave assemby removal and i...

Страница 136: ...ct further resistance 6 Remove the StepWave removal and insertion tool 7 Invert the seal breaker and locator tool and locate it over the end of the StepWave assembly Figure 4 36 StepWave assembly Adap...

Страница 137: ...K ion block support Tip To fit an O ring in its groove start fitting the O ring at the notch in the groove and then progressively work the ring into the groove in either direction from the notch 3 Fit...

Страница 138: ...e that the liquid outlet connection is grounded 1 If the probe assembly is connected to the fluidics open the access door to the IntelliStart Fluidics system see Waters ACQUITY Xevo TQ S UPLC MS syste...

Страница 139: ...stall a new probe assembly see Installing the probe assembly 4 17 Replacing the ESI probe tip and gasket Replace the ESI probe tip if a blockage occurs in the internal metal sheathing through which th...

Страница 140: ...procedure Warning To avoid puncture injuries handle sample needles syringes fused silica lines and borosilicate tips with extreme care 1 Remove the ESI probe adaptor from the source see Removing the...

Страница 141: ...g the ESI probe tip and gasket Required materials Chemical resistant powder free gloves 10 mm open end wrench 7 mm open end wrench New metal gasket To fit the ESI probe tip and gasket Warning To avoid...

Страница 142: ...he mass spectrometer s online Help 4 18 Cleaning the APCI probe tip Clean the APCI probe tip when you detect buffer buildup on the probe tip or when the signal intensity weakens See the mass spectrome...

Страница 143: ...eater Warning To avoid burn injuries take great care while working with the probe and source these components can be hot Warning To avoid personal contamination with biohazards toxic materials and cor...

Страница 144: ...ispose of all waste materials according to local environmental regulations 3 Dispose of the probe heater in accordance with local environmental regulations 4 19 2 Fitting the new APCI probe heater Req...

Страница 145: ...nections Notice To avoid damaging the probe heater s electrical connections do not twist the heater when removing it from or refitting it to the probe adaptor 2 Fit the probe adaptor to the instrument...

Страница 146: ...d borosilicate tips with extreme care 1 Remove the corona pin from the source see Removing the corona pin from the source 2 Replace the corona pin if it is deformed or damaged Otherwise clean its tip...

Страница 147: ...al contamination with biohazards toxic materials and corrosive materials wear chemical resistant gloves when performing this procedure 1 Remove the ion block assembly from the instrument see Removing...

Страница 148: ...xtraction tool to loosen the captive PEEK terminal block securing screw Figure 4 46 PEEK terminal block securing screw Heater cartridge assembly wires Notice To avoid damaging the heater cartridge ass...

Страница 149: ...lock Ceramic heater mounting block 7 Use the combined 2 5 mm Allen wrench and cone extraction tool to loosen the two screws securing the heater wires to the PEEK terminal block 8 Disconnect the heater...

Страница 150: ...idge assembly to the ion block 15 Use the combined 2 5 mm Allen wrench and cone extraction tool to tighten the captive PEEK terminal block securing screw 16 Fit the ion block cover plate to the ion bl...

Страница 151: ...oid personal contamination with biohazards toxic materials and corrosive materials wear chemical resistant gloves when performing this procedure 1 Remove the source enclosure from the instrument see R...

Страница 152: ...ure seal Nebulizer gas seal Desolvation gas seal Figure 4 50 Source enclosure seals Desolvation gas seal Source enclosure seal Nebulizer gas seal Warning To avoid spreading contamination dispose of al...

Страница 153: ...from dirt and debris Tip If contamination is present use 1 1 methanol water applied to a lint free cloth to carefully clean the grooves 2 Fit the new source enclosure seal to the source enclosure Imp...

Страница 154: ...ng the air filter inside the front door Required materials Needle nose pliers New filter To replace the air filter inside the front door 1 Open the access door to the fluidics pump see the figure on W...

Страница 155: ...ecessary use the needle nose pliers to grasp the filter Figure 4 54 5 Dispose of the filter 6 Fit the new filter into the instrument 7 Fit the filter cover to the instrument 8 Tighten the thumbscrew o...

