FurnacePros LA-309, Руководство пользователя

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MSDS No: 203 Date Prepared: 08/01/1987 Current Date: 4/13/2006
Last Revised: (04/13/2006)
Page 7 Of 10
TOXICOLOGY:
A number of toxicological studies designed to identify any potential health effects from RCF exposure have been
completed. In one study, conducted by the Research and Consulting Company, (Geneva, Switzerland), rats and
hamsters were exposed to 30 mg/m³ (about 200 fibers/cc) of specially-prepared RCF for 6 hours/day, 5 days/week, for
up to 24 months. In rats, a statistically significant increase in lung tumors was observed; two mesotheliomas (cancer of
the pleural lining between the chest wall and lung) were also identified. Hamsters did not develop lung tumors;
however, interstitial fibrosis and mesothelioma was found. Some, in the scientific community, have concluded that the
“maximum tolerated dose” was exceeded and that significant particle contamination was a confounding issue; therefore,
these study findings may not represent an accurate assessment of the potential for RCF to produce adverse health
effects.
In a related multi-dose study with a similar protocol, other rats were exposed to doses of 16 mg/m³, 9 mg/m³, 3 mg/m³
which corresponds to about 115, 75, and 25 fibers per cubic centimeter respectively. This study found no statistically
significant increase in lung cancer. Some cases of pleural and parenchymal fibrosis were seen in the 16 mg/m³ dose
group. Some cases of mild fibrosis and one mesothelioma were observed in the 9 mg/m³ group. No acute respiratory
effects were seen in the rats in the 3 mg/m³ exposure group, which suggests that there may be a dose/response
threshold, below which irreversible respiratory impacts do not occur.
Other toxicological studies have been conducted which utilized non-physiological exposure methods such as
intrapleural, intraperitoneal and intratracheal implantation or injection. Some of these studies have found that RCF is a
potential carcinogen. Some experts, however, suggest that these tests have limited relevance because they bypass
many of the biological mechanisms that prevent fiber deposition or facilitate fiber clearance.
Silica, amorphous: Toxic effects described in animals from single inhalation exposures of amorphous silica include
upper respiratory irritation, lung congestion, bronchitis, and emphysema. Repeated inhalation exposures at
concentration of 50 or 150 mg/m
3
produced increased lung weights and lung changes. No progressive pulmonary
fibrosis was seen and the observed lung changes were reversible. No adverse effects were observed in this study at 10
mg/m
3
. No animal test reports are available to define the carcinogenic, mutagenic, or reproductive effects.
To obtain more epidemiology or toxicology information, please call the toll free telephone number for the Thermal
Ceramics Product Stewardship Program found in Section 16 - Other Information.
12. ECOLOGICAL INFORMATION
No ecological concerns have been identified.
13. DISPOSAL CONSIDERATIONS
WASTE MANAGEMENT:
To prevent waste materials from becoming airborne during waste storage, transportation and disposal, a covered
container or plastic bagging is recommended.
DISPOSAL:
RCF, as manufactured, is not classified as a hazardous waste according to Federal regulations (40 CFR 261). As
manufactured, RCF was tested using EPA’s Toxicity Characteristic Leaching Procedure (TCLP). Results showed there
were no detectable contaminants or detectable leachable contaminants that exceeded the regulatory levels. Any
processing, use, alteration or chemical additions to the product, as purchased, may alter the disposal requirements.
Under Federal regulations, it is the waste generator's responsibility to properly characterize a waste material, to
determine if it is a "hazardous" waste. Check local, regional, state or provincial regulations to identify all applicable
disposal requirements.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION (DOT)
Hazard Class: Not Regulated United Nations (UN) Number: Not Applicable
Labels: Not Applicable North America (NA) Number: Not Applicable
Placards: Not Applicable Bill of Lading: Product Name