FTS LYOSTAR 3, Operator'S Manual

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Praxair’s ControLyo™ Nucleation On-Demand
Technology FTS Systems LyoStar™ 3
50 Rev 006, 01/14
© SP Scientific 2014
Key Steps
Key steps for utilizing Praxair’s ControLyo™ Nucleation On-Demand Technology are
outlined below:
Load product containers into the lyophilizer and securely latch the chamber 1.
doors.
Connect the supply gas source to the compressed gas inlet of the lyophilizer. 2.
Note: The identity of the gas can significantly impact the efficacy of Praxair’s
ControLyo™ Nucleation On-Demand Technology. Inert gases are generally
recommended for lyophilization processes. Both argon and nitrogen are suitable gases
with argon possessing superior efficacy. For laboratory-scale freeze-dryers, the gases
may be supplied from a gas cylinder or from a liquid dewar in combination with an
appropriately sized vaporizer.
Purge the drying chamber with the same inert gas used for nucleation control 3.
to make sure the majority of the gas atmosphere in the freeze-dryer has the
desired identity.
Pressurize the product chamber with the same inert gas to the highest 4.
pressure permitted by the Maximum Allowable Working Pressure (MAWP) of
the lyophilizer (
e.g. , the MAWP of the LyoStar™ 3 is 28.5 psig). A higher
initial pressure is more favorable for product nucleation.