Christ 111122 Operating Manual Download Page 137

Page: 137 / 161

Freeze-dryer Epsilon 2-10D LSCplus

8 Maintenance and service

Version 07/2022, Rev. 3.0 of 20/07/2022

• sb

137 / 161

Translation of the original operating manual

System/
Component

Detail / Part

Inspection

Periodical Maintenance

Repair / Rebuild

r wo

Cal

Water content of the
heat transfer medium

Test sample (visual
inspection, freezing
point, boiling point)

Heat exchanger:
corrision

5 years

Replace insulation
(Armaflex) at heat
exchanger and
remove corrosion

Hydraulic
system

Mechanical
components:
operation

Leakages

Max. pressure
reading

Oil in reservoir

Hydraulic hose lines:
condition

after

5 years

Replace hose lines
even if no safety-
relevant defects can
be noticed

Cylinder: travel
speed

Instrumentation

Vacuum sensors

Calibration

Temperature sensors
at freeze-dryer

Calibration

Pressure sensors
chamber

Calibration

Product temperature
sensors

Calibration,
replacement of
connectors

Level switch(es)

Pilot valves
(Solenoid valves)

Electrical
installation

Switch cabinet:
temperature inside

Infrared readings if
possible

Switch cabinet: con-
dition of components

Summary of Contents for 111122

Page 1: ...original operating manual sb Rev 3 0 of 20 07 2022 Epsilon 2 10D LSCplus Version 07 2022 Epsilon 2 10D LSCplus Part no 111122 Freeze dryer Operating Manual Read the manual thoroughly before use and retain it for later use ...

Page 2: ...Freeze dryer Epsilon 2 10D LSCplus 2 161 Version 07 2022 Rev 3 0 of 20 07 2022 sb Translation of the original operating manual ...

Page 3: ...al operating manual In case of inquiries please state the following numbers Order number Serial number Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel 49 0 5522 5007 0 Fax 49 0 5522 5007 12 Web www martinchrist de E mail info martinchrist de ...

Page 4: ...Freeze dryer Epsilon 2 10D LSCplus 4 161 Version 07 2022 Rev 3 0 of 20 07 2022 sb Translation of the original operating manual ...

Page 5: ...nd operating elements 14 2 1 2 Name plate 18 2 2 Mode of operation 19 2 2 1 General information on freeze drying 19 2 2 2 Freeze drying process 21 2 2 2 1 Preparation 21 2 2 2 2 Freezing 22 2 2 2 3 Main drying 22 2 2 2 4 Final drying 23 2 2 2 5 End of drying and aeration 23 2 2 2 6 Defrosting 23 3 Safety 24 3 1 Marking of the unit 24 3 2 Explanation of the symbols and notes 25 3 3 Responsibility o...

Page 6: ...ing vacuum pump hazards caused by contaminated exhaust air 36 3 7 13 Hazards caused by noise 36 3 7 14 Hazards caused by the loading door 36 3 7 15 Hazards caused by shelves 36 3 7 16 Hazards caused by hot surfaces 37 3 7 17 Hazards caused by cold surfaces 37 3 7 18 Hazards caused by overpressure in the chamber 37 3 8 Safety devices 38 3 9 Procedures in the event of hazards and accidents 39 3 10 M...

Page 7: ...1 1 Main window Manual 61 6 7 1 2 Main window Program 74 6 7 1 3 Main window Options 75 6 7 1 4 Main window 90 6 7 2 Manual freeze drying 90 6 7 2 1 Entering set values in the manual mode 91 6 7 3 Freeze drying with the PGMplus programmer module 93 6 7 3 1 Creating a program 97 6 7 3 2 Editing a program 105 6 7 3 3 Copying a program 106 6 7 3 4 Loading a program 106 6 7 3 5 Deleting a program 107 ...

Page 8: ...p 125 8 1 9 Refrigeration system 126 8 1 10 Heat transfer medium system 126 8 1 11 Hydraulic system 127 8 1 12 Vacuum sensor 127 8 1 13 Accessories 128 8 2 Disinfection of the drying chamber and accessories 128 8 3 Maintenance schedule 129 8 4 Maintenance schedule 134 8 5 Service 139 8 6 Return of defective parts 139 9 Disposal 141 9 1 Disposal of the freeze dryer 141 9 2 Disposal of the packaging...

Page 9: ...ng instructions of the CHRIST SCADA software LPCplus instructions for the operation of the freeze dryer by way of a SCADA system 1 3 Intended use Freeze dryer Do not use the freeze dryer unless the following requirements are fulfilled The freeze dryer has been properly installed The freeze dryer is in a perfect technical state The freeze dryer is not located in an area with an explosion hazard No ...

Page 10: ...ed use also includes Observation of all of the notes and instructions that are included in the operating manual see chapter 1 2 Further applicable documents Compliance with the inspection and maintenance instructions see chapter 8 Maintenance and service Exclusion of liability Any use of the freeze dryer other than the one described here or any use going beyond this description is regarded as impr...

Page 11: ...f these factors are listed below Fabrication Stress generated while sawing sanding machining drilling polishing and or forming Exposure Length of exposure stresses induced during the life of the product due to various loads changes in temperature etc Application of chemicals by contact rubbing wiping spraying etc The following table can be used as a general guide for the expected degradation durin...

Page 12: ... and equipment related precautions are taken Otherwise there is a risk of damage to property and personal injury Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken 1 3 3 Freeze drying of azide containing products Freeze drying of products containing azides is only permissible following a case by case examination...

Page 13: ...compliance may be prosecuted under criminal law 1 6 Explanation of symbols In this operating manual specialist terms that are explained in the glossary see chapter 12 Glossary are marked by an arrow and printed in italics e g sublimation 1 7 Standards and regulations EC declaration of conformity in accordance with the EC Machinery Directive and EC declaration in accordance with the Pressure Equipm...

Page 14: ...ontrol system 2 Drying chamber with loading door 3 Vacuum pump example chapter 5 2 4 Vacuum pumps Fig 1 Front of the freeze dryer example illustration 4 Connection bar for the product sensors 5 Connection for the intermediate valve 6 Intermediate valve 7 Shelf 8 Hydraulic cylinder 9 Push button Up hydraulic system 10 Push button Down hydraulic system 11 Door latch see chapter 8 1 3 2 Door latch 12...

Page 15: ...on of the original operating manual Fig 2 Detailed view A drying chamber 13 Switch cabinet behind the side panel 14 Control system on off 15 Drying cartridge adsorption filter chapter 5 2 7 Drying cartridge adsorption filter 16 Sight glass of the heat transfer medium 17 Steerable castors Fig 3 Right side of the freeze dryer ...

Page 16: ...l 18 Aeration valve 19 Vacuum sensor behind the side panel 20 Sight glass of the ice condenser 21 Vacuum connection 22 Precision control needle valve for gas injection 23 Access flanges DN40 e g for standard option WTMplus behind the side panel 24 Connection for standard option LyoCam 25 Media drain valve 26 Fixed castors Fig 4 Left side of the freeze dryer ...

