SP Scientific Freezemobile Series, Operator'S Manual, Page: 29 / 54

VirTis Freezemobile 25L and 35L Basic Operation
Rev 005, 02/12 19
© SP Scientific 2012
Operation Instructions
1. Ensure that the condenser is clean and dry before proceeding. Check the
drain line for residual moisture, which can cause slow vacuum pump-down.
2. Pre-freeze the product to a minimum of -40 °C.
3. If you are freeze-drying your product on manifold shelves or in a chamber,
insert product probes into the product close to the bottom of the sample, but
not touching it.
4. Check that all connections and ports are secure. Ensure that Quickseal and
condenser drain valves are closed, and that the condenser door is closed and
secured.
5. Press the COND button to begin cooling the condenser. Allow the condenser
to reach at least -40 °C before proceeding. Confirm that the condenser
temperature status light is green on the LED Wave display.
6. Enable vacuum by pressing the VAC button. Before proceeding, confirm that
the vacuum status light is green on the LED Wave display and that the
selected vacuum level is shown on the Synoptic screen.
Note: If your vacuum pump is not connected to the Freezemobile unit, the Sentry 2.0
controller will not be able to enable it. Switch on the vacuum manually. See your
vacuum pump operator’s manual for more information.
7. If using a manifold, attach a flask with pre-frozen product to a Quickseal valve
and turn the valve to the open position to begin the freeze-drying process.
Allow the vacuum to recover to at least 350 millitorr or your vacuum control
setpoint before connecting additional flasks.
8. Ensure that system parameters (refrigeration and vacuum) stay within
acceptable ranges. The LED Wave display on the control panel provides a
quick reference. Periodically check condenser ice build-up and defrost
whenever necessary.
9. Observe the product to determine when drying is complete. For manifold
drying, the process is complete when the outside of the flask loses
condensation and the product appears dry.
For heated shelf and chamber drying, the process is complete when one or
more of the following indicators occurs:

Condenser temperature approaches its maximum low.

Vacuum approaches a constant low reading.

Product temperature displays steady temperatures close to shelf
temperature (use product probe).

Appearance of the product indicates the extent of dryness (
i.e.,
uniformly powdery or fluffy).
If using a product probe, it should read near ambient or the heated rack
temperature (if equipped with the heated rack option).
10. Switch off the vacuum and refrigeration systems.
11. For manifold flask drying, close Quickseal valves and remove flasks. If using
a chamber or manifold shelves, break vacuum and remove the product.
12. If your system is still under vacuum, release vacuum by inserting the drain
plug into the drain valve or by opening a Quickseal valve.