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Caution - refer to accompanying documents

Caution - risk of electric shock

Caution - hot surface

This manual provides installation and operation instructions for the Thermo

Electron

ModulyoD Freeze Dryer, abbreviated to ModulyoD in the remainder of this manual. You
must use the ModulyoD as specified in this manual.

Read this manual before installing and operating the ModulyoD. Important safety infor-
mation is highlighted as WARNING and CAUTION instructions; you must obey these
instructions. The use of WARNINGS and CAUTIONS is defined below.

WARNING: Warnings are given where failure to observe the instruction could

result in injury or death to people.

CAUTION:

Cautions are given where failure to observe the instruction could
result in damage to equipment, associated equipment and process.

In accordance with the recommendations of IEC1010, the following warning symbols
may appear on the freeze dryer:

1.0

INTRODUCTION

1.1

SCOPE OF THE MANUAL

The ModulyoD is the ice condenser section of a freeze drying system. It is designed
specifically for freeze drying biological samples and pharmaceutical preparations in a
laboratory environment. The ModulyoD, when used in conjunction with a vacuum source
and manifold or other sample container, forms a complete freeze drying system. The
ModulyoD may also be suitable for use as a low temperature (-50 °C.) vapor trap.
Please refer to Appendix A for specific limitations regarding the use of the ModulyoD as
a vapor trap.

The ModulyoD is used with a variety of optional accessories to freeze materials in bulk
trays, flasks, tubes, vials or ampules. These optional accessories are described in
Section 6.0 and depicted in Appendix B. The ModulyoD may also be used as a low tem-
perature vapor trap (cold trap) for a variety of devices. These include vacuum concen-
trators, rotary evaporators and vacuum ovens.

The ModulyoD itself is made of three basic parts, the condenser chamber, a refrigera-
tion system and the user interface. The refrigerant used in the ModulyoD is CFC free.
All ModulyoD components are housed in a steel cabinet that is designed for bench-top
use. The major components of the ModulyoD are described in the following sections.
(Please refer to Figures 1 and 2 on page 4 for the location of each component.)

1.2

GENERAL DESCRIPTION

1.2.1 THE

MODULYOD

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Содержание ModulyoD

Страница 1: ... NSTRUCTION ANUAL 0 6 0 SFF F SZFS 5HY ...

Страница 2: ... 2 ModulyoD Back view 5 1 2 1 1 The Accessory Flange Condenser Chamber 6 1 2 1 2 The Refrigeration System 5 Figure 3 Inside ModulyoD 7 Figure 4 Refrigeration Circuit Diagram 7 1 2 1 3 User Interface 8 Table 1 Control Panel Description 8 Figure 5 ModulyoD Control Panel 9 Figure 6 Temperature Progress Bar 9 Figure 7 Vacuum Progress Bar 9 1 2 1 4 Front Fascia 9 1 2 1 5 Connections 10 Table 2 Drain Ou...

Страница 3: ...on 19 4 1 Safety 19 4 2 Sequence of Operation 19 Table 4 Sequence of Operation 19 4 3 Prepare the ModulyoD 20 4 4 Fit the Sample Container and Other Accessories 20 4 5 Pre Cool the ModulyoD 20 21 4 6 Drying 21 22 4 7 Shut Down 22 4 8 Defrost the ModulyoD 23 4 9 Operation With No Load 24 Section Section Title Maintenance Page 5 0 Maintenance 24 5 1 Safety 24 5 2 Precautions 24 5 3 Refrigerant Leaks...

Страница 4: ...reeze drying biological samples and pharmaceutical preparations in a laboratory environment The ModulyoD when used in conjunction with a vacuum source and manifold or other sample container forms a complete freeze drying system The ModulyoD may also be suitable for use as a low temperature 50 C vapor trap Please refer to Appendix A for specific limitations regarding the use of the ModulyoD as a va...

Страница 5: ...hamber 2 Steel Cabinet with Refrigeration System 3 User Interface 4 Front Fascia 5 Drain Outlet 6 Drain Valve 7 Vacuum Port 5 4 7 6 5 2 Figure 2 MODULYOD BACK VIEW 2 Power IEC Outlet to Vacuum Pump 1 Power IEC Inlet 3 RS232 Port 4 Power Switch with Circuit Breaker 3 1 ...

Страница 6: ... replaced The electrical fan item 6 simultaneously cools down the condenser coil item 7 and the compressor See Section 2 2 on page 12 for refrigerant type and charge 1 2 1 2 THE REFRIGERATION SYSTEM The accessory flange and condenser chamber are made entirely of stainless steel The chamber itself is a thin walled cylinder with a dish shaped bottom It has a total capacity of 5 liters of ice The acc...