Page 17: ...2 Name plate 30 Heat exchanger for the heat transfer medium behind the panel 31 Mains cable 32 Heat exchanger of the refrigeration unit behind the panel 33 Standard option Access flange to the ice condenser chamber Fig 5 Rear view of the freeze dryer 34 Ethernet connection 35 USB connection only in function if the standard option USB process recording is installed 36 Connection for the standard op...

Page 18: ...b Translation of the original operating manual 2 1 2 Name plate 1 Serial number 2 Type 3 Refrigerant data of RM 1 1st stage 4 Refrigerant data of RM 1 2nd stage 5 Nominal voltage 6 Year of manufacture month year 7 Part number 8 Refrigerant data of RM 2 9 Rated current apparent power Fig 7 Example of a name plate ...

Page 19: ...to the gas phase This happens under vacuum The following section describes the process of sublimation based on the example of water since most products that are processed by freeze drying are aqueous solutions Their behaviour is based on identical fundamental principles The vapour pressure curve for ice and water sublimation pressure curve describes the phase transition as a function of the pressu...

Page 20: ...ered to the value that corresponds to the freezing temperature in accordance with the vapour pressure curve for ice and water 3 Sublimation Thermal energy is added to the product thus starting the sublimation process Due to the added energy the water in the product is converted into water vapour Since the ice condenser is much colder than the product that is to be dried the vapour pressure in the ...

Page 21: ...is released by the product 2 2 2 1 Preparation The ice condenser chamber must be clean and dry Any water residues from a preceding drying run must be removed The media drain valve and the aeration valve must be closed In the case of units that are equipped with a pressure control valve standard on LSCplus and LSCbasic units the vacuum pump should be warmed up warm up for at least 15 minutes prior ...

Page 22: ...e vacuum pump is switched on The pressure inside the drying chamber will be lowered to the value that corresponds to the freezing temperature in accordance with the vapour pressure curve for ice and water sublimation pressure curve At the same time thermal energy will be added to the product In the case of products in round bottom flasks wide neck bottles etc this is realised through the environme...

Page 23: ...end of the drying process is the behaviour of the vacuum and of the ice condenser temperature The ice condenser is no longer subject to load and reaches the final temperature of approximately 55 C or 85 C The pressure in the drying chamber decreases in accordance with the ice condenser temperature The vacuum pump will be switched off and the drying chamber will be aerated via a rubber valve or via...

Page 24: ...Caution Risk of bruising Name plate see chapter 2 1 2 Name plate Attention consult the operating manual Filled with natural inflammable refrigerants Protective earth ground CE mark in compliance with the directive 2006 42 EC Earth ground China RoHS 2 mark only for China Unplug the mains plug NOTE Safety indications on the freeze dryer must be kept readable at all times If necessary they must be re...

Page 25: ...p to life endangering injuries DANGER This symbol stands for a direct hazard to the life and health of persons due to electrical voltage Non observance of these symbols causes serious health problems up to life endangering injuries WARNING This symbol stands for a potential hazard to the life and health of persons Non observance of these symbols can cause serious health problems up to life endange...

Page 26: ... the personnel concerning the operation maintenance and care of the unit are clearly defined standard operating procedures SOPs concerning the various products that are freeze dried in the freeze dryer are provided see the section below Work area the safety conscious work of the personnel in compliance with the operating manual and the relevant EC health and safety directives and the national laws...

Page 27: ...er 3 8 Safety devices replace without delay any parts or components that are not in perfect working order 3 3 1 Freeze drying of solvent containing products With regards of corrosion resistance the use of some organic in aqueous solutions with low concentrations is acceptable Under certain circumstances the freeze drying of products containing solvents may lead to the formation of explosive mixtur...

Page 28: ...his manual uses the following personnel qualifications for various areas of activity Operating personnel users The operating personnel operates and monitors the freeze dryer during normal operation and within the framework of its intended use In the event of malfunctions or other problems the operating personnel informs the respective specialised personnel It must be ensured that the persons opera...

Page 29: ...In addition to the operating manual the general and operational rules and regulations for the prevention of accidents and the protection of the environment must be provided All of the safety and hazards notes on the freeze dryer must be kept readable at all times If necessary they must be replaced 3 6 Safety notes concerning the transport set up and connection and initial start up of the freeze dr...

Page 30: ...r other consequences of improper connections Improper connections may lead to problems e g a hazardous electrical incident or the escape of media depending on the configuration of the freeze dryer e g hot water nitrogen hydrogen peroxide at a later time during the operation of the freeze dryer This may lead to severe damage to health or even life threatening injuries Ensure that the supply and dis...

Page 31: ...avier than air and high concentration levels of it may collect on the floor or in pits There is a risk of suffocation in the case of high concentration levels Possible symptoms are paralysis and unconsciousness Affected persons do not notice the fact that they suffocate Only qualified persons are authorised to perform work on the refrigeration system of the freeze dryer Ensure good aeration extrac...

Page 32: ...d correctly There is a risk of suffocation in the case of high concentration levels Possible symptoms are paralysis and unconsciousness Affected persons do not notice the fact that they suffocate Use the freeze dryer only if it is equipped with pipes that are properly connected Only qualified persons are authorised to perform work on the nitrogen lines of the freeze dryer 3 7 5 Hazards caused by h...

Page 33: ...ia or the listed solvents in a concentration higher than 10 by volume must not be used Refer to the safety data sheets of the products that are used 3 7 7 Hazards caused by acids in the products DANGER Risk of injury caused by acids in the products Products containing acids may damage the material of the components of the freeze dryer and affect the mechanical strength This may lead to severe inju...

Page 34: ...a risk of pulmonary oedemas in the case of inhalation Wear suitable protective clothes gloves and respiratory protection or use an isolater sytem on the freeze dryer DANGER Risk of poisoning caused by azides in the products When performing maintenance work on parts coming into contact with the product e g all parts inside the chamber vacuum pump the personnel may be exposed to product residues Ski...

Page 35: ... hot and contaminated vacuum pump oil WARNING Risk of scalding caused by the vacuum pump oil When working on the vacuum pump and exhaust gas filter especially when changing the oil or filter the maintenance personnel are exposed to the hot vacuum pump oil There is a risk of scalding in the event of skin contact Wear suitable protective clothes and gloves Use a suitable collecting vessel WARNING Ri...

Page 36: ...RNING Risk of noise induced hearing loss Depending on the local conditions a harmful sound pressure level may occur High sound pressure levels can cause noise induced hearing loss Wear suitable personal hearing protection if necessary 3 7 14 Hazards caused by the loading door WARNING Risk of crushing caused by the movement of the loading door Due to its relative high mass the movement of the loadi...

Page 37: ...s Wear suitable protective clothes and gloves Do not touch the surfaces on purpose Prior to performing any work on the freeze dryer let the components cool 3 7 17 Hazards caused by cold surfaces WARNING Risk of freezing to cold surfaces The shelves and ice condenser coils can already be cold during the loading phase There is a risk of freezing to the shelves or ice condenser coils when touching th...

