3 Changing the mode of operation
This chapter describes how to prepare the mass spectrometer for the following modes of
operation:
• ESI (electrospray ionization)
• ESCi (combined electrospray and atmospheric pressure chemical ionization)
• APCI (atmospheric pressure chemical ionization)
• UniSpray
For details about other Waters and third-party source options, refer to the documentation
supplied with the source.
Note:
Depending on the software used to control the instrument, some sources may not be
available.
3.1 ESI, ESCi, and APCI modes
ESI, ESCi, and APCI modes are all configured using a standard source enclosure.
3.1.1 ESI mode
To operate in ESI mode, you must fit the ESI probe adapter to the source enclosure and install a
probe assembly.
The ESI probe adapter fitted with a standard ESI probe assembly accommodates eluent flow
rates as fast as 2 mL/min.
For further details, see
Electrospray ionization (Page 27)
3.1.2 ESCi mode
To operate in ESCi mode, you must fit an ESI probe adapter and corona pin to the source
enclosure.
The system, with the ESI probe adapter installed and corona discharge pin fitted, can alternate
between ESI and APCI ionization modes, facilitating data acquisition in ESI and APCI modes in
parallel.
January 10, 2022, 715006200 Ver. 01 (previously released as Rev. A)
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