Appendix
Operator´s Manual PiCCO
2
Page
Version 3.1
E-13
CO = [(Tb
–
Ti)
x
Vi
x
K] / [
³'
Tb
x
dt]
where
CO
=
Cardiac Output (l/min)
Tb
=
Blood temperature before the injection of cold bolus (°C)
Ti
=
Temperature of the injection solution (injectate) (°C)
Vi
=
Injection volume (ml)
³'
Tb
x
dt
=
Area under the thermodilution curve
K
=
Correction constants, made up of specific weights and specific heat
of blood and injectate
CI= CO / BSA
where
CI
=
Cardiac Index (l/min/m
2
)
CO
=
Cardiac Output (l/min)
BSA
=
Body Surface Area (m
2
)
5.3
Preload Volume
GEDV = [CO
x
1000]
x
[(MTt
TDa
–
DSt
TDa
) / 60]
GEDV = ITTV - PTV
where
GEDV
=
Global End-Diastolic Volume (ml)
ITTV
=
Intrathoracic Thermal Volume (ml)
where: ITTV = (CO
x
1000)
x
MTt
TDa
PTV
=
Pulmonary Thermal Volume (ml)
where: PTV = (CO
x
1000)
x
DSt
TDa
and
CO
=
Cardiac Output (l/min)
MTt
TDa
=
Mean transit time of the cold indicator from the site of injection to
the site of detection
DSt
TDa
=
Exponential downslope time of the arterial thermodilution curve
GEDI = GEDV / PBSA
where
GEDV
=
Global End-Diastolic Volume (ml)
GEDI
=
Global End-Diastolic Volume Index (ml/m
2
)
PBSA
=
Predicted Body Surface Area (m²)
ITBV = 1.25
x
GEDV
where
ITBV
=
Intrathoracic Blood Volume (ml)
GEDV
=
Global End-Diastolic Volume (ml)
