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6. TH E U S E O F DRO N A BINO L
If dosage is too low increase the amount of dronabinol.
If dosage is too high reduce the amount of dronabinol.
Drug
(Filling
Chamber Con-
tent)
Dronabinol/THC
(10 mg)
THC: 10 mg
approx. 7 mg
approx. 4,6 mg
Cannabinoid
content in drug
Cannabinoid
content in Valve
Balloon after
vaporization with
210°C (410°F)
Cannabinoid
content in blood
stream (systemic
bioavailability)
after inhalation
6.2. MEDIC VALVE Balloon
6.2.1. Efficiency of vaporized Dronabinol (THC)
By following the procedure listed in the Instructions for Use the systemic bioavail-
ability of vaporized dronabinol is approximately 46%.
For comparison: The systemic bioavailability of cannabinoids administered orally
is below 15%.
When observing the Instructions for Use and with a vaporization temperature of
210°C (410°F) the following reference values are validated in studies:
Stretch Valve
Balloon tight
When the actual temperature has
reached 210°C (410°F), tighten the
Valve Balloon, place it on the Filling
Chamber and let it lock in place. For
filling, the Valve Balloon stands verti
-
cally on the Hot Air Generator. This
opens the Valve. Press the touch but-
ton pump (AIR). The Valve Balloon will
now fill with dronabinol aerosol.
6.2.2. Application
Summary of Contents for Volcano MEDIC 2
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