Page 38: ...nd the prevention of accidents Main switch line disconnector and control switch Position see chapter 2 1 1 Functional and operating elements The main switch is used to disconnect the freeze dryer from the mains power supply As a result all of the automatic valves will be closed and all of the units will be switched off A running process will be interrupted and can be resumed at a later time In ord...

Page 39: ...hing apparatus remove the affected persons to fresh air Keep them warm and calm Get medical attention immediately In case of respiratory arrest give artificial respiration Electric shock While ensuring your own safety interrupt the circuit as quickly as possible switch off the main switch and the control switch Keep the affected persons warm and calm Get medical attention immediately Check conscio...

Page 40: ...dical attention immediately Oesophagus Do not put anything into the mouth of an unconscious person Wash the mouth out with water If the person is conscious Give the affected person plenty of water to drink 2 glasses maximum Do not induce vomiting In case of spontaneous vomiting keep the head of the affected person lying on his her stomach low in order to prevent any liquid from entering the respir...

Page 41: ...e chapter 7 3 Service contact Ensure that all repairs are performed only by authorised and specialised personnel Fire prevention Fuses protect certain electrical circuits within the freeze dryer against over current conditions Always use fuses of the same type and rating Safety area Maintain a safety distance of at least 30 cm 12 inches around the freeze dryer Do not store any dangerous goods in t...

Page 42: ...sample with hazardous materials such as strong acids or bases radioactive substances or volatile organics is spilled inside a chamber they must be cleaned up immediately Caution when handling solvents Keep sources of ignition away from solvents When using flammable or hazardous solvents the vacuum pump must be vented to or operate inside a fume hood 3 13 Remaining hazards All Christ freeze dryers ...

Page 43: ...ction Weight approx 665 kg 4 2 Storage conditions In order to ensure the protection against mechanical and climatic influences the guidelines of the German Federal Association for Wooden Packages Pallets and Export Packaging Bundesverband Holzpackmittel Paletten Exportverpackung e V the so called HPE packaging guidelines must be applied when packing and storing the freeze dryer The storage must be...

Page 44: ... Wear personal protective equipment safety shoes work gloves and hardhat DANGER Risk of injury caused by the uncontrolled movement of loads Freeze dryer components that are not properly fastened or secured may shift or fall over Take the centre of gravity of the load in consideration off centre Prior to transporting the freeze dryer read this chapter of the operating manual thoroughly CAUTION The ...

Page 45: ...may shift or fall over Take the centre of gravity of the load in consideration off centre Prior to transporting the freeze dryer read this chapter of the operating manual thoroughly CAUTION The freeze dryer Epsilon 2 10D LSCplus weighs approx 665 kg NOTE Freeze dryers of the type Epsilon 2 10D LSCplus that are filled with natural flammable refrigerants are not approved as air freight Use suitable ...

Page 46: ...fety devices must be removed prior to start up Remove the polystyrene blocks between the shelves Unscrew the sealing cap of the expansion vessel of the heat transfer medium and install the drying cartridge adsorption filter see chapter 5 2 7 Drying cartridge adsorption filter Install the vacuum sensor see chapter 5 2 6 Vacuum sensor NOTE Prior to any transport the transport safety devices must be ...

Page 47: ...petent and specialised persons under consideration of the corresponding connection specifications see the instructions in this chapter and chapter 10 Technical data The connections to the on site pipes must be force free and torque free 5 1 Installation site Operate the freeze dryer only in closed and dry rooms NOTE Refrigeration problems of the freeze dryer are often caused by insufficient condit...

Page 48: ...trical equipment of the freeze dryer must be checked at regular intervals by a qualified electrician Defects such as loose connections or burnt cables must be eliminated immediately DANGER The operating voltage on the name plate must correspond to the local supply voltage Christ freeze dryers are units of safety class I Epsilon 2 10D LSCplus units have a five wire power cord with a 5 pin CEE plug ...

Page 49: ... branch and an aeration branch The gas injection branch includes a precision needle valve for the preadjustment see chapter 5 2 2 1 Precision control needle valve for air injection and a solenoid valve which are installed in series In combination with the pressure control valve in the suction line of the vacuum pump this configuration enables very precise vacuum control during the freeze drying pr...

Page 50: ...e The volume flow is now correctly preadjusted The approach speed can be increased by opening the needle valve slightly wider but the readings must not overshoot the new vacuum set value if needed the preadjusting procedure has to be repeated 5 2 3 Drain WARNING Risk of poisoning infection caused by contaminated condensate defrosting water The condensate may contain harmful substances originating ...

Page 51: ...es originating from the product Inhalation may cause severe damage to health Use the freeze dryer only if it is equipped with a pipe that is properly connected to the outlet of the vacuum pump exhaust filter oil mist separator and led to the outside via the roof Depending on the product that is dried in the freeze dryer it may be necessary to install a suitable filter system in the exhaust gas pip...

Page 52: ... pump it may be necessary to wear suitable protective clothing gloves and a breathing mask depending on the product NOTE Refer to the separate instruction manual of the vacuum pump and silencer The freeze dryer is equipped with a dry running vacuum pump As a result the vacuum exhaust gases are completely free from oil particles However small quantities of debris from worn seals may be emitted That...

Page 53: ...vacuum pump and ice condenser chamber During certain specified process phases it interrupts the volume flow to the vacuum pump see chapter 2 2 1 General information on freeze drying CAUTION The pressure control valve must be installed in the direction of the volume flow in the indicated installation direction see illustration below 1 Installation direction of the pressure control valve Fig 10 Vacu...

Page 54: ...or against transport damage it comes supplied in its original packaging Prior to commissioning the freeze dryer the sensor must be installed Switch the unit off by actuating the mains power switch The screws for the left hand side panel are located at the back of the unit Loosen the screws and take the panel off diagonally towards the back Take the vacuum sensor out of its original packaging and f...

Page 55: ...sealing cap 1 from the valve Connect the supplied adapter 5 together with the drying cartridge 4 to the valve 2 Open the valve 2 by turning it anti clockwise up to the stop 1 Sealing cap 2 Valve 3 Connection of the expansion vessel inside the unit Fig 11 Valve with sealing cap for transport 4 Drying cartridge adsorption filter 5 Adapter Fig 12 Valve with drying cartridge adsorption filter NOTE The...

Page 56: ...tions must be checked for leaks by specialised persons 6 2 Installation of accessories The accessories must be completed in accordance with the drying method that is applied as well as in accordance with the scope of supply 6 3 Preparation The ice condenser chamber must be clean and dry Remove any water residues from the preceding run Close the aeration valve and the media drain valve Ensure that ...

Page 57: ...r with the aid of the locking handle The locking handle is now in a perpendicular position with regard to the door edge see figure below When a vacuum builds up inside the drying chamber during the drying process the loading door will be pulled closer to the flange of the drying chamber As a result the locking handle will be loosened and it will hang down loosely NOTE If the locking handle does no...