Страница 7: ...7 Figure 3 INSIDE MODULYOD 3 2 4 5 7 1 6 1 Compressor 2 Thermo Expansion Valve 3 Suction line Accumulator 4 Filter Dryer 5 Liquid Receiver 6 Fan 7 Condenser Coil Figure 4 REFRIGERATION CIRCUIT DIAGRAM ...

Страница 8: ...ressing from approximately 40 to 7 Red bars indicate temperatures pro gressing from 7 to ambient see Figure 6 page 8 To switch vacuum pump on and off if the pump is plugged into auxiliary power outlet of the ModulyoD see Section 3 5 page 15 The lamp is on when the vacuum pump is on To show absolute pressure in the condenser chamber Readings start when pressure is less then 50 mbar and are in milli...

Страница 9: ...nd portion of this surface The drain outlet drain valve and vacuum port are located on the lower left hand portion 1 2 1 4 FRONT FASCIA 8 Temperature Color C Figure 6 TEMPERATURE PROGRESS BAR Pressure Color mbar Figure 7 VACUUM PROGRESS BAR T 40 40 T 34 34 T 21 21 T 7 7 T 7 7 T Green Amber Amber Amber Red Red H 1 0 1 H 3 95 3 95 H 6 58 6 58 H 13 16 13 16 H 52 6 52 6 H Green Amber Amber Amber Red R...

Страница 10: ...nection Figure Item Use Vacuum port 1 7 To connect your vacuum pump to the ModulyoD Drain valve 1 6 Close the valve turn it fully clockwise to isolate the condenser chamber from the drain outlet Open the valve turn it anti clockwise to admit air into the vacuum system and to drain water from the condenser chamber after it has been defrosted Drain outlet 1 5 This outlet is used to drain water from ...

Страница 11: ...ection 6 0 for a list of optional freeze drying accessories Optimal freeze drying conditions are nor mally determined empirically For this reason we recommend the user keep a detailed log of operating parameters see Appendix C Freeze Drying User s Log ModulyoD performance data may be collected by connecting a computer to the RS232 port See Figure 2 The following sections contain general infor mati...

Страница 12: ... try to optimize the drying cycle for a particular product it is important to observe the physical appearance of the product whenever possible during the drying process If the product has been cor rectly frozen it will usually appear to be uniform in color and compact If the product is uneven in color or if signs of boiling are visible then the product may have been incor rectly frozen or may have...

Страница 13: ...C Condenser chamber Ice capacity in 12 hours 1 2 kg 2 6 lb Maximum ice capacity 4 5 kg 9 9 lb Operating temperature 50 5 C Surface area 0 15m2 233 in2 Volume 7 21l Average evaporation rate 95 cm3 h 1 Instrumentation Temperature display range 60 C to ambient Vacuum display pressure range 10 microbar to 50 millibar 2 0 TECHNICAL DATA 2 1 GENERAL MODULYOD 230 MODULYOD 115 Nominal electrical supply 22...

Страница 14: ...e pump For freeze drying your vacuum pump must meet the following specification Type of pump Two stage oil sealed rotary pump Ultimate pressure 1 x 10 2 to 3 x 10 2 mbar 1 to 3 Pa Pumping rate 50 l min or more Recommended pump Thermo Electron LyoPumpTM 2 5 VACUUM PUMP REQUIREMENTS The ModulyoD has been designed in compliance with the following legislation and standards CE Directives 2 4 CONSTRUCTI...

Страница 15: ... Retain all packing materials for inspection Do not use the ModulyoD if it is damaged Check that your package contains the items listed in Table 3 below If any of these items are missing notify your supplier in writing within three days 3 1 UNPACK AND INSPECT The ModulyoD is designed for use on a laboratory benchtop Locate the ModulyoD in its required operating position within convenient access to...

Страница 16: ...igh vacuum pump with the ModulyoD These pumps are suitable for freeze drying products which contain sodi um azides If you do not use a Thermo Electron vacuum pump the pump must meet the require ments specified in Section 2 5 To connect another type of pump to the ModulyoD refer to the instruction manual supplied with the pump 3 4 CONNECT THE VACUUM PUMP If you have a Thermo Electron high vacuum pu...

Страница 17: ... the ModulyoD if it fails the installation test If you do poor performance may result in the loss of the sample being freeze dried Use the following procedure to test the ModulyoD If any of the checks below fail turn the mains switch item 4 Figure 2 off then switch off the external electrical supply and disconnect the supply from the ModulyoD Contact your supplier for advice Do not attempt to use ...