Страница 156: ...Prepare the instrument for working on the source see Preparing the instrument for working on the source Warning To avoid burn injuries take great care while working with the probe and source these co...

Страница 157: ...lamp drive assembly 7 Insert the new bulb into the lamp drive assembly Tip The lamp glass is magnesium fluoride Avoid touching it because dirt or other contaminants on the window significantly reduce...

Страница 158: ...epare the instrument for working on the source see Preparing the instrument for working on the source 2 Pull the source enclosure release located at the bottom right hand side outwards and swing open...

Страница 159: ...laid on its face Warning To avoid personal contamination with biohazards toxic materials and corrosive materials wear chemical resistant gloves when performing this procedure Warning To avoid electri...

Страница 160: ...e source enclosure release handle screws and remove the handle Figure 4 57 Release handle Lamp drive cover screws Source enclosure cover screws 7 Use the combined 2 5 mm Allen wrench and cone extracti...

Страница 161: ...Tip The cables remain attached to the shaft which you fully withdraw and lay on the bench beside the source enclosure Figure 4 59 Repeller electrode Electrode screw Insulator retaining screw PEEK insu...

Страница 162: ...ing removal kit to carefully remove the O ring sealing the lamp bulb from inside the bulb holder see Removing O rings and seals Figure 4 60 Lamp bulb sealing O ring 18 Use the O ring removal kit to ca...

Страница 163: ...nce with local environmental regulations 4 26 2 Fitting the new APPI lamp drive assembly O rings Required materials Chemical resistant powder free gloves 3 mm hex wrench Phillips screwdriver 0 POZIDRI...

Страница 164: ...enclosure side 5 Fit the mounting shaft insertion tool to the mounting shaft Figure 4 63 Mounting shaft insertion tool Note To prevent damage to the mounting shaft O rings fit the mounting shaft inse...

Страница 165: ...ndle and secure it with the two screws 19 Refit and reconnect the source enclosure to the machine refit the corona pin and probe Refer to Installing the combined APPI APCI source for instructions 4 27...

Страница 166: ...ing the UniSpray probe assembly 4 27 2 Fitting the UniSpray probe assembly Required Materials Chemical resistant powder free gloves UniSpray probe assembly Warning To avoid lacerations puncture injuri...

Страница 167: ...into the probe inlet shaft atop the source enclosure and tighten the probe fitting Notice To avoid damaging the capillary on instruments where the source is situated above eye level remove the source...

Страница 168: ...mination with biohazards or compounds that are toxic wear clean chemical resistant powder free gloves when performing this procedure To install the UniSpray impactor pin in the source 1 Prepare the in...

Страница 169: ...pping film HPLC grade or better methanol Lint free tissue Impactor pin Warning To avoid personal contamination with toxic materials wear clean chemical resistant powder free gloves when performing thi...

Страница 170: ...nnector assembly at the point where it connects to the ionKey source module You must replace the capillary tubing and the PEEK assembly as a single unit No parts of the fluid line are reusable once de...

Страница 171: ...ive materials wear chemical resistant gloves when performing this procedure Warning To avoid electric shock ensure that the instrument is prepared for working on the source before commencing this proc...

Страница 172: ...Figure 4 68 iKey surround 3 Unlock and remove any iKey installed in the iKey clamp 4 Remove the gas line using a flat blade screwdriver June 9 2016 715004990 Rev A Page 172...

Страница 173: ...Figure 4 69 Gas line 5 Disconnect the fluidic line being replaced from its source 6 Remove two T10 Torx screws securing the end plate bracket June 9 2016 715004990 Rev A Page 173...

Страница 174: ...ary tubing out of the iKey clamp 8 Gently pull the O ring from around the tube s fitting and slide the O ring to the left 9 Pull enough of the line being replaced to the right and allow the capillary...

Страница 175: ...the instrument is prepared for working on the source before commencing this procedure To install a fluidic line 1 Prepare the instrument for working on its source see Prepare the instrument for workin...