Page 58: ...NGER Risk of crushing caused by the movement of the shelves The shelves can be moved upwards downwards by hydraulic force In addition the shelves may sag down in an uncontrolled manner in the event of a malfunction of the hydraulic system There is a risk of crushing of body parts under and between the shelves Do not reach into the chamber while the shelves are in movement Do not manipulate remove ...

Page 59: ...eleased or the upper or lower hard stop position has been reached CAUTION In order to seal the product vials by means of the hydraulic shelf movement facility the shelves must be completely loaded with identical vessels to avoid damaging shelves and guiding rods as well as breakage of vessels For partially loaded shelves use empty vessels with stoppers put in or spacers according to the height of ...

Page 60: ...drying processes The clear user interface enables the intuitive operation of the unit Fig 15 Start screen of the LSCplus control unit example 6 7 1 User interface The system is operated via a touch panel i e by touching the buttons on the display Every button is marked by a frame Pressing the button activates the associated function Depending on the function a dialog box opens a value can be chang...

Page 61: ...d for personalised settings that enable the users to adapt the system as far as possible to their respective area of activity In this window the users can find all of the relevant information concerning the control system at a glance In the event of enquiries at the factory these data facilitate the assignment and expediting of the processing of the enquiries 6 7 1 1 Main window Manual This main w...

Page 62: ...nnected Process recording on a USB storage device active Network available but no network drive connected Network drive connected e g LPCplus LyoLogplus Network drive connected and process recording active Set process values 2 In the manual mode the set values for the individual phases of the freeze drying process must be entered prior to the start of the process Value ranges have been saved for t...

Page 63: ...le to configure a personalised overview of the actual values Dialog box Tools 5 This dialog box is used to call up various aids and resources Vapour pressure curve above ice A diagram shows the relationship between the pressure and sample temperature for aqueous systems The pressure and temperature values can be changed by pressing the buttons or by moving the arrows see figure below item 1 The ot...

Page 64: ...SB process recording Option Pressure increase test only with the double chamber method see chapter 6 8 Optional extensions and special equipment The pressure increase test can only be performed when the freeze dryer is equipped with an intermediate valve The performance is possible in the manual mode as well as in the program mode Additionally the pressure increase test can be automatically perfor...

Page 65: ...ensions and special equipment then the corresponding parameters must be configured in this dialog box NOTE Please refer to the separate operating instructions of the weighing system Dialog box Schematic system diagram 6 Pressing the button Schematic system diagram displays a schematic diagram of the system on the left hand side of the screen including all the components Active components are displ...

Page 66: ...t The colour of the button quit changes from blue to grey once the message has been acknowledged Fig 23 Representation of an error message The advantage of this system is that malfunctions that occurred during the night can be discovered the next day even if the cause of the malfunction has already been eliminated The dialog box cannot be quit until all of the messages have been acknowledged If a ...

Page 67: ... has occurred and the time stamp of the last error message Use the arrow keys to call up the individual windows NOTE The error message text is always followed by an error code Always indicate the error code in the event of enquiries or service requests 4 Error message 5 Error code 6 Detailed information 7 Error counter and time stamp of the last error 8 Arrow keys Fig 25 Details concerning an erro...

Page 68: ...yed depends on the equipment of the freeze dryer Button Standard unit test Apart from the process phases of the freeze drying process Freezing Warm up Main drying and Final drying and the operating mode Defrosting the button Standard unit test is also available This button opens a selection of various tests with fixed parameters After consultation with the manufacturer these tests can be performed...

Page 69: ...t ensure that the chamber is dry and unloaded Procedure In the main window Manual select the button Operating mode select start Standard unit test Select Performance Test and start the test via the Run button The test will be performed The parameters will be measured at defined points of time evaluated and displayed in a dialog box see the following illustration If the freeze dryer is equipped wit...

Page 70: ...t be reached It is not until the conditions are fulfilled that the pressure control valve closes Then the actual leakage test is performed in a second step The result will be indicated by way of a dialog box If the freeze dryer is equipped with the LPCplus SCADA software the results will be documented in the event list Evaluation The leakage rate that is calculated after the test provides informat...

Page 71: ...freeze drying program for verifying the ice condenser capacity when the shelves are cooled to 50 C in the Freezing phase For this purpose the shelves must be loaded Procedure Load the shelves evenly with water in dishes for the test The water quantity must be 2 3 of the maximum ice condenser capacity that is specified for the freeze dryer In the main window Manual select the button Operating mode ...

Page 72: ...owing the confirmation of this enquiry the freeze dryer will be switched to standby Evaluation Please contact the Christ support team for the evaluation of the test run Shelf mapping test 6 The shelf mapping test is a freeze drying program for bringing the shelves to a temperature of 20 C 40 C and 40 C for a specific period of time in order to be able to determine the temperature distribution on t...

Page 73: ...ith a safety enquiry confirmation prompt opens Following the confirmation of this enquiry the freeze dryer will be switched to standby The external measurement recording process can then be stopped Evaluation Please contact the Christ support team for the evaluation of the test run Button Stop 9 Pressing this button stops the current process The system switches to the standby status ...

Page 74: ...Buttons Load Fig 29 Overview of the main window Program Program list 1 After the selection of the main window Program an overview of the programs that have already been saved will be displayed Pressing the button Load 3 behind the program name calls up the program data Programs can be loaded edited copied or deleted see chapter 6 7 3 Freeze drying with the PGMplus programmer module Dialog box New ...

Page 75: ...l system in order to adapt it perfectly to the respective area of application of the freeze dryer General General options 1 Language 2 Scale unit 3 Special equipment Preselection of aeration medium 4 Special equipment Gas injection 5 Special equipment Inertisation Fig 30 Overview of the main window Options General Language 1 The control system can be used in several languages which can be selected...

Page 76: ...gram If the freeze dryer is equipped with an automatic aeration valve and automatic valves for media selection this dialog box can be used to preselect the medium that is to be used for all of the aeration medium requests in the manual mode as of the start of the main drying phase and during the Aeration section The phases Freezing and Warm up in the manual mode and the operating modes Defrosting ...

Page 77: ...used Fig 34 Dialog box Gas injection The following methods are possible Button Off The gas injection is deactivated Vacuum control is ensured solely by opening and closing the pressure control valve in the suction line of the vacuum pump Button Standard Vacuum control is ensured by combined evacuation and gas injection The gas injection solenoid valve that is installed in series with the proportio...

Page 78: ...owing operating modes Manual Program Defrosting Media drain All other operating modes can be started without successfully completing the inerting sequence The following parameters can be set The inertisation time determines the effective inertisation duration with open inlet and outlet valves and can be set in a range of 1 9999 seconds The parameter Delay on determines the duration from the openin...

