Freeze-dryer Epsilon 1-4 LSCplus
Freeze-dryer Epsilon 2-4 LSCplus
6 Operation
Version 07/2022, Rev. 3.0 of 20/07/2022
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Translation of the original operating manual
"Aeration, (stoppering), storage" procedure:
1. Aeration up to the desired partial vacuum ("Aeration" value):
After the actual freeze-drying process has been completed, the ice
condenser continues to be cooled and the shelves are held at the
temperature of the last drying section. The system is aerated until the
desired partial vacuum is reached ("Aeration" value, see the illustration
above, item 2).
NOTE
The product vials must be sealed at a chamber pressure below 900 mbar
in order to prevent the stoppers from being pushed out of the vials at low
atmospheric pressure.
NOTE
If the set value for the aeration is below the current chamber pressure, the
aeration phase will be skipped. The current chamber pressure will be
maintained.
2. Stoppering followed by aeration up to atmospheric pressure
While the ice condenser continues to be cooled and the shelf
temperature is maintained, the shelves are moved together in order
press the Lyo stoppers into the product vials. The stoppering pressure
is maintained over the specific "Stoppering" time (see the illustration
above, item 4). The subsequent final aeration is performed in two steps.
In the first step, the system is aerated up to the partial vacuum that is
stated under "Aeration after stoppering" (see the illustration above, item
3). Then, the shelves are moved apart into the drying position. In the
second step, the system is aerated up to atmospheric pressure. This
method prevents the stoppers from being ejected from the vials (if the
shelves are moved apart without any prior aeration) and also from
sticking to the shelves (if the shelves are not moved apart until the
aeration to atmospheric pressure is complete).
3. Storage under defined conditions
The shelves are brought to the set "Storage" temperature (see the
illustration above, item 5) in order to store the product under optimum
conditions. These conditions are kept constant until the system is
manually set to the standby mode for unloading.
NOTE
If the variant "Aeration, storage" has been selected, the product is stored
at the "Aeration" pressure. In this case, the system must be aerated
manually up to atmospheric pressure prior to opening the loading door.
Parameter
No.
Value range
Default setting
Aeration
2
0.001
mbar…900 mbar
500 mbar
Aeration after stoppering
3
0.001
mbar…900 mbar
500 mbar
Stoppering
4
1 sec
….999 sec
10
Storage
5
-
99.9°C…60.0°C
20°C
