Haemonetics MCS+, Operator And Maintenance Manual

Page: 112 / 112

7-10 Reference Information
P/N 39551-00
, Rev. F
A
NTICOAGULANTS
ACD-A
ACD-A is the most commonly used anticoagulant. The anticoagulant ratio used
depends on which component is being collected. The anticoagulant ratio is typ-
ically between 1:8 and 1:12. Refer to the appropriate protocol manual for opti-
mal anticoagulant ratios.
ACD-B
ACD-B is occasionally used in therapeutic apheresis. The anticoagulant ratio
used depends on the type of procedure performed. The anticoagulant ratio used
for ACD-B is typically between 1:8 and 1:12. Refer to the appropriate protocol
manual for optimal anticoagulant ratios.
Sodium Citrate
Sodium Citrate may be substituted for ACD-A or ACD-B in therapeutic apheresis
procedures. The most frequently used concentration of citrate is 4% citrate at a
1:16 anticoagulant ratio.
To make a known citrate concentration (% Citrate), mix 46.7% (14g citrate/30ml)
Trisodium Citrate with the Saline, ACD-A or ACD-B. The volume of 46.7% cit-
rate required for each of the solutions is given in Table 7-3.
Heparin
Heparin may be substituted for citrate anticoagulants during therapeutic plasma
exchange. The dosages most frequently used are:
• 35,000 units / 500 ml 0.9% Normal Saline if using a 1:16 anticoagulant
ratio.
• 17,500 units / 500 ml 0.9% Normal Saline if using a 1:8 anticoagulant
ratio.
Note: Physician discretion determines anticoagulant used as well as whether
heparin may be substituted.
Table 7-3:
Milliliters of 46.7% Sodium Citrate required for given concentrations of Citrate
% Citrate
Required
500 ml ACD-A
(3%)
500 ml ACD-B
(2%)
500 ml
Normal Saline
250 ml
Normal Saline
2 — — 21.6 10.8
3 — 10.8 32.0 16.0
4 10.8 21.6 42.8 21.5
5 32.0 42.8 64 32.0
✍