2
Preparation and operation
For optimal system performance, you must prepare the solvent manager for operation.
To do so, you must prime the seal wash and then the solvent manager. Be sure to prime all four
solvent lines, the seal wash tubing, and the solvent selection valve tubes (if installed).
Warning:
Observe Good Laboratory Practice (GLP) at all times, particularly when
working with hazardous materials. Consult the Material Safety Data Sheets regarding
the solvents you use. Additionally, consult the safety representative for your
organization regarding its protocols for handling such materials.
Requirement:
To maintain the efficiency of the solvent manager and to obtain accurate,
reproducible chromatograms, use only LC/MS-grade solvents, water, and additives. For details,
see the Solvent Considerations information and
Controlling Contamination in Ultra Performance
LC/MS and HPLC/MS Systems
(part number 715001307).
Notice:
To avoid damaging solvent manager components,
• do not use chloroform, methylene chloride, or toluene;
• do not use ethyl acetate, hexane, or tetrahydrofuran (THF) without the hexane/THF
compatibility kit for ACQUITY UPLC systems;
• do not pressurize solvent reservoirs above 34.5 kPa (0.34 bar, 5 psi).
Recommendation:
For optimal solvent manager performance, ensure that solvent bottles are
elevated above the pump inlet and vented.
2.1 Installation recommendations for fittings
Warning:
Observe Good Laboratory Practice (GLP) at all times, particularly when
working with hazardous materials. Consult the Material Safety Data Sheets regarding
the solvents you use. Additionally, consult the safety representative for your
organization regarding its protocols for handling such materials.
Warning:
To avoid personal contamination with biohazards or compounds that are toxic, wear
clean, chemical-resistant, powder-free gloves when performing this procedure.
Requirement:
Wear clean, chemical-resistant, powder-free gloves when performing
this procedure.
August 8, 2016, 715005050 Rev. C
Page 19
