www.pall.com/biopharm
25
4.4.1
Flush the Retentate and Permeate Line to Waste
Direct the retentate and permeate lines to waste.
Figure 17
System Setup for Flushing
Procedure
1. Drain, wash and refill feed tank with water (or attach feed line to water supply).
2. Direct the retentate and permeate lines to waste.
3. Open the retentate and permeate valve.
4. Adjust the pump to deliver a flow rate of 5 to 10 L/min/m
2
(0.5 to 1 L/min/ft
2
).
Do not exceed a feed pressure of 2 barg (30 psig).
5. Adjust the retentate valve to split flow 25% retentate, 75% permeate.
6. Readjust pump to give required retentate flow rate.
7. Pass 30 L/m
2
(3.0 L/ft
2
) to waste.
8. Stop the pump.
4.4.2
Water Recirculation
Volume Required:
8 L/m
2
(0.85 L/ft
2
) minimum
Temperature: 25 °C
Retentate
Permeate
Feed
Tank
Waste
Waste
Feed
Pump
Pp
Rp
Fp