Waters 1500-Series, Operator'S Manual

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Solvent compatibility C-3
Buffers
When you use buffers, dissolve salts first, adjust the pH, then filter to remove
insoluble material.
Tetrahydrofuran (THF)
When using unstabilized THF, ensure that your solvent is fresh. Previously
opened bottles of THF contain peroxide contaminants, which cause baseline
drift.
Solvent compatibility
A Waters 1500-series HPLC pump is constructed of stainless steel (316)
components that, with some minor restrictions, can be used with all solvents.
This section lists the solvents that have and have not been approved for
use with a 1500-series HPLC pump.
Solvents to avoid
You can use any solvent with a 1500-series HPLC pump. However, long-term
static exposure to halide salts (for example, fluoride, bromide, chloride, and
iodide) cause pitting and corrosion of stainless steel parts. When using these
salts, flush your system thoroughly with water if the pump will be idle for
more than two days.
Solvents to use
Materials of construction used in a 1500-series HPLC pump do not react with
most acids, bases, salts, and organic solvents.
The solvents listed in the tables on
page C-4 through page C-5 are approved
for use with the 1500-series HPLC pump. These include salts, acids and bases
in concentrations up to 1 M (unless otherwise noted), and organic solvents in
concentrations of up to 100% (unless otherwise noted). Higher concentrations
can be used in many instances.
Warning:
THF contaminants (peroxides) are potentially explosive if
concentrated or taken to dryness.