Rev 006, 01/14
39
© SP Scientific 2014
Chapter
7
Stoppering
The LyoStar™ 3’s stoppering system provides bottom-up shelf collapse allowing you
to fully seat partially inserted stoppers into product vials at the end of a freeze dry
cycle.
A compact hydraulic power unit, mounted below the product chamber, is used to
create the required stoppering pressure. The pump is typically preset to apply enough
force on each shelf to fully stopper three full trays of 5 milliliter (ml) or larger vials.
Note: If you intend to stopper full trays of vials smaller than 5 ml, the stoppering pressure may
need to be increased. This adjustment should only be made by an SP Scientific authorized
service technician. Please contact SP Scientific Service for assistance.
While it is possible to process product in vials of different sizes simultaneously, to
avoid glassware breakage and/or damage to your product never place vials of
different heights on the same shelf.
PROPERTY CAUTION! TO PREVENT GLASSWARE BREAKAGE, DO NOT PLACE VIALS
OF DIFFERENT HEIGHTS ON THE SAME SHELF.
The stoppering mechanism applies significant force to the vials when stoppering,
therefore, SP Scientific does not recommend stoppering partially loaded shelves. In
cases where you only have enough product to process a partially loaded shelf,
consider positioning empty vials and stoppers around the product-filled vials to load
the shelf completely.
Main Components
The main components of the stoppering system for LyoStar™ 3 lyophilizers include a
hydraulic power unit (pump) with internal check valve and pressure gauge, a hydraulic
cylinder and a method of operation such as a rocker switch or stoppering controls
accessible from the control system human-machine interface (HMI).
The hydraulic cylinder rod is attached to the compressing platform. The terminal / top
shelf is stationary, but all other shelves are moveable. The hydraulic cylinder rod
raises and compresses the shelves during the stoppering process. Stoppering is
achieved when the compressing force is fully transferred to the terminal shelf,
pressing the shelves together.
6
Siliconized rubber stoppers are recommended. Standard rubber stoppers used in dry vials will increase the required pressure.
Summary of Contents for LYOSTAR 3
Page 2: ......
Page 6: ...iv Rev 006 01 14 SP Scientific 2014...
Page 10: ...Contents FTS Systems LyoStar 3 viii Rev 006 01 14 SP Scientific 2014...
Page 18: ...Getting Started FTS Systems LyoStar 3 8 Rev 006 01 14 SP Scientific 2014...
Page 30: ...Operating your Lyophilizer FTS Systems LyoStar 3 20 Rev 006 01 14 SP Scientific 2014...
Page 36: ...Liquid Nitrogen Trap FTS Systems LyoStar 3 26 Rev 006 01 14 SP Scientific 2014...
Page 48: ...Sample Extractor Assemblies FTS Systems LyoStar 3 38 Rev 006 01 14 SP Scientific 2014...
Page 52: ...Stoppering FTS Systems LyoStar 3 42 Rev 006 01 14 SP Scientific 2014...
Page 56: ...Shelf Latching FTS Systems LyoStar 3 46 Rev 006 01 14 SP Scientific 2014...
Page 74: ...Appendix A Sample Recipe FTS Systems LyoStar 3 64 Rev 006 01 14 SP Scientific 2014...
Page 80: ...Appendix C Stainless Steel Cleaners FTS Systems LyoStar 3 70 Rev 006 01 14 SP Scientific 2014...
Page 81: ......