Страница 176: ...yl alcohol Compressed air Notice To avoid damaging the iKey Handle it with care The component parts are fragile For recommendations regarding the maximum pressure to subject the device to see the iKey...

Страница 177: ...ently swab the fluid line connectors and outer edges of the docking port with a lint free tissue saturated with isopropanol or methanol 4 30 1 To remove buildup from electronic connectors To remove bu...

Страница 178: ...ces of the ionKey source To clean the outside surfaces of the ionKey source 1 Use a lint free tissue dampened with water 2 Clean the other system components according to the supplied documentation Jun...

Страница 179: ...or property damage resulting from the failure of individuals to comply with any safety precaution when installing repairing or operating any of its instruments or devices The following symbols warn o...

Страница 180: ...ning To avoid injury from bursting nonmetallic tubing heed these precautions when working in the vicinity of such tubing when it is pressurized Wear eye protection Extinguish all nearby flames Do not...

Страница 181: ...nstalled to interrupt the flow of LC solvent should the nitrogen supply fail A 1 1 4 Biohazard warning The following warning applies to Waters instruments and devices that can process material contain...

Страница 182: ...mbol and its associated statement alert you to such risk Notice To avoid damaging the instrument s case do not clean it with abrasives or solvents A 3 Bottles Prohibited symbol The Bottles Prohibited...

Страница 183: ...isateur exploiter l quipement Warnung Jedwede nderungen oder Modifikationen an dem Ger t ohne die ausdr ckliche Genehmigung der f r die ordnungsgem e Funktionst chtigkeit verantwortlichen Personen kan...

Страница 184: ...z d utiliser des tubes s v rement d form s ou endommag s Evitez d utiliser des tubes non m talliques avec du t trahydrofurane THF ou de l acide sulfurique ou nitrique concentr Sachez que le chlorure d...

Страница 185: ...riducendo notevolmente la pressione di rottura dei tubi stessi Advertencia se recomienda precauci n cuando se trabaje con tubos de pol mero sometidos a presi n El usuario deber protegerse siempre los...

Страница 186: ...p cifi e par le fabricant la protection assur e par le mat riel risque d tre d fectueuses Warnung Der Benutzer wird darauf aufmerksam gemacht dass bei unsachgem er Verwendung des Ger tes die eingebaut...

Страница 187: ...oujours les fusibles par d autres du type et de la puissance indiqu s sur le panneau proximit du couvercle de la boite fusible de l instrument Warnung Zum Schutz gegen Feuer die Sicherungen nur mit Si...

Страница 188: ...r mit Sicherungen ersetzen deren Typ und Nennwert im Abschnitt Sicherungen ersetzen des Kapitels Wartungsverfahren angegeben sind Avvertenza per garantire protezione contro gli incendi sostituire i fu...

Страница 189: ...r chassis terminal Fuse Functional ground Input Output A 8 Handling symbols The following handling symbols and their associated statements can appear on labels affixed to the packaging in which instru...

Страница 190: ...Symbol Description Use no hooks Upper limit of temperature Lower limit of temperature Temperature limitation June 9 2016 715004990 Rev A Page 190...

Страница 191: ...ging procedures B 1 External wiring and vacuum connections Rear panel connections appear in the figure below Note that the connectors and controls not identified are for use by Waters engineers only F...

Страница 192: ...Nitrogen exhaust Nitrogen inlet Pilot valve port Turbo vacuum Source vacuum Collision cell gas inlet B 2 Connecting the EBARA oil free roughing pump To ensure proper ventilation install the pump in a...

Страница 193: ...ng Exhaust silencer Control signal connector Power connector Vacuum hose Required materials Chemical resistant powder free gloves 7 mm nut driver Sharp knife The following items are included in the in...

Страница 194: ...ntamination with biohazards or compounds that are toxic wear clean chemical resistant powder free gloves when performing this procedure Warning To avoid injury do not lift the pump To move the pump us...