Page 79: ...ent unauthorised access to the Inertisation dialog box we recommend protecting the access to the control system by way of a password see chapter 6 7 1 3 Main window Options section Administration Access protection 4 Administration Administration options 1 Date Time 2 Network 3 System properties 4 Access protection 5 Device options 6 Configuration of sensors 7 WTMplus configuration Fig 36 Dialog bo...

Page 80: ... after a restart of the unit Fig 38 Dialog box Network System properties 3 This dialog box is used to change various system settings Fig 39 Dialog box System properties Beeper The beeper sounds in the event of a malfunction for example If the setting is On the beeper sounds every few seconds until the user acknowledges the message If the setting is Silent the beeper sounds once when the malfunctio...

Page 81: ...ain deactivates the function button controlled Access protection 4 In this dialog box the access rights can be managed on several levels and they can be protected with a password In the factory setting with an activated access protection data can be viewed but not edited Fig 40 Dialog box Access protection NOTE The other buttons cannot be activated unless the access protection is active Password t...

Page 82: ...ed in the following table Action Operator Maintenance Administrator Editing of the data of the current process run e g selection of the operating mode changing of set values Editing of maintenance functions e g oil change of the vacuum pump Editing of the default settings e g editing of the access protection creating and editing of programs editing of system settings Device options 5 This dialog b...

Page 83: ...n of the unit If the configuration is incorrect the correct operation of the unit cannot be guaranteed This dialog box is used for the configuration of the existing sensors Fig 44 Dialog box Configuration of sensors example Vacuum sensors see the illustration above item A For the vacuum as well as pressure there are two different measuring methods and for each of these methods different sensors ca...

Page 84: ...e section Conditions for switching to the next section If the freeze dryer is equipped with a wireless WTMplus temperature measurement system it is also possible to select a different wired product temperature sensor or a WTMplus sensor Select the button of the product temperature sensor A drop down menu showing the available sensors opens Select the sensor that you would like to use for determini...

Page 85: ...LPCplus user interface This dialog box shows all of the existing WTMplus sensors Every sensor is assigned to a measuring channel based on its serial number Next to the Number of the measuring channel and the serial number of the sensor the associated temperature and a signal quality index SQI are displayed A bar in the fields indicates the signal quality Green good signal quality Yellow medium sig...

Page 86: ... 47 Dialog box Service varies depending on the type of system Operating hours 1 This dialog box is used to call up the number of operating hours of the various components of the freeze dryer e g the refrigeration unit vacuum pump or pressure control valve In addition to the name the reference designator is also displayed These data are provided for the purpose of information only They cannot be ed...

Page 87: ...hese messages can be viewed in this dialog box The failure memory includes the last 32 messages If this number is exceeded the oldest message will be overwritten Use the arrow keys to call up the individual messages The error message text is always followed by an error code NOTE Always indicate the error code in the event of enquiries or service requests Fig 49 Dialog box Failure memory ...

Page 88: ...he system monitors the oil change interval of the vacuum pump The interval can be adapted to the vacuum pump model and utilisation When the end of an oil change interval is reached a corresponding message will be displayed Acknowledge the message Change the oil of the vacuum pump Reset the operating hour counter in the dialog box Vacuum pump oil change by pressing the reset button Fig 50 Dialog bo...

Page 89: ...yed Acknowledge the message Make an appointment for the maintenance of your freeze dryer After the maintenance our service engineer will reset the operating hour counter in the dialog box Maintenance Fig 51 Dialog box Maintenance Sensor adjustment 5 In this dialog box the sensors are adjusted in terms of a predefined reference value CAUTION Misadjusted sensors will lead to incorrect measurement va...

Page 90: ...tches manually from one freeze drying phase to the next The manual mode is activated by calling up the main window Manual The set values for the individual process phases freezing warm up main drying and final drying are defined prior to the start of the process Then the freeze drying process can be started via the dialog box Operating mode select start NOTE If the freeze drying process is to be s...

Page 91: ...on of the warm up phase The unit will remain in the warm up phase until you confirm The transition from main drying to final drying again takes place automatically After the completion of the final drying phase the system displays another enquiry with which the freeze drying process will be terminated The unit remains in the run mode until the enquiry is confirmed The process can be stopped any ti...

Page 92: ...pped with an automatic aeration valve this button is used to define the aeration pressure Defrosting 2 This button is used to pre define the defrosting time and temperature not for hot water defrosting In addition this button is used to define whether the operating mode media drain see below will be started automatically after the defrosting process Media drain 3 If the freeze dryer is equipped wi...

Page 93: ...al keypad by pressing the button Accept Confirm the input and quit the dialog box via the button Accept If the dialog box is closed by the button return the changes will be discarded 6 7 3 Freeze drying with the PGMplus programmer module Unlike in the manual mode an entire freeze drying process can be executed fully automatically and under reproducible conditions with the aid of the PGMplus progra...

Page 94: ...perature and vacuum These ramps start with the set value of the previous section and end with the set value of the current section As a result there is not abrupt change of the set value from section to section but a steady adaptation Fig 57 Graphical representation of the course of the control set value In order to protect the product a safety pressure value can be entered in every drying section...

Page 95: ...e set value By default the wired product temperature sensor 1 is used If the freeze dryer is equipped with the wireless WTMplus temperature measurement system it is also possible to select a different wired product temperature sensor or a WTMplus sensor see chapter 6 7 1 3 Main window Options section Administration Sensor configuration During the freezing phase the product temperature may exceed t...

Page 96: ...m up Apart from the execution of the various sections the PGMplus programmer module also controls other tasks that need to be performed during the process run e g the automatic activation of the vacuum pump If the pressure control valve is closed the PGMplus programmer module shifts the warm up phase of the vacuum pump to the freezing phase so that it is before the first drying section Since the p...

Page 97: ...ading section In this phase the start conditions of the programs are defined The room temperature 20 C is the standard default NOTE If the product is frozen outside the freeze dryer double chamber method the shelf temperature must be adapted accordingly in section 1 For all the other sections the set values must be defined see figure below Press the button Insert section 4 and select the position ...

Page 98: ...f freeze dryer see the sections below Proceed in this manner in order to create an entire program according to your specific needs Pressing the button Diagram 3 displays the program in the form of a diagram Pressing the button Program name 2 calls up an input field in which the name of the program can be changed The button Save 7 can be used in between or at the end of the program creation in orde...

Page 99: ...repeated pressing of the button in the program mode enables the selection of different variants Periodic pressure increase test The test will be performed periodically during the entire main or final drying phase The parameters Duration test and Time between tests apply The maximum pressure increase is limited to 100 referring to the actual value at the beginning of the measurement If the value is...

Page 100: ...ssure increase is limited to 100 referring to the actual value at the beginning of the measurement If the actual value exceeds the set value before the preselected time has elapsed the test will be aborted in order to prevent the product from thawing If during both tests the values of the pressure increase test are not greater than the preset Pressure increase parameter the drying process will be ...