Страница 18: ...ture of the condenser chamber in approximately 40 minutes The temperature should be at or below 45 C with an ambient temperature of 24 C or less Check that green light on the temperature progress bar item 4 Figure 5 is illuminated 8 Attach any empty drying accessory to the accessory flange of the condenser chamber item 1 Figure 1 Refer to Section 6 0 for optional accessories 9 Turn the drain valve...

Страница 19: ...uitable for this purpose If you do not use a Thermo Electron pump your vacuum pump and vacuum pipeline may not be suitable for freeze drying products containing sodium azide Check with your vacuum pump manufacturer to determine its suitability if you intend to freeze dry prod ucts containing sodium azide 4 0 OPERATION 4 1 SAFETY Operation of the ModulyoD can involve a number of different steps as ...

Страница 20: ... mance of the ModulyoD will be poor 5 Confirm that both the vacuum pump and the ModulyoD are properly con nected to the interconnecting vacuum tubing 6 Select a suitable drying accessory for the product Wipe clean the seal ing ring of the accessory and check the sealing ring for damage if it is damaged fit a new sealing ring The accessory sealing ring should not need lubricating 4 3 PREPARE THE MO...

Страница 21: ...efer to the pump instruction manual 2 Activate the pump ON by pressing Pump button item 5 Figure 5 if the pump is electrically connected to the ModulyoD vacuum pump power outlet item 2 Figure 2 Take note of the following when freeze drying products Switch on a heated accessory only when the pressure is 1 mbar or less Green light on the vacuum progress bar is illuminated item 8 Figure 5 When a load...

Страница 22: ...e and the appearance of the product and consult data gathered from previous freeze drying operations to determine when the freeze drying process has finished Note that the pressure shown on the gauge will fall significantly when vapor is no longer being released from the sample Once the process has finished shut down the ModulyoD as follows 1 If you use a manifold accessory use the manifold valves...

Страница 23: ... up the defrost ing process This method is useful if you wish to use the ModulyoD again immediate ly Use the following procedure 1 Remove the drying accessory from the accessory flange 2 Close the drain valve 3 Pour warm water at a maximum temperature of 50 C into the condenser chamber Note Do not fill the chamber above the level of the vacuum pipeline item 2 Figure 8 4 Wait for a few minutes to a...

Страница 24: ...s and their possible solutions and are intended as a guide to the user and to qualified service engineers Some of the solu tions may be carried out by the user but others which are clearly identified must be carried out only by approved Thermo Electron service engineers 5 0 MAINTENANCE WARNING Obey the safety instruction given below and take note of appropriate precautions If you do not you may ca...

Страница 25: ...with tepid water for at least 15 minutes apply a sterile dress ing and treat the wound as you would a heat burn 5 3 REFRIGERANT LEAKS 6 0 ACCESSORIES DRYING ACCESSORIES Appendix B p 26 Accessory Item Catalog 8 port column manifold 1 F05656000 16 port drum manifold 2 F05628000 24 port drum manifold 3 F05621000 24 port column manifold 4 F05622000 Bell Jar 5 F02960000 VC45 Vial Cell Stoppering shelf ...

Страница 26: ...source is connected in the manner described in Section 3 4 Operation The ModulyoD must be pre cooled to operate as a vapor trap The fridge button must be switched on and the temperature progress display must be in the green range Switch on the vacuum source and begin to monitor the vacuum progress display This indicator should grad ually progress progress from a reading of Hpr to green as the vacu...

Страница 27: ...e Controller Rack Assembly Heater Kit FLASK TRAY VIAL Spin Freezer Secondary Drying Manifold Specimen Dryer Adapter Flange Pipeline Attachment Bell Jar AMPULE SPECIMEN MISC Isolation Valve ModulyoD 27 1 4 14 3 2 13 7 8 6 5 9 10 11 12 Not used with Spin Freezer and Pipeline Attachment Appendix B Decision Tree 15 16 17 18 19 20 21 22 ...

Страница 28: ...Appendix C Freeze Drying User s Log Date Sample Freezing Sample of Sample Total Drying Comments Formulation Temperature Container Containers Sample Time Volume 28 ...

Страница 29: ......

Страница 30: ... 1101 Fax 91 22 2778 1103 Bangaalore India 81 45 453 9122 Fax 81 45 453 9222 Yokohama City Japan International Sales Office Locations Bioscience Technologies Thermo Electron Corporation 866 9 THERMO 866 984 3766 Molecular Biology info molbio thermo com Sample Preparation info sampleprep thermo com New Labs newlabs thermo com Services services biosciencetech thermo com Laboratory Pipetting and Cons...

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