Rev. Date: 23-May-12
Art: 716969-00J
BNP - 5
Non-Heart Failure Population - Females (Age Group)
All
<45
Years
45-54
Years
55-64
Years
65-74
Years
75+
Years
Sample Size (N=)
465
98
75
77
133
82
Median (pg/mL)
26
23
23
37
23
25
Mean (pg/mL)
46
34
34
51
46
69
SD (pg/mL)
70
37
36
48
63
126
95th Percentile
150
89
111
155
159
266
Percentage < 100 pg/mL
88.4%
95.9%
90.7%
89.6%
85.7%
80.5%
Minimum (pg/mL)
0
0
0
0
0
0
Maximum (pg/mL)
837
263
142
230
374
837
* Representative data, results in individual laboratories may vary from these data.
Due to demographic population differences, the reference range should be established at each laboratory.
Heart Failure Population
Plasma samples from 693 patients with diagnosed heart failure (231 females, 462 males) were tested
with the AxSYM BNP assay. All patients in this population were categorized according to the functional
classification system published by the New York Heart Association (NYHA).
22
This system divides heart
failure patients into one of four categories of increasing disease progression (classes I to IV) based upon
a subjective assessment of the patient’s clinical signs and symptoms. The data from this study are
summarized in the following table.*
Heart Failure Population - All
NYHA Functional Class
All
I
II
III
IV
Sample Size (N=)
693
124
319
190
60
Median (pg/mL)
298
133
266
335
1531
Mean (pg/mL)
578
320
432
656
1635
SD (pg/mL)
771
388
574
841
1097
5th Percentile
14
9
15
12
188
95th Percentile
2154
1257
1534
2516
>4000
Percentage
≥
100 pg/mL
74.2%
58.1%
73.0%
79.0%
98.3%
Minimum (pg/mL)
0
3
0
0
14
Maximum (pg/mL)
>4000
1651
>4000
>4000
>4000
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