Страница 195: ...r of the Xevo TQ XS mass spectrometer Roughing pump electrical cable attached to vacuum hose Vacuum hose to roughing pump NW40 clamps NW25 clamps Flexible vacuum tubing NW40 NW25 reducer NW40 tee piec...

Страница 196: ...pump Exhaust tubing NW40 NW16 reducer Exhaust silencer NW40 clamps Vacuum hose from rear of the Xevo TQ XS 2 Make the electrical connections to the roughing pump see Making connections to the Ebara oi...

Страница 197: ...onics ON OFF switch for use by Waters engineers only Pump override switch for use by Waters engineers only To make the electrical connections for the oil free roughing pump 1 Connect the roughing pump...

Страница 198: ...tubing included in the Xevo G2 S Tof Installation Kit Nitrogen regulator not supplied To connect the nitrogen gas supply 1 Connect one free end of the 6 mm PTFE tubing to the nitrogen inlet port on th...

Страница 199: ...teel tube supplied with the mass spectrometer Argon regulator not supplied To connect the collision cell gas supply 1 Use the 1 8 inch Swagelok nut and ferrule to connect the 1 8 inch stainless steel...

Страница 200: ...rap bottle in an enclosed cabinet Warning To avoid personal contamination with biohazards toxic materials and corrosive materials wear chemical resistant gloves when performing this procedure Notice T...

Страница 201: ...instrument to the nitrogen exhaust trap bottle 6 Connect one end of the tubing to the exhaust port on the instrument s rear panel 7 Connect the free end of the tubing to the inlet port on the nitrogen...

Страница 202: ...s procedure 1 Place a suitable waste container below the mass spectrometer Notice To avoid distorting the drip tray or causing the drain cup to leak restrain the drain cup when attaching or removing t...

Страница 203: ...he waste container empty the waste container before the lower end of the drain tubes are covered by waste solvent 3 Route the waste lines to the waste container If necessary shorten the waste tubes so...

Страница 204: ...crossover network cable to the Ethernet port in the top right hand corner of the mass spectrometer s rear panel B 9 Connecting Ethernet cables systems with ACQUITY LC Requirement Use shielded network...

Страница 205: ...do not apply voltages higher than those shown in the tables Two removable connectors designated External Connections 1 and External Connections 2 on the mass spectrometer s rear panel hold the screw t...

Страница 206: ...100 mA 9 CE Interlock Out normally closed N C 30 V d c 100 mA 10 CE Interlock Out normally open N O 30 V d c 100 mA Table B 2 External connections 2 Pin Function Rating 1 Analog Out instrument driven...

Страница 207: ...oltage stability Warning To avoid electric shock use the SVT type power cord in the United States and HAR type or better cord in Europe The main power cord must be replaced only with one of adequate r...

Страница 208: ...t evaluate the safety issues if the solvents used in your application differ from the solvents typically used with these items See Solvents used to prepare mobile phases for details about the most com...

Страница 209: ...sed to prepare mobile phases These solvents are the most common ingredients used to prepare mobile phases for reverse phase LC MS API Water Methanol Acetonitrile Formic acid 0 1 Acetic acid 0 1 Ammoni...

Страница 210: ...solvents are used as additives to the mobile phases at reduced concentration or as sample diluents June 9 2016 715004990 Rev A Page 210...

Страница 211: ...You can find this document on www waters com click Services and Support Support D 2 Plumbing schematic For further information refer to the diagram on the inside of the fluidics valve access door see...

Страница 212: ...te Wash Vial C Vial B Vial A Analyte pump Selector valve Diverter valve D 3 ionKey and TRIZAIC source plumbing Figure D 2 ionKey and TRIZAIC source plumbing 2 1 6 3 4 5 2 1 3 4 2 1 6 3 4 5 June 9 2016...

Страница 213: ...ernal diameter ID external diameter ED color length and quantity for the IntelliStart Fluidics tubing Table D 1 Replacement tubing specifications Connection ID inches ED inches Color Length mm Quantit...

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