Page 101: ...ted by pressing the button in the dialog box Progress condition If the difference between the readings of the Pirani and the capacitive vacuum sensor at the end of the last main drying section is below the limit p Comparative the drying process will be considered complete at the current shelf temperature and chamber vacuum Thus the progress condition for switching to the next section is fulfilled ...

Page 102: ... value Aeration 3 Set value Aeration after stoppering 4 Set value Stoppering 5 Set value Storage Fig 64 Dialog box Aeration stoppering storage Repeated pressing of this button enables the user to choose between the following variants Deactivated Aeration up to the Aeration value and subsequent storage Stoppering at drying vacuum followed by aeration up to atmospheric pressure with subsequent stora...

Page 103: ...he specific Stoppering time see the illustration above item 4 The subsequent final aeration is performed in two steps In the first step the system is aerated up to the partial vacuum that is stated under Aeration after stoppering see the illustration above item 3 Then the shelves are moved apart into the drying position In the second step the system is aerated up to atmospheric pressure This metho...

Page 104: ... backfilling as well as for the final aeration up to atmospheric pressure The following media preselection settings are possible Air Preselects the media connection Air Inert gas Preselects the media connection Inert Gas Automatic Automatic media connection preselection depending on the chamber pressure and stoppering status of the product vials Chamber pressure 950 mbar or product vials already s...

Page 105: ...e here a recipe for nutrient media bacteria After the conformation of the information the program template will be displayed Similar to a blank program sections can be added or deleted and the set values can be adapted accordingly 6 7 3 2 Editing a program An existing program can be modified as long as it has not been loaded Select the program to be edited from the list in the main window Program ...

Page 106: ...6 7 3 1 Creating a program Close the dialog box by pressing the Program button The program will be automatically assigned to the first free program storage location 6 7 3 4 Loading a program If a freeze drying process is to be executed and controlled by a program the program must be loaded Call up the main window Program This window includes a list of all the programs that are saved Press the butt...

Page 107: ... If however section 01 Load is to be used as the starting point of the program this section must be selected manually In this case the button Program continue will be displayed after the start of the program When the precooling loading process is complete this button must be pressed in order to continue with the program 6 7 3 5 Deleting a program The PGMplus programmer module offers 32 program sto...

Page 108: ...oned directly in the product They transfer their measurement values to an antenna that is integrated in the drying chamber This enables the continuous monitoring of all of the phases of the freeze drying process Option Pressure increase test see also chapter 6 7 3 1 Creating a program button more The pressure increase test can only be performed with the double chamber method During the pressure in...

Page 109: ...s feature enables the recording of a running process directly on a PC laptop computer During the process recording the process data can be viewed on the PC with LyoLogplus and they can be printed It is also possible to import the data directly into an Excel file after the completion of the process recording Option LyoControl measuring system The Lyo Control measuring system can be used to determin...

Page 110: ...ogrammer module and if the freeze dryer is equipped with an automatic aeration valve and a hydraulic shelf movement system It offers automatic sealing of the product vials with pre inserted rubber stoppers under partial vacuum and subsequent storage on the shelves under defined conditions as an integral part of a freeze drying program Special equipment Gas injection with a proportional valve see a...

Page 111: ...0 07 2022 sb 111 161 Translation of the original operating manual 6 9 Switching the freeze dryer OFF The freeze dryer must be in the standby status Switch the control system off by pressing the control switch Pressing the main switch disconnects the freeze dryer from the power ...

Page 112: ...hapter 7 3 Service contact The password input fails The password is not correct Inform the administrator If you have lost the administrator password contact the service department see chapter 7 3 Service contact Insufficient vacuum Incorrect connection of the small flange connection s Loosen the connection Place the centring ring with the inner sealing ring in a centred manner between the flange c...

Page 113: ...ads to a pressure increase Acknowledge the message If the message is displayed repeatedly inform the service department see chapter 7 3 Service contact NOTE If it is impossible to eliminate the errors contact the Christ service department 7 1 1 Power failure The control system continues with the process after a power failure The preselected conditions remain saved even during a process run In the ...

Page 114: ... small flange connections between the various components and hose connections or to leakages in the valves Loosen the connection and place the centring ring with sealing ring inside in a centred manner between the flange connections Seal the connection with the clamping ring by tightening the wing nut Ensure that the centring ring neither slips out of place nor gets jammed Fig 69 Small flange and ...

Page 115: ...l source are contaminants such as product residues within the valve Switch the freeze dryer off and disconnect the mains plug Clean the valve see chapter 8 1 4 Aeration valve media drain valve Put the freeze dryer into operation again If there is still a leakage the freeze dryer must be checked by qualified specialist personnel see chapter 7 3 Service contact 7 1 2 3 Pressure control valve A malfu...

Page 116: ... freeze drying process The refrigeration unit is equipped with a protective device against overpressure in the refrigeration system and with a thermal motor protection switch The protective devices trip when the ambient temperature is too high when the air circulation of the heat exchanger of the refrigeration system is insufficient when the refrigeration system is overloaded In these cases the re...

Page 117: ...re part enquiries From Germany Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode Germany Tel 49 0 55 22 50 07 33 33 E mail support epsilon martinchrist de Outside Germany Contact our agency in your country All agencies are listed at www martinchrist de Sales Partners NOTE If you would like to utilise our after sales service please state the type of your free...

Page 118: ...eeze drying of solvent containing products non aqueous media Use soap water or other water soluble mild cleaning agents for cleaning the freeze dryer and the accessories Do not use corrosive and aggressive substances Do not use solvents Do not use agents with abrasive particles Do not expose the freeze dryer or its accessories to intensive UV radiation e g sunlight or thermal stress e g by heat ge...

Page 119: ...oducts When performing maintenance work on parts coming into contact with the product e g all parts inside the chamber vacuum pump the personnel may be exposed to product residues Skin contact or the inhalation of particles may cause severe damage to health depending on the product in question Take suitable decontamination measures prior to commencing the maintenance Wear suitable protective cloth...

Page 120: ...it must be ensured that there is no water left inside the drying chamber after every freeze drying process If necessary wipe the chamber dry with a cloth 8 1 3 1 Lamination of the loading door with a special film Freeze dryers with an acrylic glass door are equipped with the special Radiation Shield film on the exterior side of the acrylic glass door see chapter 6 5 Loading door NOTE For technical...

Page 121: ... agents Do not use hard sponges cloths or brushes for cleaning Avoid strong mechanical stress during cleaning 8 1 3 2 Door latch There is a slide pad on the door latch of the loading door This slide pad is included in the scope of supply as a spare part part no 18189991 It must be inspected regularly for signs of wear When its thickness is 0 5 mm it must be replaced 1 Door latch 2 Slide pad 3 Torx...

Page 122: ...g the seals Contaminants such as product residues may lead to an insufficient vacuum In this case the aeration valve and the media drain valve must be cleaned Switch the freeze dryer off and disconnect the mains plug Remove the valve core Clean the valve core and the opening with a moist cloth Clean the O rings and inspect them for any damage Damaged O rings must be replaced 1 Valve opening 2 Valv...

