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XCell
TM
ATF System with C410:V3 Controller
User Guide
Figure 2.
XCell
TM
ATF System Pump Cycles
Note on the Exhaust Cycle:
WARNING
Glass bioreactors
or single-use bioreactors (SUBs), unless otherwise specified by the manufacturer of
the vessel, should not be pressurized. Such vessels can explode if pressurized.
Therefore, to increase the pressure in the vessel relative to the Diaphragm Pump, a vacuum
service is required. The PA chamber can then be alternately pressurized and evacuated to
produce ATF flow while maintaining the process vessel at atmospheric pressure.
On the other hand, when using a vessel that can be pressurized, vessel pressure can be used
to drive the liquid from the vessel to the PL chamber. When vessel pressure is limited, it
may be supplemented with vacuum. In either of the above schemes, one is driving the liquid
from the vessel to the Diaphragm Pump by increasing the pressure in the vessel relative to
the Diaphragm Pump.
When using a glass vessel or SUB, be sure to maintain an unrestricted vent from
the vessel. In the case a diaphragm fails, the air flow into the Diaphragm Pump will
proceed through the HFM or SM into the vessel. A free exhaust from the vessel will
minimize the buildup of pressure in the vessel.