Table D-3 Source-Dependent Parameters (continued)
Parameter
Description
Ion source
temperature
(TurboIonSpray
probe)
Controls the temperature of the heater gas in the TurboIonSpray probe.
The best sensitivity is achieved when the combination of temperature and
ion source gas 2 flow rate causes the LC solvent to reach a point at which
it is nearly all vaporized.
As the organic content of the solvent increases, the optimal probe
temperature decreases. With solvents consisting of 100% methanol or
acetonitrile, the probe performance might optimize as low as 300 °C.
Aqueous solvents consisting of 100% water at flows of approximately
1,000 µL/min require a maximum probe temperature of 750 °C.
If the ion source temperature is set too low, then vaporization is
incomplete, and large, and visible droplets are expelled into the ion source
housing.
If the ion source temperature is set too high, then solvent might vaporize
prematurely at the probe tip, especially if the probe is set too low (5 to 13).
Ion source
temperature (APCI
probe)
Controls the temperature of the APCI probe.
As the organic content of the solvent increases, the optimal probe
temperature should decrease. With solvents consisting of 100% methanol
or acetonitrile the probe performance might optimize at temperatures as
low as 400 °C at flow rates of 1,000 µL/min. Aqueous solvents consisting
of 100% water set at flows of approximately 2,000 µL/min require a
minimum probe temperature of 700 °C.
If the ion source temperature is set too low, then vaporization is
incomplete, and large, and visible droplets are expelled into the ion source
housing.
If the ion source temperature is set too high, then thermal degradation of
the sample occurs.
Source Parameters and Voltages
System User Guide
RUO-IDV-05-6475-C
SCIEX 3200 Systems
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