Page 123: ...ay cause the unit to fail This is why the selected set up location should be as clean as possible Check the heat exchanger at least once per month for soiling and clean it if necessary Please contact the Christ service department if you have any queries see chapter 7 3 Service contact 8 1 6 Electrical system DANGER Danger of life caused by electric shock There is a risk of electric shock when touc...

Page 124: ... pump and exhaust gas filter especially when changing the oil or filter the maintenance personnel are exposed to the vacuum pump oil which may contain harmful substances originating from the product In addition synthetic oils can release toxic fumes when they are ignited or heated above 300 C The inhalation of the fums that are released by the oil or contact with the skin can cause severe damage t...

Page 125: ...table protective clothes and gloves WARNING Danger of poisoning infection due to contaminated exhaust air The exhaust air may contain harmful substances originating from the product Contact with particles in the exhaust air especially by inhalation may result in severe damage to health Use a silencer with integrated filter elements or depending on the product guide the exhaust gases from the outle...

Page 126: ...n the case of skin contact with liquid refrigerant cold burns or frostbite may result Only qualified persons are authorised to perform work on the refrigeration system of the freeze dryer DANGER Risk of explosion due to refrigerants The natural refrigerants used are highly flammable and can form an explosive mixture if their concentration in the ambient air is sufficiently high There is an explosi...

Page 127: ...or leaks by a specialist at regular intervals and replace them immediately if they are damaged Replace the hydraulic hose lines at appropriate intervals depending on the operating conditions and under consideration of the specifications and recommendations of the manufacturer even if no safety relevant defects can be noticed 8 1 12 Vacuum sensor NOTE Please refer to the separate operating manual o...

Page 128: ...place any damaged components immediately for your own safety Immediately rinse off the accessories if any liquids that may cause corrosion come into contact with them Clean the accessories outside the freeze dryer once a week or preferably after each use 8 2 Disinfection of the drying chamber and accessories DANGER If dangerous materials e g infectious and pathogenic substances are used the freeze...

Page 129: ...dryer e g electrical equipment safety devices refrigeration systems in accordance with the specifications System Component Detail Part Inspection Periodical Maintenance Repair Rebuild Before start Per working day Inspection Replacement Operation Calibration Safety devices chapter 3 8 Safety devices X X Drying chamber and loading door Drying chamber dry and clean X X Stainless steel bellow clean un...

Page 130: ... X X Machinery general Switch cabinet X X Leakages X X Noise emission above average X X Dynamic gaskets diaphragmas 50 steril cycles Static gaskets O rings clamp KF 100 steril cycles Wires fastened X Cable trays closed X Framework no corrosion X Remove corrosion Aeration system Aeration filter 50 steril cycles Vacuum system Pump oil level X X X Pump oil condition colour contamination X X X oil cha...

Page 131: ...frigeration system Icing of components X Pressure readings performance tests X Noise level above average X Solenoid valves operation X Ice condenser temperature low end X Cooling water controller X X Cleaning of the valve Heat exchanger X X Cleaning Drain system Condensate drain glass debris X X Media drain valve X Disassemble and clean in regular intervals Heat transfer medium system Expansion ve...

Page 132: ... heat exchanger and remove corrosion Hydraulic system Mechanical components operation X Leakages X X Maximum pressure reading X Oil in reservoir X Hydraulic hose lines condition X 5 years Replace hose lines even if no safety relevant defects can be noticed Cylinder travel speed X Instrumentation Vacuum sensor s X Calibration Temperature sensors at freeze dryer X Calibration Pressure sensors chambe...

Page 133: ...erating manual System Component Detail Part Inspection Periodical Maintenance Repair Rebuild Before start Per working day Inspection Replacement Operation Calibration Switch cabinet cooling system X 1 year X Replacement of the filter Wiring X Power reading of components X LSCplus control system X 6 years X Replacemant of the buffer battery ...

Page 134: ...yer e g electrical equipment safety devices refrigeration systems in accordance with the specifications System Component Detail Part Inspection Periodical Maintenance Repair Rebuild Before start Per working day Inspection Replacement Operation Calibration Safety devices chapter 3 8 Safety devices X X Drying chamber and loading door Drying chamber dry and clean X X Stainless steel bellow clean and ...

Page 135: ...ery general Switch cabinet X X Leakages X X Noise emission above average X X Dynamic gaskets diaphragmas 50 steril cycles Static gaskets O rings clamp KF 100 steril cycles Wires fastened X Cable trays closed X Framework no corrosion X Remove corrosion Aeration system Aeration filter 50 steril cycles Vacuum system Pump Inlet strainer X Inspection and cleaning annually Pump Gas ballast control X Ins...

Page 136: ...Vacuum leak test X Refrigeration system Icing of components X Pressure readings performance tests X Noise level above average X Solenoid valves operation X Ice condenser temperature low end X Cooling water controller X X Cleaning of the valve Heat exchanger X X Cleaning Drain system Condensate drain glass debris X X Media drain valve X Disassemble and clean at regular intervals Heat transfer mediu...

Page 137: ... at heat exchanger and remove corrosion Hydraulic system Mechanical components operation X Leakages X X Max pressure reading X Oil in reservoir X Hydraulic hose lines condition X after 5 years Replace hose lines even if no safety relevant defects can be noticed Cylinder travel speed X Instrumentation Vacuum sensors X Calibration Temperature sensors at freeze dryer X Calibration Pressure sensors ch...

Page 138: ...erating manual System Component Detail Part Inspection Periodical Maintenance Repair Rebuild Before start Per working day Inspection Replacement Operation Calibration Switch cabinet cooling system X 1 year X Replacement of the filter Wiring X Power readings of components X LSCplus control system X 6 years X Replacemant of the buffer battery ...

Page 139: ...ntact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode Germany Tel 49 0 55 22 50 07 33 33 E mail support epsilon martinchrist de Outside Germany Contact our agency in your country All agencies are listed at www martinchrist de Sales Partners NOTE If you would like to utilise our after sales service please state the type of your freeze dryer and its serial number 8 ...

Page 140: ...ta They facilitate the assignment and they enable the quick processing of the return If several parts are returned together in one packaging please enclose a separate problem description for every defective part A detailed problem description is necessary in order to perform the repair quickly and economically Upon request we will prepare and submit to you a cost estimate prior to performing the r...

Page 141: ...l of the freeze dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use Comply with all local rules and regulations 9 2 Disposal of the packaging Dispose of the packaging after having separated the individual materials Comply with all local rules and regulations ...

Page 142: ...er Cascade system with 2 compressors 1 2 kW each Shelf temperature control 1 compressor 0 9 kW Refrigerants heat transfer media and hydraulic oil Refrigerant data of refrigeration circuit 1 Refrigerant Global warming potential GWP Filling quantity Max permissible pressure CO2 equivalent Refrigerant Global warming potential GWP Filling quantity Max permissible pressure CO2 equivalent R1270 3 140 g ...

