Thermo Scientific Vanquish VF-D20, Operating Manual, Page: 112 / 182

6 • Operation
Page 112 Vanquish Charged Aerosol Detectors Operating Manual
6.8.2 Long-Term Shutdown
Shutting Down the Detector
NOTICE
Observe the following to avoid damage to the charged aerosol detector:
• Always flush the detector with an appropriate pure solvent before
interrupting operation. Follow the steps below.
•
Avoid leaving the detector exposed to highly acidic or basic mobile
phases for long periods.
•
If the detector was operated with organic solvents in high
concentration that may form peroxides upon evaporation, such as
un-stabilized tetrahydrofuran or isopropanol, flush the detector with
LC/MS-grade water before shutdown.
TIP
Shutting down the detector affects the operation of the system.
When shutting down the detector, also observe the shutting down
instructions for the other Vanquish system modules and take
appropriate action (refer to the
Operating Manuals
for the modules).
To interrupt operation for a longer period, follow the instructions below.
1. Flush the system with an appropriate, pure solvent (minimum
LC/MS-grade). Make sure that residual sample components,
impurities from the column, or buffers are completely removed from
the detector.
Observe the following:
♦ Detector remains in the laboratory after shutdown
♦
If no buffer solution is used, flush the system, for example
with methanol. 100% acetonitrile should not be used.
♦
If a buffer solution is used, flush the system with several
volumes (for example, 1.0 mL/min for 10 minutes with the
standard system) of methanol and water (50:50) to prevent
salt buildup in the fluidics. If the solvents in the detector are
not miscible with water, use an appropriate intermediate
solvent.