Dionex UltiMate 3000 Series, Operating Instructions Manual

Page: 224 / 236

UltiMate 3000 Series:
SD, RS, and BM Pumps
Page 210 Operating Instructions
12.2 Solvent Miscibility
Miscibility describes the ability of liquids to form homogeneous mixtures in all
proportions (one-phase system). Solvent miscibility is important during elution and when
changing from one solvent to another. Thus, when you prepare solvents consider the
miscibility and homogeneous mixing of the single components. Note that certain
compositions of some solvent systems may result in miscibility gaps.
For information about solvent miscibility, see the table (source: Handbuch der HPLC , GIT
Verlag, 1995). The table provides a general idea of solvent miscibility. Under certain
conditions, non-miscible liquids may mix or miscible liquids may separate.
Name
Acetone
= miscible
Acetonitrile
Benzene
= non-miscible
Butanol
t-Butylmethylether
Cyclohexane
Cyclopentane
Dichloroethane
Dichlorromethane
Di-Ethylether
Dimethylformamide
Dimethylsulfoxide
Dioxan
Di-Propylether
Acetic acid
Ethanol
Ethyl acetate
Heptane
Hexane
Methanol
Methyl ethyl ketone
Octane
Pentane
Propylalcohol
Tetrachloromethane
Tetrahydrofurane
Toluene
1.1.1.
Trichloroethane
Trichloromethane
Water
Xylene
Acetone Acetonitrile Benzene Butanol t-Butylmethylether Cyclohexane Cyclopentane Dichloroethane Dichlorromethane Di-
E
thylether
Dimeth
yl
fo
rmamid
e
Dim
ethylsulf
oxide
Dioxan Di-
Pr
opylether
Acetic acid E
thanol
Ethyl acetate Heptane Hexane M
ethanol
M
ethyl ethyl ketone
Octane Pentane Pr
opylalcohol
Tetrachloromethane T
etr
ahydr
of
ur
ane
Toluene 1.
1.
1.
T
richlor
om
ethane
Water Xylene