Page 143: ...le below see table below approx 55 C to 60 C 1 C max on one shelf and from shelf to shelf Vacuum Final vacuum double stage Leak rate test time 12 15 h 5 x 10 3 mbar 5 x 10 3 mbar sec Connection requirements Electrical connection 3 x 400 V 50 Hz other supply data on request Protection class I IP protection categoryaccording to DIN 60529 20 Apparent power depending on the vacuum pump see technical d...

Page 144: ...95 Ø mm 21 22 23 25 5 27 32 36 36 43 52 Number of shelves Area Distance The data indicate the maximum loading Substract 10 when using frames 1 1 0 14 354 363 326 290 243 218 147 117 117 83 54 2 1 0 28 169 726 652 580 486 436 294 234 234 166 108 3 1 0 42 108 1089 978 870 729 654 441 351 351 249 4 1 0 56 77 1452 1304 1160 972 872 588 468 5 1 0 70 59 Standard 6 1 0 84 47 Only trays 7 1 0 98 38 Only t...

Page 145: ...e section elapsed tion previous of value set value set control Example Section Set values Section time h min Temperature C Preceding 30 Current 1 00 60 C min 0 5 min 60 30 min 60 30 60 C C C gradient After an elapsed section time of 30 minutes for example the control set value for the temperature is C C C value set Control t 45 min 5 0 min 30 30 min 30 Calculation of the control set value for the ...

Page 146: ...Freeze dryer Epsilon 2 10D LSCplus 11 Appendix 146 161 Version 07 2022 Rev 3 0 of 20 07 2022 sb Translation of the original operating manual ...

Page 147: ...yer Epsilon 2 10D LSCplus 11 Appendix Version 07 2022 Rev 3 0 of 20 07 2022 sb 147 161 Translation of the original operating manual 11 2 EC declaration of conformity in accordance with the EC Machinery Directive ...

Page 148: ...Freeze dryer Epsilon 2 10D LSCplus 11 Appendix 148 161 Version 07 2022 Rev 3 0 of 20 07 2022 sb Translation of the original operating manual ...

Page 149: ... Epsilon 2 10D LSCplus 11 Appendix Version 07 2022 Rev 3 0 of 20 07 2022 sb 149 161 Translation of the original operating manual 11 3 EC declaration of conformity in accordance with the Pressure Equipment Directive ...

Page 150: ...Freeze dryer Epsilon 2 10D LSCplus 11 Appendix 150 161 Version 07 2022 Rev 3 0 of 20 07 2022 sb Translation of the original operating manual ...

Page 151: ...370 24 0 700 44 0 080 64 0 006 5 4 020 25 0 630 45 0 070 65 0 0054 6 3 690 26 0 570 46 0 060 66 0 0047 7 3 390 27 0 520 47 0 055 67 0 0041 8 3 010 28 0 470 48 0 050 68 0 0035 9 2 840 29 0 4202 49 0 045 69 0 0030 10 2 560 30 0 370 50 0 040 70 0 0026 11 2 380 31 0 340 51 0 035 71 0 0023 12 2 170 32 0 310 52 0 030 72 0 0019 13 1 980 33 0 280 53 0 025 73 0 0017 14 1 810 34 0 250 54 0 024 74 0 0014 15 ...

Page 152: ...Freeze dryer Epsilon 2 10D LSCplus 11 Appendix 152 161 Version 07 2022 Rev 3 0 of 20 07 2022 sb Translation of the original operating manual ...

Page 153: ...hereby molecules are released from the surface of a solid In order to be able to desorb the particle must have or be provided with a sufficient amount of energy in order to overcome the binding energy Double chamber method Freezing and drying of the product on several temperature controlled shelves inside a separated drying chamber is referred to as a double chamber system The advantage compared t...

Page 154: ...imes to identify every single component within the system in an unambiguous manner The reference designators are affixed to the components and entered into the technical documentation e g circuit diagrams Safety pressure Since the vacuum has a dominating influence on the product temperature Martin Christ Gefriertrocknungsanlagen GmbH has integrated a so called safety pressure feature into the free...

Page 155: ... value and of the gradient for the temperature 145 Calculation of the control set value for the vacuum 145 Capacity test 30 C 70 Capacity test 50 C 71 CE mark in compliance with the directive 2006 42 EC 24 Changing of operating supplies 40 Chemical burns 39 Chemical reactions 128 Circuit diagram 144 Cleaning 40 Cleaning agents 118 128 Cleaning the accessories 118 Cleaning the freeze dryer 118 Clic...

Page 156: ...r 141 Disposal of the packaging 141 Door latch 121 Double chamber method 153 Drain standard connection 143 Drying cartridge 55 Drying chamber cleaning and care 120 E EC declaration of conformity Machinery Directive 13 147 EC declaration of conformity Pressure Equipment Directive 13 149 Editing a program 105 Electrical connection 143 Electrical system maintenance 123 Electricity hazards 31 48 123 E...

Page 157: ...ents 33 Hazards surfaces cold 37 Hazards surfaces hot 37 119 124 125 Hazards transport 30 44 45 Hazards vacuum pump exhaust gases 35 51 Hazards vacuum pump oil 35 124 Health and safety 26 Health and safety rules and regulations and regulations for the prevention of accidents 26 28 Heat emission 142 Heat exchanger 123 Heat transfer media 142 Heat transfer medium system 142 Heat transfer medium syst...

Page 158: ...ce schedule oil sealed vacuum pump 129 Malfunction of the pressure control valve 115 Malfunctions 112 Manual freeze drying 90 Manufacturer 118 128 141 142 Manufacturer contact data 90 Marking of the unit 24 Materials of construction damage 118 Mathematical relations 145 Max humidity 144 Measures to be taken to ensure safe operation 41 Media drain valve 50 Media drain valve cleaning and care 122 Me...

Page 159: ...tive 109 Prevention of accidents 9 Process and equipment messages 66 Process and error messages 116 Process data 61 Product residues 119 Product temperature measurement system WTMplus 108 Products containing acids 12 Products containing azides 12 Products harmful hazards 32 119 Program list 74 Program sections 94 Program templates 105 Protection class 143 Q Qualified electrician 29 R Radiation Shi...

Page 160: ...ards 37 Surfaces hot hazards 37 119 124 125 Switching the freeze dryer OFF 111 System properties 80 T Table of the sublimation pressure curve 151 Technical data 142 Technical documentation 144 Thermal stress 47 118 Tools 63 Topping up of operating supplies 40 Touchpanel does not react 112 Toxic substances 119 Training 26 Transport 43 Transport hazards 30 44 45 Transport hazards general 44 45 Trans...

Page 161: ... 161 Translation of the original operating manual Weighing system 102 Weighing system LyoBalance 65 110 Weight 43 142 Wireless product temperature measurement system WTMplus 108 WTMplus configuration 85 WTMplus wireless product temperature measurement system 108 Y Year of manufacture 18 ...

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