Millipore Sigma Pellicon 3 Cassettes Installation And User Manual Download Page 1

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Contents

Introduction ..................................... 2

Membrane Type ........................... 2
Pump Capacity ............................ 2
Water Quality .............................. 2

Installation ...................................... 2

Pellicon

3 88 cm

and 0.11 m

Cassette Holder Installation ........... 2
Pellicon

3 0.57 or 1.14 m

Cassette

Benchtop Holder Installation .......... 3
Manual Process-Scale Holder

Installation ................................. 4
Hydraulic Process Scale Holder

Installation ................................. 5

Maintenance ................................... 7

Flushing and Cleaning ....................... 7

Flushing ..................................... 8
Cleaning ..................................... 8

Sanitization ..................................... 9

Depyrogenation .............................. 10

Integrity Testing ............................. 10

Measurement of Normalized Water

Permeability................................... 11

Storage ......................................... 12

Troubleshooting .............................. 14

Warranty ....................................... 15

The life science business of Merck KGaA, Darmstadt,

Germany operates as MilliporeSigma in the U.S. and Canada.

Pellicon

3 Cassettes

Installation and User

Guide

Summary of Contents for Pellicon 3 Cassettes

Page 1: ...ale Holder Installation 4 Hydraulic Process Scale Holder Installation 5 Maintenance 7 Flushing and Cleaning 7 Flushing 8 Cleaning 8 Sanitization 9 Depyrogenation 10 Integrity Testing 10 Measurement of...

Page 2: ...TE Pellicon 3 88 cm2 and 0 11 m2 Cassettes must be installed in a Pellicon Cassette Holder Catalog Number XX42PMINI Holder Installation 1 Loosen the nuts on the tie rods of the holder and remove the n...

Page 3: ...wipe 4 Slide the manifold adapter plate onto the holder against the holder s manifold plate with the solid light grey side labeled Manifold Side towards the manifold and the wings resting on the tie...

Page 4: ...ary Tri Clover connection Pellicon Cassette hex nut washer stainless steel bushing handle PERMEATE RETENTATE FEED Pellicon10_2_06_2 eps Gasket Plate manifold adapter plate nut PERMEATE R E T E N T A T...

Page 5: ...wrench and 15 16 in deep hex socket turn each nut 1 8 turn in the sequence shown in Figure 4 When the wrench clicks this indicates that the set force has been reached DO NOT OVER TORQUE Evenness of to...

Page 6: ...d tight 4 Turn on the air supply to the Hydraulic Power Unit A minimum of 80 psig air pressure should be available Check the air pressure on the pressure gauge PI 1 on Hydraulic Power Unit front panel...

Page 7: ...ut replacement of nuts and washers should be considered after every ten installations to maintain high sealing force in the holder 7 When new nuts do not spin freely refurbish the threaded rods with a...

Page 8: ...se the tank drain valve V1 and the tank valve V2 2 Fill the tank with the flushing solution 3 Fully open the retentate valve V4 and permeate valve V5 if present and direct both the retentate and filtr...

Page 9: ...iofilms Biopolymer Proteins and Polyphenolic Membrane Cleaning Agent Concentration Temperature C pH Time min Ultracel NaOH 0 1 N 0 5 N 25 50 13 13 7 30 60 Biomax NaOH 0 1 N 0 5 N 25 50 13 13 7 30 60 N...

Page 10: ...c Acid 0 1M 30 50 1 30 NaOH 0 1N 25 50 13 30 Ultracel NaOH 0 1N 25 50 13 30 Use milder conditions if effectiveness of agent is still observed Better membrane life is expected with lower concentration...

Page 11: ...l the tank with filtered deionized water water for injection or reverse osmosis permeate The flush water must be extremely pure to avoid fouling the membranes or introducing other contaminants into th...

Page 12: ...0 40 0 734 75 2 24 1 023 46 4 8 1 551 102 2 39 0 748 73 4 23 1 047 44 6 7 1 598 100 4 38 0 762 71 6 22 1 072 42 8 6 1 648 98 6 37 0 777 69 8 21 1 098 41 0 5 1 699 Based on Water Fluidity Relative to...

Page 13: ...ess compression and ensures that the units will not leak externally NOTE The storage agent used must comply with applicable local regulations Recommended Storage Solutions for Pellicon 3 Cassette Filt...

Page 14: ...completely flushed Flush system and cassette System and cassette not completely cleaned Clean system and cassette Symptom Possible Cause Remedy High NWP Damage to membrane or cassette Integrity test...

Page 15: ...xed below fluid air interface Vortex in feed container Add baffle to break vortex or reduce mixing speed Retentate splashing Fix retentate line below fluid in feed air interface container Pump cavitat...

Page 16: ...atory matters to the best of our knowledge and ability but without obligation or liability Existing laws and regulations are to be observed in all cases by our customers This also applies in respect t...

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